期刊
DRUG DISCOVERY TODAY
卷 23, 期 5, 页码 1062-1070出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.drudis.2018.01.019
关键词
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资金
- European Community through the ERC [307384]
- ERC chair project ERA@UC [669088]
- Compete 2020-Operational Programme for Competitiveness and Internationalisation
- Fundacao para a Ciencia e a Tecnologia (FCT) [POCI-01-0145-FEDER-016390:CANCEL STEM, POCI-01-0145-FEDER-007440]
- FCT [SFRH/BD/81705/2011]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/81705/2011] Funding Source: FCT
- European Research Council (ERC) [307384] Funding Source: European Research Council (ERC)
New therapies based on the use of biomolecules [e.g., proteins, peptides, and non-coding (nc)RNAs] have emerged during the past few years. Given their instability, adverse effects, and limited ability to cross cell membranes, delivery systems are required to fully reveal their biological potential. Sophisticated nanoformulations responsive to light offer an excellent opportunity for the controlled release of these biomolecules, enabling the control of timing, duration, location, and dosage. In this review, we discuss the design principles for the delivery of biomolecules, in particular proteins and RNA-based therapeutics, by light-triggerable formulations. We further discuss the opportunities offered by these formulations in terms of endosomal escape, as well as their limitations.
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