Article
Biochemistry & Molecular Biology
Ranjithkumar Rajendran, Vinothkumar Rajendran, Mario Giraldo-Velasquez, Fevronia-Foivi Megalofonou, Fynn Gurski, Christine Stadelmann, Srikanth Karnati, Martin Berghoff
Summary: MS is a chronic inflammatory and degenerative disease of the central nervous system commonly affecting the cerebellum. FGFs and FGFRs are involved in demyelinating pathologies such as MS. Recent research shows that cell-specific deletion of FGFR1 has anti-inflammatory and neuroprotective effects in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jennifer Enrich-Bengoa, Gemma Manich, Irene R. Degano, Alex Peralvarez-Marin
Summary: This study identified molecules associated with demyelinating disorders and multiple sclerosis through transcriptomic analysis, and discovered the interaction and related genes between microglia and oligodendrocyte progenitor cells. This research provides clues for further study on the treatment of demyelinating disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Hengri Cong, Mengru Liang, Yupeng Wang, Haoxiao Chang, Li Du, Xinghu Zhang, Linlin Yin
Summary: Icariin treatment can alleviate CPZ-induced demyelination in mice by preserving MBP and BDNF proteins and modulating the numbers of Ols, microglia, and astrocytes in the brain.
BRAIN RESEARCH BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Ilias Kalafatakis, Domna Karagogeos
Summary: This review summarizes the regulation of myelination by oligodendrocytes under physiological and pathological conditions, as well as the role of microglia in myelin generation, regeneration, and repair. The beneficial and detrimental roles of microglia in remyelination are discussed, along with the cellular and molecular components involved. Recent findings related to preclinical models using human stem cells for studying microglia in human pathologies and the impact of the microbiome on glial cell functions are also presented.
Review
Biochemistry & Molecular Biology
V. S. B. Wies Mancini, V. S. Mattera, J. M. Pasquini, L. A. Pasquini, J. D. Correale
Summary: Microglia play a crucial role in the central nervous system and can be activated to different states, releasing extracellular vesicles that have both pro-inflammatory and pro-regenerative effects. These vesicles can influence neighboring cells and contribute to processes such as synapse development, inflammation, and remyelination.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Yuanyuan Wang, Roxanne V. Kyauk, Yun-An A. Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J. Greene, Morgan Sheng, Tracy J. Yuen
Summary: Disability in multiple sclerosis (MS) is partially caused by the failure of remyelination and progressive neurodegeneration. The role of microglia, especially triggering receptor expressed on myeloid cells 2 (TREM2), in remyelination is significant. In this study, using a mouse model of focal demyelination, we found that TREM2 knockout mice had persistent demyelination and subsequent neurodegeneration lasting more than 6 weeks. Furthermore, TREM2 knockout microglia showed defects in migration and phagocytosis of myelin debris.
Article
Neurosciences
Ksenija Martinovic, Jan Bauer, Markus Kunze, Johannes Berger, Sonja Forss-Petter
Summary: X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disease caused by mutations in the ABCD1 gene. We combined two mouse models to investigate the role of X-ALD oligodendrocytes in demyelination. We found that Abcd1 deficient mice exhibited increased vulnerability in the early demyelinating phase, leading to more severe axonal damage.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2023)
Review
Neurosciences
Martin Zirngibl, Peggy Assinck, Anastasia Sizov, Andrew Caprariello, Jason R. Plemel
Summary: This review provides an updated understanding of cuprizone-induced demyelination, showcasing two modes of action: intrinsic cell damage and extrinsic cellular damage. Recent developments in research on different forms of cell death induced by cuprizone are also summarized.
