期刊
FITOTERAPIA
卷 128, 期 -, 页码 213-217出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.05.026
关键词
Mushroom; Stereum hirsutum; Antibacterial activity; Mixed terpene
资金
- National Key R&D Program of China [2017YFD0201104]
- National Natural Science Foundation of China [31760018, 31560016]
- Applied Basic Research Foundation of Yunnan Province [2018FA0XX]
The mushroom Stereum hirsutum is parasitized by Tremella aurantia to form a heterogeneous basidiocarp Jin'er, which has been used as food and folk medicine in Chinese society. In present work, the S. hirsutum was fermented in YMG broth, and four novel mixed terpenes, stereumamides A-D (1-4), which are sesquiterpenes combined with alpha-amino acids to form quaternary ammonium hybrids, were isolated from the Stereum hirsutum FP-91666 and their structures were elucidated by spectroscopic data analysis. Stereumamides A and D showed antibacterial activity against Escherichia coli, Staphylococcus aureus, and Salmonella typhimurium, with the minimum inhibitory concentration (MIC) values of 12.5-25.0 mu g/mL. The stereumamides A-D should be apparently the first example of naturally occurring a quaternary ammonium compound (QAC) conjugated by sesquiterpene with an alpha-amino acid. QAC is a common antibacterial agent in food industry, which is found in the mycelium of Stereum hirsutum would suggest that the complex basidiocarp is a functional food and veritable folk medicine.
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