Review
Pharmacology & Pharmacy
Xiangjun Ji, Baitang Ning, Jinghua Liu, Ruth Roberts, Larry Lesko, Weida Tong, Zhichao Liu, Tieliu Shi
Summary: Pharmacogenomics plays essential roles in optimizing drug responses and avoiding adverse events. Population-specific therapeutic interventions and genotyping can improve clinical outcomes, highlighting the importance of precision medicine strategies. Challenges and regulatory efforts still exist in advancing this field further.
DRUG DISCOVERY TODAY
(2021)
Article
Oncology
Runcong Nie, Foping Chen, Mariano Provencio, Yun Wang, Tom van den Ende, Hanneke W. M. van Laarhoven, Shuqiang Yuan, Miklos Pless, Stefanie Hayoz, Zhiwei Zhou, Yuanfang Li, Sacha I. Rothschild, Muyan Cai
Summary: This study analyzed clinical trials of neoadjuvant immune checkpoint inhibitors and found that ORR, MPR, pCR, and RFS can effectively predict overall survival. Rating: 9 out of 10.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Verena M. C. Reichert, Zaher Alwafai, Marek T. Zygmunt, Marcus Vollmer, Guenter Koehler
Summary: Uterine leiomyosarcoma (LMS) is a rare malignant gynecological tumor often diagnosed after surgery for benign leiomyoma (LM). This study investigated the impact of morcellation of LMS on local and distant metastases as well as overall survival.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jwa Hoon Kim, Shinkyo Yoon, Dae Ho Lee, Se Jin Jang, Sung-Min Chun, Sang-We Kim
Summary: This study demonstrated the clinical utility of NGS in detecting actionable mutations in lung adenocarcinoma patients, leading to improved survival outcomes with targeted therapy based on NGS results.
Article
Oncology
Mingkun Zhao, Minzhi Lv, Yuan Fang, Aobo Zhuang, Qian Wu, Hanxing Tong, Weiqi Lu, Yong Zhang
Summary: This study investigated the relationship between sarcopenia and severe postoperative complications, relapse-free survival, and overall survival in RLPS patients. The results showed that sarcopenia was associated with severe postoperative complications, but had no impact on relapse-free survival and overall survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kseniya Khamina, Andreas B. Diendorfer, Susanna Skalicky, Moritz Weigl, Marianne Pultar, Teresa L. Krammer, Catharine Aquino Fournier, Amy L. Schofield, Carolin Otto, Aaron Thomas Smith, Nina Buchtele, Christian Schoergenhofer, Bernd Jilma, Bernhard J. H. Frank, Jochen G. Hofstaetter, Regina Grillari, Johannes Grillari, Klemens Ruprecht, Christopher E. Goldring, Hubert Rehrauer, Warren E. Glaab, Matthias Hackl
Summary: The plasma levels of tissue-specific microRNAs can serve as diagnostic, disease severity and prognostic biomarkers. Combining diverse microRNAs into biomarker signatures using multivariate statistics is powerful in terms of tissue and condition specific microRNA shedding into the plasma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Pedro M. Rodrigues, Arndt Vogel, Marco Arrese, Domingo C. Balderramo, Juan W. Valle, Jesus M. Banales
Summary: The early and non-invasive diagnosis of cholangiocarcinoma (CCA) remains a challenge, contributing to increased mortality rates globally. Efforts to identify novel biomarkers for CCA diagnosis and prognosis prediction are ongoing, with the hope of improving patient outcomes in the future. High-throughput omics-based approaches hold promise for identifying circulating biomarkers that may aid in early detection and treatment stratification in large-scale validation studies.
