Review
Medicine, General & Internal
Rachel P. Rosovsky, Eva Kline-Rogers, Leslie Lake, Tracy Minichiello, Gregory Piazza, Bishoy Ragheb, Beth Waldron, Daniel M. Witt, Stephan Moll
Summary: In clinical practice, direct oral anticoagulants (DOACs) are used for venous thromboembolism treatment and prevention. The use of DOACs in obese patients is still controversial, with limited supporting data previously. There are also evidence gaps regarding the treatment of severe obesity and the appropriate use of DOACs in different situations.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Hematology
David Spirk, Tim Sebastian, Stefano Barco, Martin Banyai, Juerg H. Beer, Lucia Mazzolai, Thomas Baldi, Drahomir Aujesky, Daniel Hayoz, Rolf P. Engelberger, Thomas Kaeslin, Wolfgang Korte, Robert Escher, Marc Husmann, Marc Blondon, Nils Kucher
Summary: In patients with cancer-associated venous thromboembolism (VTE), the risk of recurrence is similar after incidental and symptomatic events. It is unknown whether the same applies to incidental VTE not associated with cancer. After comparing baseline characteristics, anticoagulation therapy, all-cause mortality, and VTE recurrence rates at 90 days between patients with incidental and symptomatic VTE, the study found that receiving anticoagulation therapy for at least 3 months was associated with lower mortality and recurrence rates in patients with incidental VTE regardless of cancer status. Additionally, among noncancer patients, early mortality and recurrence rates were similar after incidental versus symptomatic VTE.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Cell Biology
Viktoria Muster, Thomas Gary
Summary: Glioblastoma patients have a high risk of developing venous thromboembolism, making therapeutic anticoagulation challenging with limited data available for this vulnerable patient group.
Review
Hematology
Diana A. Gorog, Ying X. Gue, Tze-Fan Chao, Laurent Fauchier, Jose Luis Ferreiro, Kurt Huber, Stavros V. Konstantinidis, Deirdre A. Lane, Francisco Marin, Jonas Oldgren, Tatjana Potpara, Vanessa Roldan, Andrea Rubboli, Dirk Sibbing, Hung-Fat Tse, Gemma Vilahur, Gregory Y. H. Lip
Summary: This article summarizes the consensus on bleeding risk assessments in patients with atrial fibrillation (AF) and venous thromboembolism (VTE), including bleeding risk factors, definitions, and the consideration of patient values and preferences in balancing bleeding against thromboembolism risks.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Oncology
Lai Heng Lee, Pongwut Danchaivijitr, Noppacharn Uaprasert, Harinder Gill, Dennis Lee Sacdalan, Gwo Fuang Ho, Rajiv Parakh, Paresh Pai, Jen-Kuang Lee, Nannette Rey, Alexander T. Cohen
Summary: Direct oral anticoagulants (DOACs) have shown comparable efficacy and safety outcomes in Asian patients with cancer-associated thrombosis (CAT) compared to other races. Apixaban, edoxaban, or rivaroxaban can be considered as reasonable alternatives to low-molecular-weight heparin (LMWH) for anticoagulation in Asian patients with CAT.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2022)
Article
Hematology
C. Heleen van Ommen, Klasien A. Bergman, Marit Boerma, Heleen A. Bouma, Albertine E. Donker, Melissa Gouvernante, Christian Hulzebos, Dalila Khandour, Ronny Knol, Marlou A. Raets, K. Djien Liem, Richard A. van Lingen, Moniek van de Loo, Enrico Lopriore, Mayke van der Putten, Jeanine J. Sol, Monique H. Suijker, Daniel C. Vijlbrief, Remco Visser, Mirjam M. van Weissenbruch
Summary: A national management guideline was developed in the Netherlands to create uniform management for catheter-related venous thromboembolism (CVTE) in critically ill (preterm) neonates. A prospective observational study of 115 infants showed that following the guideline led to a low incidence of recurrent venous thrombotic events and death due to CVTE, but major bleeding occurred in a small percentage of infants.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Medicine, General & Internal
Xiaole Su, Bingjuan Yan, Lihua Wang, Hong Cheng, Yipu Chen
Summary: DOACs have similar efficacy as warfarin in the treatment of acute VTE, reducing recurrent VTE and VTE-related death, but are significantly superior to warfarin in reducing the risk of bleeding. There is no significant difference in the efficacy and safety of DOACs across different CrCl stratifications, but apixaban might be associated with a lower risk of bleeding in patients with VTE and CrCl >80 mL/min.
Article
Medicine, General & Internal
Faizan Khan, Kednapa Thavorn, Doug Coyle, Sasha van Katwyk, Tobias Tritschler, Brian Hutton, Gregoire Le Gal, Marc Rodger, Dean Fergusson
Summary: This study aims to assess the differences in clinical benefits, harms, and costs of stopping versus continuing anticoagulant therapy indefinitely for a first unprovoked venous thromboembolism (VTE). A probabilistic Markov model will be developed to estimate life-years, quality-adjusted life-years, costs, and incremental cost-effectiveness ratios. The results will be disseminated through conferences and a peer-reviewed journal.
