Article
Urology & Nephrology
Marcel G. Naik, Wolfgang Arns, Klemens Budde, Fritz Diekmann, Frank Eitner, Wilfried Gwinner, Nils Heyne, Jan Steffen Jurgensen, Christian Morath, Udo Riester, Katharina M. Heller, Michael Fischereder
Summary: The study retrospectively analyzed 726 renal transplant recipients converted to sirolimus, showing lower cancer incidence rates after conversion. Patients with prior malignancy were older but had lower cancer rates after conversion. Renal function and graft survival were better in all cancer types compared to patients converted to sirolimus without cancers. Patient survival was largely dependent on tumor entity.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Pediatrics
Matko Marlais, Kate Martin, Stephen D. Marks
Summary: This study found that pre-emptively transplanted children have improved 5-year renal allograft survival compared to children on dialysis at the time of transplantation. Longer time spent on dialysis pre-transplant negatively correlated with renal allograft survival, but short periods of dialysis did not significantly affect renal allograft survival.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Medicine, General & Internal
Florian Terrec, Johan Noble, Hamza Naciri-Bennani, Paolo Malvezzi, Benedicte Janbon, Camille Emprou, Diane Giovannini, Lionel Rostaing, Thomas Jouve
Summary: This study showed that protocol kidney biopsy at 3 months post-transplantation was associated with improved graft survival, potentially by early treatment of subclinical immunological events or better management of immunosuppressive regimen. The presence of IF/TA score and cv lesions had significant impacts on graft survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Felix Becker, Anne-Sophie Mehdorn, Vasilios Getsopulos, Katharina Schuette-Nuetgen, Stefan Reuter, Barbara Suwelack, Andreas Pascher, Jens G. Brockmann, Ralf Bahde
Summary: The study found that renal transplant recipients with a history of pretransplant malignancy (PTM) have inferior graft survival rates, highlighting the need for enhanced monitoring of these recipients and heightened vigilance for cancer recurrence.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Kris Denhaerynck, Alexander S. Goldfarb-Rumyantzev, Gurprataap Sandhu, Sonja Beckmann, Uyen Huynh-Do, Isabelle Binet, Sabina De Geest
Summary: This study analyzed the impact of pre-transplant social determinants of health on post-transplant outcomes using data from the Swiss Transplant Cohort Study (STCS), and found that there was no significant association between SAI score and mortality or return to dialysis in this Swiss sample.
CLINICAL TRANSPLANTATION
(2021)
Review
Transplantation
Dermot Michael Wildes, Caoimhe S. Costigan, Mairead Kinlough, Joan Flynn, Niamh Dolan, Michael Riordan, Clodagh Sweeney, Maria Stack, Mary Waldron, Orla Walsh, Kathleen M. Gorman, Atif Awan
Summary: Adolescence is a crucial period of transformation for patients, guardians, and clinicians. There is a lack of specific models for transitional care tailored to kidney transplant recipients. Further research and validation studies are needed to determine the optimal approach for providing effective transitional care to these patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Biochemistry & Molecular Biology
Kathleen M. Job, Jessica K. Roberts, Elena Y. Enioutina, Silvia M. IIIamola, Shaun S. Kumar, Jahidur Rashid, Robert M. Ward, Tsuyoshi Fukuda, Joseph Sherbotie, Catherine M. Sherwin
Summary: This review examines the impact of pharmacokinetic variability on renal transplantation and its association with various factors. Pharmacodynamics are outlined for each immunosuppressant, along with potential adverse effects and the utility of pharmacodynamic biomarkers. Acquiring a better quantitative understanding of immunosuppressant pharmacokinetics and pharmacodynamics can help clinicians maintain the balance between therapeutic efficacy and drug-related toxicity.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2021)
Article
Surgery
Abhishek Jaiswal, David A. Baran, Supanee Sinphurmsukskul, William L. Baker
Summary: This study investigates the trends, characteristics, and outcomes associated with heart donations from donors with significant renal dysfunction. The results show that a large portion of these hearts are discarded, but recipients who receive hearts from donors with renal dysfunction have lower mortality rates post-transplantation.
CLINICAL TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Muhammad Y. Jan, Sharon M. Moe, Oluwafisayo Adebiyi, Jeannie Chen, John Powelson, Heather N. Burney, Muhammad S. Yaqub, Dennis P. Mishler, Ranjani N. Moorthi, Tim E. Taber, Melissa D. Anderson, Yang Li, Xiaochun Li, Jonathan A. Fridell, William C. Goggins, Asif A. Sharfuddin
Summary: Hypotension after deceased donor kidney transplant (DDKT) is a common complication that can lead to delayed graft function and poor graft survival. This study found that using vasopressin to treat hypotensive DDKTRs can effectively increase blood pressure without increasing mortality, and it has no adverse effects on graft function and survival.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Pediatrics
Safaa M. Abdelrahman, Basma Samir, Eman Abobakr Abd Alazem, Noha Musa
Summary: Obesity is an independent risk factor for graft function and survival in pediatric kidney transplantation. Pre-transplant weight reduction is crucial in improving post-transplant outcomes.