MOLECULAR NEURODEGENERATION
(2022)
Article
Neurosciences
Simon Hametner, Sara Silvaieh, Majda Thurnher, Assunta Dal-Bianco, Hakan Cetin, Markus Ponleitner, Karin Zebenholzer, Berthold Pemp, Siegfried Trattnig, Karl Roessler, Thomas Berger, Hans Lassmann, Johannes A. Hainfellner, Gabriel Bsteh
Summary: In this case report, a 22-year-old woman presented with acute dizziness, gait dysbalance, and blurred vision. Magnetic resonance imaging revealed a lesion in the white matter affecting the right optic radiation. Ophthalmologic examination showed mild quadrantanopia, but no signs of optic neuropathy. Biopsy and neuropathological evaluation revealed a demyelinating lesion with unique cellular changes. Multiple sclerosis was excluded, but the exact etiology of the lesion remains unknown.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jacopo Angelini, Davide Marangon, Stefano Raffaele, Davide Lecca, Maria P. Abbracchio
Summary: The study identified a significant increase of GPR17-expressing cells in multiple sclerosis (MS) patients, mainly accumulating in the normal appearing white matter (NAWM) with moderate inflammation. Additionally, two distinct subpopulations of GPR17-expressing oligodendroglial cells were found in the white matter of healthy controls and MS patients, characterized by different morphologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Julie J. Ahn, Yusra Islam, Cheryl Clarkson-Paredes, Molly T. Karl, Robert H. Miller
Summary: Multiple sclerosis is a disease characterized by compromised blood-brain barrier and peripheral lymphocytes entering the central nervous system. Although T cells have been considered the main contributors to neuroinflammation, the success of B cell depletion therapies suggests an important role for B cells. In an animal model of MS, B cell depletion affects glial cell function and CNS vasculature.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Biology
Yanan Chen, Rejani B. Kunjamma, Molly Weiner, Jonah R. Chan, Brian Popko
Summary: Enhancing the integrated stress response (ISR) can promote remyelination in inflammatory environments of multiple sclerosis (MS) patients, potentially providing reparative benefits.
Review
Cell Biology
Ivo H. Hernandez, Mario Villa-Gonzalez, Gerardo Martin, Manuel Soto, Maria Jose Perez-Alvarez
Summary: Ischemic stroke, as the second leading cause of death and the first cause of long-term disability worldwide, poses a significant socioeconomic burden. Current approved treatments such as thrombectomy and rtPA administration are effective in some cases but not suitable for a large proportion of patients. Advancements in glial cell-related therapies, particularly in promoting protective phenotypes and inhibiting neurotoxic profiles, show promising results in different in vivo models of stroke. Oligodendrogenesis after brain ischemia seems beneficial, but these cells are less studied players and potential negative effects may arise in the future.
Article
Cell Biology
Christina B. Schroeter, Alexander M. Herrmann, Stefanie Bock, Anna Vogelsang, Susann Eichler, Philipp Albrecht, Sven G. Meuth, Tobias Ruck
Summary: This study introduces a new protocol for the simultaneous purification of all major CNS-resident cell types from adult mice, including microglia, oligodendrocytes, astrocytes, and neurons, offering a sophisticated and comprehensive way to investigate complex cellular networks ex vivo and simultaneously reduce the number of sacrificed mice. The purity of each cell isolation averaged 90%, with all cells displaying cell-type-specific morphologies and expressing specific surface markers.
Article
Biochemistry & Molecular Biology
Laura Moles, Ander Egimendia, Inaki Osorio-Querejeta, Leire Iparraguirre, Ainhoa Alberro, Jose Suarez, Lucia Sepulveda, Tamara Castillo-Trivino, Maider Munoz-Culla, Pedro Ramos-Cabrer, David Otaegui
Summary: This study characterized microbial changes in murine demyelinating models and found correlations with disease progression, resembling characteristics of dysbiosis in multiple sclerosis (MS) patients. The findings provide insights into the interplay between microbiota and demyelination processes, highlighting the potential for modulating microbiota as a therapeutic strategy for MS.
ACS CHEMICAL NEUROSCIENCE
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Kaitlyn Thompson, Stella Tsirka
Article
Immunology
Barrett D. Allen, Amber Syage, Mattia Maroso, Al Anoud D. Baddour, Valerie Luong, Harutyun Minasyan, Erich Giedzinski, Brian L. West, Ivan Soltesz, Charles L. Limoli, Janet E. Baulch, Munjal M. Acharya
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Pharmacology & Pharmacy
Alexandros G. Kokkosis, Stella E. Tsirka
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2020)
Article
Hematology
Catherine C. Smith, Mark J. Levis, Olga Frankfurt, John M. Pagel, Gail J. Roboz, Richard M. Stone, Eunice S. Wang, Paul L. Severson, Brian L. West, Mai H. Le, Sabine Kayser, Bao Lam, Henry H. Hsu, Chao Zhang, Gideon Bollag, Alexander E. Perl
Article
Neurosciences
Dave E. Marzan, Valerie Brugger-Verdon, Brian L. West, Shane Liddelow, Jayshree Samanta, James L. Salzer
Summary: The activated microglia play a crucial role in demyelination, with CSF1 signaling being implicated in these events.
