Article
Endocrinology & Metabolism
Lorenzo Nesti, Nicola Riccardo Pugliese, Lorenza Santoni, Silvia Armenia, Martina Chiriaco, Luca Sacchetta, Nicolo De Biase, Lavinia Del Punta, Stefano Masi, Domenico Trico, Andrea Natali
Summary: Effort intolerance is common in overweight/obese and/or type 2 diabetes (T2D) patients. T2D and body mass index (BMI) have independent effects on cardiopulmonary capacity. T2D is associated with lower VO2peak and subclinical cardiovascular dysfunctions.
DIABETES OBESITY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Lorenzo Nesti, Nicola Riccardo Pugliese, Paolo Sciuto, Nicolo De Biase, Matteo Mazzola, Iacopo Fabiani, Domenico Trico, Stefano Masi, Andrea Natali
Summary: This study aimed to quantify effort intolerance in T2D and dissect the associated cardiopulmonary alterations. The results showed that effort intolerance and reduced VO2peak are severe and highly prevalent conditions in uncomplicated T2D patients, resulting primarily from a major defect in skeletal muscle oxygen extraction and subtle myocardial systolic dysfunction.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Critical Care Medicine
Timothy A. Morris, Timothy M. Fernandes, Richard N. Channick
Summary: Long-term dyspnea and exercise intolerance are common problems after acute pulmonary embolism. This article presents a stepwise approach to evaluating post-pulmonary embolism patients, using a hierarchy of clinically validated diagnostic tests. The algorithm, represented by the acronym SEARCH, includes symptom screening, exercise testing, arterial perfusion, resting echocardiography, confirmatory chest imaging, and hemodynamics measured by right heart catheterization. The article illustrates the algorithm with a patient in a pulmonary embolism follow-up clinic.
Article
Clinical Neurology
Macarena Cabrera-Serrano, Laure Caccavelli, Marco Savarese, Anna Vihola, Manu Jokela, Mridul Johari, Thierry Capiod, Marine Madrange, Enrico Bugiardini, Stefen Brady, Rosaline Quinlivan, Ashirwad Merve, Renata Scalco, David Hilton-Jones, Henry Houlden, Halil Ibrahim Aydin, Serdar Ceylaner, Sarah Drewes, Jerry Vockley, Rhonda L. Taylor, Chiara Folland, Aasta Kelly, Hayley Goullee, Emil Ylikallio, Mari Auranen, Henna Tyynismaa, Bjarne Udd, Alistair R. R. Forrest, Mark R. Davis, Drago Bratkovic, Nicholas Manton, Thomas Robertson, Cullen O'Gorman, Pamela McCombe, Nigel G. Laing, Liza Phillips, Pascale de Lonlay, Gianina Ravenscroft
Summary: Biallelic loss-of-function variants in the gene encoding obscurin (OBSCN) predispose individuals to recurrent and severe episodes of rhabdomyolysis, typically with onset in the teenage years. Variants in OBSCN may affect sarcoplasmic reticulum function and calcium handling, leading to increased susceptibility to rhabdomyolysis. Follow-up studies are needed to further understand OBSCN-related disease and its clinical course.
Article
Geriatrics & Gerontology
Aysha Amjad, Peter H. Brubaker, Bharathi Upadhya
Summary: HFpEF, the most rapidly increasing form of heart failure, primarily affects older women and is associated with high morbidity, mortality, and healthcare costs. It is now recognized as a systemic disorder influenced by aging processes.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Clinical Neurology
Federica Rachele Danti, Federica Invernizzi, Isabella Moroni, Barbara Garavaglia, Nardo Nardocci, Giovanna Zorzi
Summary: Paroxysmal exercise-induced neurological symptoms (PENS) encompass a wide spectrum of clinical phenomena that are commonly seen in childhood and may be part of more complex disease phenotypes. Differential diagnosis can be challenging and delayed, but prompt diagnosis is crucial as some of these disorders are treatable.
