Article
Pharmacology & Pharmacy
Andreia Bagliotti Meneguin, Rafael Miguel Sabio, Mauricio Palmeira Chaves de Souza, Richard Perosa Fernandes, Anselmo Gomes de Oliveira, Marlus Chorilli
Summary: Cellulose nanofibers were used as nanoreinforcement in retrograded starch/pectin excipient to optimize colon-specific properties. Factors such as thermal stability, encapsulation efficiency, and drug loading were improved through a complete factorial design. The presence of CNF decreased burst effect in release, targeting drug delivery to the colon affected by inflammatory bowel disease.
Article
Pharmacology & Pharmacy
Aline Martins dos Santos, Andreia Bagliotti Meneguin, Dewan Taslima Akhter, Nicholas Fletcher, Zachary H. Houston, Craig Bell, Kristofer J. Thurecht, Maria Palmira Daflon Gremia
Summary: Encapsulation of chitosan nanoparticles loaded with 5-fluorouracil within retrograded starch and pectin microparticles allowed for controlled release rates of the chemotherapeutic agent, providing enhanced protection along the gastrointestinal tract. In vivo studies demonstrated faster clearance of chitosan nanoparticles, highlighting the importance of specific degradability by colon microbiota in preventing unwanted absorption into the bloodstream. This research shows the potential of using retrograded starch and pectin microparticles as carriers for delivering drug-loaded nanoparticles to the colon, offering insights for the development of oral systems for colorectal cancer therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Physical
Valeria Maria de Oliveira Cardoso, Natalia Araujo Pereira de Brito, Natalia Noronha Ferreira, Fernanda Isadora Boni, Leonardo Miziara Barboza Ferreira, Suzana Goncalves Carvalho, Maria Palmira Daflon Gremiao
Summary: Nanotechnology has been applied in the development of polymer nanocarriers for oral delivery of biomolecules. This study focused on the preparation of nanoparticles based on gellan gum and chitosan blends, with different polymer mass ratios and addition orders influencing particle size. Encapsulation of polymyxin B reduced particle size, while Fourier transform infrared spectroscopy and X-ray diffraction revealed interactions and organized structures. Scanning electron microscopy showed spherical and uniform nanoparticles with mucoadhesive properties, indicating potential for enhanced oral peptide delivery.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Engineering, Chemical
Meilin Chen, Peng Yu, Chuanbei Ao, Miao Zhang, Jiaqi Xing, Chunmei Ding, Jing Xie, Jianshu Li
Summary: This research presents a new design for solvent-responsive polysaccharide hydrogel materials by preparing hydrogels that exhibit solvent-responsive properties to ethanol. This expands the possibilities for the application of solvent-responsive polysaccharide hydrogels.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Polymer Science
Hong-Ting Victor Lin, Jenn-Shou Tsai, Hsiao-Hui Liao, Wen-Chieh Sung
Summary: This study investigated the interactions among agar, gellan gum, gelatin, and modified waxy corn starch in the formation of mixed gels. It was found that agar had the most significant impact on increasing gel strength, breaking force, and rigidity, while gellan gum was more effective against syneresis during storage periods. The results provided useful information for selecting appropriate hydrocolloids and modified corn starch from refrigerated binary gum gels for food product development.
Review
Chemistry, Multidisciplinary
Dhruvi Solanki, Preksha Vinchhi, Mayur M. Patel
Summary: Wound healing is a complex physiological process that involves cellular and molecular events to reconstruct the skin after tissue damage. It is crucial to treat chronic wounds to improve patients' quality of life. Hydrogels, which have moistening and biocompatible properties, are playing a leading role in engineering ideal wound dressings.
Article
Biochemistry & Molecular Biology
Pegah Hosseini, Mohammad Hojjatoleslamy, Hooman Molavi
Summary: This study investigated the impact of three different biopolymers (quince seed gum, potato starch, and gellan gum) on optimizing the biodegradable film. The properties of the mixed edible film, including texture, water vapor permeability, water-solubility, transparency, thickness, color parameters, acid solubility, and microstructure, were evaluated. The optimal conditions for the production of the biodegradable film were determined. The results showed that the predicted and laboratory results were statistically similar, indicating a good fit for the model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Pharmacology & Pharmacy
Anna Froelich, Emilia Jakubowska, Barbara Jadach, Piotr Gadzinski, Tomasz Osmalek
Summary: This article provides a summary of the recent studies on polysaccharide compounds obtained from natural sources, and their potential as drug carriers. These compounds are biocompatible, biodegradable, and sensitive to degradation by the colon microbiome, making them attractive for pharmaceutical applications. The article focuses on the formulation and application of micro- and nanoparticles derived from gums and their blends with other polymers.
