期刊
FREE RADICAL BIOLOGY AND MEDICINE
卷 86, 期 -, 页码 295-307出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.freeradbiomed.2015.05.013
关键词
Polycystic ovary syndrome; Metabolism; Follicle fluid; Cumulus cells; Pregnant outcome
资金
- National Natural Science Funds [31230047, 31371521, 81170538, 81471427]
- Ministry of Science and Technology of China Grants (973 program) [2014CB943203]
- Beijing Nova Program [xxjh2015011]
- Specialized Research Fund for the Doctoral Program of Higher Education [20120001130008]
Classic polycystic ovary syndrome (PCOS) is a high-risk phenotype accompanied by increased risks of reproductive and metabolic abnormalities; however, the local metabolism characteristics of the ovaries and their effects on germ cell development are unclear. The present study used targeted metabolomics to detect alterations in the intermediate metabolites of follicular fluid from classic PCOS patients, and the results indicated that hyperandrogenism but not obesity induced the changed intermediate metabolites in classic PCOS patients. Regarding the direct contact, we identified mitochondrial function, redox potential, and oxidative stress in cumulus cells which were necessary to support oocyte growth before fertilization, and suggested dysfunction of mitochondria, imbalanced redox potential, and increased oxidative stress in cumulus cells of classic PCOS patients. Follicular fluid intermediary metabolic profiles provide signatures of classic PCOS ovary local metabolism and establish a close link with mitochondria dysfunction of cumulus cells, highlighting the role of metabolic signal and mitochondrial cross talk involved in the pathogenesis of classic PCOS. (C) 2015 Flsevier Inc. All rights reserved.
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