Article
Chemistry, Organic
Nikitas G. Malliaros, Michael Orfanopoulos
Summary: An innovative and efficient method for regioselective functionalization of C-60 with 9H-fluorenes has been developed. This approach involves the use of fluorenyl radicals derived from fluorenes in a HAT process mediated by tetrabutylammoniumdecatungstate to produce [60]fullerene-fluorene dyads in a single step. Kinetic isotope effect measurements suggest a stepwise mechanism with C-H (D) bond scission as the rate-limiting step.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Zhan Liu, Zheng-Chun Yin, Wen-Qiang Lu, Dian-Bing Zhou, Guan-Wu Wang
Summary: In this study, an unexpected Diels-Alder reaction of [60]fullerene (C-60) with ferrocenes bearing electron-withdrawing groups as cyclopentadiene surrogates was developed to selectively afford single isomers of [2 + 4] cycloadducts of C-60. Mechanistic studies showed the in situ generation of cyclopentadienes from electron-deficient ferrocenes in the presence of an oxidant and an acid, followed by [2 + 4] cycloadditions with dienophiles. A Michael addition reaction using a Grignard reagent was utilized to transform the Diels-Alder adducts of C-60 into more stable fullerene derivatives.
CHEMICAL COMMUNICATIONS
(2021)
Review
Food Science & Technology
Lina Sheng, Xiran Li, Luxin Wang
Summary: PDI is a promising technology for mitigating foodborne illnesses, food loss and waste, and the occurrence of antibiotic-resistant bacteria. The review summarizes the antimicrobial mechanisms of PDI against food-related microorganisms, highlighting its efficiency in disrupting cell structure and function, oxidation of macromolecules, and inhibition of quorum sensing. Further research is needed to investigate long-term impacts and optimize application parameters for advanced application in food systems.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anzhela Galstyan, Konstantin Strokov
Summary: The study investigated nanofibrous membranes with antibacterial and antiviral activities, and found that increasing the content of chitosan enhances the activity of the material, rather than increasing the concentration of the photosensitizer. These materials have important implications for topical antimicrobial photodynamic therapy and environmental remediation.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Article
Polymer Science
Sofia C. Santamarina, Daniel A. Heredia, Andres M. Durantini, Edgardo N. Durantini
Summary: The emergence of antibiotic-resistant microbes necessitates the development of alternative therapies. In this study, two polymers were synthesized and found to possess strong antibacterial activity, particularly in the presence of potassium iodide, inhibiting the growth of Staphylococcus aureus.
Article
Engineering, Environmental
Jenny Flores, Alberto Blazquez-Moraleja, Mariles Bonet-Aracil, Pilar Moya, Francisco Bosca, Luisa Marin
Summary: Heterogeneous photocatalysts based on fabric materials have great relevance for water disinfection. This study focuses on determining the best percentage of a photosensitizer on fabric for efficient bacterial inactivation. Polyamide fabrics dyed at different Rose Bengal percentages were tested, and the results showed that fabrics with 1% Rose Bengal showed 100% inactivation efficiency against Enterococcus faecalis in just 15 minutes. Optimizing the percentage of dye is crucial to avoid aggregation of photosensitizers and achieve an adequate net negative charge distribution for antimicrobial fabrics.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Nanoscience & Nanotechnology
Irene Villa, Chiara Villa, Roberta Crapanzano, Valeria Secchi, Massimo Tawfilas, Elena Trombetta, Laura Porretti, Andrea Brambilla, Marcello Campione, Yvan Torrente, Anna Vedda, Angelo Monguzzi
Summary: The multicomponent nanomaterial developed in this study shows remarkable ability to enhance singlet oxygen production, providing significant efficacy as an adjuvant for radiotherapy, especially at low doses.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Multidisciplinary
Edwin J. Gonzalez Lopez, Ariel M. Sarotti, Sol R. Martinez, Lorena P. Macor, Javier E. Durantini, Melisa Renfige, Miguel A. Gervaldo, Luis A. Otero, Andres M. Durantini, Edgardo N. Durantini, Daniel A. Heredia
Summary: The novel BOPHY-fullerene C-60 dyad (BP-C-60) serves as a heavy-atom-free photosensitizer with potential applications in medical fields, demonstrating efficient ROS production and acting as an effective photodynamic agent.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Green & Sustainable Science & Technology
Shih-Chen Shi, Shu-Wen Yang, Yu-Chen Xu, Fu- Lu
Summary: Photodynamic inactivation (PDI) utilizes photosensitizing substances and specific wavelengths of light to generate reactive oxygen species, causing oxidative damage in cells. This study employed erythrosine as the photosensitizer and a green light-emitting diode as the light source. Gold nanoparticles were added for their excellent biocompatibility and acted as a carrier for erythrosine, linking it to Escherichia coli (E. coli) cells. The synergic PDI effect of the photosensitizer, light, and gold nanoparticles resulted in a bacterial death rate higher than 97% after 9 minutes of irradiation. Reactive oxygen species tests revealed that the bacterial death was due to the production of singlet oxygen (Type II reaction).
