Research progress of indoleamine 2,3-dioxygenase inhibitors

Synthesis and biological evaluation of novel tryptoline derivatives as indoleamine 2,3-dioxygenase (IDO) inhibitors

(2013) Minoru Tanaka et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Indoleamine 2,3-dioxygenase inhibitors: a patent review (2008 – 2012)

(2013) Eduard Dolušić et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Lignans from Carthamus tinctorius suppress tryptophan breakdown via indoleamine 2,3-dioxygenase

(2013) Susanne Kuehnl et al.   PHYTOMEDICINE

Interaction of Carthamus tinctorius lignan arctigenin with the binding site of tryptophan-degrading enzyme indoleamine 2,3-dioxygenase

(2013) Veronika Temml et al.   FEBS Open Bio

Natural Product-Inspired Pyranonaphthoquinone Inhibitors of Indoleamine 2,3-Dioxygenase-1 (IDO-1)

(2012) David J. A. Bridewell et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Indoleamine 2,3-dioxygenase inhibitory activity of derivatives of marine alkaloid tsitsikammamine A

(2012) Eduard Dolušić et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

(2012) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors

(2011) David Meininger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis and inhibition study of monoamine oxidase, indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by 3,8-substituted 5H-indeno[1,2-c]pyridazin-5-one derivatives

(2011) J. Reniers et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors

(2011) Eduard Dolušić et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structure–activity relationship and enzyme kinetic studies on 4-aryl-1H-1,2,3-triazoles as indoleamine 2,3-dioxygenase (IDO) inhibitors

(2011) Qiang Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In Vitro Modulation of Cytochrome P450 Reductase Supported Indoleamine 2,3-Dioxygenase Activity by Allosteric Effectors Cytochromeb5and Methylene Blue

(2010) Josh T. Pearson et al.   BIOCHEMISTRY

S-Benzylisothiourea derivatives as small-molecule inhibitors of indoleamine-2,3-dioxygenase

(2010) Kenji Matsuno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity

(2010) X. Liu et al.   BLOOD

The first step of the dioxygenation reaction carried out by tryptophan dioxygenase and indoleamine 2,3-dioxygenase as revealed by quantum mechanical/molecular mechanical studies

(2010) Luciana Capece et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Rational Design of Indoleamine 2,3-Dioxygenase Inhibitors

(2010) Ute F. Röhrig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hydroxyamidine Inhibitors of Indoleamine-2,3-dioxygenase Potently Suppress Systemic Tryptophan Catabolism and the Growth of IDO-Expressing Tumors

(2010) H. K. Koblish et al.   MOLECULAR CANCER THERAPEUTICS

Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase

(2009) Sara A. Rafice et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Selenazal Drug Ebselen Potently Inhibits Indoleamine 2,3-Dioxygenase by Targeting Enzyme Cysteine Residues

(2009) Andrew C. Terentis et al.   BIOCHEMISTRY

Discovery of Potent Competitive Inhibitors of Indoleamine 2,3-Dioxygenase with in Vivo Pharmacodynamic Activity and Efficacy in a Mouse Melanoma Model

(2009) Eddy W. Yue et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitory Substrate Binding Site of Human Indoleamine 2,3-Dioxygenase

(2009) Changyuan Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Genotyping and Expression Analysis of IDO2 in Human Pancreatic Cancer: A Novel, Active Target

(2009) Agnieszka K. Witkiewicz et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease

(2008) Antonio Macchiarulo et al.   AMINO ACIDS

Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors

(2008) Hitomi Nakashima et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Expression and prognosis role of indoleamine 2,3-dioxygenase in hepatocellular carcinoma

(2008) Ke Pan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

The missing link between indoleamine 2,3-dioxygenase mediated antibacterial and immunoregulatory effects

(2008) Anika Müller et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Indoleamine 2,3-Dioxygenase Is the Anticancer Target for a Novel Series of Potent Naphthoquinone-Based Inhibitors

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Indoleamine 2,3-Dioxygenase Inhibitory Analogues of the Sponge Alkaloid Exiguamine A

(2008) Gavin Carr et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Based Development of Phenylimidazole-Derived Inhibitors of Indoleamine 2,3-Dioxygenase

(2008) Sanjeev Kumar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biomimetic synthesis of the IDO inhibitors exiguamine A and B

(2008) Matthew Volgraf et al.   Nature Chemical Biology