Article
Immunology
Esther Benamu, Kiran Gajurel, Jill N. Anderson, Tullia Lieb, Carlos A. Gomez, Hon Seng, Romielle Aquino, Desiree Hollemon, David K. Hong, Timothy A. Blauwkamp, Mickey Kertesz, Lily Blair, Paul L. Bollyky, Bruno C. Medeiros, Steven Coutre, Simona Zompi, Jose G. Montoya, Stan Deresinski
Summary: This study evaluated the ability of Karius microbial cell-free DNA sequencing test (KT) to identify infectious etiologies in patients with febrile neutropenia (FN) and its impact on antimicrobial treatment. The results showed that KT was able to detect organisms that were not identified by conventional microbiological tests, and it had the potential to improve the diagnosis and optimize the antimicrobial therapy for FN.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Nanoscience & Nanotechnology
Peng Qi, Ya-ling Zeng, Xu Ye, Ya-mei Li, Feng-jiao Wang, Wang-yang Pu, Rong Zhang, Min Li, Li Xiao, Gang Huang, Sirois Pierre, Jun Chuan, Jingjing Luo, Duan-fang Liao, Hongyan Wen, Kai Li
Summary: In this study, several strategies were tested to limit or abolish self-ligation of next generation sequencing adapters. Experimental data showed that these strategies can significantly reduce or completely eliminate self-ligation. Minimizing or eliminating self-ligation is crucial in improving the sensitivity, efficiency, and reproducibility of enzyme-mediated methylation assays. These strategies may also have applications in other nanotechnologies.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Oncology
Yucong Li, Rui Chen, Mingming Yuan, Dong Wang, Chunling Fu, Rongrong Chen, Cuirong Lei, Qi Zhou
Summary: This study investigates the feasibility of molecular classification using comprehensive next-generation sequencing techniques and its relationship with survival outcomes in patients with endometrial cancer. The results show that comprehensive next-generation sequencing is a reliable method for stratifying the prognosis of endometrial cancer and has the potential to guide the treatment of patients in clinical practice.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Immunology
Ravina Kullar, Emanuele Chisari, James Snyder, Christopher Cooper, Javad Parvizi, Jason Sniffen
Summary: This article discusses the gaps in traditional culture and introduces the utility of next-generation sequencing (NGS) in diagnosing and treating peri-prosthetic joint infections. It highlights the clinical benefits of using NGS compared to culture alone and emphasizes the potential of NGS in improving the yield of identifying infective organisms in challenging cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Marianna A. Zolotovskaia, Max A. Kovalenko, Victor S. Tkachev, Alexander M. Simonov, Maxim Sorokin, Ella Kim, Denis Kuzmin, Betul Karademir-Yilmaz, Anton A. Buzdin
Summary: Activation levels of algorithmically reconstructed gene-centric pathways are a potent class of new-generation diagnostic and prognostic biomarkers for gliomas.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Infectious Diseases
Hongxia Duan, Xuan Li, Aihong Mei, Ping Li, Yang Liu, Xiaofeng Li, Weiwei Li, Changhui Wang, Shuanshuan Xie
Summary: The study found that mNGS had a higher sensitivity than the traditional method, especially in blood, bronchoalveolar lavage fluid and sputum samples. The positive mNGS group had a higher hospital stay and 28-day mortality, with age being significant in multivariate logistic analyses of positive results of mNGS.
BMC INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Silvia Marce, Blanca Xicoy, Olga Garcia, Marta Cabezon, Natalia Estrada, Patricia Velez, Concepcion Boque, Miguel Sagues, Anna Angona, Raul Teruel-Montoya, Francisca Ferrer-Marin, Paula Amat, Juan Carlos Hernandez-Boluda, Mariana M. Ibarra, Eduardo Anguita, Montserrat Cortes, Andres Fernandez-Ruiz, Sandra Fontanals, Lurdes Zamora
Summary: The study found that the expression of e14a2 or e13a2 transcripts in chronic myeloid leukemia (CML) patients does not affect treatment outcomes. Specifically, e14a2 transcripts are associated with better molecular responses in the first 6 months of treatment, while e13a2 is linked to improved long-term overall survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sushmaa Chandralekha Selvakumar, K. Auxzilia Preethi, Kehinde Ross, Deusdedit Tusubira, Mohd Wajid Ali Khan, Panagal Mani, Tentu Nageswara Rao, Durairaj Sekar
Summary: Personalized or precision medicine combines genetic information with phenotypic and environmental characteristics to tailor healthcare to individuals, enabled by cancer genome sequencing. The advantages of NGS, such as limited sample requirements and the development of biomarkers, have accelerated personalized medicine.
