Article
Microbiology
Arianne Lovey, Mila Krel, Allen Borchardt, Thomas Brady, Jason N. Cole, Quyen-Quyen Do, Joanne Fortier, Grayson Hough, Wanlong Jiang, Alain Noncovich, Les Tari, Qiping Zhao, James M. Balkovec, Yanan Zhao, David S. Perlin
Summary: ADCs have the potential to bind strongly to drug-resistant G- pathogens, regardless of lipopolysaccharide modifications, indicating a promising treatment alternative in infections caused by drug-resistant G- bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Immunology
Arsheena Yassin, Mariya Huralska, Jason M. Pogue, Deepali Dixit, Robert G. Sawyer, Keith S. Kaye
Summary: The prevalence of multidrug-resistant gram-negative bacterial infections has significantly increased in the past decade, leading to higher rates of morbidity and mortality. Treating these infections presents challenges, particularly for critically ill patients with limited margin for error. The availability of new therapies has improved treatment options, but optimal clinical and therapeutic approaches for managing these infections still need to be established.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Chemistry, Medicinal
Kenneth I. Onyedibe, Ansley M. Nemeth, Neetu Dayal, Richard D. Smith, Jones Lamptey, Robert K. Ernst, Roberta J. Melander, Christian Melander, Herman O. Sintim
Summary: Researchers have discovered a compound called HSD1624 that enhances the effectiveness of the antibiotic colistin against resistant bacteria in multiple strains.
ACS INFECTIOUS DISEASES
(2023)
Article
Microbiology
Yi Zhang, Yijia Han, Lingbo Wang, Jingchun Kong, Wei Pan, Xiaodong Zhang, Lijiang Chen, Zhuocheng Yao, Tieli Zhou, Jianming Cao
Summary: The combination of colistin and flufenamic acid (FFA) has synergistic activity against multidrug-resistant (MDR) Gram-negative bacteria. This combination treatment shows effective antibacterial and antibiofilm activities in vitro and improves the survival rates of infected larvae in animal models. It has the potential to be a promising therapeutic tool for combating MDR bacteria and improving patient outcomes.
MICROBIOLOGY SPECTRUM
(2023)
Article
Public, Environmental & Occupational Health
Z. Elnasser, R. Elsamarneh, H. Obeidat, Z. Amarin, S. Jaradat, N. Kaplan
Summary: The study identified multidrug-resistant Gram negative bacteria isolates with high resistance to various antibiotics, including approximately 21.4% resistance to tigecycline. These pathogens also carried resistance-related genes such as AcrB, RamR, and TetA.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Microbiology
Yuvaneswary Veloo, Syahidiah S. A. Thahir, Sakshaleni Rajendiran, Lim K. Hock, Norazah Ahmad, Vickneshwaran Muthu, Rafiza Shaharudin
Summary: The indiscriminate use of antibiotics in poultry farming has led to the emergence of antibiotic-resistant bacteria in poultry products and the surrounding environment. This study found high rates of multidrug-resistant Gram-negative bacteria in the environment of poultry farms, with some strains exhibiting resistance to multiple antibiotics. The presence of these bacteria poses a significant threat to the effectiveness of available antibiotics in treating infectious diseases. Efforts to regulate antibiotic use and conduct research on One Health issues are necessary to combat and prevent the spread of antibiotic-resistant bacteria.
MICROBIOLOGY SPECTRUM
(2022)
Review
Infectious Diseases
Michael Thy, Jean-Francois Timsit, Etienne de Montmollin
Summary: Aminoglycosides are effective antibiotics against resistant Gram-negative bacterial infections, but their use in sepsis and septic shock has been reduced due to renal and cochleovestibular toxicity. This article reviews their spectrum of activity and current indications, with a focus on multidrug-resistant bacteria.
Review
Immunology
Flora Cruz-Lopez, Adrian Martinez-Melendez, Rayo Morfin-Otero, Eduardo Rodriguez-Noriega, Hector J. Maldonado-Garza, Elvira Garza-Gonzalez
Summary: Infections caused by Gram-negative multi-drug resistant (MDR) bacterial species are difficult to treat due to widespread antibiotic resistance. New antibiotics and combinations with existing drugs have shown potential in treating these infections, but there are reports of resistance to these treatments.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Selene Rebecca Boncompagni, Maria Micieli, Tiziana Di Maggio, Noemi Aiezza, Alberto Antonelli, Tommaso Giani, Gloria Padoani, Silvia Vailati, Lucia Pallecchi, Gian Maria Rossolini
Summary: This study investigated the activity of fosfomycin, colistin, and their combination against multidrug-resistant Gram-negative pathogens. The results showed that the combination of fosfomycin and colistin exhibited synergistic effects against biofilms and reduced the emergence of drug-resistant subpopulations.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Sisi Zhen, Hui Wang, Sizhou Feng
Summary: CAZ-AVI is a valuable therapeutic option for MDR-GNB infections, particularly for KPC or OXA-48 CRE infections. It shows significant benefits and improved clinical outcomes, even in immunocompromised patients. Early use of CAZ-AVI is associated with better efficacy. However, resistance development in CRE and MDR-PA against CAZ-AVI is a concern, and further investigations are needed.
