期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 46, 期 3, 页码 144-151出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000149
关键词
peak oxygen uptake; cardiovascular function; skeletal muscle function; exercise training; cardiac reinnervation
资金
- Moritz Chair in Geriatrics at the University of Texas at Arlington
- NIH [R15NR016826-01]
- American Heart Association [1GSDG27260115]
- Harry S. Moss Heart Trust
- University of Texas at Arlington Interdepartmental Research Grant
- NATIONAL INSTITUTE OF NURSING RESEARCH [R15NR016826] Funding Source: NIH RePORTER
We hypothesize that the reduced peak aerobic power (peak VO2) after heart transplantation is due to impaired cardiovascular and skeletal muscle function, and its improvement with short-term (<= 1 yr) exercise training is primarily due to favorable skeletal muscle adaptations. Furthermore, the increased peak VO2 with long-term (>2 yr) training is primarily mediated by cardiac (sympathetic) reinnervation.
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