Article
Surgery
Boonying Siribumrungwong, Jiro Kurita, Tatsuo Ueda, Daisuke Yasui, Ken-ichiro Takahashi, Takashi Sasaki, Yasuo Miyagi, Shun-ichiro Sakamoto, Yosuke Ishii, Tetsuro Morota, Takashi Nitta
Summary: Operative mortality rates did not significantly differ between EVAR and OSR, with EVAR showing less blood loss, shorter operative times, and shorter length of hospital stay but with higher re-intervention rates.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Multidisciplinary Sciences
Hamdy Awad, Esmerina Tili, Gerard Nuovo, Hesham Kelani, Mohamed Ehab Ramadan, Jim Williams, Katherine Binzel, Jayanth Rajan, David Mast, Alexander A. Efanov, Kareem B. Rasul, Sarah Moore, Michele Basso, Adel Mikhail, Mostafa Eltobgy, Raphael A. Malbrue, Eric Bourekas, Michael Oglesbee, Valerie Bergdall, Michael Knopp, Jean-Jacques Michaille, Hosam El-Sayed
Summary: This study compared the pathophysiology of spinal cord injury after EVR versus OR using a newly developed EVR dog model, and found unique patterns of proprioceptive ataxia and evolving paraparesis in EVR versus irreversible paraplegia in OR. MRI and histopathology results also showed different manifestations between the two interventions.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Abdulhakim Ibrahim, Miroslav Dimitrov Yordanov, Mohammad Hasso, Benjamin Heine, Alexander Oberhuber
Summary: The aim of this study was to analyze the outcomes and complications in patients who underwent open surgical treatment for AAA in the endovascular era. The study found that open aneurysm repair is safe and effective when performed in specialized high-volume centers.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Polymer Science
Gianmarco de Donato, Edoardo Pasqui, Claudia Panzano, Brenda Brancaccio, Gaia Grottola, Giuseppe Galzerano, Domenico Benevento, Giancarlo Palasciano
Summary: Abdominal aortic aneurysm (AAA) is a condition where the abdominal aorta dilates and grows until it ruptures. EVAR is a minimally invasive procedure using stent grafts to treat this condition. Recent advancements have introduced polymer-based technology as a safe and effective alternative to seal AAA.
Article
Cardiac & Cardiovascular Systems
Alexander Gombert, Mohammad Barbati, Drosos Kotelis, Tim-Philipp Simon, Thomas Breuer, Oliver Hartmann, Karine Santos, Deborah Bergmann, Janin Schulte, Gernot Marx, Michael Jacobs, Christian Stoppe
Summary: This study assessed the prognostic capabilities of cDPP3 for predicting patient survival and organ failure following open and endovascular thoraco-abdominal aortic aneurysm (TAAA) repair. The results showed that cDPP3 levels had remarkable predictive accuracy for in-hospital mortality and development of organ failure, highlighting its role as an early, highly specific postoperative biomarker.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Article
Surgery
Andrew J. Soo Hoo, James J. Fitzgibbon, Mohamad A. Hussain, Rebecca E. Scully, Andrew B. Servais, Louis L. Nguyen, Edwin C. Gravereaux, Marcus E. Semel, Edward J. Marcaccio, Matthew T. Menard, C. Keith Ozaki, Michael Belkin
Summary: This study aims to define the indications for open aneurysm repair (OAR) and its impact on outcomes in the era of endovascular aneurysm repair (EVAR). The results show that no single anatomical contraindication is a predictor of worse outcomes with OAR in patients who do not meet the criteria for EVAR. Patients who choose OAR based on preference have lower rates of perioperative complications, shorter hospital stays, and superior long-term survival rates compared to those who undergo OAR due to anatomical or systemic contraindications to EVAR.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Medicine, General & Internal
Johanna Gruel, Eberhard Grambow, Malte Weinrich, Thomas Heller, Justus Gross, Matthias Leuchter, Mark Philipp
Summary: This retrospective study aimed to compare the health-related quality of life (HRQoL) between patients who underwent open repair (OR) or endovascular treatment (EVAR) for abdominal aortic aneurysm. The study found that neither OR nor EVAR provided a significant advantage in HRQoL. However, the occurrence of incisional hernia (IH) after OR significantly reduced HRQoL in patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Diletta Loschi, Andrea Melloni, Alessandro Grandi, Domenico Baccellieri, Fabrizio Monaco, Germano Melissano, Roberto Chiesa, Luca Bertoglio
Summary: This study evaluated the outcomes of open and endovascular treatment for downstream aortic pathology in patients who previously underwent frozen elephant trunk (FET) repair, finding that the endovascular treatment group had lower incidence of major adverse events and higher assisted primary clinical success rate at 5 years.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Review
Cardiac & Cardiovascular Systems
Shahin Nargesi, Ali Abutorabi, Vahid Alipour, Masih Tajdini, Javad Salimi
Summary: The study evaluated the cost-effectiveness of endovascular repair (EVAR) versus open surgical repair (OSR) for patients with AAA through a systematic review of published health economics studies. The results showed that EVAR technique is more cost-effective for high-risk patients.