Review
Medicine, General & Internal
Aaron Matlock, Joshua Allan Garcia, Kayvan Moussavi, Brit Long, Stephen Yuan-Tung Liang
Summary: Antimicrobial resistance poses a growing threat to public health, making it increasingly important for acute care physicians to be familiar with novel antibiotics for appropriate utilization in combating infections caused by resistant gram-negative bacteria in the acute care setting.
INTERNAL AND EMERGENCY MEDICINE
(2021)
Article
Chemistry, Medicinal
Wenhui Guo, Yan Liu, Zhuocheng Yao, Huijing Zhou, Xiuxiu Wang, Zeyu Huang, Xiaotuan Zhang, Qing Wu, Tieli Zhou
Summary: This study found that bithionol (BT), an FDA-approved anthelminthic drug, exhibited a synergistic antibacterial effect with colistin (COL) against colistin-resistant Gram-negative bacteria (COL-R GNB). In addition to reversing the sensitivity of COL-R GNB to COL, BT also reduced bacterial biofilm formation and showed a scavenging effect on mature biofilm. The BT/COL combination demonstrated a synergistic antibacterial effect both in vitro and in vivo, and BT was considered safe at the concentrations used.
ACS INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Kade D. Roberts, Yan Zhu, Mohammad A. K. Azad, Mei-Ling Han, Jiping Wang, Lynn Wang, Heidi H. Yu, Andrew S. Horne, Jo-Anne Pinson, David Rudd, Nicolas H. Voelcker, Nitin A. Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J. Hecker, Philip E. Thompson, Roger L. Nation, Michael N. Dudley, David C. Griffith, Tony Velkov, Jian Li
Summary: The emergence of multidrug-resistant Gram-negative pathogens poses a global medical challenge. Polymyxin antibiotics are often the last therapeutic option against these pathogens, but they have limitations in safety and efficacy. This study reports the discovery and development of a synthetic lipopeptide that shows improved safety and efficacy against top-priority multidrug-resistant Gram-negative pathogens.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Mengxin Xu, Zhuocheng Yao, Yining Zhao, Shiyi Shi, Yao Sun, Luozhu Feng, Cui Zhou, Xiaodong Zhang, Jianming Cao, Tieli Zhou
Summary: Combining naringenin (NG) with colistin has been shown to effectively inhibit multidrug-resistant Gram-negative bacteria, reduce biofilm formation, and improve survival rates and microbial load in infection models. This combination does not exhibit cytotoxicity and has potential clinical therapeutic value.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Christine A. Pybus, Christina Felder-Scott, Victor Obuekwe, David E. Greenberg
Summary: The study compared the antimicrobial activity of Cefiderocol with seven commonly used antibiotics against multidrug-resistant pathogens, finding that Cefiderocol had potent inhibitory effects on biofilms of various pathogens, with consistently lower MIC90 values compared to other antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Letter
Virology
Giancarlo Ceccarelli, Gabriele d'Ettorre, Alessandro Russo, Silvia Fabris, Massimo Ciccozzi, Gabriella d'Ettorre
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Elda Righi, Lorenza Lambertenghi, Anna Gorska, Concetta Sciammarella, Federico Ivaldi, Massimo Mirandola, Assunta Sartor, Evelina Tacconelli
Summary: This study found that COVID-19 patients receiving antibiotic treatment may shift the gut microbiome composition towards opportunistic bacteria (OBs), particularly Enterococcus. The treatment-induced dysbiosis may impact infections and long-term consequences, providing important clues to the role of gut homeostasis in COVID-19 recovery.
Article
Instruments & Instrumentation
I. Mateos Dominguez, G. Blanchot, P. Chatagnon, S. Cooperstein, A. Di Mattia, A. Honma, K. Klein, M. Kovacs, A. La Rosa, I. Makarenko, Y. Otarid, A. Pauls, Z. Pissaki, K. Schleidweiler, S. Seif El Nasr, A. Zografos
Summary: Fifty thousand hybrid circuits of five different types will be manufactured for the Phase-2 Upgrade of the CMS Outer Tracker. These circuits must undergo functional testing and visual inspection before being assembled into modules. Software tools are developed to carry out these tasks and store the results in the CMS production database.
