Article
Pharmacology & Pharmacy
A. Abruzzo, B. Giordani, A. Miti, B. Vitali, G. Zuccheri, T. Cerchiara, B. Luppi, F. Bigucci
Summary: The study designed chitosan nanoparticles and evaluated their use as mucoadhesive and/or mucopenetrating systems for vancomycin delivery. The nanoparticles showed sizes ranging from 150 nm to 350 nm with good polydispersity index and positive zeta-potential, allowing for fast and complete release of vancomycin while maintaining antibacterial activity.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Pharmacology & Pharmacy
Bhavana Valamla, Pradip Thakor, Rashmi Phuse, Mayuri Dalvi, Pratik Kharat, Ankaj Kumar, Dilip Panwar, Shashi Bala Singh, Pastorin Giorgia, Neelesh Kumar Mehra
Summary: Vaginal drug delivery is effective for treating and preventing various conditions, including infections and cancer. By improving drug absorption and providing sustained release and precise targeting, it enhances the efficacy of prophylactic and therapeutic treatments. This review summarizes the role of the mucosal vaginal barrier in drug delivery, with a focus on mucoadhesive drug delivery systems and their applications for vaginal tissue.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mariacristina Gagliardi, Sara Chiarugi, Chiara De Cesari, Giulia Di Gregorio, Alessandra Diodati, Laura Baroncelli, Marco Cecchini, Ilaria Tonazzini
Summary: The study presents a method to obtain stable and cytocompatible crosslinked chitosan nanoparticles for intranasal drug delivery. The nanoparticles showed a stable size and surface charge, and exhibited good cytocompatibility in vitro. This synthetic system has potential as a drug carrier for intranasal delivery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Silvia Voci, Cristina Pangua, Maria Cristina Martinez-Oharriz, Paula Aranaz, Maria Collantes, Juan M. Irache, Donato Cosco
Summary: The study characterizes Brij O2-stabilized gliadin nanoparticles for potential oral drug delivery. Physico-chemical evaluations and in vivo studies in rats and Caenorhabditis elegans confirmed the nanoparticles' ability to accumulate in the mucosa and move along the digestive system. The nanoparticles showed antioxidant activity, decreased age-related lipofuscin pigment, and demonstrated a safe profile. These findings support the future application of these nanoparticles for oral delivery of bioactives.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Sadaf Ejaz, Bridget Hogg, Delyan R. Hristov, David J. Brayden, Muhammad Imran, Sourav Bhattacharjee
Summary: Crosslinked chitosan nanocarriers entrapping coumarin-6 with or without surface mannosylation were synthesized and evaluated for their cytotoxicity, cellular uptake, permeation, and mucin adhesion. Results showed that mannosylated and non-mannosylated nanocarriers exhibited similar biocompatibility in cell experiments, but differed in cellular uptake. Additionally, chitosan nanocarriers enhanced adhesion to porcine gut mucin through increased cationic charge density.
Review
Polymer Science
Syed Sarim Imam, Sultan Alshehri, Mohammed M. Ghoneim, Ameeduzzafar Zafar, Omar Awad Alsaidan, Nabil K. Alruwaili, Sadaf Jamal Gilani, Md. Rizwanullah
Summary: The review discusses the loading of phytochemicals in biodegradable and biocompatible nanoparticles based on chitosan for improved bioavailability and bioactivity. Chitosan's properties such as mucoadhesiveness, non-toxicity, stability in harsh gastrointestinal conditions, and enhanced intestinal permeability make it suitable for oral delivery of phytochemicals.
Article
Medicine, Research & Experimental
Dhruti Avlani, Avichal Kumar, H. N. Shivakumar
Summary: TDF-loaded bioadhesive chitosan microparticles (CM) were successfully developed using an emulsification internal gelation technique. These microparticles demonstrated high drug entrapment efficiency and sustained drug release. They were incorporated into dispersible tablets (DT-TCM) to create a promising novel drug delivery platform for pre-exposure prophylaxis against HIV.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Renas Rzgar Jalal, Twana Mohammed M. Ways, Mahmoud H. Abu Elella, Diyar Ahmed Hassan, Vitaliy V. Khutoryanskiy
Summary: Mucoadhesive nanoparticles based on methacrylated chitosan (MeCHI) were designed and compared with unmodified chitosan nanoparticles for the delivery of ciprofloxacin. The MeCHI nanoparticles showed smaller particle size, lower polydispersity index, higher encapsulation efficiency, and sustained drug release compared to their chitosan counterpart. The mucoadhesion study also demonstrated that the ciprofloxacin-loaded MeCHI nanoparticles had better retention on the mucosal surface.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Stavroula G. Nanaki, Evi Christodoulou, Nikolaos D. Bikiaris, Afroditi Kapourani, Konstantinos N. Kontogiannopoulos, Souzan Vergkizi-Nikolakaki, Panagiotis Barmpalexis
Summary: The aim of the study was to prepare a leflunomide sustained release transdermal delivery system for psoriasis treatment. Using SDAEM-modified CS resulted in improved wetting and solubilization properties, better in vitro dissolution profile characteristics, and enhanced antibacterial properties in the LFD-loaded NPs. Embedding the NPs in polymeric thin-film patches resulted in sustained drug release for up to approximately twelve days, with CS-SDAEM NPs showing the most promising formulation approach.
