Article
Immunology
Yakun Tian, Wei Hua, Yaxin Wu, Tong Zhang, Wen Wang, Hao Wu, Caiping Guo, Xiaojie Huang
Summary: A meta-analysis study found that a double dose and multiple injections of the HBV vaccine were more effective in inducing immune responses in people living with HIV compared to the standard dose. Participants with higher CD4+ T-cell levels showed better vaccine response rates, highlighting the importance of timely HBV vaccination in individuals infected with HIV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Veterinary Sciences
Shijun Yan, Baicheng Huang, Xiaofei Bai, Ying Zhou, Linghua Guo, Tongyan Wang, Yihong Shan, Yuzhou Wang, Feifei Tan, Kegong Tian
Summary: In China, a variant strain of pseudorabies virus (PRV) has caused large-scale outbreaks in swine herds vaccinated with classical PRV vaccines since 2011. Researchers have constructed a recombinant PRV based on the variant HN1201 strain, which showed similar growth characteristics and smaller plaques compared to the parental virus. Vaccination with this recombinant PRV elicited earlier and higher levels of antibodies, providing protective immunity against both classical and variant strains of PRV. Clinically, pigs immunized with the recombinant PRV showed lower body temperature and were protected against infection with the variant PRV strain. These results suggest that this recombinant PRV could be a promising vaccine candidate for preventing the current pseudorabies epidemic in China.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Veterinary Sciences
Lina Ye, Siyu Zhou, Huiling Zhang, Tangjie Zhang, Daiqi Yang, Xingping Hong
Summary: Domestic DHAV vaccines can effectively protect ducklings. The subjects immunized (breeding ducks or ducklings) and vaccine valence had no effect on the protective effect. Both small-scale experiments and large-scale clinical conditions conferred immune protection on ducklings, but vaccine immunization under small-scale experimental conditions had slightly better protective effects than large-scale clinical immunization.
BMC VETERINARY RESEARCH
(2023)
Article
Virology
Caiyun Huo, Dandan Huang, Zhihong Ma, Guiping Li, Tieliang Li, Wutong Lin, Na Jiang, Wei Xing, Guanling Xu, Huanhuan Yu, Lin Luo, Huiling Sun
Summary: This study successfully developed DNA vaccines against IHNV, confirmed their effectiveness, and found that DNA vaccines can provide good immune protection. Moreover, the J genogroup IHNV-G DNA vaccine showed better immune efficacy and cross-immune protection compared to the U genogroup IHNV-G or bivalent vaccine.
Article
Fisheries
Bin Yin, Xuheng Yan, Sedong Li, Ding Liu, Jinlei Liu, Jianguo He, Chaozheng Li
Summary: This study developed a WSSV latency model through low multiplicity infection and found that this method can establish WSSV latency in shrimp. It also discovered that multiple host factors and stimuli can reactivate WSSV latency, including bacterial infection and low salinity stress.
Article
Immunology
Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified shared gene expression pathways in response to influenza and vaccinia virus stimulation in different immune cells. The immune response signaling pathways identified can be targeted for the development of broad therapeutics and vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Meggan Bandrick, Monica Balasch, Andrea Heinz, Lucas Taylor, Vickie King, Jeri Toepfer, Dennis Foss
Summary: Recent studies suggest that PCV2 vaccine-induced protection is more effective when the vaccine and challenge are closely matched. Designing a bivalent vaccine can increase the epitope breadth of the vaccine. The results demonstrate that the bivalent vaccine shows superior efficacy compared to monovalent vaccines in both homologous and heterologous challenges.
VETERINARY RESEARCH
(2022)
Article
Chemistry, Medicinal
Nereida Jimenez de Oya, Patricia Perez, Ana-Belen Blazquez, Estela Escribano-Romero, Mariano Esteban, Juan-Carlos Saiz, Juan Garcia-Arriaza, Miguel A. Martin-Acebes
Summary: The Zika virus is a flavivirus transmitted by mosquitoes, which can cause birth defects and Guillain-Barre syndrome. Recent local infections in Europe and the spread of the Asian tiger mosquito raise concerns about future outbreaks in this region. However, the antigenic similarities of Zika with other flaviviruses pose challenges for vaccine development. This study found low cross-reactivity and no antibody-dependent enhancement between the Zika vaccine candidate and the West Nile virus, supporting the safety of the vaccine in areas where West Nile virus is endemic.
