MECHANISMS IN ENDOCRINOLOGY: SGLT2 inhibitors: clinical benefits by restoration of normal diurnal metabolism?

Efficacy and safety of dapagliflozin in patients with inadequately controlled type 1 diabetes (DEPICT-1): 24 week results from a multicentre, double-blind, phase 3, randomised controlled trial

(2017) Paresh Dandona et al.   Lancet Diabetes & Endocrinology

Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan

(2016) Valter D. Longo et al.   Cell Metabolism

Shift to Fatty Substrate Utilization in Response to Sodium–Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes

(2016) Ele Ferrannini et al.   DIABETES

Empagliflozin, via Switching Metabolism Toward Lipid Utilization, Moderately Increases LDL Cholesterol Levels Through Reduced LDL Catabolism

(2016) François Briand et al.   DIABETES

Can a Shift in Fuel Energetics Explain the Beneficial Cardiorenal Outcomes in the EMPA-REG OUTCOME Study? A Unifying Hypothesis

(2016) Sunder Mudaliar et al.   DIABETES CARE

SGLT2 Inhibitors and Cardiovascular Risk: Lessons Learned From the EMPA-REG OUTCOME Study

(2016) Muhammad Abdul-Ghani et al.   DIABETES CARE

CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis

(2016) Ele Ferrannini et al.   DIABETES CARE

Dapagliflozin Enhances Fat Oxidation and Ketone Production in Patients With Type 2 Diabetes

(2016) Giuseppe Daniele et al.   DIABETES CARE

SGLT2 Inhibition and cardiovascular events: why did EMPA-REG Outcomes surprise and what were the likely mechanisms?

(2016) Naveed Sattar et al.   DIABETOLOGIA

EMPA-REG: Glucose excretion and lipid mobilization – not storage – saves lives

(2016) Nils Bruun Jørgensen et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

The EMPA-REG study: What has it told us? A diabetologist’s perspective

(2016) Ralph A. DeFronzo   JOURNAL OF DIABETES AND ITS COMPLICATIONS

EMPA-REG – the “diuretic hypothesis”

(2016) John McMurray   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Mitochondrial quality control in the diabetic heart

(2016) Qiangrong Liang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Empagliflozin and Progression of Kidney Disease in Type 2 Diabetes

(2016) Christoph Wanner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Pancreatic β Cell Mass Death

(2016) Husnia I. Marrif et al.   Frontiers in Pharmacology

Metabolic consequences of modern immunosuppressive agents in solid organ transplantation

(2016) Oluwatoyin Bamgbola   Therapeutic Advances in Endocrinology and Metabolism

Autophagy and mitophagy in diabetic cardiomyopathy

(2015) Satoru Kobayashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

(2015) Moshi Song et al.   Cell Metabolism

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

Fatty Acid Trafficking in Starved Cells: Regulation by Lipid Droplet Lipolysis, Autophagy, and Mitochondrial Fusion Dynamics

(2015) Angelika S. Rambold et al.   DEVELOPMENTAL CELL

SGLT-2 inhibitors and cardiovascular risk: Proposed pathways and review of ongoing outcome trials

(2015) Silvio E Inzucchi et al.   Diabetes & Vascular Disease Research

Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

(2015) Caroline Bonner et al.   NATURE MEDICINE

Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

(2015) Bernard Zinman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glucagon Couples Hepatic Amino Acid Catabolism to mTOR-Dependent Regulation of α-Cell Mass

(2015) Mark J. Solloway et al.   Cell Reports

Regulation of autophagy and mitophagy by nutrient availability and acetylation

(2014) Bradley R. Webster et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

(2014) Deborah M. Muoio   CELL

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production

(2014) Aurora Merovci et al.   JOURNAL OF CLINICAL INVESTIGATION

Long–echo time MR spectroscopy for skeletal muscle acetylcarnitine detection

(2014) Lucas Lindeboom et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of Nutrient-Sensing Signals in the Pathogenesis of Diabetic Nephropathy

(2014) Shinji Kume et al.   Biomed Research International

Mitochondrial dysfunction and mitophagy: the beginning and end to diabetic nephropathy?