CARDIOVASCULAR DRUGS AND THERAPY
(2021)
Article
Surgery
Safwan Omran, Ben Raude, Matthias Buerger, Sebastian Kapahnke, Jan Christoph Carstens, Haidar Haidar, Frank Konietschke, Jan Paul Frese, Andreas Greiner
Summary: In this study comparing aortoduodenal fistulas (ADFs) after endovascular abdominal aortic aneurysm repair (EVAR) vs after open aortic repair (OAR), it was found that patients in the OAR group had significantly higher postoperative complication rates compared to the EVAR group. The most common bacteria identified in blood cultures were Escherichia coli, with Candida spp. being the predominant pathogen found on intra-abdominal smears.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Curtis Woodford, Rym El Khoury, Joel L. Ramirez, Iris H. Liu, Elizabeth M. Lancaster, Joyce Nacario, Jade S. Hiramoto, Charles M. Eichler, Linda M. Reilly, James C. Iannuzzi, Michael S. Conte
Summary: This study reviewed open abdominal aortic surgery cases performed at a tertiary care center from 2007 to 2020 and found that complex open aortic aneurysm repair (OAR) comprised the majority, but were not accounted for in the Vascular Quality Initiative (VQI). The study suggests the creation of a VQI module for complex OAR to improve benchmarking for volume and outcomes in aortic surgery.
JOURNAL OF VASCULAR SURGERY
(2022)
Article
Surgery
Livia E. V. M. de Guerre, Kirsten Dansey, Chun Li, Jinny Lu, Priya B. Patel, Joost A. van Herwaarden, Douglas W. Jones, Philip P. Goodney, Marc L. Schermerhorn
Summary: The diameter of aortic abdominal aneurysm (AAA) is associated with late outcomes following repair, with patients with large AAA having higher rates of reintervention, rupture, mortality, and loss to follow-up after EVAR compared to those with smaller AAA or after open repair. Patients with large AAAs who are medically fit should consider undergoing open repair for better long-term outcomes and rigorous follow-up after EVAR is essential.
JOURNAL OF VASCULAR SURGERY
(2021)
Article
Surgery
Fabrizio Monaco, Gaia Barucco, Margherita Licheri, Monica De Luca, Rosa Labanca, Margherita Rocchi, Germano Melissano, Luca Bertoglio, Roberto Chiesa, Alberto Zangrillo
Summary: This study compared the short term clinical outcomes of patients undergoing the visceral step of TAAA with different types of anesthesia and found that the type of anesthesia had no effect on procedure success, peri-operative morbidity, or mortality in patients undergoing F/BEVAR.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
M. Gruber, A. Sotir, J. Klopf, S. Lakowitsch, C. Domenig, A. Wanhainen, C. Neumayer, A. Busch, W. Eilenberg
Summary: This study assessed the time trends of open abdominal aortic aneurysm repair in a high-volume single center in Austria over a 20-year period, focusing on operation time and clinical outcomes. The results showed that both endovascular aortic repair and open surgical repair had stable operation time and clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Surgery
Jelle Frankort, Barend Mees, Panagiotis Doukas, Andres Keszei, Nikolaos Kontopodis, George A. Antoniou, Michael J. Jacobs, Alexander Gombert
Summary: This study aimed to investigate the effect of prophylactic use of cerebrospinal fluid (CSF) drainage on post-operative spinal cord ischemia (SCI) in endovascular descending thoracic aortic aneurysm (DTAA) and thoraco-abdominal aortic aneurysm (TAAA) repair. The results showed that CSF drainage placement was not associated with a reduced SCI rate, and had a high incidence of complications. Due to the low quality of evidence, no clear recommendation on the pre-operative use of CSF drainage placement can be made.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Isabelle Durand-Zaleski, Gregory Ducrocq, Maroua Mimouni, Jerome Frenkiel, Cristina Avendano-Sola, Jose R. Gonzalez-Juanatey, Emile Ferrari, Gilles Lemesle, Etienne Puymirat, Laurence Berard, Marine Cachanado, Joan Albert Arnaiz, Manuel Martinez-Selles, Johanne Silvain, Albert Ariza-Sole, Gonzalo Calvo, Nicolas Danchin, Sandra Paco, Elodie Drouet, Helene Abergel, Alexandra Rousseau, Tabassome Simon, Philippe Gabriel Steg
