Article
Environmental Sciences
Etimad Huwait, Seham M. Awaji, Taha A. Kumosani, Elie K. Barbour, Khalid O. Abulnaja, Said S. Moselhy
Summary: The study found that the ethanol extract of Ruthana date has cytotoxic effects on human hepatocellular carcinoma cells, which is achieved through DNA fragmentation and activation of the proapoptotic BAX gene.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Jiajie Tan, Yuling Xiang, Yuanguo Xiong, Yaoyuan Zhang, Boyang Qiao, Hong Zhang
Summary: In this study, crebanine, a bioactive compound derived from Stephania, was found to effectively inhibit the growth and migration capacity of hepatocellular carcinoma cells. It induces apoptosis through increasing reactive oxygen species levels and disrupting mitochondrial membrane potential. Additionally, crebanine affects the biological function of hepatocellular carcinoma cells through the ROS-AKT-FoxO3a signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dahae Lee, Jae Sik Yu, Ji Won Ha, Seoung Rak Lee, Bum Soo Lee, Jin-Chul Kim, Jung Kyu Kim, Ki Sung Kang, Ki Hyun Kim
Summary: This study investigated the cytotoxicity of Withania somnifera against human hepatocellular carcinoma (HCC) cells and identified potential antitumoral withanolide glycosides. The study also elucidated the molecular mechanisms of these bioactive compounds and found that they induced apoptosis and inhibited angiogenesis in HCC cells.
Article
Chemistry, Medicinal
Nari Shin, Hyo-Jung Lee, Deok Yong Sim, Eunji Im, Ji Eon Park, Woon Yi Park, Ah Reum Cho, Bum Sang Shim, Sung-Hoon Kim
Summary: This study investigated the mechanism of action of Compound K, an active ginseng saponin metabolite, in human hepatocellular carcinoma cells, revealing that it induces apoptosis through inhibition of glycolysis and AKT/mTOR/c-Myc signaling. These findings suggest that Compound K could be a promising candidate for liver cancer therapy.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jing-Yan Gao, Chih-Shiang Chang, Jin-Cherng Lien, Ting-Wei Chen, Jing-Lan Hu, Jing-Ru Weng
Summary: Trytanthrin, a natural compound found in Ban-Lan-Gen, has anti-inflammatory and anti-viral properties. Two derivatives, A1 and A6, showed higher cytotoxicity in HCC cells and targeted multiple aspects of cancer cell growth, making them potential candidates for clinical applications.
Article
Biochemistry & Molecular Biology
Xiao-Qi Yu, Qiu-Lin Yan, Shuai Shen, Zhuo-Yang Cheng, Xiao-Xiao Huang, Guo-Dong Yao, Shao-Jiang Song
Summary: The study found that the biflavone CE from Stellera chamaejasme root exhibited strong inhibitory effects against HCC Hep3B cells. This inhibition may be achieved by targeting c Met. CE also suppressed cell proliferation, colony formation, and migration ability of HCC cells, and showed efficacy without toxicity in a tumor xenograft model.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Chao-Jie Wang, Xinxin Guo, Rui-Qin Zhai, Changning Sun, Guokai Xiao, Jin Chen, Mei-Yan Wei, Chang-Lun Shao, Yuchao Gu
Summary: The study successfully synthesized a derivative with cytotoxic activity in HCC patients by synthesizing the 2-benzoylquinazolin-4(3H)-one skeleton and demonstrated its potential as a chemotherapy agent.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Hui Liu, Junya Li, Wenwen Yuan, Shengyu Hao, Meng Wang, Fei Wang, Hongzhuan Xuan
Summary: The study found that the bioactive components in poplar propolis extract CP were mainly flavonoids and esters. CP induced HepG2 apoptosis through a mitochondrial-dependent intrinsic pathway, as well as through the regulation of various signaling pathways and molecules to achieve anti-proliferation and pro-apoptosis effects.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Ping Song, Huiqi Huang, Yuanren Ma, Chaoqun Wu, Xinzhou Yang, Ho-Young Choi
Summary: The study found that davidone C inhibited the proliferation of hepatocellular carcinoma cells and induced apoptosis through multiple pathways, possibly involving the mitochondrial apoptotic pathway, ERS pathway, and autophagy signal pathway.
