Review
Biology
Aro Daniela Arockiam, Ankit Agrawal, Joseph El Dahdah, Bianca Honnekeri, Tahir S. Kafil, Saleem Halablab, Brian P. Griffin, Tom Kai Ming Wang
Summary: Infective endocarditis (IE) is a diverse disease with high morbidity and mortality rates. It can affect native valves, prosthetic valves, and intra-cardiac devices, causing systemic complications. Early diagnosis and risk stratification of IE rely on a combination of clinical, laboratory, and cardiac imaging evaluation. Various imaging modalities, including transthoracic echocardiography and advanced techniques such as cardiac computed tomography and F-18-fluorodeoxyglucose positron emission tomography, play important roles in providing essential diagnostic and prognostic information for IE.
Article
Cardiac & Cardiovascular Systems
Albert Roque, Maria N. Pizzi, Nuria Fernandez-Hidalgo, Guillermo Romero-Farina, Gemma Burcet, Jose Luis Reyes-Juarez, Carina Espinet, Joan Castell-Conesa, Manuel Escobar, Ignacio Ferreira-Gonzalez, Santiago Aguade-Bruix, Hug Cuellar-Calabria
Summary: This study validated a new parameter, the valve uptake index (VUI), for the diagnosis of prosthetic valve endocarditis (PVE). VUI showed good diagnostic accuracy for PVE and increased the diagnostic ability of traditional morphometabolic parameters. Further research is needed to assess the potential value of integrating VUI into the PVE diagnostic algorithm.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Vasken Dilsizian, Ricardo P. J. Budde, Wengen Chen, Sunil Mankad, Jonathan R. Lindner, Koen Nieman
Summary: The diagnosis and localization of cardiac device infection remain clinically challenging. Recent studies suggest that cardiac computed tomography (CT) or CT angiography and functional imaging with F-18-fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) with CT (FDG PET/CT) may have a role in inconclusive cases on echocardiography. This document provides consensus on best practices in imaging studies, including the detection of infection, differentiation from inflammation, image-guided patient management, and detailed recommendations on patient preparation, image acquisition, processing, interpretation, and standardized reporting.
JACC-CARDIOVASCULAR IMAGING
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Saberio Lo Presti, Shinya Unai, Reza Reyaldeen, Wael Jaber, Vidyasagar Kalahasti, Bo Xu
Summary: Additional digital content is available within the text.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Anna Reid, Marc Richard Dweck
Summary: Imaging is crucial in modern cardiovascular practice, with the UK playing a key international role in this field and being home to many leading global centers in multimodality cardiovascular imaging.
Article
Oncology
Steven P. Rowe, Martin G. Pomper
Summary: Molecular imaging, defined as visualizing, characterizing, and measuring biological processes at the molecular and cellular levels, has rapidly developed in recent years, with a particular focus on oncology for early detection and optimal disease management. The expansion of molecular imaging is driven by new animal models, sensitive imaging devices, high-throughput methods, genetic manipulation techniques, and cloud computing. Researchers and clinicians are utilizing molecular imaging for a variety of physiological processes, with a focus on oncology for its potential in detecting diseases at an early stage.
CA-A CANCER JOURNAL FOR CLINICIANS
(2022)
Review
Medicine, General & Internal
Frank A. Flachskampf, Tomasz Baron
Summary: Heart failure is a central issue in cardiology, with cardiac imaging playing a crucial role in its identification and monitoring. While echocardiography is the first diagnostic step, other imaging techniques are often needed for further clarification of the underlying diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Agostina M. Fava, Bo Xu
Summary: Right-sided infective endocarditis, mainly caused by Staphylococcus aureus, is a disease entity that is increasingly recognized. The diagnosis relies on clinical manifestations, blood cultures, and the detection of valvular vegetations by echocardiography. Multislice computed tomography is helpful for evaluating extra-cardiac complications.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Review
Chemistry, Multidisciplinary
Ya-Qiong Yan, Hao Wang, Yuliang Zhao
Summary: Radionuclide imaging is a premier imaging method in clinical practice, utilizing PET and SPECT to detect anatomical abnormalities. Peptides as targeting vectors for contrast agents offer high specificity and low toxicity. Radiolabeled peptide probes have become essential tools for clinical radionuclide diagnosis.
