Review
Microbiology
Mika Ogata, Jun Kido, Kimitoshi Nakamura
Summary: Cow's milk allergy is a common IgE-dependent food allergy in children, with severe cases potentially benefiting from oral immunotherapy but with a risk of anaphylaxis. New therapies such as omalizumab, sublingual immunotherapy, and epicutaneous immunotherapy have also become options for treating cow's milk allergy.
Review
Nutrition & Dietetics
Laurien Ulfman, Angela Tsuang, Aline B. Sprikkelman, Anne Goh, R. J. Joost van Neerven
Summary: The incidence of food allergies has increased worldwide in the past 20 years. Early introduction of allergenic foods has been shown to reduce the risk of allergies, but less is known about the introduction of cow's milk. Recent studies suggest that early introduction of cow's-milk-based formulas with intact milk proteins can reduce the risk of cow's milk allergy, while very early introduction followed by discontinuation may increase the risk.
Article
Nutrition & Dietetics
Nicolette W. de Jong, Marloes E. van Splunter, Joyce A. M. Emons, Kasper A. Hettinga, Roy Gerth van Wijk, Harry J. Wichers, Huub F. J. Savelkoul, Aline B. Sprikkelman, R. J. Joost van Neerven, Liu Liu, Gerbrich van der Meulen, Irene Herpertz, Yvonne C. M. Duijvestijn, Mijke Breukels, Marianne I. Brouwer, Jaap Schilperoord, Olga van Doorn, Berber Vlieg-Boerstra, Jochum van den Berg, Linette Pellis, Severina Terlouw, Astrid I. Hendriks, Marco W. J. Schreurs, Frank E. van Boven, Nicolette J. T. Arends
Summary: The aim of this study was to evaluate the safety and tolerability of a new heated cow's milk protein product in cow's milk allergic children. The results showed that 72% of the children tolerated the product, while some experienced adverse events. Skin prick tests and specific IgE levels may predict the tolerability of the product.
Review
Food Science & Technology
Carlos Franco, Cristina Fente, Cristina Sanchez, Alexandre Lamas, Alberto Cepeda, Rosaura Leis, Patricia Regal
Summary: The functionality of breast milk in terms of immunity is well-known, however, many breastfed infants exhibit sensitization to potential allergens and clinical reactivity before the introduction of complementary feeding. The potential induction of early oral tolerance through allergen exposure in breast milk remains controversial. This scoping review critically appraised the content of cow's milk antigens in human milk to better understand their impact on allergic disease development.
Article
Food Science & Technology
Natalia Zofia Maryniak, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bggh
Summary: Cow's milk allergy is the most prevalent type of food allergy among infants. There is a growing demand for more options for infant feeding, especially for the prevention and management of cow's milk allergy. Milk from other mammalian sources and proteins from plant sources have gained increased interest due to their potentially lower allergenicity.
Article
Allergy
Sebastian A. Jensen, Alessandro Fiocchi, Ton Baars, Galateja Jordakieva, Anna Nowak-Wegrzyn, Isabella Pali-Scholl, Stefano Passanisi, Christina L. Pranger, Franziska Roth-Walter, Kristiina Takkinen, Amal H. Assa'ad, Carina Venter, Erika Jensen-Jarolim
Summary: The immunopathogenesis of cow's milk protein allergy is affected by industrial processing, leading to structural changes and increased allergenicity of milk allergens. Unprocessed fresh milk contains tolerogenic factors that are impaired by industrial processing.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Nutrition & Dietetics
Frank E. E. van Boven, Nicolette J. T. Arends, Aline B. B. Sprikkelman, Joyce A. M. Emons, Astrid I. I. Hendriks, Marloes van Splunter, Marco W. J. Schreurs, Severina Terlouw, Roy Gerth van Wijk, Harry J. J. Wichers, Huub F. J. Savelkoul, R. J. Joost van Neerven, Kasper A. Hettinga, Nicolette W. W. de Jong
Summary: Accelerating tolerance induction to cow's milk can reduce the burden of cow's milk allergy. This study aimed to investigate the tolerance induction of a novel heated cow milk protein in children with cow's milk allergy. Results showed that 73% of children in the treatment group had a negative food challenge test, compared to 57% in the control group.