Article
Chemistry, Multidisciplinary
Han Ki Lee, Subin Bae, Jongsung Lee, Hyo Sun Cha, Myeong Jin Nam, Jongbok Lee, Kyungmoon Park, Yung-Hun Yang, Kyu Yun Jang, Kwang-Hyeon Liu, See-Hyoung Park
Summary: The aim of this study was to investigate the apoptotic effects and anticancer mechanism of the biflavonoid bilobetin against human hepatocellular carcinoma (HCC) cells. The results showed that bilobetin inhibited cell proliferation, induced apoptosis and DNA fragmentation, elevated ROS levels, and caused DNA damage in HCC cells. It also regulated the expression of apoptotic signaling pathway proteins.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ahmed Attia Ahmed Abdelmoaty, Ping Zhang, Wen Lin, Ying-juan Fan, Sheng-nan Ye, Jian-hua Xu
Summary: Heat shock protein 90 (Hsp90) is a common molecular chaperone that plays an important role in the maturation of oncogenic proteins. Curcumin and its derivative compound C0818 are potential inhibitors of Hsp90 and have shown anti-tumor effects in hepatocellular carcinoma (HCC) cells by inducing apoptosis and inhibiting proliferation. C0818 treatment leads to the degradation of Hsp90 client proteins and affects multiple signaling pathways involved in tumor growth, making it a promising novel Hsp90 inhibitor for HCC therapy.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Medicine, Research & Experimental
Ritesh Urade, Wen-Tsan Chang, Ching-Chung Ko, Ruei-Nian Li, Hui-Min Yang, Hsuan-Yu Chen, Lin-Ya Huang, Meng-Yang Chang, Chang-Yi Wu, Chien-Chih Chiu
Summary: In this study, a novel fluorene derivative, 9-methanesulfonylmethylene-2, 3-dimethoxy-9 H-fluorene (MSDF), was found to have anticancer potential in human hepatocellular carcinoma (HCC) cells. MSDF induced apoptosis through both receptor-mediated extrinsic and mitochondrial-mediated intrinsic pathways. It also caused anoikis and cell death by disrupting cell-ECM contact. MSDF suppressed the MAPK/ERK and PI3K/Akt signaling pathways and downregulated the expression of immune checkpoint proteins.
Article
Chemistry, Medicinal
Jingjing Wang, Qi Su, Qing Wu, Kun Chen, Asmat Ullah, Mohsin Ahmad Ghauri, Yanmin Zhang
Summary: This study investigated the antitumor effects of sanguinarine (Sang) on hepatocellular carcinoma (HCC) and found that Sang impairs lysosomal function, induces ROS-dependent mitophagy and apoptosis in HCC cells. The findings suggest that Sang could be a potential therapeutic option for treating HCC by targeting these mechanisms.
ARCHIVES OF PHARMACAL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Ling Qiao, Siyuan Qin, Ningna Weng, Bowen Li, Maochao Luo, Zhe Zhang, Li Zhou, Dong Wang, Canhua Huang
Summary: Toceranib phosphate exhibits potent antitumor activity against human hepatocellular carcinoma (HCC) by stimulating apoptosis and inducing autophagy. The protective role of TOC-induced autophagy in HCC cell death is associated with the inactivation of the Akt/mTOR pathway. Additionally, the combination therapy of sorafenib and TOC shows pronounced synergistic effects on HCC cells.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Anhui Yang, Ping Zhang, Zhen Sun, Xin Liu, Xinrui Zhang, Xingkai Liu, Di Wang, Zhaoli Meng
Summary: The study demonstrated that lysionotin exhibited significant anti-liver cancer effects by potentially involving the caspase-3 mediated mitochondrial apoptosis pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Chen-Yi Liao, Ting-Chien Wu, Shun-Fa Yang, Jinghua Tsai Chang
Summary: N-acetylcysteine (NAC) can act as both an antioxidant and a pro-oxidant. The effect of NAC on cell proliferation varies depending on the antioxidant activity of the cells. The sensitivity of cells to NAC is determined by their intracellular ROS levels.
