Article
Endocrinology & Metabolism
Sonia Norberto, Heloisa Balan Assalin, Dioze Guadagnini, Natalia Tobar, Patricia Aline Boer, Min-Cheol Kang, Mario Jose Abdalla Saad, Young-Bum Kim, Patricia Oliveira Prada
Summary: This study suggests that deletion of CLK2 in GABAergic neurons can affect energy homeostasis and behavioral and cognitive functions in mice, with differences observed between genders. These findings have important implications for further research and treatment of obesity and psychological disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Alexis C. Blackie, Daniel J. Foley
Summary: This review discusses the roles of Cdc2-like kinases (CLKs) in cancer cells and the effects of small molecule CLK inhibitors, providing insights into the research progress of CLKs in cancer.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Momoko Ohori, Yusuke Nakayama, Mari Ogasawara-Shimizu, Hiroyoshi Toyoshiba, Atsushi Nakanishi, Samuel Aparicio, Shinsuke Araki
Summary: This study provides a comprehensive description of the transcriptome landscape of replicative senescent human umbilical vein endothelial cells, identifying key genes and pathways involved in age-related processes such as lipid metabolism and chromosome organization. The research also reveals the involvement of alternative splicing in endothelial cell senescence.
Review
Plant Sciences
Long Wang, Fan Xu, Feng Yu
Summary: Plants have developed adaptation mechanisms to respond to environmental signals, and receptors/sensors play a crucial role in recognizing these signals. RNA metabolism is also important in regulating gene expression and protein synthesis. Recent advances in RNA biotechnology have shed light on the roles of RNA metabolism, particularly alternative splicing and translation, in response to environmental signals. Understanding these mechanisms at the posttranscriptional level improves our ability to breed stress-tolerant plants for changing environments.
PLANT CELL AND ENVIRONMENT
(2023)
Review
Biochemical Research Methods
Jiashu Liu, Cui-Xiang Lin, Xiaoqi Zhang, Zongxuan Li, Wenkui Huang, Jin Liu, Yuanfang Guan, Hong-Dong Li
Summary: Alternative splicing (AS), a key pathway for transcriptional regulation, has been shown to be associated with complex diseases. Computational approaches for detecting disease-associated AS events have been developed. This review discusses the metrics used for characterizing AS events quantitatively. It also reviews and discusses three types of methods for detecting disease-associated splicing events: differential splicing analysis, aberrant splicing detection, and splicing-related network analysis. Additionally, methods for detecting genetic variants that potentially regulate splicing are described. Experimental comparisons are conducted to illustrate the performance of each method. The limitations of these methods are discussed, as well as potential ways to address them. This review aims to provide a systematic understanding of computational approaches for analyzing disease-associated splicing.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Oncology
Yunting Jian, Xinjian Huang, Lishan Fang, Meng Wang, Qinghua Liu, Hongyi Xu, Lingzhi Kong, Xiangfu Chen, Ying Ouyang, Xi Wang, Weidong Wei, Libing Song
Summary: The study elucidated a novel mechanism by which ACTL6A prolongs the retention of MYC in TNBC, and suggested that pharmacological targeting of the ACTL6A/MYC/CDK2 axis may have therapeutic potential in patients with TNBC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Lijing Wang, Shuchen Gu, Fenfang Chen, Yi Yu, Jin Cao, Xinran Li, Chun Gao, Yanzhen Chen, Shuchong Yuan, Xia Liu, Jun Qin, Bin Zhao, Pinglong Xu, Tingbo Liang, Hongyan Tong, Xia Lin, Xin-Hua Feng
Summary: Loss of TGF-beta-mediated growth suppression is a major contributor to cancer development, and this study investigates the molecular mechanisms involved in the oncogene-induced modulation of TGF-beta signaling. The researchers found that the oncogenic BCR-ABL1 kinase phosphorylates and inactivates Smad4, thereby blocking the antiproliferative TGF-beta signaling. They also demonstrated that inhibition of BCR-ABL1 kinase restores the beneficial TGF-beta anti-growth responses.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Genetics & Heredity
Si Qi, Shuisen Chen, Wei Wang, Wenhan Li, Xueliang Xu, Ming Zhong, Jingwei Lin, Yueying Yu, Yongsheng Chen, Haoge Li
Summary: Research has shown that alternative splicing and duplication of MADS-box genes in maize lead to functional divergence. While Zmm16 plays a new role in flower development, the duplicated genes Zmm18/29 have not shown typical B class gene function. The study also analyzed the transcripts of these genes, examining their effects on protein-protein interactions and phylogenetic relationships.
