Article
Psychiatry
Masanori Isobe, Matilde Vaghi, Naomi A. Fineberg, Annemieke M. Apergis-Schoute, Edward T. Bullmore, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: The study demonstrates a link between cognitive inflexibility and putamen morphology in OCD patients and their relatives, indicating a familial marker of OCD. The findings suggest a shared abnormality in basal ganglia structure associated with cognitive rigidity among individuals with OCD and their asymptomatic relatives.
BRITISH JOURNAL OF PSYCHIATRY
(2022)
Article
Neurosciences
Demetrio Milardi, Gianpaolo Antonio Basile, Joshua Faskowitz, Salvatore Bertino, Angelo Quartarone, Giuseppe Pio Anastasi, Alessia Bramanti, Rosella Ciurleo, Alberto Cacciola
Summary: This study aimed to test the effects of different tractography-based approaches for the reconstruction of subthalamic nucleus (STN) functional territories. Four parcellation pipelines were compared, and it was found that each parcellation provided consistent results in terms of location of the identified parcels, but with variations in size and shape. It is suggested that fine-tuning of tractography-based parcellation may lead to higher reproducibility and aid the development of an optimized surgical targeting protocol.
Article
Anatomy & Morphology
Puck C. Reeders, M. Vanessa Rivera Nunez, Robert P. Vertes, Aaron T. Mattfeld, Timothy A. Allen
Summary: The midline thalamus plays a crucial role in cognition, memory, and stress regulation in humans and is linked to various neurological and psychiatric disorders. A new method using probabilistic tractography and k-means clustering with diffusion weighted imaging data has been developed to identify the midline thalamus in vivo. This approach successfully classifies midline thalamic clusters based on cortical and subcortical connectivity profiles, and segments the midline thalamus according to anatomical connectivity tracer studies. This anatomical connectivity-based identification offers an opportunity to investigate the midline thalamus in humans and its relationship to cognitive functions and disorders.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Cell Biology
Ahmed Jorge, Witold J. Lipski, Dengyu Wang, Donald J. Crammond, Robert S. Turner, R. Mark Richardson
Summary: This study provides evidence for the involvement of the subthalamic nucleus (STN) in speech production and highlights the unique connections between the inferior frontal gyms and the STN. The findings suggest that these connections may be specific to humans and have evolved alongside the development of speech.
Article
Geriatrics & Gerontology
Vineeth Radhakrishnan, Cecile Gallea, Romain Valabregue, Syam Krishnan, Chandrasekharan Kesavadas, Bejoy Thomas, Praveen James, Ramshekhar Menon, Asha Kishore
Summary: This study validated the structural connectivity within the cerebellum-basal ganglia reciprocal network in a larger dataset of human subjects across a wider age range. It found age-related neurodegeneration in the subcortical cerebello-basal ganglia tracts and their association with different cognitive functions. These findings have significant implications for understanding neurodevelopmental and neurodegenerative diseases.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Mathematical & Computational Biology
Ankur Gupta, Rohini Bansal, Hany Alashwal, Anil Safak Kacar, Fuat Balci, Ahmed A. Moustafa
Summary: This review provides an in-depth account of the recent advances in research on the drift-diffusion model (DDM), including its application in different brain areas and parameter changes in various clinical disorders.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2022)
Article
Cell Biology
Nathan F. Parker, Avinash Baidya, Juli Cox, Laura M. Haetzel, Anna Zhukovskaya, Malavika Murugan, Ben Engelhard, Mark S. Goldman, Ilana B. Witten
Summary: This study investigates the role of different input pathways in the nucleus accumbens in guiding choices. It finds that the prelimbic cortical inputs represent actions and choices, while the midline thalamic inputs represent cues. The choice-selective activity in the prelimbic cortical inputs is organized in sequences that persist beyond the outcome.
Article
Neurosciences
Samantha Baldi, Stijn Michielse, Chris Vriend, Martijn P. van den Heuvel, Odile A. van den Heuvel, Koen R. J. Schruers, Liesbet Goossens
Summary: Rich-club organization is crucial for efficient global neuronal signaling and information integration. This study focused on examining alterations in rich-club organization in patients with obsessive-compulsive disorder (OCD) and found that OCD patients displayed weaker structural connectivity between rich-club nodes, resulting in lower network integration and higher network segregation. These findings emphasize the importance of investigating network-based alterations in brain organization and function when studying the neurobiological basis of OCD.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Liao Dong, Huai-Bin Liang, Jiaxin Du, Yingying Wang, Qichen Zhou, Ziyue Xin, Yue Hu, Yi-Sheng Liu, Rong Zhao, Yuan Qiao, Chenglin Zhou, Jian-Ren Liu, Xiaoxia Du
Summary: This study examined microstructural abnormalities in the brains of patients with somatic symptom disorders (SSDs) using diffusion kurtosis imaging (DKI). The findings identified significant changes in diffusion measures in the cerebellum, thalamus, basal ganglia, and limbic cortex, highlighting the role of the cerebellum-thalamus-basal ganglia-limbic cortex pathway in SSDs.
