Review
Chemistry, Medicinal
Ashwani Kumar, Meenakshi Bhatia, Archana Kapoor, Parvin Kumar, Sunil Kumar, Sunil Kumar
Summary: Monoamine oxidase enzyme plays an essential role in brain function regulation, with its inhibitors showing potential in the treatment of neurological disorders. Reversible MAO inhibitors, which have been recently studied, may serve as safer alternatives to old monoamine oxidase inhibitors.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Neurosciences
Steven M. Graves, Sarah E. Schwarzschild, Rex A. Tai, Yu Chen, D. James Surmeier
Summary: Abusing methamphetamine is linked to a higher risk of developing Parkinson's disease by increasing mitochondrial oxidant stress in SNc dopaminergic neurons. This damage was confirmed by observing degeneration in these neurons after chronic methamphetamine use, which could be prevented by inhibiting MAO. Shorter bouts of methamphetamine use also caused oxidative stress and degeneration, with different sensitivities to MAO and Cav1 Ca2+ channel inhibition, pointing towards potential pharmacological strategies to reduce the risk of PD in patients with methamphetamine use disorder.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Behavioral Sciences
Xiaoyu Pan, Ling Chen, Wen Xu, Shihui Bao, Jun Wang, Xiao Cui, Shichao Gao, Kaiping Liu, Shivani Avasthi, Meixi Zhang, Ruijie Chen
Summary: J147 demonstrated antidepressant- and anxiolytic-like effects in mouse models, potentially through increasing serotonin and noradrenaline levels.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Clinical Neurology
Elze R. Timmers, Martijn van Faassen, Marenka Smit, Anouk Kuiper, Ingrid H. Hof, Ido P. Kema, Marina A. J. Tijssen, Klary E. Niezen-Koning, Tom J. de Koning
Summary: This study revealed alterations in dopaminergic and serotonergic metabolism in patients with dystonia, with subtype-specific changes. Low levodopa concentrations, but not serotonin metabolites, were associated with both motor and non-motor symptoms.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Behavioral Sciences
Emmanuelle Courtiol, Edenia C. Menezes, Catia M. Teixeira
Summary: Serotonin plays a critical role in development and behavior, with its involvement in reward being a topic of debate. Classical studies using electrical stimulation and pharmacological approaches have produced contradictory results on the role of serotonin in reward. More recent optogenetic studies suggest that activation of the serotonergic cells in the Raphe to VTA pathway can mediate reinforcement learning through the excitation of dopaminergic neurons. Understanding the interaction between the serotonergic and dopaminergic systems is crucial for insights into neuropsychiatric disorders.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Chemistry, Medicinal
Wen Wang, Kate M. Voss, Jinqian Liu, Mikhail F. Gordeev
Summary: The newly developed oral oxazolidinone compound contezolid and its injectable prodrug contezolid acefosamil showed significantly reduced propensity to induce MAO-related serotonergic neurotoxicity in experiments, with no observed neurotoxicity or significant increase in blood pressure in mice and rats.
CHEMICAL RESEARCH IN TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Chunpu Li, Mingbo Su, Wei Zhu, Weijuan Kan, Tianpeng Ge, Gaoya Xu, Shuni Wang, Li Sheng, Feng Gao, Yunfei Ye, Jiang Wang, Yubo Zhou, Jia Li, Hong Liu
Summary: In this study, a series of potent and selective LSD1 inhibitors were designed by analyzing the binding site of LSD1 and other FAD-dependent enzymes. Compound 7e showed selective antiproliferative activities against MV-4-11 cell lines and had the ability to activate CD86 expression and induce differentiation of AML cell lines. This research provides a promising lead compound for the development of novel LSD1 inhibitors for the treatment of AML.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Leon Jesus German-Ponciano, Gilberto Uriel Rosas-Sanchez, Jonathan Cueto-Escobedo, Rafael Fernandez-Demeneghi, Gabriel Guillen-Ruiz, Cesar Soria-Fregozo, Emma Virginia Herrera-Huerta, Juan Francisco Rodriguez-Landa
Summary: Depressive disorders are a highly disabling global disease, with increasing incidence in recent decades. Flavonoids hold promise as potential antidepressants, with mechanisms that are not fully understood. Individuals with depression have low levels of serotonin and BDNF, which can be reversed by flavonoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Cem Yamali, Halise Inci Gul, Mehtap Tugrak Sakarya, Begum Nurpelin Saglik, Abdulilah Ece, Goksun Demirel, Merve Nenni, Serkan Levent, Ahmet Cihat Oner
Summary: This study synthesized a series of 4-((2-(aryl)-4-oxoquinazolin-3(4H)-yl)amino) benzenesulfonamides and investigated their inhibition potentials against MAOs. The most potent compounds 7 and 8 showed high selectivity and reversibility towards MAO-A, suggesting their potential as therapeutic agents for neurodegenerative diseases.