Review
Neurosciences
Roman Sloutsky, Margaret M. Stratton
Summary: Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a crucial regulator in the post-synapse during long-term potentiation, encoded by four genes in humans with alternative splicing leading to a diversity of proteins. Advances in sequencing technologies have led to the discovery of new CaMKII transcripts and suggest the adoption of a new naming scheme for CaMKII variants to better understand their biological implications.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Panyisha Wu, Moya Zhang, Nicholas J. G. Webster
Summary: Alternative RNA splicing is an important biological process that has been linked to various clinical syndromes, but its applicability to common diseases is still uncertain. This review focuses on the changes in alternative RNA splicing in fatty liver disease and the role of splicing regulation in disease progression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junrui Zhou, Tingfang Li, Xin Geng, Lei Sui, Feng Wang
Summary: The study investigates the use of antisense oligonucleotides to inhibit telomerase activity as a potential new approach for cancer therapy. After chemical modification of some oligonucleotides, it was found that some of them could significantly reduce telomerase activity.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Immunology
Frank Fang Yao Lee, Scott Alper
Summary: While TLR signaling is necessary to combat infection, persistent inflammation can cause damage and contribute to various inflammatory disorders. Alternative pre-mRNA splicing plays a role in terminating TLR signaling by producing dominant negative inhibitors that limit inflammation. Understanding the production and function of these alternative isoforms may provide insights into inflammatory disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Carmelo Gurnari, Simona Pagliuca, Valeria Visconte
Summary: Alternative RNA splicing is an essential physiological function that plays a crucial role in cellular development. RNA splicing dysfunction has been implicated in the development of several cancers, including myeloid malignancies. Cancer cells exhibit marked gene expression alterations, including different usage of AS isoforms, potentially causing tissue-specific effects and disruptions of downstream pathways.
Review
Immunology
Jianli Zhou, Qiao Zhang, Yuzhen Zhao, Yuchen Song, Yanan Leng, Moxian Chen, Shaoming Zhou, Zhaoxia Wang
Summary: Inflammatory bowel disease (IBD) is a group of chronic diseases including Crohn's disease and ulcerative colitis, which have a global impact on both children and adults. The burden of IBD is increasing worldwide, and the costs associated with it are high. The pathogenesis of IBD is still unclear, but is believed to be related to environmental factors, gut microbiota, immune imbalance, and genetic susceptibility. This article reviews the research progress on alternative splicing events, splicing factors, and splicing mutations associated with IBD.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Anthony J. Murphy, Alex H. Li, Peichao Li, Hong Sun
Summary: Alternative splicing plays a crucial role in diversifying the proteome and has significant implications in cancer development. Recent studies have highlighted the important roles of SR proteins in cancer progression. Understanding the spliceosome and its relationship to cancer has opened up new opportunities for therapeutic interventions based on alternative splicing.
FRONTIERS IN ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Daisuke Nakata, Kazuhide Nakayama, Tsuneo Masaki, Akira Tanaka, Masami Kusaka, Tatsuya Watanabe
Article
Endocrinology & Metabolism
Daisuke Nakata, Ryokichi Koyama, Kazuhide Nakayama, Satoshi Kitazawa, Tatsuya Watanabe, Takahito Hara
Article
Chemistry, Medicinal
Ryo Mizojiri, Daisuke Nakata, Yoshihiko Satoh, Daisuke Morishita, Sachio Shibata, Misa Iwatani-Yoshihara, Yohei Kosugi, Mai Kosaka, Junpei Takeda, Shigekazu Sasaki, Kazuaki Takami, Koichiro Fukuda, Masahiro Kamaura, Shinobu Sasaki, Ryosuke Arai, Douglas R. Cary, Yasuhiro Imaeda
ACS MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Pharmacology & Pharmacy
Akira Tanaka, Daisuke Nakata, Tsuneo Masaki, Masami Kusaka, Tatsuya Watanabe, Hisanori Matsui
EUROPEAN JOURNAL OF PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Hisanori Matsui, Tsuneo Masaki, Yumiko Akinaga, Atsushi Kiba, Yoshihiro Takatsu, Daisuke Nakata, Akira Tanaka, Junko Ban, Shin-ichi Matsumoto, Satoshi Kumano, Atsuko Suzuki, Yukihiro Ikeda, Masashi Yamaguchi, Tatsuya Watanabe, Tetsuya Ohtaki, Masami Kusaka
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Pharmacology & Pharmacy
Daisuke Nakata, Tsuneo Masaki, Akira Tanaka, Mie Yoshimatsu, Yumiko Akinaga, Mari Asada, Reiko Sasada, Michiyasu Takeyama, Kazuhiro Miwa, Tatsuya Watanabe, Masami Kusaka
EUROPEAN JOURNAL OF PHARMACOLOGY
(2014)
Article
Chemistry, Medicinal
Kazuhiro Miwa, Takenori Hitaka, Takashi Imada, Satoshi Sasaki, Mie Yoshimatsu, Masami Kusaka, Akira Tanaka, Daisuke Nakata, Shuichi Furuya, Satoshi Endo, Kazumasa Hamamura, Tomoyuki Kitazaki
JOURNAL OF MEDICINAL CHEMISTRY
(2011)
Article
Endocrinology & Metabolism
Takahiro Kimura, Hiroshi Kiyota, Daisuke Nakata, Tsuneo Masaki, Masami Kusaka, Shin Egawa
Article
Biochemistry & Molecular Biology
Daisuke Nakata, Shoichi Nakao, Kazuhide Nakayama, Shinsuke Araki, Yusuke Nakayama, Samuel Aparicio, Takahito Hara, Atsushi Nakanishi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Ophthalmology
K Takahata, H Katsuki, T Kume, D Nakata, K Ito, S Muraoka, F Yoneda, S Kashii, Y Honda, A Akaike
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2003)
Article
Pharmacology & Pharmacy
H Katsuki, R Yamamoto, D Nakata, T Kume, A Akaike
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2004)