期刊
ENVIRONMENTAL POLLUTION
卷 239, 期 -, 页码 493-498出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2018.04.010
关键词
Acrylonitrile; N-Acetyl-S-(2-Cyanoethyl)-L-cysteine (CEMA); 8-HydroxyDeoxyguanosine (8-OHdG); Oxidative stress
资金
- National Health Research Institute of Taiwan [NHRI EX95-9531PI, EX96-9531PI, EX97-9531PI]
- Ministry of Science and Technology of Taiwan [NSC 101-2314-B-002-184-NY3, NSC 99-2314-B-385-001-MY3, NSC 106-2314-B-385 -001]
- Environmental Medicine Collaboration Center of National Taiwan University Hospital, Taiwan [NTUH 103-A123]
Acrylonitrile is a colorless volatile liquid mostly present in tobacco smoke. Acrylonitrile exposure has shown to increase oxidative stress in animal studies; however, there was no previous research in human epidemiology. In this study, 853 subjects were recruited from a cohort of Taiwanese adolescents and young adults to investigate the association between urinary concentrations of the acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine (CEMA), the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) and cardiovascular disease (CVD) risk factors. The geometric mean (SD) of CEMA and 8-OHdG concentrations were 4.67 (8.61) mu g/L and 2.97 (2.14) mu g/L, respectively. 10% elevated in CEMA (mu g/L) was positively correlated with the change of 8-OHdG levels (mu g/L) (beta = 0.325, SE = 0.105, P = 0.002) in multiple linear regression analyses. The urinary CEMA was not related to other CVD risk factors. In subpopulation analyses, the association between CEMA and 8-OHdG was evident in all genders, adolescents, homeostasis model assessment of insulin resistance score >= 0.89, and environmental tobacco smokers. In this study, we observed that higher levels of CEMA levels were correlated with increased levels of 8-OHdG in this cohort. Future research on exposure to acrylonitrile and oxidative stress was warranted. (C) 2018 Elsevier Ltd. All rights reserved.
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