BIOORGANIC CHEMISTRY
(2022)
Article
Psychiatry
Keren Nitzan, Dekel David, Motty Franko, Roni Toledano, Sharon Fidelman, Yaarit Simchon Tenenbaum, Maya Blonder, Shir Armoza-Eilat, Alon Shamir, Moshe Rehavi, Yair Ben-chaim, Ravid Doron
Summary: Depression and anxiety disorders are common, and traditional Chinese medicine can be a safe and effective alternative to conventional drugs. Shan Zha, a herb that is sold as a nutritional supplement, has been found to have similar anxiolytic and antidepressant effects as conventional drugs by activating 5-HT1A receptors and increasing BDNF levels. Its transition to clinical trials may be easier due to its availability as a nutritional supplement.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Neurosciences
Benjamin Malcolm, Kelan Thomas
Summary: This review evaluates the risks of serotonin toxicity (ST) when combining psychedelics with available serotonergic pharmacotherapy options, describing signs and symptoms of ST, mechanisms of ST risk, known information about serotonergic psychedelic drug interactions, and potential management strategies. The severity of serotonin-related adverse reactions ranges from serotonin syndrome being the most severe manifestations of ST, and the varying serotonergic mechanisms of psychedelics and psychotropics suggest that some combinations may pose a significant risk for ST while others are likely benign.
PSYCHOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yangjing Lv, Zhiyuan Zheng, Renzheng Liu, Jianan Guo, Changjun Zhang, Yuanyuan Xie
Summary: This review summarizes the structure-activity relationship (SAR) of MAO-B inhibitors based on naturally privileged scaffolds over the past 20 years. It discusses the advantages and limitations of natural scaffold-based MAO-B inhibitors and provides a future perspective in drug development.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Medicinal
Maria J. Matos, Paula Novo, Lucia Mayan, Iria Torres, Eugenio Uriarte, Matilde Yanez, Jose Angel Fontenla, Francesco Ortuso, Stefano Alcaro, Francesca Procopio, Maria Isabel Rodriguez-Franco, Cristina Val, Maria I. Loza, Jose Brea, Fernanda Borges, Dolores Vina
Summary: Psychiatric and neurological disorders affect millions of people worldwide, and current treatments are limited in their effectiveness. New therapeutic solutions are urgently needed to improve the lives of patients.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Neurosciences
Alan F. Sved, Jillian J. Weeks, Anthony A. Grace, Tracy T. Smith, Eric C. Donny
Summary: Cigarette smoking reduces MAO activity, enhancing the addictive properties of nicotine. Low-dose nicotine self-administration is increased by MAO inhibition. The impact of MAO inhibition should be considered in VLNC cigarettes and tobacco product regulation, especially in vulnerable populations with nicotine addiction.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Muhammad Shahid Nadeem, Jalaluddin Azam Khan, Umer Rashid
Summary: The study focuses on synthesizing multi-target compounds that can inhibit both cholinesterases and monoamine oxidase. A series of fluoxetine and sertraline hybrids showed excellent inhibition activity, with compounds 17 and 22 potentially blocking neurodegenerative effects in mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Verena Krauth, Ferdinando Bruno, Simona Pace, Paul M. Jordan, Veronika Temml, Maria Preziosa Romano, Haroon Khan, Daniela Schuster, Antonietta Rossi, Rosanna Filosa, Oliver Werz
Summary: 5-Lipoxygenase (LO) is a key enzyme in the formation of pro-inflammatory leukotrienes (LT) that are important mediators in allergic reactions and inflammatory disorders. In this study, modifications were made to catechol derivatives to increase their effectiveness as selective 5-LO inhibitors. Two compounds, 3,4-dihydroxy-3 '-phenoxybiphenyl (6b) and 2-(3,4-dihydroxyphenyl)benzo[b]thiophene (6d), showed potent inhibition of human 5-LO in both cell-free and cell-based assays. Furthermore, these compounds were effective in inhibiting 5-LO in human blood and in a murine peritonitis model. These novel catechol derivatives have high selectivity and effectiveness as inhibitors of 5-LO under pathophysiological conditions.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Sajad Fakhri, Ebrahim Darvish, Fatemeh Narimani, Seyed Zachariah Moradi, Fatemeh Abbaszadeh, Haroon Khan