Article
Ophthalmology
Chia-Chen Lin, Chia-Yi Lee, Jing-Yang Huang, Sheng-Min Hsu, Jia-Horung Hung, Shun-Fa Yang
Summary: This study provides an in-depth analysis of the trends in DR, DME, and related comorbidities in patients with T2DM. It shows that the prevalence and incidence of DR and PDR decreased over time, while the prevalence and incidence of DME increased. Additionally, the percentage of patients with hyperlipidaemia increased in all forms of DR, while the percentage of patients with ESRD increased only in DME.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Environmental Sciences
Chung-Yuan Lee, Yung-Chuan Ho, Chiao-Wen Lin, Min-Chieh Hsin, Po-Hui Wang, Ya-Cheng Tang, Shun-Fa Yang, Yi-Hsuan Hsiao
Summary: The synthetic curcumin analog, EF-24, has been shown to have enhanced bioavailability and stronger anti-inflammatory and anti-cancer activity compared to curcumin. This study investigated the effects of EF-24 on TPA-induced cellular migration of cervical cancer and found that EF-24 significantly reduced cellular migration and invasion. Further analysis revealed that EF-24 modulated MMP-9 expression by inhibiting the phosphorylation of the p38 signaling pathway. These findings suggest that EF-24 may have potential as a chemopreventive agent for cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Ophthalmology
Hsiang-Wen Chien, Chia-Yi Lee, Jing-Yang Huang, Hung-Chi Chen, Kai Wang, Shun-Fa Yang
Summary: This study, using the National Health Insurance Research Database of Taiwan, found a relationship between congenital cytomegalovirus (CMV) infection and late-onset keratitis. Severe congenital CMV infection was found to be significantly correlated with late-onset keratitis in individuals with congenital CMV infection.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Oncology
Hung-Ju Chien, Chung-Jung Liu, Tsung-Ho Ying, Pei-Ju Wu, Jiunn-Wei Wang, Yi-Hsuan Ting, Yi-Hsien Hsieh, Shih-Chiang Wang
Summary: This study aimed to evaluate Timosaponin AIII (TSAIII) as a potential therapeutic approach for cervical cancer. The results showed that TSAIII suppresses cell migration, invasion, p38 activation, and uPA expression in cervical cancer. Additionally, TSAIII demonstrated antimetastatic properties and inhibited the growth of cervical cancer stem cells. These findings suggest that TSAIII may be a potential auxiliary therapy for cervical cancer.
Article
Cell Biology
Chu-Che Lee, Jen-Pi Tsai, Hsiang-Lin Lee, Yung-Jen Chen, Yong-Syuan Chen, Yi-Hsien Hsieh, Jin-Cherng Chen
Summary: In this study, Timosaponin AIII (TSAIII) was found to inhibit the growth of glioma cells by inducing cell death, mitochondrial dysfunction, and autophagy activation. The results suggest that TSAIII exhibits antitumor effects and may have potential as a therapy for glioma.
