Article
Neurosciences
Clara Bourrelly, Corentin Massot, Neeraj J. Gandhi
Summary: Sensorimotor transformation is the process of sensing and responding to stimuli, and this study investigates the neural activity in the superior colliculus during visually guided eye movements. The study compares spike bursts and local field potential (LFP) modulations along the dorsoventral axis of the superior colliculus and finds a transition from sensory to motor response in both signals, with the LFP transition occurring deeper than the spike burst transition. The results suggest a fast and efficient transformation between LFP modulation and spike burst during sensation, but not during action.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Yann Zerlaut, Stefano Zucca, Tommaso Fellin, Stefano Panzeri
Summary: Recent studies have shown that cortical network states play a role in modulating sensory responses and perceptual outcomes. This study used simultaneous LFP and intracellular recordings in awake mice to design a network state classification from the LFP, called the Network State Index (NSI). The findings revealed that population signal levels predict single-cell depolarization levels in nonrhythmic states, while rhythmicity in the LFP mapped into a stereotypical oscillatory pattern of membrane potential in delta oscillatory states. Additionally, the variability of network states beyond slow oscillatory activity influenced the average correlations between single-cell and population signals. The application of NSI to mouse visual cortex data showed its potential in understanding the flexibility of sensory processing during behavior.
Article
Clinical Neurology
Chayaporn Reakkamnuan, Ekkasit Kumarnsit, Dania Cheaha
Summary: Impairments in motor control are the primary feature of Parkinson's disease, which is caused by dopaminergic imbalance in the basal ganglia. Identification of neural biomarkers of dopamine D2 receptor (D2R) suppression would be useful for monitoring the progress of neuropathologies and effects of treatment. The study found that administration of the D2R antagonist HAL led to decreased movement velocity, increased latency to descend, and decreased latency to fall in mice, suggesting these changes as potential biomarkers for monitoring Parkinson's disease.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Zhen Wang, Qing Lin, Yuan B. Peng
Summary: The study investigated the neurophysiological mechanisms underlying nitroglycerin-induced migraine attacks by recording local field potential (LFP) changes in multiple brain regions. The results revealed alterations in LFP powers and brain coherence, as well as the induction of photophobia. These findings provide valuable insights into the understanding and treatment of migraine.
Article
Biology
Lu Luo, Xiongfei Wang, Junshi Lu, Guanpeng Chen, Guoming Luan, Wu Li, Qian Wang, Fang Fang
Summary: This study investigates the receptive fields (RFs) of neurons in the human visual cortex using intracranial local field potentials (LFPs) and spiking activity. The results show that the RF sizes and temporal profiles measured from low-gamma activity (LGA) and high-gamma activity (HGA) closely match those measured from spiking activity, suggesting the important role of LGA and HGA in early visual information processing.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Biology
Cecilia Gallego-Carracedo, Matthew G. Perich, Raeed H. Chowdhury, Lee E. Miller, Juan alvaro Gallego, Srdjan Ostojic
Summary: This study investigates the relationship between latent dynamics and local field potentials (LFPs), and finds that this relationship remains stable throughout behavior, bridging the gap between studies on neural correlates of behavior using different types of recordings.
Article
Biochemistry & Molecular Biology
Carolina G. Ferroni, Davide Albertini, Marco Lanzilotto, Alessandro Livi, Monica Maranesi, Luca Bonini
Summary: This research investigated the neural activity in the action observation network (AON) during self and others' action encoding, revealing temporal and tuning specificities of distinct brain areas and neuronal classes. Different areas within AON showed varied prevalence of facilitated and suppressed neurons during task execution and observation, with distinct cell classes carrying specific visuomotor signals. The findings elucidated the firing properties and time course of activity at both system and local levels in the AON.
Editorial Material
Neurosciences
Sung Eun Kwon
Summary: The study reveals a key cortical circuit in the brain for executing delayed motor responses following specific sensory inputs, shedding light on how the brain processes sensory information to produce motor outputs.
Article
Neurosciences
Jae-Hyun Kim, Dong-Hyun Ma, Eunji Jung, Ilsong Choi, Seung-Hee Lee
Summary: In this study, Kim et al. found that visual inputs trigger gated feedforward inhibition of ACC neurons, which disinhibits striatal motor neurons and initiates precise responses in mice performing a visual Go/No-go task. The characteristics of ACC neurons can predict response times in mice, and optogenetic activation of visual inputs in the ACC prompts task-relevant actions by suppressing ACC motor neurons and disinhibiting downstream striatal neurons.
