期刊
DRUG DISCOVERY TODAY
卷 23, 期 9, 页码 1635-1643出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2018.04.010
关键词
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资金
- National Institutes of Health Grant [R01CA204552, R01CA210192, R01CA206069]
- UTHSC-College of Pharmacy-Dean's Seed Grant
- UTHSC New Grant Mechanism Award
- UTHSC-CORNET
- UTHSC-Clinical CORNET award
- [K22CA174841]
- [CA213232]
Long noncoding RNAs (lncRNAs) are a class of noncoding RNA, involved in regulation of diverse physiological and pathological processes. Ovarian cancer is the leading cause of death among all gynecological malignancies in the world and its underlying mechanism is still unclear. LncRNAs exhibit multiple biological functions in various stages of ovarian cancer development. We will discuss and summarize the new and important lncRNAs and their involvement in disease, which might represent promising therapeutic targets. Therapeutic intervention based on silencing or functional inhibition of target lncRNAs will be beneficial for ovarian cancer patients.
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