Article
Oncology
Josephine K. K. Dermawan, Nooshin Dashti, Sarah Chiang, Gulisa Turashvili, Brendan C. C. Dickson, Lora H. H. Ellenson, Martina Kirchner, Albrecht Stenzinger, Gunhild Mechtersheimer, Abbas Agaimy, Cristina R. R. Antonescu
Summary: In this study, we report a series of endometrial stromal sarcoma (ESS) cases with novel gene fusions. These cases demonstrate morphological and molecular heterogeneity. The identified fusion genes play important roles in the regulation of the PRC2 and/or NuA4/TIP60 complexes.
GENES CHROMOSOMES & CANCER
(2023)
Article
Pathology
Felix K. F. Kommoss, Lisa-Marie Mar, Brooke E. Howitt, Krisztina Hanley, Gulisa Turashvilli, Rolf Buslei, Julie A. Irving, Brendan C. Dickson, Christian Koelsche, Hans-Peter Sinn, Peter Schirmacher, Andreas von Deimling, Sarah Chiang, W. Glenn McCluggage, Sabrina Croce, Colin J. R. Stewart, Cheng-Han Lee
Summary: This study molecularly characterized 36 cases of high-grade endometrial stromal sarcoma (HGESS), and found that these tumors frequently harbor recurrent events involving the CDKN2A locus on chromosome 9p. The study showed that CDKN2A alterations are a cooperative driver of tumorigenesis in a subset of HGESSs with the YWHAE::NUTM2 gene fusion, and that p16 may be a potential prognostic marker.
Article
Pathology
Cherry Pun, Gulisa Turashvili, Anna Marie Mulligan, Elzbieta Slodkowska
Summary: Mammary spindle cell proliferations (SCPs) cover a wide range of lesions and are difficult to diagnose accurately on core needle biopsies (CNBs). Most SCPs require excision for definitive diagnosis, but in some cases, conservative follow-up may be possible. This study aimed to examine SCPs diagnosed on CNB and evaluate the necessity of excision for benign/indeterminate SCPs. Among 197 SCPs that met the inclusion criteria, 53% were classified as benign, 26% as indeterminate, and 19% as malignant on CNB. Excision was performed in 47% of benign, 87% of indeterminate, and 86% of malignant CNBs. Of the 123 excised SCPs, 63% were benign and 36% were malignant. Most benign lesions showed no suspicious radiological features, while indeterminate and malignant lesions were more likely to be suspicious. Proper ancillary tests can safely exclude some malignant entities, and accurate pathological diagnosis with correlation to imaging and clinical data can potentially spare surgery for patients with mammary SCPs.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Cell Biology
Joep M. A. Bogaerts, Majke H. D. van Bommel, Rosella P. M. G. Hermens, Miranda P. Steenbeek, Joanne A. de Hullu, Jeroen A. W. M. van Der Laak, Michiel Simons
Summary: It is crucial to diagnose or exclude serous tubal intraepithelial carcinoma (STIC), a precursor lesion of tubo-ovarian high-grade serous carcinoma (HGSC), in a reliable and safe manner. This study aimed to optimize STIC diagnosis and increase reproducibility through a three-round Delphi study involving an international panel of expert gynecologic pathologists. The resulting consensus statements provide recommendations for more consistent STIC diagnosis.
