Article
Physiology
Evan M. Zeitler, J. Charles Jennette, Jennifer E. Flythe, Ronald J. Falk, John S. Poulton
Summary: This study on zebrafish shows that a high-calorie diet, regardless of fat content, can lead to kidney pathology, but these changes can be reversed after 4 weeks of calorie restriction.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Natalia Ferreira Mendes, Carlos Poblete Jara, Ariane Maria Zanesco, Eliana Pereira de Araujo
Summary: Under high-fat feeding, the hypothalamus undergoes pro-inflammatory signaling activation, with recent data revealing microglial heterogeneity throughout the brain. The roles of microglial subpopulations in hypothalamic inflammation have been studied, but how each subset functions in response to inflammatory stimuli remains unclear. Novel experimental models have been developed to study the characteristics and roles of microglial subtypes, and transcriptomic data is being used to identify changes in hypothalamic microglial signature under short-term and long-term high-fat feeding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Violet Kayamba
Summary: Upper gastrointestinal (UGI) cancers are common and have significant associations with certain types of food. Fruit and vegetables are believed to reduce UGI cancer risk, while processed foods increase the risk. Specific diets may be associated with reduced cancer risk, but their effectiveness in high-risk locations is unclear.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Food Science & Technology
Shaohong Zhang, Shuoshuo Sun, Xiao Wei, Mengxiao Zhang, Yu Chen, Xiaodong Mao, Guofang Chen, Chao Liu
Summary: This study explores the anti-obesity effects of short-term moderate calorie restriction (CR) by improving energy metabolism via the SIRT1/AMPK pathway in white adipocytes and liver. The results show that CR decreases obesity, increases thermogenesis, and inhibits inflammation in a mouse model of obesity.
FOOD & NUTRITION RESEARCH
(2022)
Article
Immunology
Arkadiusz D. Liskiewicz, Daniela Liskiewicz, Lukasz Marczak, Marta Przybyla, Konstancja Grabowska, Sebastian Student, Magdalena Debiec, Anna Slugocka, Joanna Lewin-Kowalik
Summary: This study found that obesity negatively impacts neurogenesis, cognitive function, and hippocampal protein expression, leading to impaired cognition and metabolic processes. However, weight loss through calorie restriction or a ketogenic diet can improve neurogenesis, cognition, and induce metabolic adjustments in the brain.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Gastroenterology & Hepatology
Magnus Holmer, Catarina Lindqvist, Sven Petersson, John Moshtaghi-Svensson, Veronika Tillander, Torkel B. Brismar, Hannes Hagstrom, Per Stal
Summary: For individuals with obesity and fatty liver, weight loss through diet can effectively improve liver conditions. This study demonstrates that both low-carb high-fat and the 5:2 diet are effective in treating fatty liver caused by obesity.
Article
Biochemistry & Molecular Biology
Laura L. Koekkoek, Margo Slomp, Julien Castel, Michael Mutersbaugh, Ian Linville, Mireille J. Serlie, Serge H. Luquet, Susanne E. la Fleur
Summary: Research shows that glutamatergic neurons in the lateral hypothalamus can differentiate between low-calorie sweeteners and caloric sweeteners, and consuming a high fat diet disrupts their ability to detect calories.
Article
Biochemistry & Molecular Biology
Xiaojing Wei, Chuanfei Wei, Yutian Tan, Ximing Dong, Zhao Yang, Jianqun Yan, Xiao Luo
Summary: This study aimed to determine the regulation of NAD+-related enzymes in the liver and their relationships with glucose and lipid metabolism. It was found that both high-fat diet feeding and calorie restriction increased hepatic NAD+ levels and the expression of related genes. In addition, high-fat diet feeding and calorie restriction had different effects on hepatic lipogenesis and gluconeogenesis. These findings highlight the importance of hepatic NAD+ metabolism in maintaining metabolic flexibility.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Review
Nutrition & Dietetics
Faidon Magkos
Summary: Studies suggest that calorie restriction and weight loss have similar beneficial effects in individuals without obesity as in those with obesity, including reduced fat deposition, increased insulin sensitivity, and improved insulin clearance rate, leading to lower blood glucose and insulin levels.
Article
Endocrinology & Metabolism
Shigenobu Matsumura, Fuka Ishikawa, Tsutomu Sasaki, Mike Krogh Terkelsen, Kim Ravnskjaer, Tomoki Jinno, Jin Tanaka, Tsuyoshi Goto, Kazuo Inoue
Summary: CRTC1 in SF1 cells is a sensitive factor for high-fat diet-induced obesity, necessary for normal appetite regulation. It is primarily expressed in the brain, playing an important role in the ventromedial hypothalamus. RNA sequencing analysis of microdissected ventromedial hypothalamus samples revealed that the loss of CRTC1 significantly altered the expression levels of certain genes.