Review
Nutrition & Dietetics
Caoimhe Cronin, Yukta Ramesh, Carlo De Pieri, Roberto Velasco, Juan Trujillo
Summary: IgE-mediated cow's milk protein allergy (CMPA) is a common food allergy in early childhood. The management methods of avoidance, the milk ladder, and oral immunotherapy (OIT) are all effective in promoting tolerance, but further research is needed to compare their safety and effectiveness.
Article
Food Science & Technology
Natalia Zofia Maryniak, Mette Halkjaer Stage, Anne-Sofie Ravn Ballegaard, Ana Isabel Sancho, Egon Bech Hansen, Katrine Lindholm Bogh
Summary: Currently, there are no specific recommendations for using any particular infant formula to prevent cow's milk allergy. There is increasing interest in alternative infant formulas made from milk proteins from animals other than cows, but their ability to prevent cow's milk allergy has not been studied.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Pediatrics
Maria Angela Tosca, Roberta Olcese, Guido Marinelli, Irene Schiavetti, Giorgio Ciprandi
Summary: Cow milk allergy is a common childhood disease that can often disappear by school age. Diagnosis and treatment are related, with elimination diet as a solution. Oral immunotherapy can achieve milk tolerance, but standardization is needed. This study provides practical experience and proposes a management approach for children with cow milk allergy.
Article
Allergy
Franziska Roth-Walter, Sheriene Moussa Afify, Luis F. Pacios, Bart R. Blokhuis, Frank Redegeld, Andreas Regner, Lisa-Marie Petje, Alessandro Fiocchi, Eva Untersmayr, Zdenek Dvorak, Karin Hufnagl, Isabella Pali-Scholl, Erika Jensen-Jarolim
Summary: Research has shown that holoBLG plays a key role in preventing allergies by reducing IgE binding and affecting mast cell degranulation. Consistently, only treatment with holoBLG in mice prevented allergic sensitization and anaphylaxis, while maintaining regulatory T cells. Additionally, holoBLG facilitates AhR activation, contributing to allergy prevention.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Ken-ichi Nagakura, Sakura Sato, Yoko Miura, Makoto Nishino, Kyohei Takahashi, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa, Noriyuki Yanagida
Summary: In this study, the safety and efficacy of low-dose oral immunotherapy with heated milk (HM) or unheated milk (UM) in children with anaphylaxis were investigated. The results showed that HM-OIT induced immunological changes more safely than UM-OIT, with significantly lower rates of moderate or severe symptoms and respiratory symptoms in the HM group.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Allergy
Yvonne M. d'Art, Lisa Forristal, Aideen M. Byrne, John Fitzsimons, Ronald van Ree, Audrey DunnGalvin, Jonathan O'Brien Hourihane
Summary: The study shows that introducing baked milk after the diagnosis of cow's milk allergy can safely and effectively improve infants' tolerance to milk. Maternal anxiety is also found to be associated with infants' progress on the milk ladder.
Article
Chemistry, Applied
Angela Maria Candreva, Paola L. Smaldini, Ana Cauerhff, Silvana Petruccelli, Guillermo H. Docena
Summary: This study explored a preventive protocol for milk allergy with the oral administration of a soy-derived peptide containing cross-reactive epitopes, successfully preventing IgE-mediated milk sensitization through the induction of Th1-mediated immunity and induction of blocking IgG. This safe soy-peptide may represent a promising alternative for preventing milk allergy.
