Review
Neurosciences
Chase R. Figley, Md Nasir Uddin, Kaihim Wong, Jennifer Kornelsen, Josep Puig, Teresa D. Figley
Summary: This paper discusses the limitations of several commonly used MRI biomarkers in diffusion imaging studies and suggests that future research should refrain from over-interpreting FA, AD, and RD values as standalone markers of cerebral white matter microstructure.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Du Lei, Kun Qin, Wenbin Li, Ziyu Zhu, Maxwell J. Tallman, L. Rodrigo Patino, David E. Fleck, Veronica Aghera, Qiyong Gong, John A. Sweeney, Melissa P. DelBello, Robert K. McNamara
Summary: This study compared the brain microstructure differences in ADHD youth with and without a family history of bipolar disorder (BD). The high-risk ADHD group showed higher FA and lower MD in certain brain regions compared to the low-risk ADHD group. Both ADHD groups exhibited higher FA compared to healthy controls. Significant correlations were found between microstructure metrics and clinical ratings in ADHD groups.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychiatry
Jia Cai, Min Xie, Liansheng Zhao, Xiaojing Li, Sugai Liang, Wei Deng, Wanjun Guo, Xiaohong Ma, Pak C. Sham, Qiang Wang, Tao Li
Summary: This study examined white matter abnormalities in adolescent early onset schizophrenia patients and found differences in several neural fiber tracts compared to healthy controls. Specifically, decreased mean diffusivity was found in the right hemisphere of schizophrenia patients. Furthermore, the fractional anisotropy values of certain neural fiber tracts were suggested to be associated with the severity of clinical symptoms in these patients.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Neurosciences
Hui Juan Chen, Rongfeng Qi, Jun Ke, Jie Qiu, Qiang Xu, Yuan Zhong, Guang Ming Lu, Feng Chen
Summary: Patients with PTSD and trauma-exposed control group both exhibited white matter abnormalities in specific regions, which were negatively correlated with clinical symptoms. Trauma exposure could lead to disruption of cerebral white matter, especially in the frontal fibers, and these alterations may be linked to the severity of PTSD symptoms.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Wencai C. Ding, Peng Ren, Liye Yi, Yao F. Si, Fan L. Yang, Zhipeng Li, Hongbo L. Bao, Shi W. Yan, Xinyu Zhang, Siyang Li, Xia Liang, Lifen Yao
Summary: This study investigated cortical and subcortical microstructural changes in frontotemporal lobar degeneration (FTLD) subtypes, finding that patients with FTLD showed alterations in cortical mean diffusivity and cortical thinning. Anomalies in subcortical white matter diffusion were widely distributed across the frontotemporal and parietal areas. Different patterns of cortical and subcortical microstructural abnormalities were observed in the different FTLD subtypes, which correlated with disease severity and language functions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Clara Engelhardt, Benoit Boulat, Michael Czisch, Mathias V. Schmidt
Summary: This study demonstrated that a lack of FKBP51 leads to alterations in brain architecture and connectivity in male mice through the use of in vivo structural MRI and DTI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Biochemical Research Methods
Allison F. Lewis, Jill C. Stewart
Summary: This study compared CST integrity measures extracted from standard versus native space in individuals with chronic stroke, finding significant differences between the two extraction methods. The influence of extraction space on diffusion-based microstructural integrity values (FA and MD) of the CST is important when considering methods for aggregating data across studies, but the relationship between CST integrity and motor impairment appears to be robust to extraction space.