JOURNAL OF INSTRUMENTATION
(2023)
Article
Microbiology
Francesco Alessandri, Giancarlo Ceccarelli, Giuseppe Migliara, Valentina Baccolini, Alessandro Russo, Carolina Marzuillo, Mariateresa Ceparano, Giovanni Giordano, Pierfrancesco Tozzi, Gioacchini Galardo, Giammarco Raponi, Claudio Mastroianni, Mario Venditti, Francesco Pugliese, Gabriella d'Ettorre
Summary: This study analyzed the incidence of bloodstream infections (BSI) due to Candida in COVID-19 patients supported with ECMO, and found that the incidence of candidemia was significantly higher in the ECMO group compared to the control group. This result was confirmed by survival analysis and multivariable analyses.
Review
Infectious Diseases
Elda Righi, Luigia Scudeller, Massimo Mirandola, Alessandro Visentin, Nico T. Mutters, Marco Meroi, Anna Schwabe, Anna Erbogasto, Gianluca Vantini, Elizabeth L. A. Cross, Maddalena Giannella, Xavier Guirao, Evelina Tacconelli
Summary: This study conducted a systematic review and meta-analysis and found that patients colonised with extended-spectrum cephalosporin-resistant Enterobacterales (ESCR-E) before surgery are more likely to develop postoperative infections. Preoperative screening for ESCR-E in adult inpatients may help reduce the incidence of surgical site infections.
INFECTIOUS DISEASES AND THERAPY
(2023)
Article
Nuclear Science & Technology
D. Marcuzzi, V. Toigo, M. Boldrin, G. Chitarin, S. Dal Bello, L. Grando, A. Luchetta, R. Pasqualotto, M. Pavei, G. Serianni, L. Zanotto, R. Agnello, P. Agostinetti, M. Agostini, D. Aprile, M. Barbisan, M. Battistella, G. Berton, M. Bigi, M. Brombin, V. Candela, V. Candeloro, A. Canton, R. Casagrande, C. Cavallini, R. Cavazzana, L. Cordaro, N. Cruz, M. Dalla Palma, M. Dan, A. De Lorenzi, R. Delogu, M. De Muri, M. De Nardi, S. Denizeau, M. Fadone, F. Fellin, A. Ferro, E. Gaio, C. Gasparrini, F. Gnesotto, P. Jain, A. La Rosa, D. Lopez-Bruna, R. Lorenzini, A. Maistrello, G. Manduchi, S. Manfrin, N. Marconato, I. Mario, G. Martini, R. Milazzo, T. Patton, S. Peruzzo, N. Pilan, A. Pimazzoni, C. Poggi, N. Pomaro, B. Pouradier-Duteil, M. Recchia, A. Rigoni-Garola, D. Rizzetto, A. Rizzolo, F. Santoro, E. Sartori, B. Segalini, A. Shepherd, M. Siragusa, P. Sonato, A. Sottocornola, E. Spada, S. Spagnolo, M. Spolaore, C. Taliercio, P. Tinti, P. Tomsic, L. Trevisan, M. Ugoletti, M. Valente, M. Valisa, F. Veronese, M. Vignando, P. Zaccaria, R. Zagorski, B. Zaniol, M. Zaupa, M. Zuin, M. Cavenago, D. Boilson, C. Rotti, H. Decamps, F. Geli, A. Sharma, P. Veltri, J. Zacks, M. Simon, F. Paolucci, A. Garbuglia, D. Gutierrez, A. Masiello, G. Mico, C. Labate, P. Readman, E. Bragulat, L. Bailly-Maitre, G. Gomez, G. Kouzmenko, F. Albajar, M. Kashiwagi, H. Tobari, A. Kojima, M. Murayama, S. Hatakeyama, E. Oshita, T. Maejima, N. Shibata, Y. Yamashita, K. Watanabe, N. P. Singh, M. J. Singh, H. Dhola, U. Fantz, B. Heinemann, C. Wimmer, D. Wuenderlich, K. Tsumori, G. Croci, G. Gorini, A. Muraro, M. Rebai, M. Tardocchi, L. Giacomelli, D. Rigamonti, F. Taccogna, D. Bruno, M. Rutigliano, S. Longo, S. Deambrosis, E. Miorin, F. Montagner, A. Tonti, F. Panin
Summary: ITER plans to use two heating neutral beam injectors plus an optional one as part of its auxiliary heating and current drive system. The expected power per injector is higher than existing facilities worldwide. To enable this development, a Neutral Beam Test Facility (NBTF) has been established, consisting of two test beds called SPIDER and MITICA. SPIDER focuses on developing and characterizing efficient negative ion sources, while MITICA is a full-scale prototype of the ITER Neutral Beam Injector. The lessons learned from the NBTF implementation and future perspectives are discussed.
