期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 23, 期 -, 页码 388-396出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/4596
关键词
MicroRNA-181a; Autophagy; Atg5; Hepatocellular Carcinoma
资金
- Surface Project of Wuxi Health and Family Planning Commission [MS201648]
Available evidence suggests that autophagy may serve as a tumor suppressor in cases of chronic liver disease and liver cirrhosis and that autophagic deficiency may lead to hepatocellular carcinoma (HCC). Recent studies suggested that the development of several tumor types could be regulated by microRNA-181a. However, the role of miR-181a in the autophagy of HCC remains unclear. In this study, we aimed to investigate the role of miR-181a in the autophagy of HCC. We found that the mRNA expression of miR-181 a is higher but the level of autophagy is lower in human HCC compared to normal liver tissue. A luciferase assay confirmed that Atg5 is the target gene of miR-181a. Moreover, the results showed that an miR-181a sponge increased apoptosis in HepG2 cells and reduced the growth of tumors in a HepG2 cell xenograft tumor model In conclusion, these results suggest that miR-181a can inhibit autophagy in HCC by targeting Atg5, resulting in decreased apoptosis of HCC cells and increased tumor growth.
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