FRONTIERS IN NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Erik H. Van Iterson, Leslie Cho, Adriano Tonelli, J. Emanuel Finet, Luke J. Laffin
Summary: In patients with HFrEF, demonstrating a restrictive pattern on spirometry yields the severest mortality risk associated with (V) over dotO(2peak). Using spirometry to screen patients with HFrEF for ventilatory defects has a potential role in improving risk stratification based on (V) over dotO(2peak).
Article
Multidisciplinary Sciences
Yuki Saito, Masaru Obokata, Tomonari Harada, Kazuki Kagami, Makoto Murata, Hidemi Sorimachi, Toshimitsu Kato, Naoki Wada, Yasuo Okumura, Hideki Ishii
Summary: Cardiopulmonary exercise testing (CPET) has potential value in differentiating HFpEF from NCD, but limited diagnostic ability was found in this study. Lower oxygen consumption (VO2) was observed in HFpEF patients compared to controls and those with NCD, but there was an overlap between HFpEF and NCD. Expired gas analysis data had modest abilities in distinguishing HFpEF from controls, but none of the variables clearly differentiated between HFpEF and NCD (all areas under the curve < 0.61). Expired gas analysis provides objective assessments of exercise capacity, yet its diagnostic value in identifying HFpEF among patients with symptoms of exertional dyspnea was modest.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Graham H. Bevan, Trevor Jenkins, Richard Josephson, Sanjay Rajagopalan, Sadeer G. Al-Kindi
Summary: Plasma ET-1 levels are significantly associated with lower exercise oxygen consumption both at baseline and longitudinally over 24 weeks in HFpEF patients. Higher ET1 levels are associated with lower pVO2, indicating a negative impact on exercise tolerance in HFpEF. Future studies should explore the potential of Endothelin-1 antagonism in improving exercise tolerance in HFpEF.
Article
Cardiac & Cardiovascular Systems
Shantanu P. Sengupta, Nduka C. Okwose, Guy A. MacGowan, Djordje G. Jakovljevic
Summary: This study found that patients with heart failure with preserved ejection fraction (HFpEF) have more severe impairment of left atrial function during exercise compared to patients with reduced ejection fraction (HFrEF), which may explain the exercise intolerance experienced by HFpEF patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
J. C. Weavil, T. S. Thurston, T. J. Hureau, J. R. Gifford, P. A. Kithas, R. M. Broxterman, A. D. Bledsoe, J. N. Nativi, R. S. Richardson, M. Amann
Summary: HFpEF patients show similar central and peripheral fatigue development as healthy controls during exercise not limited by cardiac output at the same relative intensity. However, HFpEF patients exhibit a greater susceptibility to neuromuscular fatigue during exercise at a given absolute intensity, which impairs functional capacity. The compromised leg blood flow response likely contributes to the attenuated fatigue resistance in HFpEF patients.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Medicine, General & Internal
Ali Albarrati, Abdulrahman Aseeri, Mohammed Taher, Monira Aldhahi, Rakan Nazer
Summary: This study found that exercise intolerance in patients with chronic heart failure was associated with dyspnea, rather than respiratory muscle strength. Only a small percentage of CHF patients had weak respiratory muscle strength, with a significant proportion terminating the 6MWT due to dyspnea.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Critical Care Medicine
Pavol Sajgalik, Andres Garzona-Navas, Ibolya Csecs, J. Wells Askew, Francisco Lopez-Jimenez, Alexander S. Niven, Bruce D. Johnson, Thomas G. Allison
Summary: This experimental study found that exercise testing is an aerosol-generating procedure, with statistically significant increases in aerosol concentration observed at exercise intensities at or above 50% of predicted heart rate reserve. The results suggest potential implications for safety recommendations in indoor exercise activities.
