期刊
FUTURE ONCOLOGY
卷 11, 期 17, 页码 2427-2441出版社
FUTURE MEDICINE LTD
DOI: 10.2217/fon.15.175
关键词
ceRNA; gastric cancer; H19; HOTAIR; lncRNA
类别
资金
- National Natural Science Foundation of China [81301996, 81272676]
- National Science and Technology Major Project of Ministry of Science and Technology of China [2013ZX09506015]
- PhD Programs Foundation of Ministry of Education of China [20130101120017]
- Zhejiang Provincial Natural Science Foundation of China [LQ13H160012]
- Medical Science and Technology Project of Department of Health of Zhejiang Provincial Government [2013KYA070]
- Medical Science and Technology Project of Zhejiang Province [2011ZDA009]
Long noncoding RNAs (lncRNAs) recently have been recognized as having a critical role in cancer development and progression. Gastric cancer remains a major clinical challenge worldwide owing to poor prognosis and limited treatment options. Accumulating studies have demonstrated that lncRNAs may play an active role in tumorigenesis, metastasis, prognosis and drug resistance of gastric cancer. Here, we collect recent knowledge to show differential expression of lncRNA in gastric cancer and their underlying mechanism of activities in gastric cancer involved in epigenetic, transcription and post-transcriptional processing. This review focuses on the regulation and function of gastric cancer-related lncRNAs and provides an overview of current effects to exploit them to be potential biomarkers and therapeutic targets for gastric cancer.
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