Article
Chemistry, Physical
Noe Escareno, Natalia Hassan, Marcelo J. Kogan, Josue Juarez, Antonio Topete, Adrian Daneri-Navarro
Summary: Nanoparticle-based drug delivery systems combined with high-affinity targeting ligands provide a sophisticated landscape in cancer theranostics. Antibodies, due to their high diversity and specificity, are extensively used to provide bioactivity to nanoparticulate systems. However, controlled assembly of nanoparticles with targeting ligands remains a challenge.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Review
Pharmacology & Pharmacy
Tomasz Osmalek, Anna Froelich, Barbara Jadach, Adam Tatarek, Piotr Gadzinski, Aleksandra Falana, Kinga Gralinska, Michal Ekert, Vinam Puri, Joanna Wrotynska-Barczynska, Bozena Michniak-Kohn
Summary: The vagina has long been considered as a potential drug administration route, with most formulations made of natural or synthetic polymers serving different functions. In addition to topical applications, the anatomical and physiological features of the vagina make it suitable for systemic drug absorption. Research shows that intravaginal products continue to attract scientific attention, with ongoing exploration of novel polymers and formulations.
Review
Pharmacology & Pharmacy
Hassan A. Albarqi, Anuj Garg, Mohammad Zaki Ahmad, Abdulsalam A. Alqahtani, Ismail A. Walbi, Javed Ahmad
Summary: Glaucoma is a chronic degenerative eye disease that leads to irreversible vision loss due to high intraocular pressure. Traditional ocular drug delivery systems have low bioavailability, making glaucoma therapy challenging. Chitosan-based nanoparticulate systems have shown promise in overcoming these limitations. This manuscript reviews recent research on chitosan-based nanoparticulate systems for glaucoma treatment, discussing their significance in improving drug residence time and ocular bioavailability. It also analyzes the impact of chitosan-based nanomedicine on corneal permeability, ocular bioavailability, and therapeutic performance of loaded antiglaucoma agents.
Article
Chemistry, Medicinal
Zahra Davoudi, Nathan Peroutka-Bigus, Bryan Bellaire, Albert Jergens, Michael Wannemuehler, Qun Wang
Summary: This study investigated the effects of different surface charges on the delivery of nanoparticles into intestinal organoids, showing that positively charged nanoparticles were more readily transported across the epithelium into the lumen.
Article
Pharmacology & Pharmacy
Hani Z. Asfour, Nabil A. Alhakamy, Osama A. A. Ahmed, Usama A. Fahmy, Mohamed A. El-moselhy, Waleed Y. Rizg, Adel F. Alghaith, Basma G. Eid, Ashraf B. Abdel-Naim
Summary: This study developed a new nanoformula called Amitrip-based biodegradable PEG-PLGA self-assembled nanoparticles (Amitrip-NPs), which expedited wound healing in diabetic rats and exhibited anti-inflammatory, antioxidant, pro-collagen, and angiogenic activities.
Article
Pharmacology & Pharmacy
Joanna Potas, Emilia Szymanska, Magdalena Wroblewska, Izabela Kurowska, Mateusz Maciejczyk, Anna Basa, Eliza Wolska, Agnieszka Zofia Wilczewska, Katarzyna Winnicka
Summary: The study developed antifungal multilayer systems composed of chitosan and pectin, showing intelligent pH-responsive properties and strong antifungal effects. The systems exhibited good release kinetics and mucoadhesion properties in a buccal mucosa model, with antifungal activity against Candida strains. The addition of chitosan improved the drug's antifungal behavior, suggesting potential utilization in resistant cases of oral candidiasis.