Article
Chemistry, Applied
Masahiko Annaka
Summary: I-127 NMR is utilized to examine the motion and selective interaction of I- ions in TMA gellan, and the conformational change is monitored by optical rotation measurement. The results show that I- ions promote conformational transition and exhibit preferential affinity for the ordered conformation of TMA gellan.
CARBOHYDRATE POLYMERS
(2023)
Article
Engineering, Chemical
Bowen Yan, Zilong Zhao, Nana Zhang, Huan Ruan, Xiaofei Yu, Jianxin Zhao, Hao Zhang, Wei Chen, Daming Fan
Summary: A 3D food printing curing technology based on the temperature-sensitive phase-change characteristics of gellan gum was developed to improve the customization of 3D food printing products. The addition of gellan gum in the printing substrate improved the extrusion and printing feasibility, resulting in the formation of a solid gel during printing. The curing performance of the slurry was influenced by the gellan gum, which affected the curing temperature and speed, and improved the hardness and adhesion of the printed products.
JOURNAL OF FOOD ENGINEERING
(2022)
Article
Engineering, Chemical
Jian Yao Ng, Peiyan Yu, Dhanya Mahalakshmi Murali, Yuan-Siang Liu, Rajeev Gokhale, Pui Lai Rachel Ee
Summary: A novel ADC-laden collagen-gellan gum hydrogel compatible with 3D bioprinting technology was developed. The hydrogel showed improved printability and scaffold quality, maintaining cell culture for 21 days. This study may contribute to the clinical application of synthetic skin grafts.
CHEMICAL ENGINEERING RESEARCH & DESIGN
(2023)
Article
Chemistry, Medicinal
Henrique Carrelo, Maria Teresa Cidade, Joao Paulo Borges, Paula Soares
Summary: In this study, the production of gellan gum-based microparticles as drug delivery systems was optimized using the coaxial air flow method. The main parameters affecting microparticle production and optimization were identified, and pH was revealed to have significant effects on swelling, degradation, and encapsulation efficiency. The developed microparticles showed promising results as drug-delivery vehicles sensitive to pH.
Article
Chemistry, Multidisciplinary
Liling Zhang, Tiantian Zheng, Linliang Wu, Qi Han, Shiyu Chen, Yan Kong, Guicai Li, Lei Ma, Hong Wu, Yahong Zhao, Yinxian Yu, Yumin Yang
Summary: In this study, new three-dimensional gellan gum/starch scaffolds were prepared by 3D printing technology to promote Schwann cells growth for peripheral nerve regeneration. The scaffolds exhibited good physiochemical properties and biocompatibility, indicating a potential application in nerve regeneration.
NANOTECHNOLOGY REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Jin Sol Seo, Nomin-Erdene Tumursukh, Joo Hee Choi, Youngeun Song, Gayeong Jeon, Na Eun Kim, Seung Jae Kim, Nahyeon Kim, Jeong Eun Song, Gilson Khang
Summary: The increasing number of individuals suffering from visual loss due to eye diseases has led to a need for corneal replacement. However, the shortage of donors and immune responses pose challenges. This study developed a GM/LAP hydrogel by blending methacrylated gellan gum (GM) with gellan gum (GG) and adding a crosslinking initiator (LAP). The GM/LAP hydrogel showed improved compressive strength and better cell viability, proliferation, and gene expression compared to the GM hydrogel, making it a promising candidate for corneal tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Laxmi Shanthi Chede, Maureen D. Donovan
Summary: Direct drug administration to the esophagus is challenging due to factors such as dilution and removal by saliva, which result in limited drug absorption into the esophageal mucosa. Various bioadhesive polymers were tested for their ability to resist saliva removal, and in situ gel-forming polysaccharide gels showed superior tissue surface retention. These gels, combined with ciclesonide, achieved therapeutic drug concentrations in esophageal tissues and offer potential for localized treatment of esophageal diseases.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Biochemistry & Molecular Biology
Franciele Garcia Baveloni, Bruno Vincenzo Fiod Riccio, Leonardo Delello Di Filippo, Mariza Aires Fernandes, Andreia Bagliotti Meneguin, Marlus Chorilli
Summary: Administration of substances through the skin is a promising alternative due to its large body surface area, offering ideal and multiple sites for drug administration. This route avoids first-pass metabolism, increases drug bioavailability, and reduces side effects. However, the stratum corneum acts as a main barrier against drug absorption through the skin.