Review
Medicine, General & Internal
Ann-Rong Yan, Indira Samarawickrema, Mark Naunton, Gregory M. Peterson, Desmond Yip, Reza Mortazavi
Summary: This study aims to investigate the available VTE risk assessment tools for ambulatory patients with lung cancer and compare their predictive performance. Systematic evaluation and meta-analysis will be conducted to determine the incidence of VTE and the performance of the risk models included in the studies.
Article
Hematology
Anetta Undas
Summary: Fibrinolysis is crucial for maintaining or restoring the patency of veins and pulmonary arteries obstructed by thrombi. Impaired fibrinolysis is implicated in venous thromboembolism (VTE) through complex mechanisms, with markers like clot lysis time predicting recurrent deep-vein thrombosis and pulmonary embolism. This overview summarizes the link between fibrinolysis and VTE, along with its long-term consequences.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2021)
Review
Biochemistry & Molecular Biology
Mario Enrico Canonico, Ciro Santoro, Marisa Avvedimento, Giuseppe Giugliano, Giulia Elena Mandoli, Maria Prastaro, Anna Franzone, Raffaele Piccolo, Federica Ilardi, Matteo Cameli, Giovanni Esposito
Summary: Acute thrombotic events can reveal occult cancer in a significant number of cases. Malignancy interacts with the hemostatic system, leading to both thrombosis and bleeding. Cancer-related thrombotic events primarily affect the venous side and present in various conditions, including unusual sites of venous thrombosis. The selection of patients for anticoagulation management is complex, taking into account individual patient goals and preferences, prognosis of specific cancers, comorbidities, drug interactions, underweight states, and competing risks of morbidity and mortality. Anticoagulant treatment in cancer is widely debated, with direct oral anticoagulants showing efficacy and safety compared to traditional treatment.
Article
Hematology
Alberto Garcia-Ortega, Raquel Lopez-Reyes, Gabriel Anguera, Grace Oscullo, Agustina Rivas, Luciano Lopez-Jimenez, Alicia Lorenzo, Isabelle Mahe, Maurizio Ciammaichella, Manuel Monreal
Summary: Treatment of venous thromboembolism in solid organ transplant recipients is associated with an increased risk of bleeding compared to non-recipients, mainly influenced by liver transplant recipients. In non-liver solid organ transplant recipients, the risk of bleeding is similar to that in non-recipients.
THROMBOSIS RESEARCH
(2021)
Article
Otorhinolaryngology
Ida E. Albertsen, Nina M. Lyhne, Torben B. Larsen, Peter B. Nielsen
Summary: VTE risk exists in head and neck surgery for both patients with and without cancer, with a higher risk among cancer patients. Risk stratification tools should be developed to recognize this hazard in cancer patients undergoing head and neck surgery to support clinical decision making on anticoagulation.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Health Care Sciences & Services
Ido Weinberg, Islam Y. Elgendy, Andrew B. Dicks, Pablo J. Marchena, Radovan Maly, Iria Francisco, Jose M. Pedrajas, Carme Font, Luis Hernandez-Blasco, Manuel Monreal
Summary: Chronic immobile patients older than 75 with VTE have a high rate of adverse events including major bleeding and recurrent VTE. Treatment beyond 90 days should take into account bleeding, recurrence risk, and associated mortality.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Hematology
Behnood Bikdeli, Heather Hogan, Ruth B. Morrison, John Fanikos, Umberto Campia, Briana M. Barns, Mariana B. Pfeferman, Julia E. Snyder, Candrika D. Khairani, Samuel Z. Goldhaber, Gregory Piazza
Summary: The HI-PRO study aims to determine whether patients with provoked VTE and enduring risk factors have fewer adverse clinical outcomes when prescribed low-intensity extended-duration anticoagulation.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Infectious Diseases
Brenig Llwyd Gwilym, Ravi Maheswaran, Adrian Edwards, Emma Thomas-Jones, Jonathan Michaels, David Charles Bosanquet
Summary: The study found no association between living in an income-deprived area and groin wound surgical site infection, clinical consequences of surgical site infection, and mortality after arterial intervention. Patients living in more income-deprived areas presented for operative intervention at a younger age, with similar rates of comorbidities to patients living in less income-deprived areas.
SURGICAL INFECTIONS
(2022)
Article
Surgery
Rebecca Lawton, Joseph Shalhoub, Alun H. Davies
Summary: This study aims to evaluate the uptake and dissemination of the NIHR HTA-funded GAPS trial among health professionals in the UK and its impact on VTE prevention policies. The survey results show that the majority of respondents have not made or do not intend to make changes to local VTE policies based on the GAPS trial.
Article
Medicine, General & Internal
Sarina Vara, Naga Venkatesh Jayanthi, Vijay Gadhvi, Ankur Thapar
Summary: This is a case of massive haematemesis and aorto-oesophageal fistula, which was successfully treated with the use of covered stents, avoiding the need for traditional surgeries. The patient has recovered well.
