Article
Computer Science, Artificial Intelligence
Aref Miri Rekavandi, Abd-Krim Seghouane, Robin J. Evans
Summary: This paper introduces robust variants of Wald, Rao and LR tests for detecting a signal subspace, which can adjust the trade-off between robustness and power using a single hyperparameter alpha. It is shown that when alpha -> 1, these tests are equivalent to their classical counterparts.
IEEE TRANSACTIONS ON IMAGE PROCESSING
(2021)
Review
Cardiac & Cardiovascular Systems
Danilo Neglia, Natallia Maroz-Vadalazhskaya, Nazario Carrabba, Riccardo Liga
Summary: In recent decades, effective management of cardiovascular risk factors has led to a decrease in coronary artery disease prevalence. However, coronary heart disease remains a leading cause of death globally, and chronic coronary syndromes continue to be targets of cardiac imaging and invasive procedures. Current guidelines recommend non-invasive imaging for CCS patients to identify high-risk individuals for referral to invasive procedures, but recent studies have raised questions about the efficacy of coronary revascularization. The role of imaging in these patients, including those with ischemic cardiomyopathy, remains debated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Okkyun Lee
Summary: This paper introduces likelihood-based bilateral filters as a post-processing method applied to the ML-based estimates of basis sinograms. The proposed filters effectively reduce the noise in the basis images and the synthesized monochromatic CT images.
Article
Medicine, General & Internal
Pontus Thorild, Georgios Mourtzinis
Summary: This retrospective observational study assessed the usefulness of exercise ECG in patients with low pre-test probability (PTP) of significant coronary artery disease and stable chest pain. The study found that exercise ECG had a high negative predictive value and a low positive predictive value in this population.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jingyi Xue, Jianqiang Li, Danghui Sun, Li Sheng, Yongtai Gong, Dingyu Wang, Song Zhang, Yilun Zou, Jing Shi, Wei Xu, Mengnan An, Chenguang Dai, Weimin Li, Linqun Zheng, Asiia Vinograd, Guangzhong Liu, Yihui Kong, Yue Li
Summary: This study aimed to investigate the diagnostic performance of FFRCT-angio with artificial intelligence assistance in patients with stable CAD. The results showed that FFRCT-angio had excellent diagnostic performance in identifying ischemic lesions, with a per-vessel diagnostic accuracy of 92.54%, sensitivity of 100%, and specificity of 88.10%.
JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE
(2022)
Article
Engineering, Electrical & Electronic
Olivier Besson, Francois Vincent, Stefania Matteoli
Summary: This paper explores local detection of a target in hyperspectral imaging using an elliptically contoured background distribution and matrix-variate t distribution for parameter inference. It presents one-step and two-step generalized likelihood ratio tests, showing that the former coincides with the Gaussian assumption and maintains a constant false alarm rate.
