One-Pot Synthesis of Highly Substituted Pyrroles by Three-Component Reactions of Donor-Acceptor Cyclopropanes, Salicylaldehydes, and Ammonium Acetate

An efficient one-pot synthesis of highly substituted pyrroles from donor-acceptor cyclopropanes, salicylaldehydes, and ammonium acetate has been developed. This reaction involves a domino sequence involving the ring-opening of donor-acceptor cyclopropanes, [3+2] annulation, and aromatization as the key steps. This elegant methodology readily afforded functionalized pyrroles under mild reaction conditions and with a wide substrate scope.