Summary: This study assessed the cost-effectiveness and cost-utility ratios of restrictive vs. liberal transfusion strategy in acute myocardial infarction patients. The results showed that the restrictive strategy was dominant at 30 days, saving costs and improving outcomes, but it no longer maintained non-inferiority on MACE at 1 year.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Andre Lamy, John Eikelboom, Wesley Tong, Fei Yuan, Shrikant Bangdiwala, Jackie Bosch, Stuart Connolly, Eva Lonn, Gilles R. Dagenais, Kelley R. H. Branch, Wei-Jhih Wang, Deepak L. Bhatt, Jeff Probstfield, Georg Ertl, Stefan Stoerk, P. Gabriel Steg, Victor Aboyans, Isabelle Durand-Zaleski, Lars Ryden, Salim Yusuf
Summary: The addition of rivaroxaban 2.5 mg BID to aspirin in patients with stable coronary artery disease or peripheral artery disease was found to reduce direct healthcare costs. In Canada, France, and Germany, the combination of rivaroxaban and aspirin was highly cost-effective in terms of lifetime cost-effectiveness.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Hematology
Isabelle Durand-Zaleski
Summary: Health economics aims to maximize population health within budget constraints. The incremental cost-effectiveness ratio (ICER) is commonly used to present the results of economic evaluations. It calculates the difference in cost and effect between two technologies and represents the cost required to gain one additional unit of health. Economic evaluations consider medical evidence of health benefits and the value of resources used. They provide information for policy makers to decide on the adoption of innovative technologies, along with other organizational, financial, and incentive data.
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
(2023)
Article
Obstetrics & Gynecology
Clement Ferrier, Sofiane Bendifallah, Stephane Suisse, Yohann Dabi, Cyril Touboul, Anne Puchar, Kevin Zarca, Isabelle Durand Zaleski
Summary: This study evaluated a saliva diagnostic test (Endotest (R)) in comparison with the conventional algorithm for diagnosing endometriosis. The cost-effectiveness analysis demonstrated the value of Endotest (R) from an economic perspective.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Morgane Michel, Mariam Arvis Souare, Christel Dindorf, Veronique Danguy, Karine Chevreul
Summary: France's social protection scheme, MSA, has implemented a two-step health promotion program for farmers and agricultural employees. The program aims to reengage under-consuming beneficiaries through nurse appointments and consultations with chosen doctors. This pilot evaluation shows promising results for future national evaluations and long-term evidence.
REVUE D EPIDEMIOLOGIE ET DE SANTE PUBLIQUE
(2023)
Article
Clinical Neurology
Charles Laidi, Laeticia Blampain-Segar, Ophelia Godin, Anne de Danne, Marion Leboyer, Isabelle Durand-Zaleski
Summary: Mental disorders often start early in life and are a significant cause of disability. In Europe, the total cost of mental disorders is estimated to be more than 4% of GDP (over 600 billion euros). This study aimed to provide an updated overall cost of mental health in France, excluding dementia, ten years after a previous study.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Health Care Sciences & Services
Luc Jaulmes, Youri Yordanov, Alexandre Descamps, Isabelle Durand-Zaleski, Aurelien Dinh, Patrick Jourdain, Agnes Dechartres
Summary: Covidom is a telemonitoring solution that effectively and safely monitored patients with mild to moderate COVID-19 in the Greater Paris area. It successfully handled alerts, detected clinical worsening, and saved costs compared to hospitalization.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Immunology
Robin van Kessel, Rebecca Forman, Ricarda Milstein, Alicja Mastylak, Katarzyna Czabanowska, Thomas Czypionka, Isabelle Durand-Zaleski, Anja Hirche, Magdalena Krysinska-Pisarek, Laia Maynou, Bjelle Roberts, Aleksandra Torbica, Karsten Vrangb, Yuxi Wang, Olivier J. Wouters, Elias Mossialos
Summary: This study investigated COVID-19 vaccination policies in ten European countries and found significant variations in authorization, priority groups, procurement and distribution, data collection, administration, and mandate requirements.