Letter
Medicine, General & Internal
Rita Redberg, Diane Jeon
Summary: This article presents the results of a trial conducted ten years ago on coronary computed tomographic angiography, which aimed to evaluate whether this method could shorten emergency department stays more quickly than usual testing. The article also raises a question for discussion regarding the necessity of further diagnostic testing.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, General & Internal
Pal Maurovich-Horvat, Maria Bosserdt, Klaus F. Kofoed, Nina Rieckmann, Theodora Benedek, Patrick Donnelly, Jose Rodriguez-Palomares, Andrejs Erglis, Cyril Stechovsk, Gintare Sakalyte, Nada Cemerlic Adic, Matthias Gutberlet, Jonathan D. Dodd, Ignacio Diez, Gershan Davis, Elke Zimmermann, Cezary Kepka, Radosav Vidakovic, Marco Francone, Malgorzata Ilnicka-Suckiel, Fabian Plank, Juhani Knuuti, Rita Faria, Stephen Schroder, Colin Berry, Luca Saba, Balazs Ruzsics, Christine Kubiak, Inaki Gutierrez-Ibarluzea, Kristian Schultz Hansen, Jacqueline Muller-Nordhorn, Bela Merkely, Andreas D. Knudsen, Imre Benedek, Clare Orr, Filipa Xavier Valente, Ligita Zvaigzne, Vojtech Suchanek, Laura Zajanckauskiene, Flip Adic, Michael Woinke, Mark Hensey, Inigo Lecumberri, Erica Thwaite, Michael Laule, Mariusz Kruk, Aleksandar N. Neskovic, Massimo Mancone, Gudrun Feuchtner, Donata Kugrnierz, Mikko Pietila, Vasco Gama Ribeiro, Tanja Drosch, Christian Delles, Gildo Matta, Michael Fisher, Balint Szilveszter, Linnea Larsen, Mihaela Ratiu, Stephanie Kelly, Bruno Garcia del Blanco, Ainhoa Rubio, Zsofia D. Drobni, Birgit Jurlander, Ioana Rodean, Susan Regan, Hug Cuellar Calabria, Melinda Boussoussou, Thomas Engstrom, Roxana Hodas, Adriane E. Napp, Robert Haase, Sarah Feger, Lina M. Serna-Higuita, Konrad Neumann, Henryk Dreger, Matthias Rief, Viktoria Wieske, Melanie Estrella, Peter Martus, Marc Dewey
Summary: This study compared the effectiveness of CT and ICA in diagnosing obstructive CAD. The results showed that among patients with stable chest pain and intermediate pretest probability of CAD, the risk of major adverse cardiovascular events was similar between the CT group and the ICA group. However, the frequency of major procedure-related complications was lower in the CT group.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Zlatko Mehmedbegovic, Igor Ivanov, Milenko Cankovic, Zoran Perisic, Tomislav Kostic, Bojan Maricic, Gordana Krljanac, Branko Beleslin, Svetlana Apostolovic
Summary: Spontaneous coronary artery dissection (SCAD) is a rare cause of acute coronary syndrome, and recent advancements in cardiac imaging have improved its diagnosis. However, due to the absence of distinct features, SCAD is often misdiagnosed, emphasizing the importance of careful interpretation of angiographic findings and the use of intravascular imaging. Accurate diagnosis of SCAD is crucial because management strategies differ from atherosclerotic coronary disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Engineering, Multidisciplinary
Jingxiaotao Fang, Jiang Yue, Bing Xu, Li-Ta Hsu
Summary: This paper introduces a new metric called ACF similarity to characterize the distortion and abnormality of the auto-correlation function (ACF) in GNSS receivers. The proposed spoofing detection algorithm based on image feature extraction techniques achieves a detection probability of 87% with a 1% false alarm rate, showing better sensitivity than the conventional SQM metrics.
Article
Mathematical & Computational Biology
Feifei Yan, Qing-Song Xu, Man-Lai Tang, Ziqi Chen
Summary: In this article, a profile likelihood ratio test (PLRT) based on the estimated error density for the multiple linear regression model is developed, which outperforms existing likelihood ratio tests in terms of type I error rates, powers, performance in the absence of error moments, and correct model selection in multiple testing problems. The proposed PLRT is illustrated with analysis of mammalian eye gene expression dataset and concrete compressive strength dataset.
STATISTICS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Carlos Cortes, Pablo M. Fernandez-Corredoira, Lili Liu, Ramon Lopez-Palop, Fernando Rivero, Octavio Jimenez, Alfonso Freites, Luis R. Goncalves-Ramirez, Carlos Minguito, Ricardo Concepcion, Ainhoa Perezi, David del Val, Gunnar Leithod, Jonas Oberhuber-Kurth, Ignacio J. Amat-Santos, Jose A. Diarte, J. Alberto San Roman, Maria Rosario Ortas Nadal, Juan Luis Gutierrez-Chico
Summary: This study aimed to confirm the prognostic value of global QFR and evaluate the long-term prognosis of QFR-concordant therapy in stable coronary artery disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Lukas D. D. Weberling, Dirk Lossnitzer, Norbert Frey, Florian Andre
Summary: Coronary artery disease (CAD) is a global burden with increasing prevalence and recommendations for non-invasive imaging prior to invasive procedures. Both coronary computed tomography angiography (cCTA) and stress cardiac magnetic resonance imaging (CMR) are appropriate imaging modalities, offering high diagnostic accuracy and safety profiles. Advances in technology have improved the quality and functional assessment capabilities of both modalities, allowing for better risk stratification. This review compares the strengths and weaknesses of cCTA and CMR in assessing CAD, providing physicians with rationales for selecting the most appropriate modality for individual patients.