Article
Neurosciences
Miriam E. Reyes-Mendez, J. Manuel Herrera-Zamora, Fernando Osuna-Lopez, Ricardo A. Navarro-Polanco, Nestor Mendoza-Munoz, Jose L. Gongora-Alfaro, Eloy G. Moreno-Galindo, Javier Alamilla
Summary: The study found that constant darkness rearing in rats can affect synaptic transmission and function between the retinohypothalamic tract (RHT) and suprachiasmatic nucleus (SCN) during early postnatal ages but lead to synaptic response strengthening at later ages. The results suggest that the environmental conditions induce a compensatory mechanism in the glutamatergic signaling to enhance synchronization to light at adult ages, and that the synaptic properties of RHT terminals during postnatal development are not critically influenced by light exposure.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Luis Eduardo Serrano-Mora, Maria L. Zambrano-Zaragoza, Nestor Mendoza-Munoz, Gerardo Leyva-Gomez, Zaida Urban-Morlan, David Quintanar-Guerrero
Summary: The study aimed to develop a novel, directly compressible, co-processed excipient for a controlled-release drug system in the pharmaceutical industry. Di-Tab(R):SLN ratio of 2:0.6 was found to have high functionality, control release for up to 8 hours, and fit the ideal profile calculated based on biopharmaceutical data.
Review
Polymer Science
Maria Luisa Del Prado-Audelo, Isaac H. Caballero-Floran, Nestor Mendoza-Munoz, David Giraldo-Gomez, Javad Sharifi-Rad, Jayanta Kumar Patra, Maykel Gonzalez-Torres, Benjamin Floran, Hernan Cortes, Gerardo Leyva-Gomez
Summary: Research on self-healable polymers for medical purposes has gained momentum in the past 20 years, with a focus on applications in tissue engineering. Natural and synthetic polymers each have their own advantages when it comes to developing self-healing hydrogels, which can be tailored based on specific requirements. The fabrication methods for self-healing hydrogels, including covalent and non-covalent crosslinking, play a crucial role in determining the properties and potential applications of these materials in the biomedical field.
IRANIAN POLYMER JOURNAL
(2022)
Review
Food Science & Technology
Araceli Ulloa-Saavedra, Claudia Garcia-Betanzos, Maria Zambrano-Zaragoza, David Quintanar-Guerrero, Susana Mendoza-Elvira, Benjamin Velasco-Bejarano
Summary: This review discusses the advances in the application of natural additives through nanosystems for extending the shelf life of meat and meat products. By using low-cost, eco-friendly methods such as nanotechnology, the incorporation of chemical additives can be reduced while enhancing the functionality of new products.
Article
Materials Science, Multidisciplinary
Tetyana Torchynska, Ricardo Cisneros-Tamayo, Georgiy Polupan, Andreas Stintz, Arturo Escobosa Echavarria
Summary: The parameters of InAs quantum dots inserted in Al0.30Ga0.70As/GaAs hetero structures with additional cap/buffer AlGaInAs quantum wells of different compositions were investigated using photoluminescence, transmission electron microscopy, and high-resolution X-ray diffraction methods. The study revealed that structure #1 exhibited a higher density of QDs, higher QD emission intensity, and smaller full width at half maximum of the PL bands compared to structure #2. Additionally, significant thermal quenching of the PL intensity was observed in structure #1 in comparison to structure #2. High-resolution X-ray diffraction analysis confirmed the perfect crystalline quality of the QD structures and sharp QW interfaces.
ECS JOURNAL OF SOLID STATE SCIENCE AND TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sergio A. Ojeda-Piedra, Maria L. Zambrano-Zaragoza, Ricardo M. Gonzalez-Reza, Claudia Garcia-Betanzos, Samantha A. Real-Sandoval, David Quintanar-Guerrero
Summary: This article investigates the application of nano-encapsulated essential oils in meat preservation and analyzes their effectiveness. The disadvantages of using essential oils, including their intense flavor, degradation under certain environmental conditions, and low solubility in water, can be addressed through nano-encapsulation.
Review
Oncology
Miguel Morales-Rodriguez, Lucero Paniagua-Garcia, Jayanthi Narayanan, Horacio Zamudio-Meza, Ramon Victor Moreno-Torres, Carlo Cesar Cortes-Gonzalez, Jose Antonio Juanico-Loran, Beatriz Martinez-Perez, Jorge Fernandez-Retana
Summary: Cervical cancer is a common neoplasm worldwide, especially in developing countries. Low quality screening tests, high incidence of locally advanced cancer stages, and tumor resistance are the main reasons for treatment failure. Advanced biological nanomaterials have been developed based on the understanding of carcinogenic mechanisms and bioengineering research. The insulin-like growth factor (IGF) system, including IGF receptor 1, plays a crucial role in the development, progression, survival, and treatment resistance of cervical cancer. This review discusses the role of the IGF system in cervical cancer and three nanotechnological applications, including Trap decoys, magnetic iron oxide nanoparticles, and protein nanotubes, for the treatment of resistant cervical cancer tumors.