Article
Chemistry, Physical
Nitin Chandra Teja Dadi, Juraj Bujdak, Veronika Medvecka, Helena Palkova, Martin Barlog, Helena Bujdakova
Summary: The study synthesized composites of polyurethane with organoclays, exhibiting antimicrobial properties. The modified layered silicate as filler changed the concentration of particles on the surface of the composite membranes. These composites showed good stability and significant photosensitizing effect in inhibiting biofilm growth and cell growth.
Article
Biochemistry & Molecular Biology
Maximiliano L. Agazzi, Javier E. Durantini, Ezequiel D. Quiroga, M. Gabriela Alvarez, Edgardo N. Durantini
Summary: DMC603+ is an effective amphiphilic photosensitizer with potential broad-spectrum antimicrobial properties, exerting a PDI effect through both photoprocesses and the type II pathway in bacteria and fungi. The presence of potassium iodide enhances the PDI effect by forming reactive iodine species.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Tong-Xin Liu, Panting Yang, Nana Ma, Xiaojun Li, Xin Wang, Jinliang Ma, Guisheng Zhang
Summary: This research presents an unprecedented Pd-catalyzed migration reaction of [60]fullerene with allyloxy-tethered aryl iodides for the synthesis of novel [60]fullerene-fused allylbenzofurans. The use of 1,2-bis(diphenylphosphino)benzene (DPPBz) as a ligand is crucial for the success of the transformation. The reaction exhibits high selectivity and flexibility, allowing allyl migration at different sites and providing a new and efficient approach to rare [60]fullerene-fused benzofurans. Control experiments suggest that the reaction most likely proceeds via a sequential C-O bond cleavage/allyl migration/intermolecular cycloaddition cascade process.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xiaolin Nie, Shuanglin Wu, Tanveer Hussain, Qufu Wei
Summary: The study synthesized PAN-PCN nanofiber membrane with photodynamic effect to eliminate bacteria, providing a potential application prospect in addressing pathogen drug resistance and spreading issues.
Article
Chemistry, Multidisciplinary
Vijay Gulumkar, Ville Tahtinen, Aliaa Ali, Jani Rahkila, Juan Jose Valle-Delgado, Antti Aarela, Monika Osterberg, Marjo Yliperttula, Pasi Virta
Summary: The Bingel cyclopropanation reaction was used to produce a hexakis-functionalized C-60 core, which can be selectively functionalized by two pericyclic click reactions, allowing control over the assembly of heteroantennary bioconjugates with appropriate ligands.
Review
Food Science & Technology
Amirhossein Sheida, Tarannomsadat Taghavi, Rana Shafabakhsh, Amirreza Ostadian, Zahra Razaghi Bahabadi, Mahmood Khaksary Mahabady, Michael R. Hamblin, Hamed Mirzaei
Summary: Concerns about long-term side effects have led to a decline in the use of conventional drugs for cardiovascular disease, with renewed interest in medicinal plant products as potential alternatives. Increased levels of free radicals and oxidative stress contribute to myocardial damage after heart attack, and treatment approaches aim to reduce free radicals and enhance antioxidant defense mechanisms. Bioactive natural products such as curcumin, resveratrol, quercitin, berberine, and tanshinone have been shown to protect the heart muscle in myocardial infarction and have potential molecular mechanisms of action.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Neurosciences
Mahnaz Kahuripour, Zahra Behroozi, Behnaz Rahimi, Michael R. Hamblin, Fatemeh Ramezani
Summary: This study conducted a meta-analysis on the effect of curcumin on functional recovery after SCI and found that daily administration of curcumin can significantly improve recovery and reduce the expression of GFAP marker.