NATURE NEUROSCIENCE
(2021)
Article
Biochemical Research Methods
Matin Asgharpour, Reza Foodeh, Mohammad Reza Daliri
Summary: The study aims to enhance the decoding performance of the KF in BCI systems by improving the estimation of parameters. A new Regularized Kalman Filter (RKF) was proposed, which outperformed existing approaches in two datasets, demonstrating its effectiveness in decoding neural activity.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Claudia Cecchetto, Stefano Vassanelli, Bernd Kuhn
Summary: The study introduces a novel multimodal technique combining two-photon imaging and multi-channel field potential recordings to investigate the spatiotemporal dynamics of neuronal signals in different layers of the barrel cortex in mice.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
Carolina Tecuatl, Diek W. Wheeler, Nate Sutton, Giorgio A. Ascoli
Summary: A systematic pipeline is presented to estimate local connection parameters between different neuron types in the hippocampal formation, greatly increasing the available quantitative assessments. The study also provides approximate measurements of synaptic distances, filling substantial gaps in the knowledge and offering useful model specifications for neural network simulations.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Mathematics, Interdisciplinary Applications
Guoxia Zou
Summary: The study aims to help individuals with movement difficulties by identifying their action ideas through EEG. The experimental results suggest that brain wave action ideas are easier to recognize in static state compared to dynamic state, with an accuracy of 99.98% and 72.27% respectively.
Article
Neurosciences
Zhen Wang, Yuan B. Peng
Summary: In this study, the differential LFP activities in various brain regions of anesthetized male rats were recorded to investigate the effects of formalin injection on neuronal activity. The results showed increased power of different frequency bands in the anterior cingulate cortex (ACC) and amygdala, while only some frequency bands in the ventral tegmental area (VTA) exhibited significant enhancement. Additionally, the connectivity among these brain regions was significantly reduced under formalin-induced nociception.
Article
Mathematical & Computational Biology
Sorinel A. Oprisan, Xandre Clementsmith, Tamas Tompa, Antonieta Lavin
Summary: This study investigated the effects of cocaine administration and parvalbumin-type interneuron stimulation on local field potentials (LFPs) recorded in vivo from the medial prefrontal cortex (mPFC) of six mice using optogenetic tools. The signal was decomposed into orthogonal Intrinsic Mode Functions (IMFs) using the adaptive, data-driven, Empirical Mode Decomposition (EMD) method. The results showed that neural activity avalanches under cocaine have longer life spans and sizes compared to the control group.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2023)
Article
Neurosciences
Farnaz Sharif, Behnam Tayebi, Gyorgy Buzsaki, Sebastien Royer, Antonio Fernandez-Ruiz
Summary: Hippocampal neurons exhibit different spatial coding characteristics in different environments, with superficial place cells more active in cue-poor environments and deep place cells more active in cue-rich environments. These differences are driven by intra-hippocampal and entorhinal inputs, supported by the interaction between excitatory gamma inputs and local inhibition.
Article
Neurosciences
Manuel Valero, Tim J. Viney, Robert Machold, Sara Mederos, Ipshita Zutshi, Benjamin Schuman, Yuta Senzai, Bernardo Rudy, Gyorgy Buzsaki
Summary: A unique neuron type called down state-active (DSA) neurons has been identified in mice and rats, which show anti-correlated spiking activity with principal cells and interneurons during non-REM sleep, especially during the down state. Despite their sparsity, DSA neurons play critical roles in physiological functions, shaping the firing sequence of neurons during down-up transitions and interfering with memory consolidation during NREM sleep.
NATURE NEUROSCIENCE
(2021)
Article
Neurosciences
Sam McKenzie, Roman Huszar, Daniel F. English, Kanghwan Kim, Fletcher Christensen, Euisik Yoon, Gyorgy Buzsaki
Summary: The study focuses on how incorporating synthetic hippocampal signals is constrained by preexisting circuit dynamics through optogenetic stimulation of CA1 neurons in mice. Stimulation induced persistent place field remapping and reflected circuit modification through altered spike transmission. The findings suggest that plasticity in recurrent/lateral inhibition may drive learning by rapidly associating existing states.
Article
Engineering, Biomedical
Yu-Ju Lin, Hyunsoo Song, Sungjin Oh, Mihaly Voroslakos, Kanghwan Kim, Xing Chen, David D. Wentzloff, Gyorgy Buzsaki, Sung-Yun Park, Euisik Yoon
Summary: This paper presents an energy-efficient, cancellation-free B-TDD transceiver for real-time closed-loop control of high channel count neural interfaces. The transceiver is designed with a duty-cycled UWB transmitter and a switching U-NII band receiver, achieving energy efficiency without power-hungry self-interference cancellation circuits. A fast-switching scheme and oversampling with winner-take-all voting are employed to suppress interference and enhance isolation. The B-TDD transceiver demonstrates low energy consumption and successful in-vivo operation in a prototype wireless bidirectional neural interface system.
IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS
(2022)
Article
Engineering, Biomedical
Sung-Yun Park, Kyounghwan Na, Mihaly Voroslakos, Hyunsoo Song, Nathan Slager, Sungjin Oh, John Seymour, Gyorgy Buzsaki, Euisik Yoon
Summary: We present a miniaturized and minimally invasive high-density neural recording interface that combines a flexible probe and a 256-channel integrated circuit chip. Custom flip-chip bonding technique and reference-replica topology were employed to achieve compact size and enhance signal-to-noise ratios. The fabricated interface showed promising performance in both in vitro and in vivo experiments, indicating its suitability for large scale and miniaturized neural recording systems.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Neurosciences
Ipshita Zutshi, Manuel Valero, Antonio Fernandez-Ruiz, Gyorgy Buzsaki
Summary: The extent to which neuronal spiking reflects local computation or responses to upstream inputs in circuit operations is a key problem in understanding. By performing experiments on the hippocampus, this study revealed that silencing the medial entorhinal cortex (mEC) largely abolished theta and gamma currents in CA1, while CA3 and local CA1 silencing strongly decreased firing of CA1 neurons. Despite these perturbations, the CA1 circuit was still able to support place field activity and maintain the spatial map.
Article
Multidisciplinary Sciences
Manuel Valero, Ipshita Zutshi, Euisik Yoon, Gyorgy Buzsaki
Summary: This study used optogenetic pulses to investigate the subthreshold dynamics of hippocampal neuronal assemblies. The results showed that excitability decreased during sharp-wave ripples accompanied by increased inhibition. However, optogenetic probing revealed increased excitability in place cells by weakening inhibition, unmasking stable place fields in initially non-place cells. Neuronal assemblies active during sharp-wave ripples in the home cage predicted spatial overlap and sequences of place fields in both place cells and unmasked preexisting place fields of non-place cells during track running.
Article
Neurosciences
Peter C. Petersen, Mihaly Voroslakos, Gyorgy Buzsaki
Summary: Biochemical mechanisms in the brain are influenced by temperature. This study demonstrates that brain temperature variations are correlated with hippocampal sharp wave ripple features, including frequency, occurrence rate, and duration. Focal manipulation of temperature in the CA1 region of the hippocampus can alter ripple frequency. Other parameters of the sharp wave-ripple complex may be determined by mechanisms upstream from the CA1 region.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Noam Nitzan, Rachel Swanson, Dietmar Schmitz, Gyorgy Buzsaki
Summary: The study found that sharp wave ripples (SPW-Rs) coincided with a transient brain-wide increase in functional connectivity, and the diversity in SPW-R features was correlated with their intrahippocampal topography along the septotemporal axis. Furthermore, variations in SPW-R features were related to the timing, sign, and magnitude of downstream responses.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Asako Noguchi, Roman Huszar, Shota Morikawa, Gyorgy Buzsaki, Yuji Ikegaya
Summary: The activation of inhibitory neurons prior to hippocampal sharp-wave ripples regulates the order of spikes, which is crucial for memory storage.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Laura Green, David Tingley, John Rinzel, Gyorgy Buzsaki
Summary: This study investigates the role of action in the neuronal organization of the hippocampus through a behavioral experiment of training rats to jump a gap. The results indicate that jumping induces consistent electrophysiological patterns in the hippocampus, while the theta spike phase versus animal position relationship remains unchanged.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Roman Huszar, Yunchang Zhang, Heike Blockus, Gyorgy Buzsaki
Summary: Huszar et al. found that hippocampal neurons born on the same day exhibit similar physiological features, participate in the same neuronal assemblies, and have overlapping spatial representations. The dynamics of hippocampal network are influenced by sequential neurogenesis, with neurons of the same birthdate displaying distinct connectivity and activity across different brain states. These observations demonstrate that sequential neurogenesis shapes the preconfigured forms of adult network dynamics.
NATURE NEUROSCIENCE
(2022)
Article
Cell Biology
Manuel Valero, Andrea Navas-Olive, Liset M. de la Prida, Gyorgy Buzsaki
Summary: This study investigates the influence of inhibitory and excitatory inputs on CA1 pyramidal cell responses and finds that inhibition is stronger than excitation and critical for place field expression.
Article
Neurosciences
Marisol Soula, Alejandro Martin-Avila, Yiyao Zhang, Annika Dhingra, Noam Nitzan, Martin J. Sadowski, Wen-Biao Gan, Gyorgy Buzsaki
Summary: The authors find that 40-Hz flickering light does not suppress A beta, activate microglia or engage native gamma oscillations. Thus, visual flicker stimulation may not be a viable mechanism for altering AD pathology and modulating deep structures.
NATURE NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Marisol Soula, Anna Maslarova, Ryan E. Harvey, Manuel Valero, Sebastian Brandner, Hajo Hamer, Antonio Fernandez-Ruiz, Gyorgy Buzsaki
Summary: Interictal epileptiform discharges (IEDs) are common electrophysiological events observed in epilepsy and other neurological diseases. This study characterizes and compares IEDs in human epilepsy patients and AD transgenic mice, finding similar features and effects on the hippocampal circuit. The findings suggest that IEDs may play a role in cognitive deficits and memory interference.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)