Article
Surgery
Lydia Hanna, Viknesh Sounderajah, Ammar A. Abdullah, Dominic C. Marshall, Justin D. Salciccioli, Joseph Shalhoub, Richard G. J. Gibbs
Summary: This study analyzed trends in thoracic aortic aneurysm (TAA) hospital admissions, interventions, and aneurysm-related mortality (ARM) in England from 1998 to 2020. The results showed an increase in non-ruptured TAA hospital admissions and a shift towards endovascular repair. There was also a significant decline in ARM, regardless of gender and age. The study confirmed the positive impact of endovascular repair, particularly for females aged > 80 years with ruptured disease.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Editorial Material
Surgery
Rebecca Lawton, Beverley J. Hunt, John Norrie, Joseph Shalhoub, Ankur Thapar, Alun H. Davies
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Review
Surgery
Benedict R. H. Turner, Ankur Thapar, Sara Jasionowska, Azfar Javed, Matthew Machin, Rebecca Lawton, Adam M. Gwozdz, Alun H. Davies
Summary: A meta-analysis was conducted to identify the rate of post-thrombotic syndrome (PTS) after isolated distal deep venous thrombosis (IDDVT). The results showed that the rate of PTS after IDDVT was 17%, with 78% of cases being mild, 11% moderate, and 11% severe. There were significant clinical and statistical heterogeneity among the studies, and a substantial risk of bias from pooled studies.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Review
Health Care Sciences & Services
Joshua Eves, Abhilash Sudarsanam, Joseph Shalhoub, Dimitri Amiras
Summary: AR technology has been widely applied in vascular and endovascular surgery, offering potential benefits such as reduced patient risk and operating times, as well as decreased radiation and contrast exposure. However, further technological advances are necessary to overcome existing limitations.
JMIR SERIOUS GAMES
(2022)
Article
Dermatology
Dorothy D. Yang, Kim Borsky, Chinmay Jani, Conor Crowley, Jeremy N. Rodrigues, Rubeta N. Matin, Dominic C. Marshall, Justin D. Salciccioli, Joseph Shalhoub, Richard Goodall
Summary: This study examined the trends in incidence, mortality, and DALYs of basal cell carcinomas (BCCs) and cutaneous squamous cell carcinomas (SCCs). The results showed that while the incidence of SCC has increased in most countries, there has been a decrease in mortality rates. This highlights the importance of addressing this global health issue.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Critical Care Medicine
Kapil Sugand, Ramla Ali, Richard Goodall, Justin Salciccioli, Dominic Marshall, James Schuster-Bruce, Hani B. Abdul-Jabar, Joseph Shalhoub
Summary: Neck of femur fractures (NOFF) pose significant socio-economic costs to society. The incidence rate has been collated within the Global Burden of Disease (GBD) database, but no comparison across countries has been reported.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2023)
Article
Oncology
Chinmay Jani, Christian Mouchati, Nour Abdallah, Melissa Mariano, Ruchi Jani, Justin D. Salciccioli, Dominic C. Marshall, Harpreet Singh, Iris Sheng, Joseph Shalhoub, Rana R. McKay
Summary: Prostate cancer is more common and deadly among black men compared to white men in the United States. The mortality rate of prostate cancer has decreased for all racial groups over the past 20 years, with a higher decrease observed in black men. However, the mortality rate remains higher among black men, highlighting the need for improved prostate cancer screening education.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Surgery
Lydia Hanna, Kim Borsky, Ammar A. Abdullah, Viknesh Sounderajah, Dominic C. Marshall, Justin D. Salciccioli, Joseph Shalhoub, Richard G. J. Gibbs
Summary: This study analyzed trends in hospital admissions, interventions, and mortality related to abdominal aortic aneurysm (AAA) in England from 1998 to 2020. The results showed a significant decrease in hospital admissions, an increase in endovascular procedures, and a decline in open surgical repair. Decreases in aneurysm-related mortality were observed overall, regardless of age, sex, and rupture status.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2023)
Article
Surgery
Dominic W. Proctor, Richard Goodall, Kim Borsky, Justin D. Salciccioli, Dominic C. Marshall, Abdulla Mohamed, Kumaran Shanmugarajah, Joseph Shalhoub
BRITISH JOURNAL OF SURGERY
(2023)
Letter
Respiratory System
Omar Al Omari, Chinmay Jani, Alaaeldin Ahmed, Harpreet Singh, Amr Radwan, Padmanabh Bhatt, Alexander Walker, Lipisha Agarwal, Richard Goodall, Joseph Shalhoub, Dominic C. Marshall, Carey Conley Thomson, Justin D. Salciccioli, Umit Tapan
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Surgery
Daniel Perez-Troncoso, David Epstein, Alun Huw Davies, Ankur Thapar
Summary: Medical therapy for stroke prevention has developed rapidly over the past 30 years, and there is an urgent need to evaluate whether surgery remains cost-effective. A decision model was developed to estimate the lifetime costs and utilities of modern medical therapy with and without carotid endarterectomy in patients with symptomatic stenosis. It was found that surgery remains cost-effective, but these results are sensitive to unknown factors.
BRITISH JOURNAL OF SURGERY
(2023)