Article
Pathology
Gulisa Turashvili, Qingqing Ding, Yi Liu, Limin Peng, Miralem Mrkonjic, Haider Mejbel, Yihong Wang, Huina Zhang, Gloria Zhang, Jigang Wang, Shi Wei, Xiaoxian Li
Summary: The latest World Health Organization classification of breast tumors recommends diagnosing malignant phyllodes tumors (MPTs) when all 5 morphologic features are present. However, a retrospective study found that the current recommendation may miss a significant number of MPTs with distant metastases, suggesting the need for refined diagnostic criteria.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Article
Oncology
Jennifer K. Litton, Meredith M. Regan, Lajos Pusztai, Hope S. Rugo, Sara M. Tolaney, Elizabeth Garrett-Mayer, Laleh Amiri-Kordestani, Reva K. Basho, Ana F. Best, Jean-Francois Boileau, Carsten Denkert, Jared C. Foster, Nadia Harbeck, Heather A. Jacene, Tari A. King, Ginny Mason, Ciara C. O'Sullivan, Tatiana M. Prowell, Andrea L. Richardson, Karla A. Sepulveda, Mary Lou Smith, Judy A. Tjoe, Gulisa Turashvili, Wendy A. Woodward, Lynn Pearson Butler, Elena I. Schwartz, Larissa A. Korde
Summary: The STEEP criteria, updated as STEEP 2.0 in 2021, provide standardized definitions for adjuvant breast cancer end points. A working group called NeoSTEEP was established to evaluate and align neoadjuvant breast cancer trial end points.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pathology
Gulisa Turashvili, Yuan Gao, Di (Andy) Ai, Abdulwahab M. Ewaz, Sandra Gjorgova Gjeorgjievski, Qun Wang, Thi T. A. Nguyen, Chao Zhang, Xiaoxian Li
Summary: This study evaluated the interobserver agreement among subspecialised breast pathologists for the assessment of HLBC and developed a practical algorithm. The results showed suboptimal agreement among the pathologists, highlighting the need for a new reliable evaluation method for HLBC.
JOURNAL OF CLINICAL PATHOLOGY
(2023)
Article
Pathology
Lawrence Hsu Lin, Douglas H. R. Allison, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, Britta Weigelt, Marc Ladanyi, Nadeem R. Abu-Rustum, Matija Snuderl, Sarah Chiang
Summary: This study found that co-occurring sporadic endometrioid endometrial carcinoma (EEC) and endometrioid ovarian carcinoma (EOC) are clonally related, but there is a shift in DNA methylation signatures between the ovarian and endometrial tumors. The results also indicate epigenetic overlap between ovarian and peritoneal tumors, suggesting a role for the tumor microenvironment in the epigenetic modulation of metastatic EEC.
Meeting Abstract
Medicine, Research & Experimental
Rofieda Alwaqfi, Gulisa Turashvili, Varshini Vasudevaraja, Ivy Tran, Jonathan Serrano, M. Herman Chui, Britta Weigelt, Robert Soslow, Lora Ellenson, Nadeem Abu-Rustum, Matija Snuderl, Sarah Chiang
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Sunil Badve, Sandra Gjorgova Gjeorgjievski, Qun Wang, Abdulwahab Ewaz, Di Andy Ai, Xiaoxian Li, Gulisa Turashvili
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Edward Dent, Jessica Chen, Di (Andy) Ai, Ji-Hoon Lee, Thi Nguyen, Gulisa Turashvili, Xiaoxian Li
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Anna Sarah Erem, Sandra Gjorgova Gjeorgjievski, Krisztina Hanley, Gulisa Turashvili
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Xiaoxian Li, Yuan Gao, Sarah Wood, Ji-Hoon Lee, Qun Wang, Sadaf Ilyas, Jane Meisel
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Xiaoxian Li, Yuan Gao, Di (Andy) Ai, Abdulwahab Ewaz, Sandra Gjorgova Gjeorgjievski, Qun Wang, Thi Nguyen, Chao Zhang, Gulisa Turashvili
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Gulisa Turashvili, Qingqing Ding, Yi Liu, Limin Peng, Miralem Mrkonjic, Haider Mejbel, Yihong Wang, Huina Zhang, Gloria Zhang, Jigang Wang, Shi Wei, Xiaoxian Li
LABORATORY INVESTIGATION
(2023)