Mitochondrial DNA replication in mammalian cells: overview of the pathway

Topoisomerase 3α Is Required for Decatenation and Segregation of Human mtDNA

(2018) Thomas J. Nicholls et al.   MOLECULAR CELL

DNA polymerases in the mitochondria A critical review of the evidence

(2017) William C Copeland   Frontiers in Bioscience-Landmark

DNA Polymerase Beta Participates in Mitochondrial DNA Repair

(2017) P. Sykora et al.   MOLECULAR AND CELLULAR BIOLOGY

Maintenance and Expression of Mammalian Mitochondrial DNA

(2016) Claes M. Gustafsson et al.   Annual Review of Biochemistry

Mitochondrial DNA repair and replication proteins revealed by targeted chemical probes

(2016) Simon Wisnovsky et al.   Nature Chemical Biology

ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

(2016) Walt F. Lima et al.   NUCLEIC ACIDS RESEARCH

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

(2016) Gokhan Akman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER-mitochondria contacts couple mtDNA synthesis with mitochondrial division in human cells

(2016) Samantha C. Lewis et al.   SCIENCE

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA

(2016) I. Ku hl et al.   Science Advances

TEFM is a potent stimulator of mitochondrial transcription elongation in vitro

(2015) Viktor Posse et al.   NUCLEIC ACIDS RESEARCH

Regulation of DNA replication at the end of the mitochondrial D-loop involves the helicase TWINKLE and a conserved sequence element

(2015) Elisabeth Jemt et al.   NUCLEIC ACIDS RESEARCH

Human REV3 DNA Polymerase Zeta Localizes to Mitochondria and Protects the Mitochondrial Genome

(2015) Bhupendra Singh et al.   PLoS One

Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid

(2015) Christian Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication

(2015) J. Bradley Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Replication-transcription switch in human mitochondria

(2015) K. Agaronyan et al.   SCIENCE

The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication

(2015) Bertil Macao et al.   Nature Communications

Overexpression of TFAM or Twinkle Increases mtDNA Copy Number and Facilitates Cardioprotection Associated with Limited Mitochondrial Oxidative Stress

(2015) Masataka Ikeda et al.   PLoS One

Unique features of DNA replication in mitochondria: A functional and evolutionary perspective

(2014) Ian J. Holt et al.   BIOESSAYS

Linear mtDNA fragments and unusual mtDNA rearrangements associated with pathological deficiency of MGME1 exonuclease

(2014) Thomas J. Nicholls et al.   HUMAN MOLECULAR GENETICS

Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases II  and II  in vertebrate mitochondria

(2014) H. Zhang et al.   NUCLEIC ACIDS RESEARCH

Holliday junction processing enzymes as guardians of genome stability

(2014) Shriparna Sarbajna et al.   TRENDS IN BIOCHEMICAL SCIENCES

In Vitro-Reconstituted Nucleoids Can Block Mitochondrial DNA Replication and Transcription

(2014) Géraldine Farge et al.   Cell Reports

In Vivo Occupancy of Mitochondrial Single-Stranded DNA Binding Protein Supports the Strand Displacement Mode of DNA Replication

(2014) Javier Miralles Fusté et al.   PLoS Genetics

TWINKLE is an essential mitochondrial helicase required for synthesis of nascent D-loop strands and complete mtDNA replication

(2013) D. Milenkovic et al.   HUMAN MOLECULAR GENETICS

Exonuclease of human DNA polymerase gamma disengages its strand displacement function

(2013) Quan He et al.   MITOCHONDRION

PrimPol, an Archaic Primase/Polymerase Operating in Human Cells

(2013) Sara García-Gómez et al.   MOLECULAR CELL

Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease

(2013) Cornelia Kornblum et al.   NATURE GENETICS

Mitochondrial DNA replication proceeds via a ‘bootlace’ mechanism involving the incorporation of processed transcripts

(2013) Aurelio Reyes et al.   NUCLEIC ACIDS RESEARCH

mtDNA makes a U-turn for the mitochondrial nucleoid

(2013) Christian Kukat et al.   TRENDS IN CELL BIOLOGY

In vivo mutagenesis reveals that OriL is essential for mitochondrial DNA replication

(2012) Sjoerd Wanrooij et al.   EMBO REPORTS

Polg2 is essential for mammalian embryogenesis and is required for mtDNA maintenance

(2012) Margaret M. Humble et al.   HUMAN MOLECULAR GENETICS

A hybrid G-quadruplex structure formed between RNA and DNA explains the extraordinary stability of the mitochondrial R-loop

(2012) P. H. Wanrooij et al.   NUCLEIC ACIDS RESEARCH

Mitochondrial Topoisomerase I is Critical for Mitochondrial Integrity and Cellular Energy Metabolism

(2012) Céline Douarre et al.   PLoS One

Mammalian transcription factor A is a core component of the mitochondrial transcription machinery

(2012) Y. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A

(2012) Géraldine Farge et al.   Nature Communications

Mitochondrial DNA nucleoid structure

(2011) Daniel F. Bogenhagen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Superresolution Fluorescence Imaging of Mitochondrial Nucleoids Reveals Their Spatial Range, Limits, and Membrane Interaction

(2011) T. A. Brown et al.   MOLECULAR AND CELLULAR BIOLOGY

Human mitochondrial transcription factor A induces a U-turn structure in the light strand promoter

(2011) Anna Rubio-Cosials et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The mitochondrial transcription and packaging factor Tfam imposes a U-turn on mitochondrial DNA

(2011) Huu B Ngo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TEFM (c17orf42) is necessary for transcription of human mtDNA

(2011) Michal Minczuk et al.   NUCLEIC ACIDS RESEARCH

Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA

(2011) C. Kukat et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High mitochondrial DNA copy number has detrimental effects in mice

(2010) Emil Ylikallio et al.   HUMAN MOLECULAR GENETICS

Mitochondrial RNA Polymerase Is Needed for Activation of the Origin of Light-Strand DNA Replication

(2010) Javier Miralles Fusté et al.   MOLECULAR CELL

G-quadruplex structures in RNA stimulate mitochondrial transcription termination and primer formation

(2010) P. H. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure–Function Defects of the TWINKLE Linker Region in Progressive External Ophthalmoplegia

(2008) Jenny A. Korhonen et al.   JOURNAL OF MOLECULAR BIOLOGY

Evidence for Variable Selective Pressures at a Large Secondary Structure of the Human Mitochondrial DNA Control Region

(2008) F. Pereira et al.   MOLECULAR BIOLOGY AND EVOLUTION

Human mitochondrial RNA polymerase primes lagging-strand DNA synthesis in vitro

(2008) S. Wanrooij et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA