Prostaglandin E2 suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection

Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis

(2017) Shashank Gupta et al.   JOURNAL OF PATHOLOGY

Antimicrobial peptides as novel anti-tuberculosis therapeutics

(2016) João P. Silva et al.   BIOTECHNOLOGY ADVANCES

Phenylbutyrate induces LL-37-dependent autophagy and intracellular killing ofMycobacterium tuberculosisin human macrophages

(2015) Rokeya Sultana Rekha et al.   Autophagy

Prostaglandin E2 and programmed cell death 1 signaling coordinately impair CTL function and survival during chronic viral infection

(2015) Jonathan H Chen et al.   NATURE MEDICINE

Cathelicidin LL-37 induces time-resolved release of LTB4 and TXA2 by human macrophages and triggers eicosanoid generation in vivo

(2014) Min Wan et al.   FASEB JOURNAL

Targeted Prostaglandin E2 Inhibition Enhances Antiviral Immunity through Induction of Type I Interferon and Apoptosis in Macrophages

(2014) François Coulombe et al.   IMMUNITY

Host-directed therapy of tuberculosis based on interleukin-1 and type I interferon crosstalk

(2014) Katrin D. Mayer-Barber et al.   NATURE

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

(2014) Alastair J O'Brien et al.   NATURE MEDICINE

Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease

(2013) J. M. Kahlenberg et al.   JOURNAL OF IMMUNOLOGY

Ibuprofen Therapy Resulted in Significantly Decreased Tissue Bacillary Loads and Increased Survival in a New Murine Experimental Model of Active Tuberculosis

(2013) Cristina Vilaplana et al.   JOURNAL OF INFECTIOUS DISEASES

Tuberculosis

(2013) Alimuddin Zumla et al.   NEW ENGLAND JOURNAL OF MEDICINE

E-type prostanoid receptor 4 (EP4) in disease and therapy

(2013) Viktoria Konya et al.   PHARMACOLOGY & THERAPEUTICS

PGE2 suppression of innate immunity during mucosal bacterial infection

(2013) Mallory Agard et al.   Frontiers in Cellular and Infection Microbiology

Prostaglandin E2 restrains macrophage maturation via E prostanoid receptor 2/protein kinase A signaling

(2012) Z. Zaslona et al.   BLOOD

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Prostaglandin E2 Suppresses Antifungal Immunity by Inhibiting Interferon Regulatory Factor 4 Function and Interleukin-17 Expression in T Cells

(2012) Patricia A. Valdez et al.   IMMUNITY

An Important Role of Prostanoid Receptor EP2 in Host Resistance to Mycobacterium tuberculosis Infection in Mice

(2012) V. Kaul et al.   JOURNAL OF INFECTIOUS DISEASES

The Cyclic AMP Pathway

(2012) P. Sassone-Corsi   Cold Spring Harbor Perspectives in Biology

Leukotriene B4/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A4 and resolvin E1

(2011) Min Wan et al.   FASEB JOURNAL

International Union of Basic and Clinical Pharmacology. LXXXIII: Classification of Prostanoid Receptors, Updating 15 Years of Progress

(2011) D. F. Woodward et al.   PHARMACOLOGICAL REVIEWS

Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive prostaglandins

(2011) C. Peres-Buzalaf et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

The lta4h Locus Modulates Susceptibility to Mycobacterial Infection in Zebrafish and Humans

(2010) David M. Tobin et al.   CELL

The Vitamin D Receptor: New Paradigms for the Regulation of Gene Expression by 1,25-Dihydroxyvitamin D3

(2010) J. Wesley Pike et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Eicosanoid pathways regulate adaptive immunity to Mycobacterium tuberculosis

(2010) Maziar Divangahi et al.   NATURE IMMUNOLOGY

Vitamin D3 Induces Autophagy in Human Monocytes/Macrophages via Cathelicidin

(2009) Jae-Min Yuk et al.   Cell Host & Microbe

cAMP Stringently Regulates Human Cathelicidin Antimicrobial Peptide Expression in the Mucosal Epithelial Cells by Activating cAMP-response Element-binding Protein, AP-1, and Inducible cAMP Early Repressor

(2009) Krishnendu Chakraborty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bacterial exotoxins downregulate cathelicidin (hCAP-18/LL-37) and human β-defensin 1 (HBD-1) expression in the intestinal epithelial cells

(2008) Krishnendu Chakraborty et al.   CELLULAR MICROBIOLOGY

The role of the multifunctional peptide LL-37 in host defense

(2008) Ylva Kai-Larsen   Frontiers in Bioscience-Landmark

Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE2and LXA4in the induction of macrophage death

(2008) Minjian Chen et al.   JOURNAL OF EXPERIMENTAL MEDICINE