Article
Allergy
Casey G. Cohen, Wei W. Zhao, Danbing Ke, Liane Beaudette, Duncan Lejtenyi, Christine McCusker, Xun Zhang, Edmond S. Chan, Julia E. M. Upton, Eyal Grunebaum, Ann E. Clarke, Bruce D. Mazer, Moshe Ben-Shoshan
Summary: Food desensitization via oral immunotherapy (OIT) is gaining acceptance in clinical practice. This study aimed to assess factors associated with the probability of reaching the maintenance dose in cow's milk (CM) OIT. The results showed that higher levels of CM-specific IgE decreased the likelihood of reaching maintenance, whereas an increased cumulative CM dose at entry challenge increased the likelihood.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Multidisciplinary Sciences
Nicola Bernabo, Juliana Machado-Simoes, Luca Valbonetti, Marina Ramal-Sanchez, Giulia Capacchietti, Antonella Fontana, Romina Zappacosta, Paola Palestini, Laura Botto, Marco Marchisio, Paola Lanuti, Michele Ciulla, Antonio Di Stefano, Elena Fioroni, Michele Spina, Barbara Barboni
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Antonio Di Stefano, Lisa Marinelli, Piera Eusepi, Michele Ciulla, Stefania Fulle, Ester Sara Di Filippo, Laura Magliulo, Giuseppe Di Biase, Ivana Cacciatore
Review
Biochemistry & Molecular Biology
Michele Ciulla, Lisa Marinelli, Ivana Cacciatore, Antonio Di Stefano
Article
Chemistry, Medicinal
Lisa Marinelli, Erika Fornasari, Piera Eusepi, Michele Ciulla, Salvatore Genovese, Francesco Epifano, Serena Fiorito, Hasan Turkez, Serkan Ortucu, Marina Mingoia, Serena Simoni, Armanda Pugnaloni, Antonio Di Stefano, Ivana Cacciatore
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Aikaterini Pagoni, Lisa Marinelli, Antonio Di Stefano, Michele Ciulla, Hasan Turkez, Adil Mardinoglu, Stamatia Vassiliou, Ivana Cacciatore
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Chemistry, Analytical
Serena Fiorito, Salvatore Genovese, Lucia Palumbo, Luca Scotti, Michele Ciulla, Pietro di Profio, Francesco Epifano
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Chemistry, Physical
Gabriella Siani, Matteo Tiecco, Pietro Di Profio, Susanna Guernelli, Antonella Fontana, Michele Ciulla, Valentino Canale
JOURNAL OF MOLECULAR LIQUIDS
(2020)
Article
Biochemistry & Molecular Biology
Ozlem Ozdemir, Lisa Marinelli, Ivana Cacciatore, Michele Ciulla, Bugrahan Emsen, Antonio Di Stefano, Adil Mardinoglu, Hasan Turkez
Summary: This study showed that novel synthesized NSAID derivatives exhibit cytotoxic effects on human glioblastoma cells and can affect gene expression levels. Specifically, the compounds AL-3, AL-6, and AL-9 demonstrated the most activity and may be suitable candidates for further development of cancer prevention drugs.
