4.7 Article

Elaboration of curcumin-loaded rice bran albumin nanoparticles formulation with increased in vitro bioactivity and in vivo bioavailability

期刊

FOOD HYDROCOLLOIDS
卷 77, 期 -, 页码 834-842

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.foodhyd.2017.11.027

关键词

Rice bran albumin; Curcumin; Nanoparticles; Bioactivity; Bioavailability

资金

  1. National Natural Science Foundation of China [31571874]
  2. Grain-oil Process and Quality Control Collaborative and Innovative Grant from Hunan Province [2013448]
  3. Special Fund for Agro-Scientific Research in the Public Interest [201303071-05]

向作者/读者索取更多资源

Curcumin, a yellow pigment present in the spice turmeric (Curcuma longa), has been linked with various bioactivities, but its optimum potential is limited by its lack of dispersibility in aqueous solvents and poor oral bioavailability. Here, we employed a protein-based nanoparticle approach to improve bioactivity and bioavailability. Curcumin was encapsulated with 95.94% efficiency in biodegradable nanoparticulate formulation based on rice bran albumin (RBA). The mean particle diameter and zeta-potential of curcumin-loaded RBA nanoparticles (Cur-RBA-NPs) were 120 nm and -36.3 mV, respectively. The in vitro bioactivity and in vivo bioavailability of Cur-RBA-NPs were evaluated. The results indicated that the in vitro bioactivities (antioxidant activity, anti-inflammatory activity, and anti-proliferative activity on tumor cells) of Cur-RBA-NPs were superior to those of free curcumin, respectively. Moreover, Cur-RBA-NPs significantly enhanced the bioavailability of curcumin in rats as compared with free curcumin. Besides, the results clearly indicated the promise of RBA-based nanoparticles for oral delivery of poorly bioavailable molecules like curcumin. (C) 2017 Elsevier Ltd. All rights reserved.

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