Article
Biochemistry & Molecular Biology
Henry W. West, Charalambos Antoniades
Summary: Coronary artery disease remains a leading cause of morbidity and mortality globally, with a focus on understanding inflammatory mechanisms driving residual CAD risk. Advances in noninvasive detection of coronary artery inflammation and targeted therapies for inflammation have become critical issues in the field.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mahmoud Mohamed, Maria Bosserdt, Viktoria Wieske, Benjamin Dubourg, Hatem Alkadhi, Mario J. Garcia, Sebastian Leschka, Elke Zimmermann, Abbas A. Shabestari, Bjarne L. Norgaard, Matthijs F. L. Meijs, Kristian A. Ovrehus, Axel C. P. Diederichsen, Juhani Knuuti, Bjrn A. Halvorsen, Vladymir Mendoza-Rodriguez, Yung-Liang Wan, Nuno Bettencourt, Eugenio Martuscelli, Ronny R. Buechel, Hans Mickley, Kai Sun, Simone Muraglia, Philipp A. Kaufmann, Bernhard A. Herzog, Jean-Claude Tardif, Georg M. Schuetz, Michael Laule, David E. Newby, Stephan Achenbach, Matthew Budoff, Robert Haase, Federico Biavati, Aldo Vasquez Mezquita, Peter Schlattmann, Marc Dewey
Summary: Combining coronary computed tomography angiography (CCTA) with coronary artery calcium (CAC) score can significantly improve the diagnosis of coronary artery disease (CAD). The addition of CAC score is particularly beneficial when CCTA alone is inconclusive.
EUROPEAN RADIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rinchyenkhand Myagmardorj, Kensuke Hirasawa, Gurpreet K. Singh, Frank Van der Kley, Arend De Weger, Juhani Knuuti, Jeroen J. Bax, Nina Ajmone Marsan, Victoria Delgado
Summary: This study investigated the prognostic implications of nonalcoholic fatty liver disease (NAFLD) among patients with severe aortic stenosis (AS) with and without significant tricuspid regurgitation (TR). The results showed that NAFLD was not significantly associated with all-cause death in patients treated with transcatheter aortic valve implantation (TAVI), and the prevalence of significant TR and clinical outcomes were similar between patients with and without NAFLD.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jeff M. Smit, Mohammed El Mahdiui, Michiel A. de Graaf, Jose M. Montero-Cabezas, Johan H. C. Reiber, J. Wouter Jukema, Arthur J. Scholte, Juhani Knuuti, William Wijns, Jagat Narula, Jeroen J. Bax
Summary: The composition of coronary plaque is closely related to the induction of myocardial ischemia. This study investigated the relationship between coronary plaque composition and myocardial ischemia in patients with chest pain symptoms. The results showed that the percentage of noncalcified tissue in plaques was significantly higher in those with abnormal myocardial ischemia. However, after adjusting for plaque load, the association lost significance. These findings contribute to a better understanding of the characteristics of coronary plaque and its relevance to myocardial ischemia.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Birgitte Krogsgaard Andersen, Daixin Ding, Lone Juul Hune Mogensen, Shengxian Tu, Niels Ramsing Holm, Jelmer Westra, William Wijns