FUSION ENGINEERING AND DESIGN
(2023)
Article
Geosciences, Multidisciplinary
Alessandro La Rosa, Martina Raggiunti, Carolina Pagli, Derek Keir, Hua Wang, Atalay Ayele
Summary: A series of earthquakes occurred in the northern Afar region, which were found to be caused by tectonic faulting without involvement of magma movements. Measurement models show that the extension from faulting corresponds to approximately 30 years of plate spreading. The observations indicate significant variation in the proportion of extension from faulting along the rift.
GEOPHYSICAL RESEARCH LETTERS
(2023)
Review
Biochemistry & Molecular Biology
Nadia Marascio, Giuseppe Guido Maria Scarlata, Francesco Romeo, Claudia Cicino, Enrico Maria Trecarichi, Angela Quirino, Carlo Torti, Giovanni Matera, Alessandro Russo
Summary: Sepsis, a life-threatening condition caused by an abnormal host response to infection, results in multiple organ dysfunction and has a high global mortality rate, with 11 million deaths per year in high-income countries. Studies have shown that septic patients often have dysbiotic gut microbiota, which is associated with increased mortality. This narrative review examines original articles, clinical trials, and pilot studies to evaluate the potential benefits of manipulating the gut microbiota in clinical practice, starting with early sepsis diagnosis and in-depth analysis of the gut microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Biochemistry & Molecular Biology
Alessandro Russo, Rita Pallone, Enrico Maria Trecarichi, Carlo Torti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Giancarlo Ceccarelli, Beatrice Perciballi, Alessandro Russo, Paolo Martini, Francesco Marchetti, Marco Rivano Capparuccia, Giancarlo Iaiani, Silvia Fabris, Massimo Ciccozzi, Ciro Villani, Mario Venditti, Gabriella D'Ettorre, Daniele De Meo
Summary: Prosthetic joint infection (PJI) and fracture-related infection (FRI) are challenging conditions in high-risk patients. For those not eligible for standard treatment, combination therapy of debridement, long-term antibiotics, and chronic oral antimicrobial suppression (COAS) can be a reasonable option. This study retrospectively analyzed 16 patients who underwent COAS after debridement and antibiotic treatment, with a median follow-up of 15 months. The monitoring of patients included clinical evaluation, laboratory tests, and radiolabeled leukocyte scintigraphy (LS). The results showed that 62.5% of patients had no relapse after cure at the last evaluation, while side effects led to COAS discontinuation in 50% of the patients who experienced a relapse.
Letter
Immunology
Maurizio Guastalegname, Enrico Maria Trecarichi, Alessandro Russo
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Sara Palma Gulli, Alessandro Russo
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Infectious Diseases
A. Russo, A. Bruni, S. Gulli, C. Borrazzo, A. Quirino, R. Lionello, F. Serapide, E. Garofalo, R. Serraino, F. Romeo, N. Marascio, G. Matera, F. Longhini, E. M. Trecarichi, C. Torti
Summary: This study observed VAP and concurrent bloodstream infections caused by CRAB, finding that chronic obstructive pulmonary disease and age were independently associated with 30-day mortality, while cefiderocol-containing regimens and cefiderocol + fosfomycin in combination were independently associated with 30-day survival.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medicine, General & Internal
Giancarlo Ceccarelli, Francesco Alessandri, Giuseppe Migliara, Valentina Baccolini, Giovanni Giordano, Gioacchino Galardo, Carolina Marzuillo, Corrado De Vito, Alessandro Russo, Massimo Ciccozzi, Paolo Villari, Mario Venditti, Claudio M. Mastroianni, Francesco Pugliese, Gabriella d'Ettorre
Summary: The study aimed to assess the accuracy of procalcitonin levels as a diagnostic tool and found that elevated levels may not always indicate bacterial superinfections or coinfections in severe COVID-19 cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Ferdinando Carmelo Pio Lionello, Salvatore Rotundo, Gabriele Bruno, Gabriella Marino, Helen Linda Morrone, Paolo Fusco, Chiara Costa, Alessandro Russo, Enrico Maria Trecarichi, Anna Beltrame, Carlo Torti
Summary: Among infectious diseases, zoonoses are becoming more important worldwide, particularly in the Mediterranean region. This study reports clinical cases from a hospital in Southern Italy and provides a review of the epidemiological and clinical features of these diseases. The review also highlights the pathogenic mechanisms used by pathogens to evade the host immune system.