Article
Endocrinology & Metabolism
Alexandre Vimont, Sophie Beliard, Rene Valero, Henri Leleu, Isabelle Durand-Zaleski
Summary: This study aimed to develop, validate, and compare models predicting the annual risk of severe complications and mortality in patients with type 2 diabetes. The models were developed using logistic regression, random forest, and neural network, and factors such as age, comorbidities, and disease duration were found to be the most important predictors. The models showed reliable performance in predicting severe complications and mortality in patients with type 2 diabetes.
DIABETOLOGY & METABOLIC SYNDROME
(2023)
Editorial Material
Pharmacology & Pharmacy
Francois R. Girardin, Karen Cohen, Matthias Schwenkglenks, Isabelle Durand-Zaleski
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Maroua Mimouni, Julie Bulsei, Meryl Darlington, Candice Estellat, Francois Rouzet, Fabien Hyafil, Isabelle Durand-Zaleski
Summary: This study evaluated the cost-effectiveness of Rb-PET-MPI compared to Tc-SPECT-MPI for detecting myocardial ischemia, and the results showed that Rb-PET-MPI was a cost-saving and outcome-improving option for patients with PTP > 15%.
Article
Medicine, General & Internal
Arnaud Nze Ossima, Daniel Szfetel, Benedicte Denoyel, Omar Beloucif, Joelle Texereau, Louis Champion, Jean Francois Vie, Isabelle Durand-Zaleski
Summary: In order to inform policy makers on the efficient provision of end-of-life care, the 12-month medical expenditures of French decedents in 2015 were estimated. The results showed that 59% of the decedents were in a hospital at the time of death, with aggregated spending totaling 9% of total health expenditures. The mean expenditure per capita was euro28,085, with 44% of it being spent during the last 3 months of life.
Article
Hematology
Dragoslav Domanovic, Leni von Bonsdorff, Pierre Tiberghien, Paul Strengers, Matthew Hotchko, Peter O'Leary, Jean-Baptiste Thibert, Karin Magnussen, Christian Erikstrup, Marloes Spekman, Stuart Chesneau, Judy Jones, Bjarne K. K. Moller, Peter Verheggen, Gerard Gogarty, Mazen Elzaabi, Vincenzo de Angelis, Fabio Candura, Polonca Mali, Francoise Rossi, Bernardo Rodrigues, Ramune Sepetiene, Thomas Lenzen, Stephan Walsemann, Robert Perry, Jean-Philippe Plancon, Cynthia So-Osman, Isabelle Durand-Zaleski, Giuseppina Facco, Daphne Thijssen-Timmer
Summary: At the symposium, experts highlighted the importance of strategies such as recruitment, retention, and protection of plasma donors, increasing the number of donors, and harmonizing guidelines and collaboration to strengthen plasma collection and meet the demand for plasma-derived medicinal products in Europe. It was also confirmed that non-profit transfusion institutions in Europe are dedicated to increasing plasma collection through various programs and research.
Article
Medicine, General & Internal
Sabrina Kepka, Kevin Zarca, Mickael Ohana, Anne Hoffmann, Joris Muller, Pierrick Le Borgne, Emmanuel Andres, Pascal Bilbault, Isabelle Durand Zaleski
Summary: The aim of this study was to compare the costs and effectiveness of diagnostic workup by ultrasound (US) and computed tomography (CT) in patients with renal colic. The study found that CT is more cost-effective and leads to shorter hospital stays compared to US.
MEDICINA-LITHUANIA
(2023)
Article
Medicine, General & Internal
Sabrina Kepka, Elena-Mihaela Cordeanu, Kevin Zarca, Anne-Sophie Frantz, Patrick Ohlmann, Emmanuel Andres, Pascal Bilbault, Isabelle Durand-Zaleski, Dominique Stephan
Summary: This study aimed to evaluate the cost-effectiveness of rivaroxaban compared to VKAs in the treatment of VTE. The results showed that the rivaroxaban treatment strategy was not only cost-saving, but also more effective and safe, making it a suitable alternative for eligible VTE patients. This study provides real-world evidence supporting the use of rivaroxaban.
MEDICINA-LITHUANIA
(2023)