Summary: This systematic review and study-level meta-analysis investigated the relationship between post-PCI FFR and the rate of major adverse cardiac events (MACE) including all-cause death, myocardial infarction (MI), and target vessel revascularization (TVR). The results showed no clear continuous association between post-PCI FFR and clinical outcomes, but in studies comparing high vs. low post-PCI FFR, high FFR was associated with better clinical outcomes.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Cardiac & Cardiovascular Systems
Inge J. van den Hoogen, Xu Wang, Steele C. Butcher, Teemu Maaniitty, Jussi Schultz, Alexander R. van Rosendael, Antti Saraste, Juhani Knuuti, Jeroen J. Bax
Summary: This study aimed to compare different models for predicting hemodynamically obstructive coronary artery disease (CAD). The study found that adding coronary artery calcium scoring (CACS) to a model including age, sex, cardiac symptoms, and number of risk factors can improve the accuracy in predicting obstructive CAD with myocardial ischemia on positron emission tomography (PET) in symptomatic patients with suspected CAD.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Antti Saraste, Juhani Knuuti, Jeroen J. Bax
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Reetta Siekkinen, Chunlei Han, Teemu Maaniitty, Mika Teras, Juhani Knuuti, Antti Saraste, Jarmo Teuho
Summary: This study evaluated the performance of BSREM reconstruction technique in quantitation analysis of patients with coronary artery disease. The results showed that BSREM reconstruction method has similar performance to OSEM-TOF-PSF in terms of myocardial blood flow values and diagnosis of ischemia.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Martine Gilard, William Wijns
CIRCULATION-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Thomas H. Schindler, William F. Fearon, Matthieu Pelletier-Galarneau, Giuseppe Ambrosio, Udo Sechtem, Terrence D. Ruddy, Krishna K. Patel, Deepak L. Bhatt, Timothy M. Bateman, Henry Gewirtz, Jamshid Shirani, Juhani Knuuti, Robert J. Gropler, Panithaya Chareonthaitawee, Riemer H. J. A. Slart, Stephan Windecker, Philipp A. Kaufmann, Maria R. Abraham, Viviany R. Taqueti, Thomas J. Ford, Paolo G. Camici, Heinrich R. Schelbert, Vasken Dilsizian
Summary: Diagnosing angina pectoris and dyspnea in patients with normal or nonobstructive coronary vessels is challenging. Invasive coronary angiography can identify nonobstructive coronary artery disease, but coronary microvascular dysfunction may actually be the cause of symptoms. Positron emission tomography (PET) allows noninvasive detection and delineation of coronary microvascular dysfunction by quantifying myocardial blood flow at rest and during vasodilation. Individualized or intensified medical therapies may improve symptoms, quality of life, and outcomes. Standardized diagnosis and reporting criteria for ischemic symptoms caused by coronary microvascular dysfunction are crucial for treatment decisions. A consensus document proposes standardized diagnosis, nomenclature, and reporting criteria for coronary microvascular dysfunction. It aims to provide an overview of its pathophysiology, assessment, and classification, which are essential for diagnosis, patient care, and clinical trials. (J Am Coll Cardiol Img 2023;16:536-548) (c) 2023 by the American College of Cardiology Foundation.