CURRENT MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Analytical
Alberto Gomes Tavares Junior, Jennifer Thayanne Cavalcante de Araujo, Andreia Bagliotti Meneguin, Marlus Chorilli
Summary: This article reviews the physicochemical characteristics, pharmacokinetics, mechanisms of action, controlled release systems, and different analytical and bioanalytical methods for the quantification of 5-ASA.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Aline Martins dos Santos, Andreia Bagliotti Meneguin, Dewan Taslima Akhter, Nicholas Fletcher, Zachary H. Houston, Craig Bell, Kristofer J. Thurecht, Maria Palmira Daflon Gremia
Summary: Encapsulation of chitosan nanoparticles loaded with 5-fluorouracil within retrograded starch and pectin microparticles allowed for controlled release rates of the chemotherapeutic agent, providing enhanced protection along the gastrointestinal tract. In vivo studies demonstrated faster clearance of chitosan nanoparticles, highlighting the importance of specific degradability by colon microbiota in preventing unwanted absorption into the bloodstream. This research shows the potential of using retrograded starch and pectin microparticles as carriers for delivering drug-loaded nanoparticles to the colon, offering insights for the development of oral systems for colorectal cancer therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2021)
Article
Chemistry, Applied
Rafael Miguel Sabio, Andreia Bagliotti Meneguin, Aline Martins dos Santos, Andreia Sofia Monteiro, Marlus Chorilli
Summary: The use of mesoporous silica nanoparticles as drug delivery systems has increased significantly, but there is a lack of research on the main exposure routes. Understanding these administration routes can help in developing smarter nanoplatforms with interesting properties.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Review
Chemistry, Applied
Andreia Bagliotti Meneguin, Amanda Leticia Polli Silvestre, Larissa Sposito, Mauricio Palmeira Chaves de Souza, Rafael Miguel Sabio, Victor Hugo Sousa Araujo, Beatriz Stringhetti Ferreira Cury, Marlus Chorilli
Summary: Polysaccharides, through nano- and microencapsulation, can protect orally administered insulin from the harsh conditions of the gastrointestinal tract and improve permeability through cellular pathways, offering advantages such as targeted delivery.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Fernanda Isadora Boni, Beatriz Stringhetti Ferreira Cury, Natalia Noronha Ferreira, Deiver Alessandro Teixeira, Maria Palmira Daflon Gremiao
Summary: Nanostructured polyelectrolyte complexes based on biopolymers are designed through computational studies to target drugs more effectively to specific action and absorption sites. The optimal pH range for preparing nano PECs was determined experimentally and computationally, resulting in successful preparation of spherical nano-sized particles with positive surface charge. The study also rationalized the addition order of biopolymers and drug, maximizing their interactions and drug entrapment efficiency.
CARBOHYDRATE POLYMERS
(2021)
Review
Microbiology
Mauricio Palmeira Chaves de Souza, Bruna Almeida Furquim de Camargo, Larissa Sposito, Giovanna Capaldi Fortunato, Gabriela Correa Carvalho, Gabriel Davi Marena, Andreia Bagliotti Meneguin, Tais Maria Bauab, Marlus Chorilli
Summary: This article emphasizes the use of micro and nanoparticles as important technological tools for the treatment of H. pylori infections, focusing on main nanotechnological systems and microtechnological systems that can improve drug delivery and treatment outcomes.