Article
Fisheries
Yuyu Sun, Chaonan Xu, Hao Wang, Guo Qiao, Zhenhui Wang, Zheng Li, Qiang Li, Chang Wei
Summary: An attenuated strain of CyHV-2 G-RP7 was obtained by subculture on RyuF-2 cells and GiCF cells. Gibel carp showed no clinical symptoms when immersed or injected intraperitoneally with G-RP7 strain. The protection rates of G-RP7 by immersion and intraperitoneal injection were 92% and 100%, respectively.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Virology
Weiyang Sun, Zhenfei Wang, Yue Sun, Dongxu Li, Menghan Zhu, Menglin Zhao, Yutian Wang, Jiaqi Xu, Yunyi Kong, Yuanguo Li, Na Feng, Tiecheng Wang, Yongkun Zhao, Songtao Yang, Yuwei Gao, Xianzhu Xia
Summary: In this study, a chimeric H5N1 candidate vaccine was constructed and shown to induce immune responses in mice. The vaccine displayed a potentially safe, attenuated, and reassortment-incompetent profile, making it a promising candidate for future influenza protection.
Article
Biochemistry & Molecular Biology
Hae-Ji Kang, Ki-Back Chu, Keon-Woong Yoon, Gi-Deok Eom, Jie Mao, Fu-Shi Quan
Summary: This study demonstrates that influenza B virus-like particle vaccines expressing hemagglutinin, neuraminidase, or both antigens can provide cross-protections against mismatched Victoria lineage virus infections, by inducing antibody and T cell responses to reduce lung viral loads and minimize infection outcomes.
Article
Immunology
Xiaoyan Huang, Yaohui Li, Ruihua Li, Shaoyan Wang, Lu Yang, Shuyi Wang, Ying Yin, Xiaodong Zai, Jun Zhang, Junjie Xu
Summary: The study demonstrates that recombinant vaccine candidates using replication-defective adenovirus vector to deliver NiV attachment glycoprotein can effectively induce specific humoral and cellular immune responses in mice. The Ad5-NiVGe vaccine candidate elicited the strongest immune responses after a single-dose immunization. Additionally, a potent conserved T-cell epitope shared by NiV and HeV was identified, providing valuable information on HNVs-specific cellular immunity mechanism.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Microbiology
Niranjana Nair, Albert D. M. E. Osterhaus, Guus F. Rimmelzwaan, Chittappen Kandiyil Prajeeth
Summary: Rift Valley Fever Virus is a mosquito-borne phlebovirus that causes febrile or haemorrhagic illness in ruminants and humans. The virus can prevent the induction of the antiviral interferon response through its NSs proteins. Mutations in the NSs gene may lead to the induction of innate proinflammatory immune responses and attenuation of the virus. Virus-specific antibodies and T cells are induced upon infection, which may provide protection against subsequent infections. These findings will help in the development of vaccines using existing platforms. Vaccines candidates have shown promise in safety and efficacy trials in susceptible animal species, which may contribute to controlling RVFV infections and preventing disease progression in humans and ruminants.
Review
Medicine, General & Internal
Marek Petras, Roman Macalik, Daniela Janovska, Alexander M. Celko, Jana Danova, Eliska Selinger, Jonas Dolecek, Sylva Neradova, Martina Franklova, Pavel Dlouhy, Jozef Rosina, Ivana Kralova Lesna
Summary: Observational studies have shown that mRNA and AdV vaccines provide early high protection against COVID-19, but the effectiveness decreases over time. New mutant variants may reduce the vaccine effectiveness. The level of protection is lower in the elderly, those with comorbidities, and those in long-term care or residential homes. The booster effect of the third dose is uncertain.
Article
Agriculture, Dairy & Animal Science
Kuandyk Zhugunissov, Muratbay Mambetaliyev, Nuraiym Sarsenkulova, Shalkar Tabys, Marzhan Kenzhebaeva, Arman Issimov, Yergali Abduraimov
Summary: Camelpox is a significant infectious viral disease in camels. A vaccine is developed and tested in mice and camels, showing safety and potential prevention of economic losses. The inactivated vaccine prepared from an attenuated strain of camelpox can be used in camel breeding farms.