期刊
EXERCISE AND SPORT SCIENCES REVIEWS
卷 46, 期 3, 页码 195-202出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000152
关键词
skeletal muscle hypertrophy; vascular endothelial growth factor; satellite cells; endothelial cells; Akt; beta-catenin
资金
- National Institute of Arthritis and Musculoskeletal and Skin Diseases [R15AR060469]
Vascular endothelial growth factor (VEGF) deletion in adult mouse muscle fibers contributes to impaired contractile and muscular adaptations to a hypertrophic stimulus suggesting a critical role in adult muscle growth. This review explores the hypothesis that VEGF is essential for adult muscle growth by impacting inflammatory processes, satellite-endothelial cell interactions, and contractile protein accumulation by functioning within known hypertrophic signaling pathways including insulin-like growth factor-1 (IGF-1-Akt) and Wnt-beta-catenin.
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