Article
Neurosciences
Michael D. Caponegro, Ki Oh, Miguel M. Madeira, Daniel Radin, Nicholas Sterge, Maryam Tayyab, Richard A. Moffitt, Stella E. Tsirka
Summary: The characterization of the tumor microenvironment in high grade gliomas is essential for understanding the progression of neoplastic lesions and identifying potential therapeutic targets. Peritumoral GAM are a unique subset of immune cells with pro-inflammatory characteristics, associated with monocyte recruitment and decreased overall survival. Their differentiation from other immune cells in the tumor-stroma interface provides a potential cellular target for tumor microenvironment interventions.
Article
Biochemistry & Molecular Biology
Alexandros G. Kokkosis, Miguel M. Madeira, Matthew R. Mullahy, Stella E. Tsirka
Summary: This study uses a repeated social defeat mouse model to reveal the long-lasting losses and transient proliferation of oligodendrocyte-lineage cells caused by chronic psychosocial stress, as well as other cellular and molecular changes associated with depression. The study also identifies the presence of immune-oligodendrocytes, a novel population of cells with immune properties and myelination deficits.
MOLECULAR PSYCHIATRY
(2022)
Editorial Material
Multidisciplinary Sciences
Stella E. Tsirka
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Miguel M. Madeira, Zachary Hage, Stella E. Tsirka
Summary: Oligodendroglia play a critical role in CNS homeostasis by myelinating neuronal axons, and dysfunction in this lineage may lead to demyelinating disorders. Under inflammatory conditions, oligodendroglia can adopt immune proteasome components, potentially playing a role in activating CD4+ T cells.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Tanya R. Victor, Zachary Hage, Stella E. Tsirka
Summary: The study examines the effects of commercially available CBD on microglia inflammatory activation and neurogenic response in the presence and absence of seizures. CBD significantly dampens microglial migration and accumulation to the hippocampus, reducing the number of ectopic neurons deposited in the hippocampal area post seizure.
Review
Immunology
Gregory T. Smith, Daniel P. Radin, Stella E. Tsirka
Summary: There has been a significant increase in understanding the role of the glioma tumor microenvironment in the development and progression of glioblastoma. However, current standard therapy only targets tumor cells and does not address the pro-tumorigenic functions of non-cancerous cells in the microenvironment, leading to poor prognosis. It is important to identify targets expressed on multiple cell types and understand how they govern tumor-promoting functions in order to better manage this disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Alexandros G. Kokkosis, Miguel M. Madeira, Zachary Hage, Kimonas Valais, Dimitris Koliatsis, Emran Resutov, Stella E. Tsirka
Summary: Chronic environmental stress and traumatic social experiences are risk factors for major depressive disorder and anxiety-related psychiatric disorders. Studies have shown that symptom severity is related to innate immune responses and upregulation of neuroinflammatory cytokine signaling in the brain's mood regulation areas. However, the role of microglia in modulating neuronal homeostasis in response to chronic stress has not been fully defined.
Review
Medicine, General & Internal
Yinghui Li, Laurel E. Schappell, Claire Polizu, James Dipersio, Stella E. Tsirka, Marc W. Halterman, Neil A. Nadkarni
Summary: Ischemic stroke is a severe disease, and the translational research in neuroprotection has had limited breakthroughs. However, the scientific community continues to investigate and the concept of cerebroprotection has gained attention recently to optimize stroke outcomes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Michael D. Caponegro, Kaitlyn Koenig Thompson, Maryam Tayyab, Stella E. Tsirka
Summary: Studying monocytic cells in isolated in vitro systems contributes significantly to understanding innate immune physiology, and integrating results with in vivo models can help develop therapeutic approaches. Current methodologies for quantifying phagocytic function of monocytic cells in vitro have technical challenges and limitations, but the proposed protocol addresses these issues and provides a comparison with existing workflows.
Article
Immunology
Kristina Berve, Brian L. West, Rudolf Martini, Janos Groh
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)