CHINESE CHEMICAL LETTERS
(2022)
Review
Engineering, Biomedical
Abhijit J. Chaudhari, Ramsey D. Badawi
Summary: Nuclear medical imaging devices are typically optimized for whole-body imaging, but application-specific devices with superior technical characteristics have shown promise for organ imaging in niche applications. Efforts are needed to overcome design limitations and gather data to define the clinical value of these devices.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ivan Ho Shon, Thomas Hennessy, Jennifer Guille, Michael P. Gotsbacher, Angelina J. Lay, Bruce McBride, Rachel Codd, Philip J. Hogg
Summary: This study evaluates the biodistribution, radiation dosimetry, safety, and tumor uptake of the novel radiopharmaceutical GA-68 ([GA-68] GA-CDI) for imaging multiple forms of cell death. The results demonstrate that GA-68 ([GA-68] GA-CDI) is safe, has low radiation dosimetry, and excellent biodistribution and imaging characteristics. It shows potential advantages over previous radiopharmaceuticals for imaging cell death and has progressed to a proof-of-concept trial.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Jordan Eber, Cyrille Blondet, Clara Le Fevre, Isabelle Chambrelant, Fabrice Hubele, Olivier Morel, Delphine Antoni, Georges Noel
Summary: Radiotherapy can unintentionally expose the heart to radiation, leading to cardiac damage. Early detection and monitoring of radiation-induced heart disease are crucial, and nuclear medicine imaging techniques show promise in detecting subclinical effects.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Wenpeng Huang, Yongbai Zhang, Qi Yang, Ge Gao, Yongkang Qiu, Liming Li, Lei Kang
Summary: This study investigated the clinicopathological manifestations and imaging features of primary pulmonary NUT carcinoma. The results showed that most patients presented with heterogeneous lobulated masses in the upper lobe of the left lung. PET/CT imaging revealed increased F-18-FDG uptake in the lesion and metastatic areas. The study suggests considering NUT cancer in patients with central lung masses, rapid disease progression, and poor response to initial treatment.
FRONTIERS IN MEDICINE
(2023)
Review
Health Care Sciences & Services
Igino Simonetti, Piero Trovato, Vincenza Granata, Carmine Picone, Roberta Fusco, Sergio Venanzio Setola, Mauro Mattace Raso, Corrado Caraco, Paolo A. Ascierto, Fabio Sandomenico, Antonella Petrillo
Summary: Interval metastasis is a specific type of lymph node metastasis in patients with melanoma. Imaging techniques such as ultrasound, CT, MRI, lymphoscintigraphy, and PET are used for evaluation. Understanding these methods and collaborating with clinicians are essential for treatment and survival.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Krystyna Pyrzynska, Krzysztof Kilian, Mateusz Pegier
Summary: This paper provides a brief overview of the application of porphyrin ligands in tumor diagnostics, including the chelation of metallic radioisotopes to form radiopharmaceuticals and the evaluation of metabolic changes in the human body through SPECT and PET. The chelation reactions are discussed in terms of the conditions, kinetics, and complex stability.
Article
Cardiac & Cardiovascular Systems
Stefan Roest, Marijke H. van der Meulen, Lennie M. Van Osch-Gevers, Ulrike S. Kraemer, Alina A. Constantinescu, Matthijs de Hoog, Ad J. J. C. Bogers, Olivier C. Manintveld, Pieter C. van de Woestijne, Michiel Dalinghaus
Summary: The study examined the outcomes of pediatric heart transplantations in the Netherlands since 1998. The results showed that children who undergo heart transplant have high survival rates up to 10 years post-transplantation, and most patients have excellent functional status despite common complications. However, waiting list mortality remains high, highlighting the limited availability of donors for this vulnerable patient group.
NETHERLANDS HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Wouter Bakhuis, Amir H. Sadeghi, Iris Moes, Alexander P. W. M. Maat, Sabrina Siregar, Ad J. J. C. Bogers, Edris A. F. Mahtab
Summary: This study aimed to investigate the clinical value of using the 3D VR technology, PulmoVR, for preoperative planning. The results showed that VR provided better insight into patient-specific anatomy and offered lung-sparing possibilities, with a 52% change in surgical plans and a 98% rate of radical resection.
ANNALS OF THORACIC SURGERY
(2023)
Article
Computer Science, Interdisciplinary Applications
Annejet Heida, Willemijn F. B. van der Does, Mathijs S. van Schie, Lianne N. van Staveren, Yannick J. H. J. Taverne, Ad J. J. C. Bogers, Natasja M. S. de Groot
Summary: This study compared conduction heterogeneity between the supervulnerable period after electrical cardioversion and long-term sinus rhythm in patients with atrial fibrillation (AF). The findings suggest that there might be no difference in biatrial conduction characteristics between these two periods.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2023)
Article
Engineering, Biomedical
Cornelis W. van der Heiden, Casper F. Zijderhand, Kevin M. Veen, Alina A. Constantinescu, Olivier C. Manintveld, Jasper J. Brugts, Jos A. Bekkers, Ozcan Birim, Ad J. J. C. Bogers, Kadir Caliskan
Summary: We investigated the incidence of mechanical device malfunction in LVADs and found that it occurred significantly less in HeartMate 3 patients compared to HeartMate II patients.
Article
Public, Environmental & Occupational Health
M. J. Sarink, W. A. van Cappellen, A. G. M. Tielens, A. van Dijk, A. J. J. C. Bogers, J. E. M. de Steenwinkel, M. C. Vos, J. A. Severin, J. J. van Hellemond
Summary: The presence of V. vermiformis in water-based heater-cooler units can contribute to the persistent presence of M. chimaera. Cleaning and disinfection protocols should take this phenomenon into account.