JOURNAL OF NEUROSCIENCE METHODS
(2021)
Article
Neurosciences
Hua-Jun Liang, Erin E. O'Connor, Thomas Ernst, Kenichi Oishi, Eric Cunningham, Linda Chang
Summary: The study found that HIV+ women had poorer sensorimotor function and lower GP_FA compared to HIV+ men. Regardless of sex, the HIV+ group performed worse in Fluency, Speed, and Attention, with lower FA and higher MD in multiple brain regions. Gender had an impact on the manifestation of cognitive impairment.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Neurosciences
Ana Alves-Pinto, Monica Emch, Renee Lampe
Summary: The study investigated the effects of 1.5 years of piano training in an adolescent with unilateral CP, looking at manual function tests and comparing metrics of fractional anisotropy, mean diffusivity, radial and axial diffusivity in neuronal pathways pre- and post-training. Results showed increased fractional anisotropy and decreased mean diffusivity in the bilateral dorsal cingulate post-training, indicating contributions to non-motor processes development.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ryckie G. Wade, Winnie Tam, Antonia Perumal, Sophanit Pepple, Timothy T. Griffiths, Robert Flather, Hamied A. Haroon, David Shelley, Sven Plein, Grainne Bourke, Irvin Teh
Summary: This study aims to compare the performance of different pipelines for processing upper limb DTI data. The results show that preprocessing improves geometric similarity, but the choice of pipeline introduces clinically important variability in diffusion parameter estimates.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Medicine, General & Internal
Ernest Tyburski, Piotr Podwalski, Katarzyna Waszczuk, Katarzyna Rek-Owodzin, Monika Mak, Piotr Plichta, Maksymilian Bielecki, Krzysztof Rudkowski, Michal Szelepajlo, Jolanta Kucharska-Mazur, Wojciech Andrusewicz, Blazej Misiak, Magdalena Kerestey, Adrianna Bober, Krzysztof Wietrzynski, Anna Michalczyk, Magdalena Wiedlocha, Piotr Marcinowicz, Jerzy Samochowiec, Leszek Sagan
Summary: This study examined the relationship between the integrity of the corpus callosum and cognitive functioning in schizophrenia patients. Results showed impaired integrity in the middle and posterior corpus callosum, with patients displaying cognitive impairments.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
G. Schwarz, B. Kanber, F. Prados, S. Browning, R. Simister, H. R. Jager, G. Ambler, C. A. M. Gandini Wheeler-Kingshott, D. J. Werring
Summary: This study found that small vessel disease is the most common cause of spontaneous intracerebral hemorrhage and is associated with widespread microstructural brain tissue disruption, which can be quantified using diffusion tensor imaging metrics. The study found that whole-brain microstructural alterations are associated with functional outcome after intracerebral hemorrhage and have better predictive ability than existing hemorrhage scores.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
G. Schwarz, B. Kanber, F. Prados, S. Browning, R. Simister, R. Jager, G. Ambler, C. A. M. Gandini Wheeler-Kingshott, David J. Werring
Summary: This study aimed to investigate the association between CST DTI metrics after ICH and 6-month functional outcome, as well as the potential improvement in predictive performance of the existing ICH score. The results showed that rFA and rMD were associated with 6-month mRS>2, and discrimination values varied among different variables. Combined models with DTI and non-DTI variables offered an improvement in discrimination.
JOURNAL OF NEUROLOGY
(2022)
Article
Veterinary Sciences
Philippa J. Johnson, Andrew D. Miller, Jonathan Cheetham, Elena A. Demeter, Wen-Ming Luh, John P. Loftus, Sarah L. Stephan, Curtis W. Dewey, Erica F. Barry
Summary: Degenerative myelopathy in dogs causes undetectable spinal cord lesions on standard MRI, but diffusion tensor imaging (DTI) can reveal alterations in spinal cord diffusivity. Dogs with DM showed significant decreases in fractional anisotropy, suggesting DTI may be a potential biomarker for lesion development.
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2021)
Article
Veterinary Sciences
Richard Shinn, Ashley Riffe, Michael Edwards, John Rossmeisl
Summary: This study compared the DTI measurements acquired using manual and semiautomated ROI methods and found that there were significant differences in the measurements. Some DTI measurements based on both methods were predictive of poor motor function recovery in dogs with intervertebral disc herniation.
VETERINARY RADIOLOGY & ULTRASOUND
(2022)
Article
Medicine, Research & Experimental
Alain Ptito, Linda Papa, Kenton Gregory, Robert L. Folmer, William C. Walker, Vivek Prabhakaran, Rima Wardini, Kim Skinner, Michael Yochelson
Summary: The study demonstrated that TLNS plus targeted PT significantly improved balance and gait, as well as reducing headaches, improving sleep quality, and decreasing fall frequency in patients with chronic balance deficit following mmTBI who had plateaued on prior conventional physiotherapy.
Article
Anesthesiology
Sean Tanabe, Rosaleena Mohanty, Heidi Lindroth, Cameron Casey, Tyler Ballweg, Zahra Farahbakhsh, Bryan Krause, Vivek Prabhakaran, Matthew I. Banks, Robert D. Sanders
BRITISH JOURNAL OF ANAESTHESIA
(2020)
Article
Behavioral Sciences
Charlene N. Rivera Bonet, Gyujoon Hwang, Bruce Hermann, Aaron F. Struck, Cole J. Cook, Veena A. Nair, Jedidiah Mathis, Linda Allen, Dace N. Almane, Karina Arkush, Rasmus Birn, Lisa L. Conant, Edgar A. DeYoe, Elizabeth Felton, Rama Maganti, Andrew Nencka, Manoj Raghavan, Umang Shah, Veronica N. Sosa, Candida Ustine, Vivek Prabhakaran, Jeffery R. Binder, Mary E. Meyer
EPILEPSY & BEHAVIOR
(2020)
Article
Behavioral Sciences
Camille Garcia-Ramos, Aaron F. Struck, Cole Cook, Vivek Prabhakaran, Veena Nair, Rama Maganti, Jeffrey R. Binder, Marybeth Meyerand, Lisa L. Conant, Bruce Hermann
Summary: This study examined the neuropsychological networks of temporal lobe epilepsy patients with different cognitive phenotypes and found that the degree of cognitive impairment is closely related to alterations in their network properties. These findings provide insights into the classification of cognitive abnormalities in temporal lobe epilepsy.