CRITICAL REVIEWS IN MICROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Natalia N. Ferreira, Edilson de Oliveira Junior, Sara Granja, Fernanda Boni, Leonardo M. B. Ferreira, Beatriz S. F. Cury, Lilian C. R. Santos, Rui M. Reis, Eliana M. Lima, Fatima Baltazar, Maria Palmira D. Gremiao
Summary: The study proposed a novel strategy combining CHC with CTX for GBM treatment via nose-to-brain delivery using a nanotechnology-based carrier system. The conjugated NP were found to effectively control CHC release, promote drug permeation, and impair EGFR activation, showing a trend of tumor reduction. The developed nanoplatform demonstrated effectiveness in enabling nose-to-brain transport and suitability as a co-delivery approach for GBM treatment upon intranasal administration.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Pharmacology & Pharmacy
Larissa Sposito, Giovanna Capaldi Fortunato, Bruna Almeida Furquim de Camargo, Matheus Aparecido dos Santos Ramos, Mauricio Palmeira Chaves de Souza, Andreia Bagliotti Meneguin, Tais Maria Bauab, Marlus Chorilli
Summary: Peptic ulcer disease is a common condition caused by acid and pepsin inducing ulcers in the mucosa of the duodenum and stomach. The pathogenesis involves an imbalance between protective and aggressive factors. Although standard oral treatment is well established, issues like drug degradation in the stomach and low bioavailability can reduce its success.
JOURNAL OF DRUG TARGETING
(2021)
Article
Pharmacology & Pharmacy
Fernanda Isadora Boni, Beatriz S. F. Cury, Natalia Noronha Ferreira, Maria Palmira Daflon Gremiao
Summary: Polymer blends of GG/RS and GG/P cross-linked with different cations resulted in microparticles with varied physical-chemical properties and mucoadhesive abilities. Aluminum cross-linking in GG:P blends produced smaller particles, while calcium cross-linking in GG:RS particles reduced size and provided protection against enzymatic degradation in the stomach. The high mucoadhesive ability of the microparticles was evident at both pH values, with stronger interactions observed at pH 6.8.
Article
Biotechnology & Applied Microbiology
Aline Leite de Farias, Maria Isabel Amaya Arbelaez, Andreia Bagliotti Meneguin, Hernane da Silva Barud, Fernanda Lourencao Brighenti
Summary: The study found that morin has good antimicrobial and anti-biofilm activity against polymicrobial biofilms, effectively reducing microbial viability and polysaccharide concentration in the biofilm matrix, and controlling acidogenicity. In addition, morin showed cytotoxicity to oral keratinocytes within a certain concentration range.
Article
Pharmacology & Pharmacy
Valeria Maria de Oliveira Cardoso, Vanessa Thomaz Rodrigues Kiraly, Fernanda Isadora Boni, Natalia Noronha Ferreira, Leonardo M. B. Ferreira, Fabiola Manhas Verbi Pereira, Julio Cesar Borges, Beatriz Stringhetti Ferreira Cury, Maria Palmira Daflon Gremiao
Summary: The study successfully designed nanoparticles based on gellan gum and retrograded starch through polyelectrolyte complexation and ionic cross-linking. The results showed that cross-linking significantly increased the association efficiency of bevacizumab, while the size of nanoparticles varied under different formulation conditions. The technological approaches used in this study provide a potential platform for the oral delivery of bevacizumab-loaded nanocarriers with tailored properties.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Liliane Neves Pedreiro, Fernanda Isadora Boni, Beatriz Stringhetti Ferreira Cury, Natalia Noronha Ferreira, Maria Palmira Daflon Gremiao
Summary: In this study, mucoadhesive solid dispersions based on chitosan and hypromellose phthalate were designed to modulate the physicochemical and pharmaceutical properties of zidovudine. The SDs showed mucoadhesive properties and controlled release rates of the drug. This innovative and scalable technology provided a feasible strategy for drug modulation.
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY
(2022)
Article
Thermodynamics
Sabrina Dias Ribeiro, Andreia Bagliotti Meneguin, Hernane da Silva Barud, Jhonatan Miguel Silva, Rafael L. Oliveira, Rosana Maria Nascimento de Asuncao, Thiago Faria Tormin, Rodrigo Alejandro Abarza Munoz, Guimes Rodrigues Filho, Clovis Augusto Ribeiro
Summary: Cellulose acetate was successfully produced from cellophane film residues and used to create membranes for controlled drug release, showing promise for the utilization of waste cellophane residues in a sustainable manner.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2022)
