期刊
FUTURE MEDICINAL CHEMISTRY
卷 7, 期 16, 页码 2143-2171出版社
FUTURE SCI LTD
DOI: 10.4155/fmc.15.136
关键词
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Photoaffinity labeling is a well-known biochemical technique that has grown significantly since the turn of the century, principally due to its combination with bioorthogonal/click chemistry reactions. This review highlights new developments and applications of clickable photoprobes in medicinal chemistry and chemical biology. In particular, recent examples of clickable photoprobes for target identification, activity- or affinity-based protein profiling (ABPP or AfBPP), characterization of sterol- or lipid-protein interactions and characterization of ligand-binding sites are presented.
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