Review
Cardiac & Cardiovascular Systems
Ya-Lin Zhao, Ping Yuan, Qin-Hua Zhao, Su-Gang Gong, Rui Zhang, Jing He, Ci-Jun Luo, Hong-Ling Qiu, Jin-Ming Liu, Lan Wang, Rong Jiang
Summary: Exercise training has significant positive effects on exercise capacity and quality of life in chronic thromboembolic pulmonary hypertension patients after pulmonary endarterectomy, and it is considered safe. Larger scale studies are required to confirm the effectiveness and safety of exercise training in these patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Kosuke Nakamura, Suguru Ishizaka, Kazunori Omote, Yutaro Yasui, Yoshifumi Mizuguchi, Sakae Takenaka, Yui Shimono, Ko Motoi, Hiroyuki Aoyagi, Yoji Tamaki, Sho Kazui, Yuki Takahashi, Kohei Saiin, Seiichiro Naito, Atsushi Tada, Yuta Kobayashi, Takuma Sato, Kiwamu Kamiya, Toshiyuki Nagai, Toshihisa Anzai
Summary: This study aimed to investigate the impact of mild tricuspid regurgitation on patients with chronic heart failure. The results showed that patients with mild TR had worse symptoms, reduced exercise capacity, and poor clinical outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Julia Durzynska
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2017)
Review
Biotechnology & Applied Microbiology
Julia Durzynska, Krzysztof Lesniewicz, Elzbieta Poreba
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2017)
Article
Biochemistry & Molecular Biology
Soohyun Park, Jie Cui, Wangsheng Yu, Ling Wu, Kendra S. Carmon, Qingyun J. Liu
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Multidisciplinary Sciences
SooHyun Park, Sheereen Majd
Article
Clinical Neurology
Elisabeth R. Barton, Jennifer Pham, Becky K. Brisson, SooHyun Park, Lucas R. Smith, Min Liu, Zuozhen Tian, David W. Hammers, Georgios Vassilakos, H. Lee Sweeney
Article
Multidisciplinary Sciences
Rui Jiang, Steven Vandal, SooHyun Park, Sheereen Majd, Erkan Tuzel, William O. Hancock
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Jianghua Tu, Soohyun Park, Wangsheng Yu, Sheng Zhang, Ling Wu, Kendra Carmon, Qingyun J. Liu
SCIENTIFIC REPORTS
(2019)
Review
Biotechnology & Applied Microbiology
Elzbieta Poreba, Julia Durzynska
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2020)
Review
Biochemistry & Molecular Biology
Elzbieta Poreba, Krzysztof Lesniewicz, Julia Durzynska
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Soohyun Park, Ling Wu, Jianghua Tu, Wangsheng Yu, Yukimatsu Toh, Kendra S. Carmon, Qingyun J. Liu
Article
Multidisciplinary Sciences
Wojciech J. Szlachcic, Agnieszka Dabrowska, Aleksandra Milewska, Natalia Ziojla, Katarzyna Blaszczyk, Emilia Barreto-Duran, Marek Sanak, Marcin Surmiak, Katarzyna Owczarek, Dariusz Grzanka, Julia Durzynska, Krzysztof Pyrc, Malgorzata Borowiak
Summary: Recent studies have found that SARS-CoV-2 can infect the adult human pancreas and cause damage. In this study, it was discovered that the receptors ACE2, TMPRSS2, and NRP1, which are necessary for SARS-CoV-2 infection, are expressed in the precursor cells of insulin-producing pancreatic beta-cells. The study also revealed that SARS-CoV-2 can efficiently enter and replicate in human multipotent pancreatic and endocrine progenitors. Interestingly, the mechanism of viral entry in pancreatic cells involves cathepsin-dependent endocytosis, which differs from the entry route in the respiratory tract. These findings have implications for studying potential drugs to inhibit viral entry and understanding the impact of SARS-CoV-2 infection on pancreas development.
Article
Biotechnology & Applied Microbiology
Elzbieta Poreba, Krzysztof Lesniewicz, Julia Durzynska
Summary: This review presents an overview of the novel noncanonical activities of KMT2 complexes in cellular processes, including DNA damage response, cell division, and metabolic activities. These discoveries have significant implications for understanding the functions of these methyltransferases in developmental processes, disease, and epigenome-targeting therapeutic strategies.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2022)
Proceedings Paper
Biophysics
SooHyun Park, Mohammad R. Abidian, Sheereen Majd
2017 39TH ANNUAL INTERNATIONAL CONFERENCE OF THE IEEE ENGINEERING IN MEDICINE AND BIOLOGY SOCIETY (EMBC)
(2017)