期刊
EVOLUTION
卷 72, 期 4, 页码 808-824出版社
WILEY
DOI: 10.1111/evo.13465
关键词
Asexual reproduction; mitochondrial genome; Potamopyrgus antipodarum; purifying selection; selective interference; sexual reproduction
资金
- Carver College of Medicine
- National Science Foundation (NSF) [MCB - 1122176, DEB - 1310825]
- Iowa Academy of Sciences (ISF) [13-10]
- Holden Comprehensive Cancer Center
- Iowa City Veteran's Administration Medical Center
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1122176] Funding Source: National Science Foundation
Harmful mutations are ubiquitous and inevitable, and the rate at which these mutations are removed from populations is a critical determinant of evolutionary fate. Closely related sexual and asexual taxa provide a particularly powerful setting to study deleterious mutation elimination because sexual reproduction should facilitate mutational clearance by reducing selective interference between sites and by allowing the production of offspring with different mutational complements than their parents. Here, we compared the rate of removal of conservative (i.e., similar biochemical properties) and radical (i.e., distinct biochemical properties) nonsynonymous mutations from mitochondrial genomes of sexual versus asexual Potamopyrgus antipodarum, a New Zealand freshwater snail characterized by coexisting and ecologically similar sexual and asexual lineages. Our analyses revealed that radical nonsynonymous mutations are cleared at higher rates than conservative changes and that sexual lineages eliminate radical changes more rapidly than asexual counterparts. These results are consistent with reduced efficacy of purifying selection in asexual lineages allowing harmful mutations to remain polymorphic longer than in sexual lineages. Together, these data illuminate some of the population-level processes contributing to mitochondrial mutation accumulation and suggest that mutation accumulation could influence the outcome of competition between sexual and asexual lineages.
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