NUTRITIONAL NEUROSCIENCE
(2023)
Review
Dermatology
Jan Kyselovic, Jozef Masarik, Hayet Kechemir, Eva Koscova, Iva Igracki Turudic, Michael Richard Hamblin
Summary: Infrared light therapy has positive effects on relieving musculoskeletal pain through several mechanisms, including increasing nitric oxide availability and reducing inflammation.
PHOTODERMATOLOGY PHOTOIMMUNOLOGY & PHOTOMEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hamed Kowsari, Amirhossein Davoodvandi, Fatemeh Dashti, Seyed Mohamad Ali Mirazimi, Zahra Razaghi Bahabadi, Michael Aschner, Amirhossein Sahebkar, Hamid Reza Gilasi, Michael R. Hamblin, Hamed Mirzaei
Summary: Acute liver injury (ALI) is a critical and fatal disorder associated with excessive alcohol consumption. Despite advances in the early diagnosis and treatment of breast cancer, it remains a leading cause of cancer-related death in women worldwide. Phytochemicals, such as resveratrol, have shown promise in preventing and treating breast cancer. While resveratrol can affect various signaling pathways in vitro, its efficacy in animal models of breast cancer has been disappointing.
CURRENT MOLECULAR PHARMACOLOGY
(2023)
Review
Oncology
Nasim Ebrahimi, Maral Afshinpour, Siavash Seifollahy Fakhr, Paniz Ghasempour Kalkhoran, Vida Shadman-Manesh, Samaneh Adelian, Sheida Beiranvand, Fatemeh Rezaei-Tazangi, Roya Khorram, Michael R. Hamblin, Amir Reza Aref
Summary: Colorectal cancer (CRC) is a major cause of cancer death worldwide. The presence of cancer stem cells (CSCs) contributes to therapy resistance and recurrence. This review examines the role of signaling pathways in colorectal CSCs and discusses potential drugs for treatment of resistant CRC.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ming Zhong, Ghanbar Mahmoodi Chalbatani, Meifang Deng, Qiuyi Li, Elahe Gharagouzloo, Michael R. Hamblin, Eloah Rabello Suarez, Lili Hu, Dingding Wang
Summary: This study investigates the potential of CAR-T cells modified with a chimeric antigen receptor (CAR) targeting the vascular endothelial growth factor 2 receptor/kinase insert domain receptor (KDR) to destroy tumors. The results demonstrate the effectiveness of this CAR construct in inhibiting the growth of lung cancer and suggest its applicability as a new treatment strategy for other vascularized solid tumors.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Mohammad Shahpouri, Mohammad Amin Adili-Aghdam, Hossein Mahmudi, Mehdi Jaymand, Zohreh Amoozgar, Mohsen Akbari, Michael R. Hamblin, Rana Jahanban-Esfahlan
Summary: Hypoxia in solid tumors contributes to drug resistance, metastasis, and cancer relapse, but also provides an opportunity for targeting hypoxic tumor regions. This study discusses various strategies for dealing with hypoxia in deep-seated tumor cells, including their combination with other approaches like photodynamic therapy. The potential and limitations of these approaches, as well as current 3D hypoxia modeling systems, are also examined. Additionally, the potential and current status of preclinical tumor hypoxia approaches in clinical trials for advanced cancer are discussed.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Chemistry, Multidisciplinary
Afshin Taheriazam, Ghazaleh Gholamiyan Yousef Abad, Shima Hajimazdarany, Mohammad Hassan Imani, Setayesh Ziaolhagh, Mohammad Arad Zandieh, Seyedeh Delaram Bayanzadeh, Sepideh Mirzaei, Michael R. Hamblin, Maliheh Entezari, Amir Reza Aref, Ali Zarrabi, Yavuz Nuri Ertas, Jun Ren, Romina Rajabi, Mahshid Deldar Abad Paskeh, Mehrdad Hashemi, Kiavash Hushmandi
Summary: Nanotechnology offers great potential in the field of nanomedicine for the treatment of various diseases, especially cancer. Graphene oxide nanoparticles have emerged as promising carbon-based nanocarriers for drug and gene delivery, photothermal therapy, overcoming chemotherapy resistance, and imaging. This review focuses on the biological functions of graphene oxide nanoparticles as regulators of apoptosis and autophagy, and their potential toxicity in major body organs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Medicine, Research & Experimental