Article
Polymer Science
Claudia I. Garcia-Betanzos, Humberto Hernandez-Sanchez, Sergio A. Ojeda-Piedra, Araceli Ulloa-Saavedra, David Quintanar-Guerrero, Maria L. Zambrano-Zaragoza
Summary: Solid lipid nanoparticles (SLN) based on candelilla wax were prepared using the hot homogenization technique. The resulting suspension had monomodal behavior with a particle size of 809-885 nm; polydispersity index < 0.31, and zeta potential of -3.5 mV 5 weeks after monitoring. The effects of temperature, film composition, and relative humidity on the microstructural, thermal, mechanical, and optical properties, as well as the water vapor barrier, were evaluated. Films with 20 g/L of SLN, 30 g/L of glycerol, and 3 g/L of xanthan gum (XG) showed the most appropriate physical properties for packaging and prolonging the shelf-life of fresh foods.
Article
Biochemistry & Molecular Biology
Jose E. Aguilar-Toala, Abraham Vidal-Limon, Andrea M. Liceaga, Maria L. Zambrano-Zaragoza, David Quintanar-Guerrero
Summary: This study demonstrates the potential of canary seed peptides (CSP) in inhibiting skin-aging factors, such as elastase and tyrosinase. Through analysis methods like fractionalization and molecular dynamics-ensemble docking, favorable peptides for passive insertion into skin membranes were identified, suggesting a promising application of CSP in skin-aging treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Moises Job Galindo-Perez, Lizbeth Martinez-Acevedo, Gustavo Vidal-Romero, Luis Eduardo Serrano-Mora, Maria de la Luz Zambrano-Zaragoza
Summary: This study aimed to preserve fresh-cut papaya using lemon oil and curcumin nanocapsules. The nanoparticles were stable and had a size smaller than 120 nm. They effectively reduced the respiration rate, maintained pH and acidity levels, improved color and texture, and preserved total phenolic compounds in the fruit. Lemon oil/EC nanocapsules showed better color retention. The findings highlight the effectiveness of these nanocapsules in preserving fresh-cut 'Maradol' papaya.
Review
Chemistry, Applied
Nestor Mendoza-Munoz, Gerardo Leyva-Gomez, Elizabeth Pinon-Segundo, Maria L. Zambrano-Zaragoza, David Quintanar-Guerrero, Maria Luisa Del Prado Audelo, Zaida Urban-Morlan
Summary: The term biopolymer refers to materials obtained by chemically modifying natural biological substances or producing them through biotechnological processes. They are biodegradable, biocompatible and non-toxic. Due to these advantages, biopolymers have wide applications in cosmetic formulations and have emerged as essential ingredients with various functions.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Review
Polymer Science
Rosy G. Cruz-Monterrosa, Adolfo A. Rayas-Amor, Ricardo M. Gonzalez-Reza, Maria L. Zambrano-Zaragoza, Jose E. Aguilar-Toala, Andrea M. Liceaga
Summary: Polysaccharide-based edible coatings can improve the quality parameters and extend the shelf life of foods, while also providing antioxidant and antimicrobial properties.
Review
Chemistry, Multidisciplinary
J. E. Aguilar-Toala, D. Quintanar-Guerrero, A. M. Liceaga, M. L. Zambrano-Zaragoza
Summary: Bioactive peptides have broad bioactivity and play a vital role in health, but their application is limited due to factors such as easy degradation and interaction with food matrix. Encapsulation can improve the stability and solubility of bioactive peptides.
Article
Polymer Science
Ricardo M. Gonzalez-Reza, Humberto Hernandez-Sanchez, David Quintanar-Guerrero, Liliana Alamilla-Beltran, Yair Cruz-Narvaez, Maria L. Zambrano-Zaragoza
Summary: The study focused on the preparation and storage of chitosan-thyme oil nanocapsules, indicating that storage time and temperature significantly altered the particle size and antioxidant capacity, with the nano-size being maintained and bioactive substance release following specific kinetic models.
