期刊
FREE RADICAL RESEARCH
卷 49, 期 3, 页码 253-268出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/10715762.2014.998665
关键词
2-(Arylazo) phenolate complexes of palladium; human lung cancer cell line; ROS; caspase-3
资金
- Centre for Advanced Studies in Biochemistry
In this study, we report the synthesis of four 2-(arylazo) phenol-Pd(II) complexes and their anti-proliferative property against the human lung cancer (A549), cervical cancer (HeLa), and ovarian teratocarcinoma (PA-1) cell lines with cisplatin as the gold standard. One of the complexes, [Pd(L-2)(2)], induced robust apoptosis in all the chosen cells, as revealed by annexin-V-positive/propidium iodide dual staining, increased sub-G1 cell cycle population, and significant morphological changes in the treated cells. The Pd complex inflicted mitochondrial dysfunction leading to mitochondrial membrane potential loss, reactive oxygen species generation and release of cytosolic cytochrome c that activated caspase-9 and caspase-3 proteins which finally caused programmed cell death.
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