Review
Behavioral Sciences
John P. O'Doherty, Sang Wan Lee, Reza Tadayonnejad, Jeff Cockburn, Kyo Iigaya, Caroline J. Charpentier
Summary: The brain is proposed to act as a Mixture of Experts, with different expert systems proposing action strategies based on reliability. The anterior prefrontal cortex is suggested to play a specific role in this process, favoring simpler expert systems. Research indicates that this reliability-based control mechanism may be domain general.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Diana Valdes Cabrera, Penelope Smyth, Gregg Blevins, Derek Emery, Christian Beaulieu
Summary: DTI and volumetric MRI revealed white matter and deep grey matter abnormalities in the limbic system of MS patients. The fornix, thalamus, and hippocampus displayed atrophy and/or abnormal diffusion metrics, with the fornix showing the most extensive changes, mainly in those with cognitive impairment. These findings suggest a strong correlation between microstructural abnormalities in the limbic system and cognitive deficits in MS.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Adam J. Culbreth, Zuzana Kasanova, Thomas J. Ross, Betty J. Salmeron, James M. Gold, Elliot A. Stein, James A. Waltz
Summary: The study found that brain responses to different forms of salience were detected, and there were no significant differences in salient event activation between SZ patients and controls in several regions, but there was a significant correlation between the magnitudes of salience contrasts and positive symptoms in SZ patients.
Article
Clinical Neurology
Keiichiro Mukai, Naomi Matsuura, Masahiro Miyauchi, Takuya Hashimoto, Kyosuke Yamanishi, Kensei Maebayashi, Kazuhisa Hayashida, Hisato Matsunaga
Summary: This study found significant differences in brain activation in the frontopolar cortex during executive function tasks between OCD patients with and without a lifetime history of tic disorder. Furthermore, the severity of compulsions in OCD patients with tic disorder had a direct causal effect on brain activation in the dorsolateral prefrontal cortex (DLPFC) during the Tower of London Task, while the severity of obsessions in OCD patients without tic disorder had a direct causal effect on brain activation in the DLPFC during the same task.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2021)
Article
Clinical Neurology
Jiali He, Shuya Yan, Zijin Song, Qianyi Lu, Shuming Zhong, Shunkai Lai, Ying Wang, Guanmao Chen, Hui Zhao, Pan Chen, Yiliang Zhang, Yanbin Jia
Summary: Both OCD and MDD patients exhibited cognitive impairment in working memory and altered neurometabolism in the prefrontal cortex (PFC). MDD patients showed more severe and broader working memory impairment compared to OCD patients. The dysfunction of PFC may underlie the neural basis of working memory impairment in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Neurosciences
Sung Ho Jang, Eun Bi Choi
Summary: This pilot study examined the association between consciousness level and structural neural connectivity of the medial prefrontal cortex (mPFC SNC) in hypoxic-ischemic brain injury (HI-BI) patients. The study used diffusion tensor tractography (DTT) to reconstruct the mPFC SNC for each patient. The results showed that the severity of injury to the mPFC SNC was closely related to consciousness level.