Summary: Neurodegenerative diseases are increasing globally, making it crucial to uncover the precise pathophysiological mechanisms and develop novel therapeutic strategies. Non-coding RNAs play a pivotal role in these diseases through various mechanisms, such as gene expression modulation, protein translation interference, and alterations in signaling pathways. The study highlights the role of different ncRNAs and investigates how phytochemicals can modulate ncRNAs in neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, epilepsy, depression, and amyotrophic lateral sclerosis.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2023)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Environmental Sciences
Maria Febrer-Serra, Nil Lassnig, Victor Colomar, Gabriela Pico, Silvia Tejada, Antoni Sureda, Samuel Pinya
Summary: Stressful situations lead to an increase in reactive oxygen species, while the introduction of new potential predators induces physiological stress in native fauna. This study found that the moorish gecko exhibited behavioral responses and changes in oxidative stress biomarkers when exposed to the invasive predator horseshoe whip snake, indicating its ability to recognize and adapt to the snake.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Ecology
Marc Gost, Samuel Pinya, Antoni Sureda, Silvia Tejada, Pere Ferriol
Summary: The adaptation of sponges to freshwater environments was a major event in their evolutionary history. This study revealed that the growth capacity of the freshwater sponge Ephydatia fluviatilis is positively associated with high alkalinity values and affected by light exposure. These findings explain the greater distribution of this species in alkaline environments and emphasize the importance of symbiosis in E. fluviatilis.
Review
Cell Biology
Javad Sharifi-Rad, Veronique Seidel, Michalak Izabela, Margalida Monserrat-Mequida, Antoni Sureda, Valeska Ormazabal, Felipe A. Zuniga, Shivaprasad Shetty Mangalpady, Raffaele Pezzani, Alibek Ydyrys, Gulmira Tussupbekova, Miquel Martorell, Daniela Calina, William C. Cho
Summary: Cancer is a leading cause of death worldwide, and its development is linked to oxidative stress. The transcription factor Nrf2 plays a vital role in protecting cells against oxidative stress in cancer growth, progression, and therapy resistance. Therefore, innovative inhibitors targeting Nrf2 are being investigated. This comprehensive review explores the potential of phenolic compounds, found in traditional plant-based remedies, as effective anticancer agents by inhibiting Nrf2. The clinical applications of naturally-occurring bioactive compounds as Nrf2 inhibitors, specifically polyphenols, are also discussed.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Miguel D. Ferrer, Clara Reynes, Margalida Monserrat-Mesquida, Magdalena Quetglas-Llabres, Cristina Bouzas, Silvia Garcia, David Mateos, Miguel Casares, Cristina Gomez, Lucia Ugarriza, Josep A. Tur, Antoni Sureda, Antoni Pons
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of hepatic fat. This study investigated the plasma levels of oxylipins, free polyunsaturated fatty acids (PUFA), and markers of lipid peroxidation in NAFLD patients. The results showed that severe NAFLD patients had higher levels of oxylipins, saturated oxylipins, and free PUFA, suggesting an association between inflammation, fatty acid oxidation dysregulation, and NAFLD progression.
Article
Biochemistry & Molecular Biology
Maria Magdalena Quetglas-Llabres, Margalida Monserrat-Mesquida, Cristina Bouzas, Isabel Llompart, David Mateos, Miguel Casares, Lucia Ugarriza, J. Alfredo Martinez, Josep A. Tur, Antoni Sureda
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by liver fat deposition without alcohol consumption. This study aimed to assess the antioxidant and pro-inflammatory state in NAFLD patients following a 12-month lifestyle intervention based on adherence to a Mediterranean diet (AMD). The intervention resulted in improvements in anthropometric and biochemical parameters, with higher reductions in alanine aminotransferase (ALT) and C reactive protein (CRP) observed in participants with high AMD. Additionally, there were decreases in prooxidant and proinflammatory markers, as well as improvements in physical fitness and intrahepatic fat contents. These improvements were more significant in individuals with higher adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Cristina Valle-Hita, Andres Diaz-Lopez, Nerea Becerra-Tomas, Estefania Toledo, Isabel Cornejo-Pareja, Itziar Abete, Antoni Sureda, Maira Bes-Rastrollo, J. Alfredo Martinez, Francisco J. Tinahones, Josep A. Tur, Tany E. Garciduenas-Fimbres, Francisco Paris-Palleja, Albert Goday, Nuria Goni-Ruiz, Jordi Salas-Salvado, Nancy Babio
Summary: The consumption of ultra-processed food (UPF) is associated with a decline in kidney function, particularly among older adults. Therefore, reducing the intake of UPF is important for maintaining kidney function.
