Inhibition of fibroblast growth factor 23 (FGF23) signaling rescues renal anemia

Inflammation and elevated levels of fibroblast growth factor 23 are independent risk factors for death in chronic kidney disease

(2017) Jair Munoz Mendoza et al.   KIDNEY INTERNATIONAL

Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production

(2016) Valentin David et al.   KIDNEY INTERNATIONAL

Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease

(2016) Saurav Singh et al.   KIDNEY INTERNATIONAL

High Fibroblast Growth Factor 23 Levels Associated With Low Hemoglobin Levels in Patients With Chronic Kidney Disease Stages 3 and 4

(2016) Ming-Hsien Tsai et al.   MEDICINE

Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy

(2015) Alexander Grabner et al.   Cell Metabolism

Renal erythropoietin-producing cells in health and disease

(2015) Tomokazu Souma et al.   Frontiers in Physiology

FGF-23 Is a Negative Regulator of Prenatal and Postnatal Erythropoiesis

(2014) Lindsay M. Coe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women

(2013) Myles Wolf et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Fibroblast Growth Factor-23 and Cardiovascular Events in CKD

(2013) J. J. Scialla et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Chronic kidney disease: global dimension and perspectives

(2013) Vivekanand Jha et al.   LANCET

Treatment of erythropoietin deficiency in mice with systemically administered siRNA

(2012) W. Querbes et al.   BLOOD

FGF23 acts directly on renal proximal tubules to induce phosphaturia through activation of the ERK1/2–SGK1 signaling pathway

(2012) Olena Andrukhova et al.   BONE

FGF23 neutralization improves chronic kidney disease–associated hyperparathyroidism yet increases mortality

(2012) Victoria Shalhoub et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-inducible factor regulates hepcidin via erythropoietin-induced erythropoiesis

(2012) Qingdu Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation and Function of the FGF23/Klotho Endocrine Pathways

(2012) Aline Martin et al.   PHYSIOLOGICAL REVIEWS

Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation

(2011) Chia Chi Sun et al.   AMERICAN JOURNAL OF HEMATOLOGY

Oxygen-regulated expression of the erythropoietin gene in the human renal cell line REPC

(2011) S. Frede et al.   BLOOD

Iron Modifies Plasma FGF23 Differently in Autosomal Dominant Hypophosphatemic Rickets and Healthy Humans

(2011) Erik A. Imel et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

FGF23 induces left ventricular hypertrophy

(2011) Christian Faul et al.   JOURNAL OF CLINICAL INVESTIGATION

Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease

(2011) Tamara Isakova et al.   KIDNEY INTERNATIONAL

Isolation and Characterization of Renal Erythropoietin-Producing Cells from Genetically Produced Anemia Mice

(2011) Xiaoqing Pan et al.   PLoS One

Iron deficiency drives an autosomal dominant hypophosphatemic rickets (ADHR) phenotype in fibroblast growth factor-23 (Fgf23) knock-in mice

(2011) E. G. Farrow et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease

(2010) Hisashi Hasegawa et al.   KIDNEY INTERNATIONAL

Angiotensin II overcomes strain-dependent resistance of rapid CKD progression in a new remnant kidney mouse model

(2010) Asada Leelahavanichkul et al.   KIDNEY INTERNATIONAL

Plasma interleukin-6 is independently associated with mortality in both hemodialysis and pre-dialysis patients with chronic kidney disease

(2009) Daniela V. Barreto et al.   KIDNEY INTERNATIONAL

Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients

(2009) Hirotaka Komaba et al.   KIDNEY INTERNATIONAL

Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation

(2009) R. Goetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron Indices in Chronic Kidney Disease in the National Health and Nutritional Examination Survey 1988-2004

(2008) S. Fishbane et al.   Clinical Journal of the American Society of Nephrology

Fibroblast Growth Factor 23 and Mortality among Patients Undergoing Hemodialysis

(2008) Orlando M. Gutiérrez et al.   NEW ENGLAND JOURNAL OF MEDICINE