(2013) G C Higgins et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure

(2013) Marc Liesa et al.   Cell Metabolism

Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion

(2013) Jing Zhou et al.   CELL RESEARCH

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

Exaggerated Glucagon-Like Peptide 1 Response Is Important for Improved β-Cell Function and Glucose Tolerance After Roux-en-Y Gastric Bypass in Patients With Type 2 Diabetes

(2013) Nils B. Jørgensen et al.   DIABETES

Dapagliflozin maintains glycaemic control while reducing weight and body fat mass over 2 years in patients with type 2 diabetes mellitus inadequately controlled on metformin

(2013) J. Bolinder et al.   DIABETES OBESITY & METABOLISM

Changes in Insulin Sensitivity and Insulin Secretion with the Sodium Glucose Cotransporter 2 Inhibitor Dapagliflozin

(2013) Sunder Mudaliar et al.   Diabetes Technology & Therapeutics

Mitochondrial Biology and Parkinson's Disease

(2013) C. Perier et al.   Cold Spring Harbor Perspectives in Medicine

Emerging role of autophagy in kidney function, diseases and aging

(2012) Tobias B. Huber et al.   Autophagy

Mitophagy: mechanisms, pathophysiological roles, and analysis

(2012) Wen-Xing Ding et al.   BIOLOGICAL CHEMISTRY

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Muscle-Specific Deletion of Carnitine Acetyltransferase Compromises Glucose Tolerance and Metabolic Flexibility

(2012) Deborah M. Muoio et al.   Cell Metabolism

Effects of Dapagliflozin on Body Weight, Total Fat Mass, and Regional Adipose Tissue Distribution in Patients with Type 2 Diabetes Mellitus with Inadequate Glycemic Control on Metformin

(2012) Jan Bolinder et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of hepatic LDL receptors by mTORC1 and PCSK9 in mice

(2012) Ding Ai et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatocyte senescence predicts progression in non-alcohol-related fatty liver disease

(2012) Aloysious Aravinthan et al.   JOURNAL OF HEPATOLOGY

FOXOphagy path to inducing stress resistance and cell survival

(2012) Marco Sandri   NATURE CELL BIOLOGY

Autophagy, mitochondria and oxidative stress: cross-talk and redox signalling

(2011) Jisun Lee et al.   BIOCHEMICAL JOURNAL

Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats

(2011) N Deblon et al.   BRITISH JOURNAL OF PHARMACOLOGY

Essential amino acids and glutamine regulate induction of mitochondrial elongation during autophagy

(2011) Ligia C. Gomes et al.   CELL CYCLE

The role of dysregulated glucagon secretion in type 2 diabetes

(2011) D. D'Alessio   DIABETES OBESITY & METABOLISM

Reversal of type 2 diabetes: normalisation of beta cell function in association with decreased pancreas and liver triacylglycerol

(2011) E. L. Lim et al.   DIABETOLOGIA

Autophagy as a Therapeutic Target in Diabetic Nephropathy

(2011) Yuki Tanaka et al.   Experimental Diabetes Research

Mitochondrial Fission Contributes to Mitochondrial Dysfunction and Insulin Resistance in Skeletal Muscle

(2011) H.-F. Jheng et al.   MOLECULAR AND CELLULAR BIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Mitochondrial biogenesis and fission in axons in cell culture and animal models of diabetic neuropathy

(2010) Andrea M. Vincent et al.   ACTA NEUROPATHOLOGICA

Mitochondrial Dynamics in Diabetes

(2010) Yisang Yoon et al.   ANTIOXIDANTS & REDOX SIGNALING

The emerging role of autophagy in the pathophysiology of diabetes mellitus

(2010) Claudio D. Gonzalez et al.   Autophagy

Prolonged Fasting Identifies Skeletal Muscle Mitochondrial Dysfunction as Consequence Rather Than Cause of Human Insulin Resistance

(2010) J. Hoeks et al.   DIABETES

Exercise and Type 2 Diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary

(2010) S. R. Colberg et al.   DIABETES CARE

The role of autophagy in β-cell lipotoxicity and type 2 diabetes

(2010) G. Las et al.   DIABETES OBESITY & METABOLISM

Role of autophagy in heart failure associated with aging

(2010) Guido R. Y. De Meyer et al.   HEART FAILURE REVIEWS

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitochondrial Turnover and Aging of Long-Lived Postmitotic Cells: The Mitochondrial–Lysosomal Axis Theory of Aging

(2009) Alexei Terman et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy: Regulation and role in disease

(2009) Alfred J. Meijer et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Diabetes regulates mitochondrial biogenesis and fission in mouse neurons

(2009) J. L. Edwards et al.   DIABETOLOGIA

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Carnitine Insufficiency Caused by Aging and Overnutrition Compromises Mitochondrial Performance and Metabolic Control

(2009) Robert C. Noland et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Autophagy in the Pathogenesis of Disease

(2008) Beth Levine et al.   CELL

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

(2008) Gilad Twig et al.   EMBO JOURNAL

Sirolimus Is Associated with New-Onset Diabetes in Kidney Transplant Recipients

(2008) O. Johnston et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY