Review
Biochemistry & Molecular Biology
Julio C. Padovan, Thales M. H. Dourado, Gustavo F. Pimenta, Thiago Bruder-Nascimento, Carlos R. Tirapelli
Summary: High consumption of ethanol increases the risk of cardiovascular diseases, particularly arterial hypertension. Ethanol-induced hypertension is a complex event involving oxidative stress as a hallmark of vascular dysfunction. Reactive oxygen species (ROS) play a crucial role in triggering various pathological processes, including intracellular calcium accumulation, reduced bioavailability of nitric oxide, activation of mitogen-activated protein kinases, endothelial dysfunction, and loss of the anticontractile effect of perivascular adipose tissue.
Article
Biochemistry & Molecular Biology
Jorge R. Soliz-Rueda, Raul Lopez-Fernandez-Sobrino, Cristina Torres-Fuentes, Francisca I. Bravo, Manuel Suarez, Miquel Mulero, Begona Muguerza
Summary: Changes in light/dark cycles and obesogenic diets are related to the disruption of circadian rhythms and metabolic disorders. Grape seed flavanols have shown beneficial effects on metabolic diseases and recently a circadian system modulation has been suggested to mediate their health-enhancing properties.
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Article
Biochemistry & Molecular Biology
Albino Carrizzo, Concetta Iside, Angela Nebbioso, Vincenzo Carafa, Antonio Damato, Sebastiano Sciarretta, Giacomo Frati, Flavio Di Nonno, Valentina Valenti, Michele Ciccarelli, Eleonora Venturini, Mariarosaria Scioli, Paola Di Pietro, Tommaso Bucci, Valentina Giudice, Marianna Storto, Bianca Serio, Annibale Alessandro Puca, Giuseppe Giugliano, Valentina Trimarco, Raffaele Izzo, Bruno Trimarco, Carmine Selleri, Lucia Altucci, Carmine Vecchione
Summary: In addition to well-known risk factors, cardiovascular events may also be associated with epigenetic and genetic alterations. This study found that the MTHFR C677T gene variant is related to increased cardiovascular risk. Interestingly, even with normal homocysteine levels, heterozygous carriers of this gene variant have an augmented risk of cardiovascular accidents, suggesting the presence of additional deregulated processes. The study suggests that targeting SIRT1 activation could be a new therapeutic strategy to control cardiovascular risk in MTHFR carriers.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yao Li, Damir Kracun, Christopher M. Dustin, Mohamed El Massry, Shuai Yuan, Christian J. Goossen, Evan R. DeVallance, Sanghamitra Sahoo, Cynthia St Hilaire, Aditi U. Gurkar, Toren Finkel, Adam C. Straub, Eugenia Cifuentes-Pagano, Patrick J. Pagano
Summary: In an investigation into signaling triggered by aging and hyperglycemia, researchers found that NADPH Oxidase (NOX) plays a crucial role in driving cell damage, inflammation, and cellular senescence. Inhibiting NOX1 can reverse age-related impairments in blood flow and angiogenesis, as well as disrupt proinflammatory signaling associated with senescence. Targeting the NOX1-SASP signaling axis is predicted to be an effective strategy for mitigating vascular and organ system senescence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Elizabeth A. Sweeny, Andrew P. Hunt, Allison E. Batka, Simon Schlanger, Nicolai Lehnert, Dennis J. Stuehr
Summary: Nitric oxide (NO) serves as a ubiquitous cell signaling molecule, mediating various processes by activating or inactivating protein targets. Research shows that NO can increase NOX5 activity through heme-dependent effects, shedding light on NOX5 regulation and the impact of NO on hemeprotein activity.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jennifer A. Davis, Jodi R. Paul, Stefani D. Yates, Elam J. Cutts, Lori L. McMahon, Jennifer S. Pollock, David M. Pollock, Shannon M. Bailey, Karen L. Gamble
Summary: Changing meal timing can rescue the cognitive and hippocampal impairments induced by HFD, even without altering body composition and total caloric intake. This suggests that short-term time-restricted feeding is an effective intervention for HFD-induced cognitive deficits and hippocampal dysfunction.