JOURNAL OF HOSPITAL INFECTION
(2023)
Article
Cardiac & Cardiovascular Systems
Maurits S. H. Blomjous, Ties A. Mulders, Ali R. Wahadat, Wilco Tanis, Ad J. J. C. Bogers, Jolien W. Roos-Hesselink, Ricardo P. J. Budde
Summary: This study evaluated the normal imaging findings in non-infected patients after sternotomy using F-18-FDG-PET/CT, and found that sternal F-18-FDG uptake decreased significantly from 5 weeks to 55 weeks post-surgery, although elevated uptake patterns may persist.
JOURNAL OF NUCLEAR CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jorik H. Amesz, Sanne J. J. Langmuur, Nina Epskamp, Ad J. J. C. Bogers, Natasja M. S. de Groot, Olivier C. Manintveld, Yannick J. H. J. Taverne
Summary: This study evaluated the direct biomechanical effects of SGLT2 inhibitor empagliflozin on myocardium from end-stage heart failure patients. The results demonstrate that empagliflozin improves contraction and relaxation kinetics without diminishing maximum force production.
CARDIOVASCULAR DRUGS AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
C. Pelosi, R. M. Kauling, J. A. A. E. Cuypers, E. M. W. J. Utens, A. E. van den Bosch, I. Kardys, A. J. J. C. Bogers, W. A. Helbing, J. W. Roos-Hesselink, Jeroen S. Legerstee
Summary: Nowadays, the long-term impact on executive functioning in adults with congenital heart disease (CHD) operated in childhood is not completely understood.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Multidisciplinary Sciences
Jorik H. Amesz, Natasja M. S. de Groot, Sanne J. J. Langmuur, Hamid el Azzouzi, Vera P. C. Tiggeloven, Manuela M. M. M. van Rooij, P. Knops, Ad J. J. C. Bogers, Yannick J. H. J. Taverne
Summary: We introduced a novel method to produce living myocardial slices (LMS) from human atria, which can maintain the 3D microarchitecture and multicellularity of intact human myocardium. These LMS can overcome the limitations of conventional myocardial cell cultures and bridge the gap between in-vitro and in-vivo atrial arrhythmia studies. This state-of-the-art platform can be used to investigate arrhythmia mechanisms and test novel therapies.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Kevin M. Veen, Grigorios Papageorgiou, Casper F. Zijderhand, Mostafa M. Mokhles, Jasper J. Brugts, Olivier C. Manintveld, Alina A. Constantinescu, Jos A. Bekkers, Johanna J. M. Takkenberg, Ad J. J. C. Bogers, Kadir Caliskan
Summary: This study aims to investigate the clinical impact and long-term course of tricuspid regurgitation (TR) after biatrial orthotopic heart transplant (OHT). The results show that TR decreases gradually over time after surgery and is influenced by pre-implant mechanical support. TR is associated with higher mortality and worse renal function. Therefore, surgical intervention for TR may not be necessary during the early phase after OHT.
FRONTIERS OF MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Wouter Bakhuis, Lea Betser, Amir H. Sadeghi, Dominique Gossot, Denis Susa, Alexander P. W. M. Maat, Sabrina Siregar, Ad J. J. C. Bogers, Agathe Seguin-Givelet, Edris A. F. Mahtab
Article
Cardiac & Cardiovascular Systems
Maximiliaan L. Notenboom, Art Schuermans, Jonathan R. G. Etnel, Kevin M. Veen, Pieter C. van de Woestijne, Filip R. Rega, Willem A. Helbing, Ad J. J. C. Bogers, Johanna J. M. Takkenberg
Summary: This study aims to provide decision-making support for children undergoing aortic valve replacement (AVR) by reviewing published outcomes and estimating age-specific outcomes with different valve substitutes. The results show suboptimal outcomes in pediatric AVR, especially in young patients, with high mortality and reintervention risks.
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Sofie Rohde, Theo M. M. H. de By, Ad J. J. C. Bogers, Martin Schweiger
Summary: This systematic review aims to summarize the clinical course in paediatric patients after weaning from a ventricular assist device (VAD). The study found that the incidence rate of myocardial recovery during VAD support was 8.7%, and long-term recovery is achievable. More research is needed to understand this favorable outcome after VAD support.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Jette J. Peek, Wouter Bakhuis, Amir H. Sadeghi, Kevin M. Veen, Arno A. W. Roest, Nico Bruining, Theo van Walsum, Mark G. Hazekamp, Ad J. J. C. Bogers
Summary: This study examines the added value of 3D printing and 3D virtual reality models for surgical planning in complex double outlet right ventricle (DORV) patients. The results show that both methods provide better visualization of spatial relationships compared to 2D imaging, leading to more accurate surgical planning.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Rohit K. Kharbanda, Nawin L. Ramdat Misier, Mathijs S. van Schie, Roxanne D. Zwijnenburg, Jorik H. Amesz, Paul Knops, Ad J. J. C. Bogers, Yannick J. H. J. Taverne, Natasja M. S. de Groot
Summary: Low-level vagus nerve stimulation through the tragus (tLLVNS) is a therapeutic strategy for atrial fibrillation. This study showed that tLLVNS led to significant increase in unipolar potential voltage and observed changes in other electrophysiological properties in some patients.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