CLINICAL NUTRITION
(2023)
Article
Endocrinology & Metabolism
Adnan Karim, Fareeha Anwar, Uzma Saleem, Saniya Fatima, Tariq Ismail, Ahmad J. Obaidullah, Rana O. Khayat, Moneerah J. Alqahtani, Ifat Alsharif, Haroon Khan, Celia Vargas-De-La-Cruz, Muhammad Ajmal Shah
Summary: This study aimed to investigate the curative effect of antioxidants on aggression in male mice. The results showed that both ALA and silymarin had therapeutic effects on aggressive behavior by down-regulating oxidative stress and inflammatory biomarkers. In addition, ALA also had a notable effect on plasma testosterone levels. In conclusion, ALA is more effective than silymarin in attenuating aggression in mice.
METABOLIC BRAIN DISEASE
(2023)
Article
Environmental Sciences
Marcus Vinicius Oliveira Barros de Alencar, Muhammad Torequl Islam, Ana Maria Oliveira Ferreira da Mata, Antonielly Campinho dos Reis, Rosalia Maria Torres de Lima, Jose Roberto de Oliveira Ferreira, Joao Marcelo de Castro e Sousa, Paulo Michel Pinheiro Ferreira, Ana Amelia de Carvalho Melo-Cavalcante, Abdur Rauf, Hassan A. Hemeg, Khalaf F. Alsharif, Haroon Khan
Summary: This study evaluates the anticancer effects of Phytol on sarcoma 180 and human leukemia cell lines. The results show that Phytol significantly reduces cell viability and division rate, induces DNA damage and apoptosis, and exhibits potential anticancer effects.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Arab Gul, Haroon Khan, Sayyed Ibrahim Shah, Khalaf F. Alsharif, Safa H. Qahl, Inayat Ur Rehman, Khang Wen Goh, Chrismawan Ardianto, Long Chiau Ming
Summary: This study aims to investigate the potential protective mechanisms of peanut methanolic crude extract and n-hexane oil fraction against gentamycin-induced nephrotoxicity. The results show that both the crude extract and the oil fraction have significant reversal effects on gentamycin-induced nephrotoxicity.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2023)
Review
Oncology
Farheen Badrealam Khan, Parul Singh, Yahya F. Jamous, Syed Azmal Ali, Abdullah, Shahab Uddin, Qamar Zia, Manoj Kumar Jena, Mohsina Khan, Mohammad Owais, Chih Yang Huang, Venkatesh Chanukuppa, Chrismawan Ardianto, Long Chiau Ming, Waqas Alam, Haroon Khan, Mohammad Akli Ayoub
Summary: This article reviews the use of proteomics to study the molecular details of phytochemicals such as curcumin, genistein, and tanshinone IIA. These phytochemicals have various pharmacological properties that are extensively studied to understand their mechanisms of action. Proteomics technology has proved to be a reliable approach to unravel the molecular intricacies of phytochemicals.
Article
Multidisciplinary Sciences
Karempudi Venkata Krishna, Jimmantiyur Madhappan Murugan, Haroon Khan, Munusamy Kumar, Veeramani Veeramanikandan, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Karthikeyan Venkatachalam, Paulraj Balaji
Summary: This study examined the antioxidant properties of extracts from eight Pleurotus mushroom species. The methanolic extract of Pleurotus florida showed the highest concentrations of antioxidant compounds and displayed the greatest antioxidant activity. It also exhibited significant antidiabetic effects, surpassing the efficiency of acarbose.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Medicine, Research & Experimental
Tayebeh Noori, Ahmad Reza Dehpour, Seyede Darya Alavi, Seyede Zahra Hosseini, Sina Korani, Antoni Sureda, Jamileh Esmaeili, Samira Shirooie
Summary: This study demonstrates that administration of ivermectin and nano-ivermectin is capable of reducing demyelination in mice, with nano-ivermectin showing better efficacy.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
