Article
Medicine, Research & Experimental
Wenjie Lai, Weian Zhu, Xiaojuan Li, Yuefu Han, Yu Wang, Qu Leng, Mingzhao Li, Xingqiao Wen
Summary: This study demonstrates that GTSE1 is significantly upregulated in prostate cancer and negatively correlates with patient prognosis. GTSE1 promotes prostate cancer cell proliferation through the SP1/FOXM1 signaling pathway, suggesting its potential as a prognostic marker and therapeutic target in prostate cancer.
LABORATORY INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Sekyu Choi, Bing Zhang, Sai Ma, Meryem Gonzalez-Celeiro, Daniel Stein, Xin Jin, Seung Tea Kim, Yuan-Lin Kang, Antoine Besnard, Amelie Rezza, Laura Grisanti, Jason D. Buenrostro, Michael Rendl, Matthias Nahrendorf, Amar Sahay, Ya-Chieh Hsu
Summary: The study revealed that corticosterone regulates hair follicle stem cell (HFSC) quiescence and hair growth in mice, with chronic stress prolonging HFSC quiescence and maintaining hair follicles in an extended resting phase. The mechanism involves corticosterone suppressing the expression of Gas6 gene through acting on dermal papillae, and restoring Gas6 expression can overcome stress-induced inhibition of HFSC activation and hair growth.
Article
Biochemistry & Molecular Biology
Hongyu Wang, Ruiqin Han, Qiao Li, Wei Kang, Qiang Dong, Hang Yin, Liang Niu, Junqiang Dai, Yunji Yan, Yuanping Su, Xuan Yao, He Zhang, Guoqiang Yuan, Yawen Pan
Summary: In this study, we found that EEF1E1 plays a crucial role in regulating the cell cycle and cell proliferation in glioma cells. It downregulates the expression of PTEN and modulates downstream cell cycle-related proteins through the PTEN/AKT signaling pathway. Our findings demonstrate that EEF1E1 knockdown effectively inhibits glioma cell proliferation, suggesting that EEF1E1 could serve as a potential therapeutic target for glioma treatment with significant clinical implications.
MOLECULAR CARCINOGENESIS
(2023)
Article
Multidisciplinary Sciences
Yoon-Chul Kye, Gil-Woo Lee, Sung-Woo Lee, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho
Summary: The study revealed that STAT1 plays a crucial role in maintaining the quiescence of naive CD8(+) T cells, with its deficiency leading to increased proliferation and abnormal expansion of memory/activated cells. This phenomenon is paradoxically dependent on type I interferon and its alternative signaling pathway.
Article
Multidisciplinary Sciences
Marco D'Ario, Rafael Tavares, Katharina Schiessl, Benedicte Desvoyes, Crisanto Gutierrez, Martin Howard, Robert Sablowski
Summary: The study reveals that cell size variability in the Arabidopsis shoot stem cell niche is corrected by adjusting the growth period before DNA synthesis. KRP4 and FBL17 proteins play key roles in removing excess cell cycle regulators, ensuring daughter cells are born with comparable amounts of KRP4. This suggests a potential mechanism where a cell cycle regulator associated with mitotic chromosomes can read DNA content as a cell size-independent scale.
Article
Pharmacology & Pharmacy
Wei Yang, Jiaqi Su, Mingjing Li, Tiantian Li, Xu Wang, Mingdong Zhao, Xuemei Hu
Summary: Myricetin inhibits the proliferation of HCC cells by downregulating MARCH1 and affecting the p38 MAPK and Stat3 signaling pathways, ultimately suppressing HCC growth. This natural flavonol also induces autophagy and cell cycle arrest in HCC cells, demonstrating its anticancer properties.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hiroaki Kito, Reiko Kawagishi, Takusei Ryu, Kyoko Endo, Junko Kajikuri, Wayne R. Giles, Susumu Ohya
Summary: This study demonstrated that KCa3.1, a Ca2+-activated K+ channel, is upregulated in preosteoblastic cells, leading to hyperpolarization and enhanced intracellular Ca2+ signaling. Inhibition of KCa3.1 attenuated cell cycle progression and inhibited osteoblast differentiation. These findings reveal the important role of KCa3.1 in regulating osteoblast maturation during bone formation.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Vanessa Schimek, Katharina Strasser, Andrea Beer, Samantha Goeber, Natalie Walterskirchen, Christine Brostjan, Catharina Mueller, Thomas Bachleitner-Hofmann, Michael Bergmann, Helmut Dolznig, Rudolf Oehler
Summary: Sporadic apoptosis of tumour cells in colorectal cancer is associated with poor patient prognosis. Apoptotic cancer cells release chemotactic factors that attract neutrophils, inducing changes in neutrophil phenotype and lifespan and promoting interaction with macrophages in the tumor microenvironment, potentially contributing to an immunologically unfavorable environment.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Qian Xu, Zhenwu Xu, Kai Zhu, Jinlan Lin, Bo Ye
Summary: The study revealed that LINC00346 plays a carcinogenic role in the development of LUAD by acting as a ceRNA through the miR-30c-2-3p/MYBL2 axis and regulating the CELL CYCLE signaling pathway. Knockdown of LINC00346 inhibited tumor growth, proliferation, metastasis and cell cycle progression while inducing apoptosis in LUAD cells. This research provides new insights for the diagnosis and treatment of LUAD guided by lncRNA.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Qing Tang, Qichun Zhou, Jing Li, Xiaobing Yang, Rui Wang, Xi Wang, Mengfei Xu, Ling Han, Wanyin Wu, Sumei Wang
Summary: This study found that solamargine (SM), a natural alkaloid derived from the fruit of Lycium tomato lobelia, inhibits the progression of non-small cell lung cancer (NSCLC) and enhances the anticancer effect of EGFR-TKIs. The mechanism involves the regulation of the MALAT1/miR-141-3p/Sp1/IGFBP1 signaling pathway. These findings provide a new strategy and potential candidate targets for overcoming EGFR-TKI resistance in NSCLC.