JACC-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Iida Kujala, Wail Nammas, Teemu Maaniitty, Iida Stenstrom, Riku Klen, Jeroen J. Bax, Juhani Knuuti, Antti Saraste
Summary: The study evaluated sex differences in disease profile and outcomes after combined computed tomography angiography (CTA) and positron emission tomography (PET) perfusion imaging in female patients with suspected obstructive coronary artery disease (CAD). The results showed that women had a higher proportion of normal coronary arteries and a lower proportion of abnormal stress myocardial blood flow. The annual adverse event rate was also lower in women. Both in women and men, coronary calcification, non-obstructive CAD, and abnormal stress myocardial blood flow were independent predictors of adverse events. The study concluded that combined coronary CTA and PET myocardial perfusion imaging can equally predict outcomes in women and men.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Review
Cardiac & Cardiovascular Systems
Antti Saraste, Juhani Knuuti, Frank Bengel
Summary: Nuclear imaging techniques play a significant role in detecting and quantifying pathophysiological processes in heart failure, providing complementary evaluation of cardiac structure and function. It enables the identification of left ventricle dysfunction caused by reversible myocardial ischemia in the presence of viable myocardium. Moreover, nuclear imaging allows assessment of various cellular and subcellular mechanisms of heart failure. It also has value in evaluating cardiac sarcoidosis and amyloidosis, predicting heart failure progression, arrhythmias, and characterizing the response to myocardial injury.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Surenjav Chimed, Jan Stassen, Xavier Galloo, Maria Chiara Meucci, Juhani Knuuti, Victoria Delgado, Pieter van der Bijl, Nina Ajmone Marsan, Jeroen J. Bax
Summary: This study investigated the prognostic significance of left ventricular global longitudinal strain (GLS) in patients with HFrEF. It found that patients with GLS ≤10% had a higher incidence of worsening HF compared to those with GLS >10%. After adjusting for various factors, baseline GLS remained independently associated with a higher risk of worsening HF and all-cause mortality in HFrEF patients.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sophie E. van Rosendael, Alexander R. van Rosendael, Jurrien H. Kuneman, Manesh R. Patel, Bjarne Linde Norgaard, Timothy A. Fairbairn, Koen Nieman, Takashi Akasaka, Daniel S. Berman, Lynne M. Hurwitz Koweek, Gianluca Pontone, Tomohiro Kawasaki, Niels Peter Ronnow Sand, Jesper M. Jensen, Tetsuya Amano, Michael Poon, Kristian A. Ovrehus, Jeroen Sonck, Mark G. Rabbat, Campbell Rogers, Hitoshi Matsuo, Jonathon A. Leipsic, Ajmone Marsan, J. Wouter Jukema, Jeroen J. Bax, Antti Saraste, Juhani Knuuti
Summary: The V/M ratio assessed by CCTA is a new parameter to investigate the relation of coronary vasculature to the myocardium supplied. Hypertension decreases this ratio by way of myocardial hypertrophy, which could explain the detected abnormal myocardial perfusion reserve in patients with hypertension.
AMERICAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Simone Fezzi, Daixin Ding, Roberto Scarsini, Jiayue Huang, Paolo Alberto Del Sole, Qiang Zhao, Gabriele Pesarini, Andrew Simpkin, William Wijns, Flavio Ribichini, Shengxian Tu
Summary: This study demonstrated that angiography-derived physiology can provide a reliable assessment of coronary circulation in patients with severe aortic stenosis, showing good accuracy in predicting FFR and stable evaluation results.
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Haitham Ballo, Fatma Doghman, Juha Hartikainen, Antti Saraste, Juhani Knuuti
Summary: This meta-analysis evaluated the diagnostic accuracy of 2DSTE strain in detecting myocardial viability at rest and during low-dose dobutamine stress. The results showed that LS and CS during LDD stress accurately identify reversible ischemic myocardial dysfunction in patients with chronic ischemic LV dysfunction or after MI. LS and CS had lower sensitivity and specificity at rest compared to LDD stress.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Jussi Schultz, Inge J. van den Hoogen, Jurrien H. Kuneman, Michiel A. de Graaf, Vasileios Kamperidis, Alexander Broersen, J. Wouter Jukema, Antonis Sakellarios, Sotirios Nikopoulos, Konstantina Tsarapatsani, Katerina Naka, Lampros Michalis, Dimitrios Fotiadis, Teemu Maaniitty, Antti Saraste, Jeroen J. Bax, Juhani Knuuti
Summary: This study evaluated CCTA-based ESS values in coronary arteries without atherosclerosis and identified factors affecting ESS values. The findings showed that ESS was highest in the left anterior descending artery and lower in men compared to women, even after adjusting for lumen diameter. ESS values were also highest in small segments and had a correlation with the distance from the ostium.
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2023)