期刊
EMBO REPORTS
卷 19, 期 8, 页码 -出版社
WILEY
DOI: 10.15252/embr.201745702
关键词
functional compensation; hematopoietic stem cells; heterogeneity; lineage priming; lymphopoietic deficiencies
资金
- USC Office of Research
- Norris Medical Library
- NIH [T32HD060549, F31HL134359, R00HL113104, R01HL135292, R01HL138225, P30CA014089]
- Rose Hills Foundation Science and Engineering Fellowship
- USC Provost's Undergraduate Research Fellowship
- California Institute for Regenerative Medicine Training Grant
- Hearst Fellowship Award
In most organ systems, regeneration is a coordinated effort that involves many stem cells, but little is known about whether and how individual stem cells compensate for the differentiation deficiencies of other stem cells. Functional compensation is critically important during disease progression and treatment. Here, we show how individual hematopoietic stem cell (HSC) clones heterogeneously compensate for the lymphopoietic deficiencies of other HSCs in a mouse. This compensation rescues the overall blood supply and influences blood cell types outside of the deficient lineages in distinct patterns. We find that highly differentiating HSC clones expand their cell numbers at specific differentiation stages to compensate for the deficiencies of other HSCs. Some of these clones continue to expand after transplantation into secondary recipients. In addition, lymphopoietic compensation involves gene expression changes in HSCs that are characterized by increased lymphoid priming, decreased myeloid priming, and HSC self-renewal. Our data illustrate how HSC clones coordinate to maintain the overall blood supply. Exploiting the innate compensation capacity of stem cell networks may improve the prognosis and treatment of many diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据