Article
Multidisciplinary Sciences
Hanlin Lu, Peidong Yuan, Xiaoping Ma, Xiuxin Jiang, Shaozhuang Liu, Chang Ma, Sjaak Philipsen, Qunye Zhang, Jianmin Yang, Feng Xu, Cheng Zhang, Yun Zhang, Wencheng Zhang
Summary: ACE inhibitors are commonly used to treat cardiovascular diseases and promote angiogenesis. This study reveals that endothelial USP7-Sp1/Sp3-Notch1 signaling plays a central role in pathophysiological angiogenesis in response to ACE inhibitor treatment.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Dian Lv, Qi Lai, Qi Zhang, Ji-Hong Wang, Yuan-Ce Li, Guang-Zhi Zeng, Jun-Lin Yin
Summary: The compound 3-desoxysulforaphane (3-DSC) isolated from Caesalpinia sinensis showed antitumor activity by inhibiting cell proliferation, migration, and invasion in HeLa and PC3 cells through modulation of multiple signaling pathways.
Article
Biochemistry & Molecular Biology
Teekaraman Dhanaraj, Manju Mohan, Jagadeesan Arunakaran
Summary: Research has shown that quercetin inhibits the survival and proliferation of human metastatic ovarian cancer cells by inactivating PI3K/Akt, Ras/Raf pathways, and EGFR expression. It also alters N-cadherin expression, decreases gelatinase secretion and MMP-2/-9 gene expression, and inhibits migration and adhesion of the cancer cells. These findings suggest that quercetin could be a valuable therapeutic drug for the treatment and prevention of metastatic ovarian cancer.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Maria Victoria Castro, Gaston Alexis Barbero, Maria Belen Villanueva, Luca Grumolato, Jeremie Nsengimana, Julia Newton-Bishop, Edith Illescas, Maria Josefina Quezada, Pablo Lopez-Bergami
Summary: Contrary to previous findings, the study reveals that ROR2 acts as a tumor suppressor in melanoma by inhibiting cell-cycle progression and melanoma cell proliferation. This effect is mediated through inhibition of Akt phosphorylation and subsequent regulation of key cell-cycle regulators, leading to reduced tumor growth both in vitro and in vivo. The expression of ROR2 is associated with favorable clinical outcomes in melanoma patients, indicating its potential as a prognostic marker.
JOURNAL OF BIOMEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Yinhua Jin, Teni Anbarchian, Peng Wu, Abby Sarkar, Matt Fish, Weng Chuan Peng, Roel Nusse
Summary: Cell proliferation is tightly regulated by various factors, including transcriptional repressors E2F7 and E2F8. In this study, it was discovered that Wnt/β-catenin signaling maintains active cell division in the liver through the transcription factor Tbx3. Tbx3 directly represses the transcription of E2f7 and E2f8, thereby promoting mitosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Editorial Material
Surgery
Wen-Tian Li, Wei Liu
INDIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Medicine, General & Internal
Shi-Ze Xiong, Tong Sha, Wei Liu
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Editorial Material
Medicine, General & Internal
Shi-Ze Xiong, Lu Chen, Wei Liu
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Editorial Material
Surgery
Meng-You Zeng, Bo-Juan Lang, Wei Liu
Summary: This case report describes an elderly man receiving long-term treatment with glucocorticoids who was diagnosed with esophageal candidiasis.
INDIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Surgery
Shi-Ze Xiong, Yu-Kui Peng, Wei Liu
INDIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Surgery
Dao-Hui Wei, Yu-Kui Peng, Wei Liu
INDIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Surgery
Zi-Ping Cai, Fa-Chao Fan, Wei Liu
Summary: IgG4-related disease is a systemic autoimmune disease that results in fibro-inflammation and affects multiple organs, including the pancreas, retroperitoneum, and lymph nodes.
INDIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Gastroenterology & Hepatology
Wei Liu, Dao-Hui Wei, Qiao-Yun Tong
Editorial Material
Gastroenterology & Hepatology
Wei Liu, Dao-Hui Wei, Qiao-Yun Tong
Editorial Material
Gastroenterology & Hepatology
Dao-Hui Wei, Yu-Kui Peng, Wei Liu
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Oncology
Wei Liu, Dongwei Hu, Jinjie Li, Qigang Xu, Zongjing Chen, Bo Xu
Summary: This study investigated the functions of the CSTF2T/ASH2L/CALB2 axis in the progression of pancreatic adenocarcinoma (PAAD). High CALB2 expression was found in PAAD tissues and cells. Mechanistically, KMT2D was enriched in the CALB2 promoter and CSTF2T upregulated ASH2L, leading to increased CALB2 expression through H3K4Me1 upregulation. Knockdown of CALB2 or CSTF2T decreased cell viability, invasion, and migration while increasing apoptosis. In vivo studies using nude mouse transplantation tumor models confirmed that CSTF2T knockdown inhibited PAAD growth and metastasis, which could be counteracted by CALB2 overexpression.
CANCER BIOLOGY & THERAPY
(2023)
Editorial Material
Gastroenterology & Hepatology
Zi-Ping Cai, Xiao-Kang He, Wei Liu
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Editorial Material
Medicine, General & Internal
Dao-Hui Wei, Yu-Kui Peng, Wei Liu
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Editorial Material
Gastroenterology & Hepatology
Ming-Dong Zhou, Dong-Ge Han, Wei Liu
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Ke-Heng Deng, Dao-Hui Wei, Wei Liu
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)