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Serena Pilato, Massimiliano Aschi, Margherita Bazzoni, Federica Cester Bonati, Gianpiero Cera, Samanta Moffa, Valentino Canale, Michele Ciulla, Andrea Secchi, Arturo Arduini, Antonella Fontana, Gabriella Siani
Summary: The study showed that the pseudo-rotaxane promotes the transmembrane transport of Cl ions more effectively than calix[6]arene, and liposomes doped with the positively charged axle exhibited rapid quenching of lucigenin. Molecular dynamics simulations and quantum-chemical calculations provided semi-quantitative support for the experimental results.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Pharmacology & Pharmacy
Ivana Cacciatore, Michele Ciulla, Rossella Grande, Valentina Puca, Iole Robuffo, Leila Chekir-Ghedira, Lisa Marinelli, Rayhane Ben Khalifa, Marilisa Pia Dimmito, Vincenzo De Laurenz, Antonio Di Stefano
Summary: This study aimed to improve the antibiotic activity of vancomycin hydrochloride (VAN) by formulating multiple lipid nanoparticles (MLNs) containing carvacrol (CAR) and VAN co-loaded (CAR-VAN-MLNs). The results showed that the drug-loaded MLNs had appropriate particle size, negative surface charges, and high encapsulation efficiencies for both CAR and VAN. The stability and sustained drug release of the formulations were confirmed, and the morphological analysis indicated that the MLNs had a spherical shape. The co-encapsulation strategy improved the antibiotic activity of VAN against Staphylococcus aureus.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Physical
Marcello Costamagna, Eleonora Micheli, Valentino Canale, Michele Ciulla, Gabriella Siani, Pietro di Profio, Matteo Tiecco, Gianluca Ciancaleoni
Summary: A low-cost Transition Temperature Mixture (TTM) with high CO2 absorption and desorption efficiency has been synthesized by mixing ethylene glycol and potassium hydroxide, with the addition of boric acid and a small amount of water for performance optimization. The optimized four-component mixture shows promising results for rapid CO2 absorption and quantitative desorption, allowing for multiple cycling of absorption/desorption.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Multidisciplinary
Pietro Di Profio, Valentino Canale, Michele Ciulla, Antonella Fontana, Luca Madia, Massimo Zampato, Stefano Carminati
Summary: In the pursuit of a low carbon economy, natural gas is considered a viable solution. However, the formation of solid gas hydrates under seabed conditions can cause pipe blockage. This study explores the use of terahertz radiation to inhibit hydrate formation and finds that the inhibition persists for several hours after the radiation is turned off.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Lisa Marinelli, Michele Ciulla, Jeffrey A. S. Ritsema, Cornelus F. van Nostrum, Ivana Cacciatore, Marilisa Pia Dimmito, Ferdinando Palmerio, Giustino Orlando, Iole Robuffo, Rossella Grande, Valentina Puca, Antonio Di Stefano
Summary: The aim of this study was to encapsulate antimicrobial peptide FS10 in PEG-PLGA nanoparticles to overcome the limitations of hydrophilic drugs. The pH value and polymeric composition were found to be influential parameters for encapsulation efficiency. FS10-PEG-PLGA nanoparticles obtained under optimized parameters showed good size and surface potential, with sustained drug release. Antimicrobial assay demonstrated that the FS10-loaded nanoparticles had a lower minimum inhibitory concentration against S. aureus.
Article
Chemistry, Analytical
Michele Ciulla, Valentino Canale, Rafal D. Wolicki, Serena Pilato, Pantaleone Bruni, Stefania Ferrari, Gabriella Siani, Antonella Fontana, Pietro Di Profio
Summary: Poly(methyl methacrylate) (PMMA) can effectively capture CO2 under mild conditions, and its capture performance can be improved by electrospinning which increases surface/volume ratio. The modified electrospun PMMAs (ePMMAs) exhibit higher kinetics and capture yields compared to powdery amorphous PMMA (pPMMA). The ePMMAs show good durability with only 5% yield loss after ten consecutive runs. Spent ePMMAs can be regenerated through melting and electrospinning and retain their capture performance. This study demonstrates that electrospun PMMAs have the potential to be used as solid sorbents for carbon capture.
Article
Biochemistry & Molecular Biology
Ivana Cacciatore, Hasan Turkez, Annalisa Di Rienzo, Michele Ciulla, Adil Mardinoglu, Antonio Di Stefano
Summary: Novel boron-based compounds (BBCs) were synthesized and evaluated for their neuroprotective and antioxidant activities, showing potential to inhibit cell death induced by Aβ1-42 exposure and acetylcholinesterase inhibition. In vitro results suggest that BBCs could serve as new structural scaffolds for developing drugs for Alzheimer's disease.
RSC MEDICINAL CHEMISTRY
(2021)