Article
Urology & Nephrology
Karim El Sakhawi, Giovanna Melica, Anne Scemla, Dominique Bertrand, Cyril Garrouste, Paolo Malvezzi, Philippe Remy, Anissa Moktefi, Alexandre Ingels, Cecile Champy, Jean-Daniel Lelievre, David Kheav, Antoine Morel, David Mokrani, Philippe Attias, Philippe Grimbert, Marie Matignon
Summary: The study found that the switch from CNI to belatacept in HIV-positive kidney allograft recipients may increase long-term kidney allograft survival rates. Results showed that the conversion treatment did not increase the risk of HIV replication after a year, but the importance of patient medication compliance and adverse events should be noted.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Mathematics
Alvaro Bevia-Romero, Francisco Quereda-Flores, Javier Diaz-Carnicero, Francisco Gomez-Palomo, Maria Ramos-Cebrian, Joaquin Espinosa-Vano, Dario J. Castillo-Anton, Enrique Broseta-Rico, David Vivas-Consuelo, Alberto Budia-Alba
Summary: The aim of this study was to analyze the survival of recipients and grafts after kidney transplant over a three-year period and to identify predictive factors over a follow-up of up to 10 years. In a retrospective consecutive cohort study of 250 kidney transplant recipients between 2010 and 2012, it was found that the mean follow-up was 8.1 +/- 3.2 years. Graft survival rates at 2, 5, and 10 years were 89.0%, 85.1%, and 78.4% respectively. Risk factors for graft loss included diabetic nephropathy, delayed graft function, chronic kidney rejection, and early surgical complications, while combined transplant was a protective factor. The recipient patient survival rates at 2, 5, and 10 years were 94.3%, 90.0%, and 76.6% respectively. Mortality risk factors included older recipient age, combined transplant, and opportunistic infections.
Article
Medicine, Research & Experimental
Ming-Hsien Tsai, Mingchih Chen, Hung-Hsiang Liou, Tian-Shyug Lee, Yen-Chun Huang, Pei -Yang Liu, Yu -Wei Fang
Summary: This study compared the clinical outcomes of patients who underwent parathyroidectomy before renal transplantation with those who did not. The results showed that severe hyperparathyroidism requiring parathyroidectomy before kidney transplantation may contribute to poor post-transplant graft outcomes.
MEDICAL SCIENCE MONITOR
(2023)
Article
Computer Science, Artificial Intelligence
Mohammadreza Nemati, Haonan Zhang, Michael Sloma, Dulat Bekbolsynov, Hong Wang, Stanislaw Stepkowski, Kevin S. Xu
Summary: This study proposes four new biologically-relevant feature representations for incorporating HLA information into survival analysis algorithms for kidney transplantation. Through evaluation on a database of over 100,000 transplants, it is found that these representations improve prediction accuracy modestly. This could have societal significance in improving transplant survival outcomes and reducing the need for re-transplants.
ARTIFICIAL INTELLIGENCE IN MEDICINE
(2023)
Article
Surgery
Ellen L. K. Dobrijevic, Eric H. K. Au, Natasha M. Rogers, Philip A. Clayton, Germaine Wong, Richard D. M. Allen
Summary: Recipients of right-sided living donor kidneys have a higher risk of delayed graft function and early graft loss compared to recipients of left-sided kidney. Technical challenges are the main cause of early graft loss.
TRANSPLANT INTERNATIONAL
(2022)
Editorial Material
Immunology
Mohamed A. Bakr, Ahmed B. Shehab El-Dein, Ayman F. Refaie, Ahmed A. Shokeir, Hussein A. Sheashaa, Bedeir Ali-El-Dein, Tarek El-Diasty, Amani M. Ismail, Mohamed A. Ghoneim
Article
Pharmacology & Pharmacy
Effrosyni Mendrinou, Mohamed Elsayed Mashaly, Amir Mohamed Al Okily, Mohamed Elsayed Mohamed, Ayman Fathi Refaie, Essam Mahmoud Elsawy, Hazem Hamed Saleh, Hussein Sheashaa, George P. Patrinos
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Immunology
Ayman F. Refaie, Batoul L. Elbassiouny, Malgorzata Kloc, Omaima M. Sabek, Sherry M. Khater, Amani M. Ismail, Rania H. Mohamed, Mohamed A. Ghoneim
Summary: MSC-based therapy for T1DM shows promise, but there are conflicting views on their immunological profile. Research focuses on understanding the mechanisms of their immunomodulatory functions and exploring ways to enhance their effects.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Transplantation
Mostafa Gamal, Ahmed M. Salah, Yasser A. Hendy, Ahmed F. Donia, Ayman F. Refaie
Summary: This study examined death with graft function in kidney transplant patients over a period of more than four decades. Male sex, pretransplant diabetes, steroid dose, and posttransplant infections were identified as significant risk factors for death with graft function. The most common causes of this event were cardiovascular disease, infections, and malignancy. Attention should be given to reducing cardiovascular disease risk factors, updating posttransplant vaccination policies, and increasing surveillance for malignancy, as well as adopting less aggressive immunosuppression regimens.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Review
