Assessment of inter-racial variability in CYP3A4 activity and inducibility among healthy adult males of Caucasian and South Asian ancestries

Evaluation of modafinil as a perpetrator of metabolic drug-drug interactions using a model informed cocktail reaction phenotyping trial protocol

(2018) Angela Rowland et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Physiologically-based pharmacokinetic modeling as an approach to evaluate the effect of covariates and drug-drug interactions on variability in epidermal growth factor receptor kinase inhibitor exposure

(2017) Madelé van Dyk et al.   Translational Cancer Research

Kinase inhibitor pharmacokinetics: comprehensive summary and roadmap for addressing inter-individual variability in exposure

(2016) Andrew Rowland et al.   Expert Opinion on Drug Metabolism & Toxicology

Relationship between mRNA expression levels of CYP3A4, CYP3A5 and SXR in peripheral mononuclear blood cells and aging in young kidney transplant recipients under tacrolimus treatment

(2015) Mariano Ferraresso et al.   PHARMACOGENOMICS

Evaluation of felodipine as a potential perpetrator of pharmacokinetic drug-drug interactions

(2014) Ben D. Snyder et al.   EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

(2013) Ulrich M. Zanger et al.   PHARMACOLOGY & THERAPEUTICS

Cytochrome P450 variations in different ethnic populations

(2012) Joseph McGraw et al.   Expert Opinion on Drug Metabolism & Toxicology

PharmGKB summary

(2011) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

A Framework for Assessing Inter-individual Variability in Pharmacokinetics Using Virtual Human Populations and Integrating General Knowledge of Physical Chemistry, Biology, Anatomy, Physiology and Genetics: A Tale of ‘Bottom-Up’ vs ‘Top-Down’ Recognition of Covariates

(2009) Masoud Jamei et al.   Drug Metabolism and Pharmacokinetics

Pharmacogenomics ofCYP3A: considerations for HIV treatment

(2009) Sukhwinder S Lakhman et al.   PHARMACOGENOMICS