Article
Biochemistry & Molecular Biology
Qiaoyu Li, Yuqi Lin, Jinlin Xu, Yukun Liu, Yuxuan Jing, Rongzeng Huang, Chengwu Song, Lijun Zhang, Shuna Jin
Summary: Diet restriction (DR) can ameliorate obesity by regulating mitochondrial function. This study evaluated the effects of graded levels of DR on obesity based on mitochondrial CL levels in the liver. The results showed significant improvements in the liver after DR, except for the 60 DR group.
Article
Endocrinology & Metabolism
Amrendra Mishra, Hamed Mirzaei, Novella Guidi, Manlio Vinciguerra, Alice Mouton, Marina Linardic, Francesca Rappa, Rosario Barone, Gerardo Navarrete, Min Wei, Sebastian Brandhorst, Stefano Di Biase, Todd E. Morgan, S. Ram Kumar, Peter S. Conti, Matteo Pellegrini, Michel Bernier, Rafael de Cabo, Valter D. Longo
Summary: Research shows that a monthly cycle of 5 days of a fasting-mimicking diet can prevent obesity and related detrimental effects on cardiometabolic health and lifespan in mice. The fasting-mimicking diet inhibits obesity by reducing fat accumulation and improves heart function and resistance to cardiotoxins. It also prevents issues like hyperglycemia, hypercholesterolemia, and hyperleptinemia, while improving glucose and insulin tolerance.
Review
Immunology
Natalia F. Mendes, Licio A. Velloso
Summary: Brain macrophages and microglia play important roles in immune surveillance of the central nervous system. They release key molecules to prevent further damage to the neuronal network upon inflammatory stimuli. Perivascular macrophages in the hypothalamic area are the first line of defense against pathogens and substances from the blood.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Nutrition & Dietetics
Zofia Strojny, Rafal Rutkowski, Alina Kanikowska, Agnieszka Zawada, Aldona Juchacz, Marian Grzymislawski, Maki Sato, Monika Litwinowicz, Katarzyna Korybalska, Andrzej Breborowicz, Janusz Witowski, Dominika Kanikowska
Summary: A study on individuals with obesity undergoing a 3-week moderate calorie restriction found that chronotype did not have a significant effect on the magnitude of weight loss, but there was a tendency for owls to reduce body fat content.
Review
Biochemistry & Molecular Biology
Ekaterina Sergeeva, Tatiana Ruksha, Yulia Fefelova
Summary: The risk of malignant tumor development is increasing worldwide, with obesity being a known risk factor. Obesity is associated with metabolic alterations that promote cancerogenesis, including increased levels of estrogens, chronic inflammation, and hypoxia. Calorie restriction has been shown to improve the condition of patients with various diseases by influencing metabolism, hormone levels, and cell processes. It can regulate signal cascades that affect cancer cell proliferation, migration, survival, apoptosis, and response to chemotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Hadi Aligholi, Maryam Safahani, Ali A. Asadi-Pooya
Summary: Six related articles regarding the effects of stem cell transplantation in patients with epilepsy were reviewed, showing no serious adverse events and insufficient data for clinical application. The effectiveness of clinical stem cell-based interventions is currently unproven.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Neurosciences
Sara Abdolahi, Hadi Aligholi, Azizollah Khodakaram-Tafti, Maryam Khaleghi Ghadiri, Walter Stummer, Ali Gorji
Summary: Research has shown that the co-application of hNS/PCs and PM after SCI can enhance cell survival and differentiation, reduce lesion volume, and improve neurological function. Additionally, transplanted hNS/PCs seeded in PM demonstrate higher migration and differentiation abilities.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Elmira Karimi, Sama Bitarafan, Seyed Mohammad Mousavi, Nikan Zargarzadeh, Pari Mokhtari, Jessie Hawkins, Alipasha Meysamie, Fariba Koohdani
Summary: Oral vitamin D supplementation does not significantly affect serum FGF23 concentrations in patients with chronic kidney disease, and further high-quality trials are needed to confirm the findings.
PHYTOTHERAPY RESEARCH
(2021)
Article
Behavioral Sciences
Zohreh Taghadosi, Asadollah Zarifkar, Vahid Razban, Maryam Owjfard, Hadi Aligholi
Summary: Stress can increase locomotor activities, impair spatial learning and memory, and lead to a significant increase in hippocampal BBB permeability.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Neurosciences
Zahra Zeraatpisheh, Esmaeil Mirzaei, Mohammad Nami, Hamed Alipour, Marzieh Mahdavipour, Parisa Sarkoohi, Somayyeh Torabi, Hassan Azari, Hadi Aligholi
Summary: The study showed that local delivery of nanofingolimod combined with NS/PCs transplantation in a mouse model of acute SCI resulted in better improvement in neurological functions and reduced tissue damage. Co-administration of nanofingolimod and NS/PCs not only increased the survival of transplanted cells, but also promoted their fate towards oligodendrocytic phenotype. This approach could be promising for restoring damaged tissues and improving neurological functions in the acute phase of SCI.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Zohreh Bagheri, Fatemeh Shamsi, Zahra Zeraatpisheh, Mahin Salman Nejad, Ahmad Soltani, Hadi Aligholi
Summary: This study revealed that the combination of methylprednisolone (MP) and neural stem/progenitor cells (NS/PCs) has adverse effects on the survival and proliferation of NS/PCs, therefore, this combination is not recommended.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Neurosciences
Zahra Zeraatpisheh, Esmaeil Mirzaei, Mohammad Nami, Hamed Alipour, Somayeh Ghasemian, Hassan Azari, Hadi Aligholi
Summary: This study introduces a new murine contusion model for spinal cord injury (SCI) research. A simple, cheap, and reproducible instrument was designed and used to induce controllable SCI in mice. The results showed that the newly designed apparatus minimized adverse spinal movement during injury induction and no additional devices were required. Motor function, tissue damage, and cell injury were deteriorated with increasing duration of weight exertion.
BASIC AND CLINICAL NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Zahra Kalantar, Gity Sotoudeh, Zahra Esmaeily, Masoumeh Rafiee, Fariba Koohdani
Summary: The study found significant interactions between CETP Taq1B gene polymorphism and dietary indices on various metabolic biomarkers, such as LDL/HDL, total antioxidant capacity, pentraxin 3, waist circumference, and interleukin-18. These results suggest the combined effects of genetic and dietary factors on metabolic health in T2DM patients.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Rehabilitation
Fatemeh Shamsi, Mohammad Nami, Hadi Aligholi, Afshin Borhani-Haghighi, Roohollah Zahediannasb, Mahshid Hekmatnia, Mohammad Taghi Karimi
Summary: The study aimed to evaluate the effects of action observation training, based on mirror neurons, on the gait performance of stroke patients. The results showed that action observation training had the potential to improve the walking quality of patients with chronic stroke.
JOURNAL OF BODYWORK AND MOVEMENT THERAPIES
(2022)
Article
Cell & Tissue Engineering
Zahra Zeraatpisheh, Fatemeh Shamsi, Parisa Sarkoohi, Somayyeh Torabi, Hamed Alipour, Hadi Aligholi
Summary: This study evaluated the effects of FTY720 on the behaviors of neural stem/progenitor cells (NS/PCs) in vitro and in a spinal cord injury (SCI) model. FTY720 increased cell survival and migration capacity, and higher doses led to the formation of more neurospheres. Furthermore, co-administration of FTY720 and NS/PCs enhanced functional recovery and the survival and migration of transplanted cells in the SCI model.
CELLULAR AND MOLECULAR BIOENGINEERING
(2022)
Article
Nutrition & Dietetics
Faezeh Abaj, Masoumeh Rafiee, Fariba Koohdani
Summary: The present study found that the PPAR-gamma Pro12Ala polymorphism can intensify the effect of dietary insulin load and insulin index on cardiovascular disease risk factors. Risk-allele carriers who consumed a diet with high insulin load and insulin index were more likely to be obese and have higher inflammatory markers.
JOURNAL OF HUMAN NUTRITION AND DIETETICS
(2022)
Article
Anatomy & Morphology
Neda Karami, Hassan Azari, Moosa Rahimi, Hadi Aligholi, Tahereh Kalantari
Summary: This study demonstrates that the selective orexin 2 receptor antagonist JNJ-10397049 can enhance the proliferation of neural progenitor cells (NPCs) and facilitate their differentiation towards the oligodendroglial lineage. These findings provide insights into the potential role of orexin 2 receptor antagonist in promoting oligodendrocyte production from NPCs.
ANATOMY & CELL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Zohreh Taghadosi, Asadollah Zarifkar, Vahid Razban, Hadi Aligholi
Summary: Prolonged exposure to stress is detrimental to brain structures, including the hippocampus. This study examined the impact of chronic stress on learning and memory in Alzheimer's disease (AD) patients and found that it alters the expression of certain receptors in the hippocampus. The findings provide new insights into potential treatment strategies for AD.
METABOLIC BRAIN DISEASE
(2022)
Review
Rehabilitation
Fatemeh Shamsi, Mohammad Nami, Hadi Aligholi, Afshin Borhani-Haghighi, Mahsa Kavyani, Mohammad T. Karimi
Summary: Action observation training may benefit patients in the chronic phase of stroke more in terms of gait and balance compared to patients with other medical conditions.
BRITISH JOURNAL OF OCCUPATIONAL THERAPY
(2022)
Article
Public, Environmental & Occupational Health
Neda Karami, Hadi Aligholi, Moosa Rahimi, Hassan Azari, Tehereh Kalantari
Summary: This study investigated the expression of GPCRs in vitro and in silico, highlighting their significant role in inducing remyelination. Among the 14 GPCRs mentioned, GPR37L1 was identified as a potential drug target for promoting remyelination.
IRANIAN JOURNAL OF PUBLIC HEALTH
(2022)