Review
Neurosciences
V. Jardon, C. Debien, S. Duhem, M. Morgieve, F. Ducrocq, G. Vaiva
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2019)
Article
Neurosciences
M. Morgieve, K. N'Diaye, A. Nguyen-Khac, L. Mallet, X. Briffault
ENCEPHALE-REVUE DE PSYCHIATRIE CLINIQUE BIOLOGIQUE ET THERAPEUTIQUE
(2019)
Letter
Clinical Neurology
Luc Mallet, Sophie Tezenas Du Montcel, Anne-Helene Clair, Christophe Arbus, Eric Bardinet, Nicolas Baup, Stephan Chabardes, Isabelle Chereau, Virginie Czernecki, Denys Fontaine, Ghina Harika-Germaneau, William Inaki Haynes, Jean-Luc Houeto, Nematollah Jaafari, Paul Krack, Bruno Millet, Soledad Navarro, Mircea Polosan, Antoine Pelissolo, Marie-Laure Welter
Letter
Neurosciences
Suhan Senova, Luc Mallet, Jean-Marc Gurruchaga, Corentin Rabu, Mathilde Derosin, Jerome Yelnik, Pierre Brugieres, Antoine Pelissolo, Stephane Palfi, Philippe Domenech
BIOLOGICAL PSYCHIATRY
(2020)
Review
Psychiatry
Charles-Edouard Notredame, M. Morgieve, F. Morel, S. Berrouiguet, J. Aze, G. Vaiva
CURRENT PSYCHIATRY REPORTS
(2019)
Article
Neurosciences
Anne Buot, Carine Karachi, Brian Lau, Hayat Belaid, Sara Fernandez-Vidal, Marie-Laure Welter, Luc Mallet
Summary: The study investigated the modulation of subthalamic nucleus (STN) neural activity by visual emotional information in patients with OCD and Parkinson's disease. The results demonstrated specific changes in STN theta band activity related to emotions in patients with OCD during different motor demands, suggesting a potential role of STN dysfunction in OCD pathophysiology.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2021)
Article
Health Care Sciences & Services
Margot Morgieve, Catherine Genty, Jerome Aze, Jonathan Dubois, Marion Leboyer, Guillaume Vaiva, Sofian Berrouiguet, Philippe Courtet
JMIR MHEALTH AND UHEALTH
(2020)
Article
Environmental Sciences
Manon Duay, Margot Morgieve, Helene Niculita-Hirzel
Summary: The COVID-19 lockdown led to sudden changes in individuals, impacting their mental well-being. Low-income populations faced financial difficulties and changes in food intake more frequently. Sport practice was associated with better mental health, but a decrease in exercise was commonly reported during the pandemic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Psychiatry
Margot Morgieve, Pierre Mesdjian, Olivier Las Vergnas, Patrick Bury, Vincent Demassiet, Jean-Luc Roelandt, Deborah Sebbane
Summary: This study identified the most frequently used terms associated with e-mental health through lexicometric analysis, dividing the text into technological and computing terms, as well as medical and public health terms. The findings revealed a gap between user perceptions of e-mental health as a tool for improving quality of life and healthcare professionals' focus on the technological potential of these digital care tools.
JMIR MENTAL HEALTH
(2021)
Article
Multidisciplinary Sciences
Axel Baptista, Maxime Maheu, Luc Mallet, Karim N'Diaye
Summary: Research found that explicit metacognition significantly influences the regulation of checking behavior, while implicit metacognition does not. Additionally, participants' self-beliefs are related to their tendencies of uncertainty-guided checking.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Edouard Leaune, Heloise Rouze, Laurene Lestienne, Kushtrim Bislimi, Benoit Chalancon, Margot Morgieve, Pierre Grandgenevre, Guillaume Vaiva, Nathalie Laplace, Emmanuel Poulet, Julie Haesebaert
Summary: The study found that people bereaved by suicide have clear needs and expectations for online resources, wishing to access information on suicide bereavement and prevention, communicate with mental health professionals, and read testimonies of others in similar situations. They identified current online resources as insufficient and called for the development of a dedicated web platform to meet their needs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
Hugues Lamothe, Christiane Schreiweis, Lizbeth Sirenia Mondragon-Gonzalez, Sana Rebbah, Oriana Lavielle, Luc Mallet, Eric Burguiere
Summary: Research has found that the behavior of Sapap3 knockout mice is more complex than previously described, including sudden and rapid twitching of the head and body, resembling tic-like movements. Aberrant hindpaw scratching may also be responsible for the skin lesions observed in this mouse model. Pharmacological treatment with aripiprazole significantly reduced the number of head/body twitches, scratching, and single-phase grooming, indicating a potential treatment for tic-like symptoms in Tourette syndrome and trichotillomania.
TRANSLATIONAL PSYCHIATRY
(2023)
Review
Health Care Sciences & Services
Arnaud d'Halluin, Marie Costa, Margot Morgieve, Deborah Sebbane
Summary: This study aimed to establish an inventory of children's, adolescents', and their parents' attitudes toward digital health interventions (DHIs). The results provide a better understanding of the factors influencing children's and adolescents' attitudes toward DHIs. The continued growth of DHIs can help reduce barriers to mental health care.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychiatry
Margot Morgieve, Deborah Sebbane, Bianca De Rosario, Vincent Demassiet, Soraya Kabbaj, Xavier Briffault, Jean-Luc Roelandt
JMIR MENTAL HEALTH
(2019)