Article
Chemistry, Medicinal
Je-Chiuan Ye, Yih-Shou Hsieh, Pei-Ni Chen, Jer-Yuh Liu, Yi-Hsien Hsieh
Summary: Our study shows that PKCa regulates the PA and MMPs systems in liver cancer cells through the p38 MAPK signaling pathway, promoting cell progression. MMP-1 and u-PA play critical roles in this pathway, and targeting these genes may be a potential treatment approach for liver cancer.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Environmental Sciences
Pei-Ju Wu, Hui-Ling Chiou, Yi-Hsien Hsieh, Chia-Liang Lin, Hsiang-Lin Lee, I-Chun Liu, Tsung-Ho Ying
Summary: Licoricidin, an active compound of Glycyrrhiza uralensis, was found to significantly inhibit cell viability and induce apoptosis in cervical cancer cells. It also triggered endoplasmic reticulum stress and upregulated the protein expression of GRP78 (Bip), CHOP, and IRE1 alpha, ultimately leading to immunogenic cell death. These findings suggest that Licoricidin may be a potential inducer of immunotherapy in advanced cervical cancer.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tsai-Yi Tseng, Chien-Hsing Lee, Hsiang-Lin Lee, Chien-Yu Su, Cheng-Yen Kao, Jen-Pi Tsai, Yi-Hsien Hsieh
Summary: Licochalcone A (LicA) is a potent anti-inflammatory, antioxidant, and anticarcinogenic substance that shows therapeutic potential against renal cell carcinoma (RCC). LicA limits cell growth, induces cell cycle arrest, promotes autophagy and LC3B expression, and inhibits migration and invasion of RCC cells. The chemotherapeutic effects of LicA on RCC are mediated through the activation of LC3B expression, ultimately modulating the FAK/Src signaling pathway-mediated Sp1 expression.
Article
Environmental Sciences
Kuan-Chun Hsueh, Po-Chung Ju, Yi-Hsien Hsieh, Shih-Chi Su, Chao-Bin Yeh, Chiao-Wen Lin
Summary: HO-3867 triggers cell cycle arrest and apoptotic responses in liver cancer, possibly involving p38-mediated activation of caspase cascades.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Tsai-Kun Wu, Tung-Wei Hung, Yong-Syuan Chen, Ying-Ru Pan, Yi-Hsien Hsieh, Jen-Pi Tsai
Summary: Corosolic acid inhibits the migration and invasion of renal cell carcinoma cells by reducing MMP2 expression and stimulating ERK1/2 phosphorylation.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wen-Chun Sun, Chia-Liang Lin, Tzong-Huei Lee, Chia-Hao Chang, Ann-Zhi Ong, Yen-Hsiu Yeh, Chen-Lin Yu, Guang-Wei Chen, Yi-Hsien Hsieh, Shih-Wei Wang
Summary: In this study, Chaetoglobosin A (ChA) was identified as a potent and selective antitumor agent in human colorectal cancer (CRC). ChA inhibited CRC cell growth and induced apoptotic cell death through mitochondrial intrinsic and caspase-dependent pathways. The expression of Heme oxygenase-1 (HO-1) was found to be associated with ChA-induced cell death, and inhibition of HO-1 increased the sensitivity of CRC cells to ChA.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Jia-Sin Yang, Chia-Hsuan Chou, Yi-Hsien Hsieh, Peace Wun-Ang Lu, Ya-Chiu Lin, Shun-Fa Yang, Ko-Hsiu Lu
Summary: The study found that Morin can suppress the migration and invasion capabilities of human osteosarcoma cells, playing an anti-metastatic role by reducing uPA expression. Therefore, Morin may be a potential drug candidate for the treatment of human osteosarcoma.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Huang-Ming Hu, Hsiang-Lin Lee, Chung-Jung Liu, Yi-Hsien Hsieh, Yong-Syuan Chen, Kuan-Chun Hsueh
Summary: The study found that MTA2 regulates HCC progression through the MTA2-FAK-MMP7 pathway. PTK7, as a downstream factor of MTA2, affects the migration and invasion abilities of HCC cells by regulating MMP7 expression. The expression level of PTK7 is correlated with tumor stage, grade, and overall survival in HCC patients, and may have diagnostic value for HCC patients.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Cell Biology
Hsueh-Ju Lu, Chun-Yi Chuang, Mu-Kuan Chen, Chun-Wen Su, Wei-En Yang, Chia-Ming Yeh, Kuan-Ming Lai, Chih-Hsin Tang, Chiao-Wen Lin, Shun-Fa Yang
Summary: ALDH7A1 polymorphisms and expression levels are associated with oral cancer development and prognosis, affecting pathological features, cell migration, and patient outcomes.