Lycorine-derived phenanthridine downregulators of host Hsc70 as potential hepatitis C virus inhibitors

Directly Acting Antivirals (DAAs) for the Treatment of Chronic Hepatitis C Virus Infection in Liver Transplant Patients: “A Flood of Opportunity”

(2014) E. J. Gane et al.   AMERICAN JOURNAL OF TRANSPLANTATION

The Combination of Alisporivir plus an NS5A Inhibitor Provides Additive to Synergistic Anti-Hepatitis C Virus Activity without Detectable Cross-Resistance

(2014) Udayan Chatterji et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Hepatitis C virus NS5A inhibitors and drug resistance mutations

(2014) Shingo Nakamoto   WORLD JOURNAL OF GASTROENTEROLOGY

Viral Resistance in Hepatitis C Virus Genotype 1-Infected Patients Receiving the NS3 Protease Inhibitor Faldaprevir (BI 201335) in a Phase 1b Multiple-Rising-Dose Study

(2013) Kristi L. Berger et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Natural Compound Cantharidin Induces Cancer Cell Death through Inhibition of Heat Shock Protein 70 (HSP70) and Bcl-2-associated Athanogene Domain 3 (BAG3) Expression by Blocking Heat Shock Factor 1 (HSF1) Binding to Promoters

(2013) Joo Ae Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Geldanamycin-Induced Osteosarcoma Cell Death Is Associated with Hyperacetylation and Loss of Mitochondrial Pool of Heat Shock Protein 60 (Hsp60)

(2013) Magdalena Gorska et al.   PLoS One

Progress in the development of anti-hepatitis C virus nucleoside and nucleotide prodrugs

(2012) Karolina Madela et al.   Future Medicinal Chemistry

Inhibition of Hepatitis C Virus NS3 Helicase by Manoalide

(2012) Kazi Abdus Salam et al.   JOURNAL OF NATURAL PRODUCTS

Comprehensive review on the HSC70 functions, interactions with related molecules and involvement in clinical diseases and therapeutic potential

(2012) Tuoen Liu et al.   PHARMACOLOGY & THERAPEUTICS

Recent Advances in Developing Small Molecules Targeting RNA

(2011) Lirui Guan et al.   ACS Chemical Biology

Comparative Study of the Genetic Barriers and Pathways towards Resistance of Selective Inhibitors of Hepatitis C Virus Replication

(2011) Leen Delang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Small molecular compounds that inhibit hepatitis C virus replication through destabilizing heat shock cognate 70 messenger RNA

(2010) Zong-Gen Peng et al.   HEPATOLOGY

Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges

(2009) Hui Li et al.   Future Medicinal Chemistry

The heat shock cognate protein 70 is associated with hepatitis C virus particles and modulates virus infectivity

(2009) Romain Parent et al.   HEPATOLOGY

Lycorine, the Main Phenanthridine Amaryllidaceae Alkaloid, Exhibits Significant Antitumor Activity in Cancer Cells That Display Resistance to Proapoptotic Stimuli: An Investigation of Structure−Activity Relationship and Mechanistic Insight

(2009) Delphine Lamoral-Theys et al.   JOURNAL OF MEDICINAL CHEMISTRY

New lycorine-type alkaloid from Lycoris traubii and evaluation of antitrypanosomal and antimalarial activities of lycorine derivatives

(2008) Yosuke Toriizuka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A single-amino acid substitution in West Nile virus 2K peptide between NS4A and NS4B confers resistance to lycorine, a flavivirus inhibitor

(2008) Gang Zou et al.   VIROLOGY