Review
Endocrinology & Metabolism
Xuemin Peng, Yong Chen
Summary: The relationship between circadian rhythms and thermogenic fat and its potential in treating obesity.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sanjeev Kumar Soni, Priyoneel Basu, Muniyandi Singaravel, Ramaswamy Sharma, Seithikurippu R. Pandi-Perumal, Daniel. P. Cardinali, Russel J. Reiter
Summary: SIRT1 plays a crucial role in regulating cardioprotection through modulating the activity of CLOCK, a core clock gene. It has protective effects in preventing atherosclerotic plaque formation, shielding the heart from oxidative damage, but elevated levels may lead to cardiac hypertrophy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Editorial Material
Cell Biology
Susmita Kaushik, Yves R. Juste, Ana Maria Cuervo
Summary: The circadian clock and chaperone-mediated autophagy (CMA) have an interdependent relationship. CMA selectively degrades core clock proteins, modulating circadian rhythm. Loss of CMA disrupts physiological circadian cycling, similar to defects observed in aging. The circadian clock temporally regulates CMA activity in different tissues, contributing to remodeling of a distinct subproteome at different times.
Article
Biochemistry & Molecular Biology
Luba Sominsky, Tamara Dangel, Sajida Malik, Simone N. De Luca, Nicolas Singewald, Sarah J. Spencer
Summary: Microglia play essential roles not only in immune defense but also in regulating satiety, memory, and pain responses. These functions are significantly influenced by circadian rhythmicity, impacting various physiological processes throughout the day.
Review
Cell Biology
Francesca Fagiani, Marieva Vlachou, Daniele Di Marino, Ilaria Canobbio, Alice Romagnoli, Marco Racchi, Stefano Govoni, Cristina Lanni
Summary: Pin1 functions as a key regulator of vascular homeostasis by modulating nitric oxide bioavailability and influencing various pathways involved in vascular diseases. Understanding the role of Pin1 in vascular endothelium could provide new insights for potential therapeutic strategies in vascular pathologies and neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Jing Cao, Guogang Zhang, Zhaoya Liu, Qian Xu, Chan Li, Guangjie Cheng, Ruizheng Shi
Summary: PXDN plays a role in AGEs-induced diabetic vascular endothelial dysfunction by inhibiting eNOS phosphorylation through the NOX2/HOCl/Akt pathway.
Article
Urology & Nephrology
Nima Abbasian, James O. Burton, Karl E. Herbert, Barbara-Emily Tregunna, Jeremy R. Brown, Maryam Ghaderi-Najafabadi, Nigel J. Brunskill, Alison H. Goodall, Alan Bevington
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2015)
Review
Pharmacology & Pharmacy
Meetal Solanki, Amy Pointon, Barry Jones, Karl Herbert
DRUG METABOLISM AND DISPOSITION
(2018)
Article
Biochemistry & Molecular Biology
William Dott, Jayne Wright, Kelvin Cain, Pratibha Mistry, Karl E. Herbert
Article
Cardiac & Cardiovascular Systems
Karl E. Herbert, Yogita Mistry, Richard Hastings, Toryn Poolman, Laura Niklason, Bryan Williams
CIRCULATION RESEARCH
(2008)
Article
Cardiac & Cardiovascular Systems
W. Richard W. Wilson, Karl E. Herbert, Yogita Mistry, Suzanne E. Stevens, Hash R. Patel, Richard A. Hastings, Matthew M. Thompson, Bryan Williams
EUROPEAN HEART JOURNAL
(2008)
Article
Surgery
S. Ehsan, G. Ball, E. Choke, K. M. Molyneux, N. J. M. London, K. E. Herbert, J. Barratt, R. D. Sayers, M. J. Bown
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2012)
Correction
Surgery
S. Ehsan, G. Ball, E. Choke, K. M. Molyneux, N. J. M. London, K. E. Herbert, J. Barratt, R. D. Sayers, M. J. Bown
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2013)
Review
Biochemistry & Molecular Biology
Qudsia Malik, Karl E. Herbert
FREE RADICAL RESEARCH
(2012)
Editorial Material
Endocrinology & Metabolism
D. R. Webb, K. Herbert, Melanie J. Davies, K. Khunti, N. Sattar, C. D. A. Stehouwer
JOURNAL OF DIABETES RESEARCH
(2013)
Article
Biochemistry & Molecular Biology
Yogita Mistry, Toryn Poolman, Bryan Williams, Karl E. Herbert
Article
Biochemistry & Molecular Biology
William Dott, Pratibha Mistry, Jayne Wright, Kelvin Cain, Karl E. Herbert
Article
Nutrition & Dietetics
KE Herbert, S Fletcher, D Chauhan, A Ladapo, J Nirwan, S Munson, P Mistry
EUROPEAN JOURNAL OF NUTRITION
(2006)
Review
Cardiac & Cardiovascular Systems
Karl E. Herbert, Clett Erridge
CARDIOVASCULAR RESEARCH
(2018)
Letter
Oncology
J. Abu, M. Batuwangala, P. Symonds, K. Herbert
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)