Seyed Mohammad Reza Hashemian, Amirhossein Sheida, Mohammad Taghizadieh, Mohammad Yousef Memar, Michael R. Hamblin, Hossein Bannazadeh Baghi, Javid Sadri Nahand, Zatollah Asemi, Hamed Mirzaei
Summary: Due to the lack of effective therapies for COVID-19, patients have to rely on supportive and nonspecific treatments. Certain proteins of SARS-CoV-2, such as 3 C-like protease (3CLpro) and major protease (Mpro), have been identified as potential targets for antiviral drugs. Nirmatrelvir, combined with ritonavir, has shown potent antiviral activity against SARS-CoV-2 variants, but there are still uncertainties regarding their efficacy, safety, and side effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pathology
Seyed Mojtaba Mousavi, Saereh Hosseindoost, Seyed Mohammad Amin Mahdian, Nasim Vousooghi, Ali Rajabi, Ameneh Jafari, Amirreza Ostadian, Michael R. Hamblin, MahmoudReza Hadjighassem, Hamed Mirzaei
Summary: This study investigated the therapeutic benefits of exosomes generated from U87 cells treated with curcumin and/or temozolomide, which can function as a new type of targeted therapy by increasing cell apoptosis and reducing the side effects of anti-tumor drugs.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Genetics & Heredity
Alireza Farokhian, Ali Rajabi, Amirhossein Sheida, Amirhossein Abdoli, Moein Rafiei, Zahra Hadian Jazi, Sahar Ahmadi Asouri, Mohammad Amin Morshedi, Michael R. Hamblin, Parisa Adib-Hajbagheri, Hamed Mirzaei
Summary: ncRNAs, particularly miRNAs, lncRNAs, and circRNAs, play a significant role in regulating gene expression and affecting multiple cellular processes, especially apoptosis. Apoptosis has recently gained great interest as a therapeutic target to improve myocardial infarction outcomes. This review summarizes studies on ncRNAs that can promote or suppress apoptosis in the context of myocardial infarction, potentially introducing new therapeutic targets for its treatment.
Correction
Nanoscience & Nanotechnology
Navid Rabiee, Mojtaba Bagherzadeh, Amir Mohammad Ghadiri, Yousef Fatahi, Abdullah Aldhaher, Pooyan Makvandi, Rassoul Dinarvand, Maryam Jouyandeh, Mohammad Reza Saeb, Masoud Mozafari, Mohammadreza Shokouhimehr, Michael R. Hamblin, Rajender S. Varma
ACS APPLIED BIO MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Arefeh Ebadati, Mojgan Oshaghi, Sara Saeedi, Parastoo Parsa, Vahid Pirhajati Mahabadi, Morteza Karimi, Atefeh Jahandideh Hajiebrahimdehi, Michael R. Hamblin, Mahdi Karimi
Summary: Multi-drug resistant bacteria pose a significant challenge in the treatment of infectious diseases. Cationic nanopolymers, specifically poly(DABCO-BBAC) nanoparticles, exhibit high efficiency as antimicrobial agents. These nanoparticles effectively inhibit and kill multi-drug resistant Pseudomonas aeruginosa, making them a potential therapeutic option for drug-resistant clinical pathogens.
BIOORGANIC CHEMISTRY
(2023)
Review
Microbiology
Hanane Joudaki, Negar Aria, Roya Moravej, Mohamadreza Rezaei Yazdi, Zarrindokht Emami-Karvani, Michael R. Hamblin
Summary: Microbial phytases are enzymes that can break down phytic acid, providing several benefits in the food industry such as improved nutrient utilization, enhanced mineral bioavailability, and improved taste and functionality of food products. Factors like enzyme production and engineering techniques play a crucial role in effectively using microbial phytases.
CURRENT MICROBIOLOGY
(2023)
Article
Oncology
Przemys law Gnatowski, Edyta Pilat, Justyna Kucinska-Lipka, Mohammad Reza Saeb, Michael R. Hamblin, Masoud Mozafari
Summary: Cancerous tumors are highly fatal, claiming almost 10 million lives in 2020 worldwide. Accurately modeling tumors is a challenging task due to their complex and dynamic nature. Hydrogel-based 3D bioprinting is emerging as a promising approach to overcome the limitations of current models and mimic cancer development and behavior.
TRANSLATIONAL ONCOLOGY
(2023)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)