Endocrinology & Metabolism
M. Abdalbary, M. Sobh, S. Elnagar, M. A. Elhadedy, N. Elshabrawy, M. Abdelsalam, K. Asadipooya, A. Sabry, A. Halawa, A. El-Husseini
Summary: Patients with chronic kidney disease (CKD) have a higher risk of fractures due to compromised bone quantity and/or quality. Fractures have a negative impact on the quality of life and mortality of CKD patients. The pathogenesis of bone loss and fracture in CKD is complex and multi-factorial. There is no consensus on the optimal diagnostic method for assessing bone quantity in CKD patients. Understanding the mechanism of bone loss is crucial for preventing fractures in CKD patients. Several non-pharmacological and therapeutic interventions have been reported to improve bone health, but their safety and efficacy in advanced CKD patients are uncertain. There is a significant gap in osteoporosis management in CKD patients.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Cell & Tissue Engineering
Mohamed A. Ghoneim, Mahmoud M. Gabr, Ayman F. Refaie, Sawsan M. El-Halawani, Mohga M. Al-issawi, Batoul L. Elbassiouny, Mai A. Abd El Kader, Amani M. Ismail, Mona F. Zidan, Mary S. Karras, Raghda W. Magar, Sherry M. Khater, Sylvia A. Ashamallah, Mahmoud M. Zakaria, Malgorzata Kloc
Summary: This study investigated allogenic immune responses following the transplantation of insulin-producing cells (IPCs) differentiated from human adipose tissue-derived stem cells (hAT-MSCs) into humanized mice. The results showed that the engrafted cells were not affected by allogenic immune response, suggesting potential for cell therapy for insulin-dependent diabetes without immunosuppression or encapsulation.
STEM CELL RESEARCH & THERAPY
(2022)
Meeting Abstract
Urology & Nephrology
B. Ali-El-Dein, A. Galal, M. H. Zahran, H. Refaie, M. E. Mashaly, M. T. Fouad, A. F. Refaie, I Saeed, M. Atteya, Y. Osman
Meeting Abstract
Transplantation
Mostafa Gamal, Ahmed Mohamed Salah, Yasser Hendy, Ayman Refaie
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Mohamed Zahab, Mohammed A. Fouda, Yasser Elhendy, Amir Elokely, Mona Abdul Rahim, Ayman F. Refaie, Sami Alobaidi, Ahmed Akl
Summary: This study included 402 SLE cases with lupus nephritis, finding that impaired renal function, proteinuria, and LN class were the most relevant prognostic factors for renal survival among Egyptian LN patients.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Urology & Nephrology
Ahmed Abdelfattah Denewar, Ezzat Mostafa Mohamed, Mabrouk Ibrahim M. Ismael, Amani Mostafa Ismail, Ayman Fathi Refaie
Summary: Immunosuppressive therapy is crucial for renal transplantation to balance the immune response and reduce the risk of rejection and infection. Adopting therapeutic dose monitoring strategy during follow-up of kidney transplant recipients can help reduce certain side effects and improve graft survival. Longer-term studies with larger sample sizes are needed to further support this approach.
SAUDI JOURNAL OF KIDNEY DISEASES AND TRANSPLANTATION
(2021)
Review
Urology & Nephrology
Muhammed Ahmed Elhadedy, Yazin Marie, Ahmed Halawa
Summary: By April 26, 2020, there were 203,818 reported deaths worldwide from COVID-19, affecting people in 210 countries. This study discusses the outcomes of COVID-19 in kidney transplant recipients, reporting 8 cases with common presenting symptoms of fever and cough. Treatment included supportive care and discontinuation of immunosuppressive drugs, resulting in the recovery of most patients and reduced burden on healthcare services.
Article
Oncology
Ahmed Farouk Donia, Mohammed Ashraf Fouda, Moatasem Elsayed Ghoneim, Ayman Fathi Refaie, Bedeir Ali-El-Dein
Summary: Kaposi sarcoma, previously the most common malignancy among kidney transplant recipients, has not been observed for almost a decade. Factors such as m-TOR inhibitors, steroid-free regimen, and CMV prophylaxis policy may have contributed to the disappearance of Kaposi sarcoma. However, only CMV prophylaxis policy showed statistically significant relation to the disappearance of Kaposi sarcoma.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Cell & Tissue Engineering
Mohamed A. Ghoneim, Ayman F. Refaie, Batoul L. Elbassiouny, Mahmoud M. Gabr, Mahmoud M. Zakaria
STEM CELL REVIEWS AND REPORTS
(2020)
Meeting Abstract
Transplantation
Mohamed Osama, Medhat Mahmoud, Salem El Deeb, Ahmed Elmowafy, Hussein Sheashaa, Ahmed Donia, Ayman Refaie, Ashraf Fouda
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Meeting Abstract
Transplantation
Ahmed Mohamed Naguib Attiya, Samar Elshahat, Ibrahim Galalah, Ahmed Elmowafy, Khaled Eldahshan, Salwa Elwasif, Ayman Refaie
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)