Article
Biochemistry & Molecular Biology
Hongyan Sun, Naying Li, Jishuang Tan, Huan Li, Jibin Zhang, Lujiang Qu, Susan J. Lamont
Summary: This study found that overexpression of NFIB accelerates APEC-induced apoptosis and inflammation through up-regulation of RIP2 mediated downstream pathways in chicken HD11 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Piet Nuijten, Natalie Cleton, Jeroen van der Loop, Birgit Makoschey, Wilco Pulskens, Geert Vertenten
Summary: Intranasal vaccination with live attenuated BRSV and BPIV3 virus strains can provide early protection against bovine respiratory disease in young calves. Vaccination induced gene expression profiles reflecting an antiviral state, early activation of innate immune and antiviral responses, and specific cellular immune pathways. The vaccinated animals were protected against nasal shedding of the challenge virus and clinical symptoms, and gene expression levels returned to values before vaccination.
Article
Agriculture, Dairy & Animal Science
Rui Magalhaes, Nicole Martins, Filipa Fontinha, Rolf Erick Olsen, Claudia Reis Serra, Helena Peres, Aires Oliva-Teles
Summary: This study aimed to investigate the effects of different dietary ratios of n-6/n-3 long-chain polyunsaturated fatty acids and CHO content on the immune response of gilthead seabream. The results showed that high levels of DHA improved the immune status of unchallenged fish, while high levels of ARA enhanced the immune response to bacterial challenges. The energy provided by dietary starch played an important role in promoting a fast immune response after a challenge.
Article
Fisheries
Chaofan Jin, Mengya Wang, Chen Gao, Xiaohan Lin, Yuxiang Liu, Miao Han, Xubo Wang, Quanqi Zhang, Yan He
Summary: This study elucidates the characteristics and functions of the COMMD family in Japanese flounder, showing diverse expression patterns of COMMD members in different tissues and their potential involvement in immune response. Regulation of COMMDs in immune-related organs following bacterial challenge suggests their role in innate immunity, and the up-regulation of COMMDs after LPS stimulation in gill cells further supports this. These findings provide more insights into the evolutionary dynamics and immune-related functions of the COMMD family in teleost fish.
Article
Entomology
Ashley L. Waring, Joshua Hill, Brooke M. Allen, Nicholas M. Bretz, Nguyen Le, Pooja Kr, Dakota Fuss, Nathan T. Mortimer
Summary: Summary: This study characterizes the gene expression changes in Drosophila fruit flies following infection by different pathogens and identifies a small number of genes that consistently show expression changes. These findings provide new insight into the transcriptional changes that accompany the immune response in fruit flies and may serve as candidate genes for further study.
Article
Immunology
Bo Lyu, Jingjing Li, Brigid Niemeyer, Deborah M. Anderson, Brenda Beerntsen, Qisheng Song
Summary: Ticks can transmit pathogens that cause severe diseases, posing a significant public health threat. Understanding the immune response of ticks to bacterial infection is essential for controlling tick-borne diseases. This study used transcriptome analysis to investigate the molecular and immune responses of Amblyomma americanum to Escherichia coli infection. The analysis revealed significant changes in gene expression profiles and identified key immune markers and enzymes that play a role in the tick's immune response. Protein interaction networks provided insights into the molecular interactions involved in the tick's response to E. coli challenge.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Fisheries
Piyatida Outama, Chinh Le Xuan, Supreya Wannavijit, Chompunut Lumsangkul, Nguyen Vu Linh, Napatsorn Montha, Sudaporn Tongsiri, Chanagun Chitmanat, Hien Van Doan
Summary: This study investigated the effects of mango peel powder (MGPP) on the growth, innate immunity, and immune-antioxidant related gene expression of Nile tilapia. The results showed that dietary inclusion of MGPP 25 significantly enhanced immune response and immune related gene expressions, but had no significant effect on growth performance and antioxidant gene expressions. These findings suggest that MGPP could be used as an immunostimulant in Nile tilapia culture.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Immunology
Patricia C. Lopes, Josh J. Faber-Hammond, Chandler Siemonsma, Sachin Patel, Suzy C. P. Renn
Summary: Sick animals show changes in behavior, such as decreased activity, food and water intake, and interest in social interactions. These behaviors, collectively known as sickness behaviors, can be influenced by social factors. In the zebra finch species, males decrease sickness behaviors when presented with novel females. The social environment plays a significant role in determining the neural responses to infection, affecting immune responses, synaptic signaling, and neural metabolic activity.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Kornelia Bodo, Zoltan Kellermayer, Zoltan Laszlo, Akos Boros, Bohdana Kokhanyuk, Peter Nemeth, Peter Engelmann