Article
Pharmacology & Pharmacy
Xuezhi Zhuo, Vito Fodera, Per Larsson, Zarah Schaal, Christel A. S. Bergstrom, Korbinian Lobmann, Aleksei Kabedev
Summary: Our previous work demonstrated that beta-lactoglobulin-stabilized amorphous solid dispersion (ASD) loaded with 70 % indomethacin remains stable for over 12 months. We further investigated the stabilization mechanisms by testing five other drug molecules and using experimental techniques and molecular dynamics simulations. The results showed that steric confinement, hydrogen bonding, and the glass transition temperature of the drug molecule play important roles in stabilizing ASDs with high drug loadings.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Sebastian Schmidt, Ulrike Holzgrabe
Summary: The binding of drugs to plasma proteins, such as human serum albumin (HSA), is crucial for determining pharmacokinetic parameters. This study investigated the enantioselective binding of S- and R-ketamine to HSA. It was found that ketamine has weak affinity to HSA, with no significant differences in binding behavior between the individual enantiomers and the racemate. The aromatic ring and N-methyl group were identified as the most strongly involved structural moieties in the binding of ketamine to HSA.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Yuchen Zhao, Han Wang, Lin Jin, Ziwei Zhang, Lianghu Liu, Mengqi Zhou, Xianzheng Zhang, Lingling Zhang
Summary: Interleukins (ILs) are important for communication between immune cells and non-immune cells, but dysregulation of ILs expression is a characteristic of autoinflammatory diseases. Drugs targeting ILs have significant clinical benefits, but may also cause adverse reactions. Fusion protein technology, with its ability to enhance therapeutic efficacy, has been explored for developing anti-inflammatory drugs. This review discusses the efficacy of fusion protein drugs developed with ILs or their receptors in treating autoinflammatory diseases, highlighting the potential of this technology in future anti-inflammatory drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Serena Bertoni, Elena Simone, Stefano Sangiorgi, Beatrice Albertini, Nadia Passerini
Summary: This study investigated the correlation between the structure and release properties of solid lipid microparticles (MPs) with different liquid additives. The additives accelerated the conversion of the unstable alpha-form of tristearin to the stable beta-polymorph and caused structural modifications in the MPs. The presence of additives prolonged the drug release in water and resulted in higher release profiles in biorelevant media. The findings suggest that the release behavior can be influenced by the polymorphism and supramolecular-level structural modification of lipid formulations containing crystal modifiers.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Juulia Jarvinen, Ahmed B. Montaser, Santosh Kumar Adla, Jukka Leppanen, Marko Lehtonen, Kati-Sisko Vellonen, Tuomo Laitinen, Aaro Jalkanen, William F. Elmquist, Juri Timonen, Kristiina M. Huttunen, Jarkko Rautio
Summary: This study attempted to alter the brain distribution pattern of Palbociclib by creating and assessing two novel prodrugs. Although the prodrug design did not significantly improve Palbociclib brain delivery, the study provides valuable insights for future prodrug development and drug delivery strategies targeting specific transporters.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Review
Pharmacology & Pharmacy
Miao Wang, Xinyu Ma, Shiyu Zong, Yaqiong Su, Rui Su, Hong Zhang, Yang Liu, Chunliu Wang, Ye Li
Summary: This article discusses the potential and limitations of nasal administration in central nervous system drug delivery. Nasal gel viscosity can alleviate the impact of nasal mucociliary clearance on drug delivery, and materials such as gellan gum, chitosan, carbomer, cellulose, and poloxamer can be used to prepare nasal gels.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Bjarke Strom Larsen, Eric Kissi, Liebert Parreiras Nogueira, Natalja Genina, Ingunn Tho
Summary: This study investigates the influence of drug load and polymer molecular weight on the structure of 3D printed tablets. The results show that drug load and polymer molecular weight have a significant impact on the porosity and size of the tablets, while the effect of drug load on the total porosity of the tablets is minimal.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Zhentao Qiao, Fuhang Wang, Dongjian Han, Yuansong Zhuang, Qingjiao Jiang, Yi Zhang, Miaomiao Liu, Quanxu An, Zhiwei Wang, Deliang Shen
Summary: In this study, it was demonstrated that periadventitial delivery of rapamycin-fibrin glue (RPM-FG) can inhibit intimal hyperplasia (IH) in a rat carotid artery injury model without compromising re-endothelialization. This provides a promising direction for the future development of a safe, effective, and minimally invasive perivascular drug delivery method to treat vascular disease.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
Article
Pharmacology & Pharmacy
Neele Puhlmann, Rodrigo Vidaurre, Klaus Kuemmerer
Summary: Active pharmaceutical ingredients and their metabolites and transformation products are pollutants that can harm human and environmental health. Designing greener APIs is an effective strategy to address this issue. The drug discovery and development process can incorporate environmental parameters to achieve this design, and this process is highly flexible.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2024)