Article
Behavioral Sciences
Aaron F. Struck, Melanie Boly, Gyujoon Hwang, Veena Nair, Jedidiah Mathis, Andrew Nencka, Lisa L. Conant, Edgar A. DeYoe, Manoj Raghavan, Vivek Prabhakaran, Jeffrey R. Binder, Mary E. Meyerand, Bruce P. Hermann
Summary: Temporal lobe epilepsy (TLE) is characterized by increased connectivity in the hippocampus/amygdala and decreased connectivity in the lateral temporal lobe. Differences in connectivity ratios between these regions are associated with neurocognitive deficits in TLE patients compared to controls.
EPILEPSY & BEHAVIOR
(2021)
Review
Clinical Neurology
E. V. R. DiBella, A. Sharma, L. Richards, V Prabhakaran, J. J. Majersik, S. K. HashemizadehKolowri
Summary: Ischemic stroke is a global problem, and MR imaging plays a crucial role in understanding brain changes and predicting recovery after stroke, especially in the nonacute stage. Recent studies suggest that certain diffusion MR imaging methods are more effective in predicting motor scores and are more sensitive than traditional DTI methods.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2022)
Article
Clinical Neurology
Jiancheng Hou, Rosaleena Mohanty, Daniel Chu, Veena A. Nair, Yuri Danilov, Kurt A. Kaczmarek, Beth Meyerand, Mitchell Tyler, Vivek Prabhakaran
Summary: This study investigated the effectiveness of translingual neural stimulation (TLNS) on patients with mild-to-moderate traumatic brain injury (TBI) and related brain connectivity. The results showed that TLNS treatment can improve balance and movement deficits in TBI patients, but there were no correlations with the sensory/somatomotor network.
JOURNAL OF NEUROIMAGING
(2022)
Article
Anesthesiology
Jennifer Taylor, Laura Eisenmenger, Heidi Lindroth, James Booth, Rosaleena Mohanty, Veena Nair, Margaret Parker, David Kunkel, Cameron Rivera, Cameron Casey, Henrik Zetterberg, Kaj Blennow, Marko Mrkobrada, Philip J. Devereaux, Robert A. Pearce, Richard Lennertz, Vivek Prabhakaran, Robert D. Sanders
Summary: This pilot study examined the incidence of preoperative and postoperative covert strokes and the relationship between postoperative brain injury and neurofilament light levels. The findings suggest that preoperative covert stroke may occur more frequently than expected, and plasma neurofilament light could be a potential biomarker for postoperative brain injury.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Neurosciences
Arman P. Kulkarni, Gyujoon Hwang, Cole J. Cook, Rosaleena Mohanty, Akhil Guliani, Veena A. Nair, Barbara B. Bendlin, Elizabeth Meyerand, Vivek Prabhakaran
Summary: In this study, a unique approach based on variance analyses was proposed to investigate the genetic influence on individual differences in brain functional connectivity. The findings suggest that genetic factors play a larger role in brain functional connectivity in males, while environmental factors have a greater impact in females. Moreover, the study reveals that environmental influences on individual differences may outweigh genetic influences in the frontal and overall brain regions.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
P. A. Rowley, M. J. Paukner, L. B. Eisenmenger, A. S. Field, R. J. Davidson, S. C. Johnson, S. Asthana, N. A. Chin, V. Prabhakaran, B. B. Bendlin, B. R. Postle, H. H. Goldsmith, C. M. Carlsson, M. A. Brooks, N. H. Kalin, L. E. Williams, H. A. Rowley
Summary: This study investigated 16,400 brain MRIs and found that incidental findings are common, ranging from trivial to life-threatening. Formal neuroradiologist interpretation yielded more reliable results compared to spontaneous detection by nonradiology scanning staff.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Article
Neuroimaging
Gyujoon Hwang, Bruce Hermann, Veena A. Nair, Lisa L. Conant, Kevin Dabbs, Jed Mathis, Cole J. Cook, Charlene N. Rivera-Bonet, Rosaleena Mohanty, Gengyan Zhao, Dace N. Almane, Andrew Nencka, Elizabeth Felton, Aaron F. Struck, Rasmus Birn, Rama Maganti, Colin J. Humphries, Manoj Raghavan, Edgar A. DeYoe, Barbara B. Bendlin, Vivek Prabhakaran, Jeffrey R. Binder, Mary E. Meyerand
NEUROIMAGE-CLINICAL
(2020)
Article
Neurosciences
Mohsen Mazrooyisebdani, Veena A. Nair, Camille Garcia-Ramos, Rosaleena Mohanty, Elizabeth Meyerand, Bruce Hermann, Vivek Prabhakaran, Raheel Ahmed
BRAIN CONNECTIVITY
(2020)