Summary: The study aimed to investigate the mechanisms of innate immunity during regeneration in Eisenia andrei earthworms, revealing dynamic changes in cell proliferation during anterior and posterior regeneration, accumulation of different immune cell subsets in the newly-formed blastema, and downregulation of pattern recognition receptors and antimicrobial peptides mRNA patterns in regenerating earthworms. Experimental coelomocyte depletion significantly impaired cell divisions and blastema formation during regeneration, indicating complex interactions between regeneration and invertebrate innate immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Fisheries
Sudhir Kumar, Abhay Kumar Choubey, Praveen Kumar Srivastava
Summary: Immunostimulants play a crucial role in enhancing fish growth and disease resistance. Innate immunity is vital for the survival of fish in their early life stages, and later plays a guiding role in adapting acquired immune responses. By using immunostimulants, fish immune responses are enhanced, and gene expression levels are increased through different signaling pathways.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Shengtao Guo, Mengsha Zeng, Lei Chen, Hanxi Chen, Wenxue Gao, Zhongyi Wang, Qiong Shi, Zhaobin Song
Summary: This study examines the expression profiling of the fadd gene in hybrid yellow catfish and reveals its up-regulation after bacterial infections. Important genes in the TLR signaling pathway in the liver are significantly up-regulated after A. hydrophila stimulation, suggesting the activation of apoptosis.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Afaf N. Abdel Rahman, Hien Van Doan, Hassnaa Mahmoud Elsheshtawy, Ali Dawood, Shimaa M. R. Salem, Nagwa I. Sheraiba, Shimaa R. Masoud, Noha S. Abdelnaeim, Tarek Khamis, Mohamed Alkafafy, Heba H. Mahboub
Summary: This study investigates the effects of Salvia officinalis leave powder (SOLP) on the growth, digestion, immune-antioxidant status, and resistance against a pathogenic bacteria in Common carp. The results show that adding SOLP4 and SOLP8 to the diet improves the growth performance and digestion of fish, enhances antioxidant and immune activities, and regulates the expression of key genes. Furthermore, SOLP8 diet intervention shows the best results in enhancing fish resistance against the pathogenic bacteria.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Cell Biology
Philip Schmassmann, Julien Roux, Alicia Buck, Nazanin Tatari, Sabrina Hogan, Jinyu Wang, Natalia Rodrigues Mantuano, Ronja Wieboldt, Sohyon Lee, Berend Snijder, Deniz Kaymak, Tomas A. Martins, Marie-Francoise Ritz, Tala Shekarian, Marta McDaid, Michael Weller, Tobias Weiss, Heinz Laeubli, Gregor Hutter
Summary: This study found that high expression of sialic acid-binding immunoglobulin-like lectin 9 (Siglec-9) is associated with reduced survival in patients with glioblastoma (GBM). Through specific knockouts of Siglec-E and single-cell RNA sequencing, the researchers demonstrated that Siglec-E inhibits phagocytosis by microglia- and monocyte-derived cells, promoting immune evasion. Loss of Siglec-E on monocyte-derived cells enhanced antigen cross-presentation and pro-inflammatory cytokine production, resulting in improved T cell priming. The combination of innate and adaptive immune responses delayed tumor growth and prolonged survival in murine models of GBM. Furthermore, the study showed the potential for targeting Siglec-9 as a treatment for GBM through the combination with other immunotherapies.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Fisheries
Fanbin Zhan, Yanan Li, Fei Shi, Zhijie Lu, Minxuan Yang, Qingqing Li, Li Lin, Zhendong Qin
Summary: This study identified two forms of TLR5 (TLR5a and TLR5b) in grass carp and investigated their role in innate immunity against flagellate and non-flagellate bacteria. It was found that TLR5b had higher expression levels and stronger response to pathogen stimulation compared to TLR5a. The results provide insight into the role of TLR5 in fish infection resistance and contribute to the research on innate immunity in grass carp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Immunology
Shengtao Guo, Wenxue Gao, Mengsha Zeng, Fenglin Liu, Qingzhuoma Yang, Lei Chen, Zesong Wang, Yanjun Jin, Peng Xiang, Hanxi Chen, Zhengyong Wen, Qiong Shi, Zhaobin Song
Summary: In this study, the TLR1 gene was identified in hybrid yellow catfish. Expression pattern analysis showed that TLR1 is mainly transcribed in the gonad, gallbladder, and kidney, and its mRNA levels were up-regulated after infection, indicating its involvement in inflammatory responses. Homologous sequence alignment and chromosomal location confirmed the conservation of the TLR signaling pathway in hybrid yellow catfish. These findings provide basic data for understanding the immune roles of TLR1 in teleosts and developing strategies to control disease outbreaks in hybrid yellow catfish.
FRONTIERS IN IMMUNOLOGY
(2023)
