期刊
ENVIRONMENT INTERNATIONAL
卷 111, 期 -, 页码 309-315出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.envint.2017.11.001
关键词
Methylmercury; Selenium; Vitamin E; Docosahexaenoic acid (DHA); Cord blood; Fetus
资金
- Ministry of the Environment, Japan
Methylmercury (MeHg) is a neurotoxicant known to affect the developing fetal brain as a sensitive target organ. As most mercury (Hg) in blood is MeHg, total mercury (THg) levels in blood are used to estimate the body burden of MeHg. The nutrients selenium (Se), vitamin E, and docosahexaenoic acid (DHA) are protective against MeHg toxicity. We compared maternal and cord blood concentrations of biochemical substances, THg and Se, vitamin E, DHA, and other elements, fatty acids, and amino acids in 54 Japanese mother-newborn pairs to elucidate the fetal risk of MeHg toxicity. Cord blood had higher hematocrit and amino acid values and lower concentrations of lipid components, including fatty acids compared with maternal blood. THg levels in cord blood (7.26 ng/g) were 1.9 times higher than levels in maternal blood (3.79 ng/g). Se concentrations in cord blood (176 ng/g) were slightly higher than concentrations in maternal blood (156 ng/g). Levels of vitamin E (0.31 mg/dL) and DHA (58.8 mu g/mL) in cord blood were much lower than levels in maternal blood (1.38 mg/dL and 147 mu g/mL, respectively). The ratios of Se/THg, vitamin E/THg, and DHA/THg in cord blood were lower than ratios in maternal blood. These results suggest that fetuses are at higher risk to MeHg toxicity.
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