Article
Biochemistry & Molecular Biology
Manuela-Ramona (Blanaru) Ozturk, Marcel Popa, Delia Mihaela Rata, Anca Niculina Cadinoiu, Frederique Parfait, Christelle Delaite, Leonard Ionut Atanase, Carmen Solcan, Oana Maria Daraba
Summary: Glaucoma is the second leading cause of blindness worldwide. This study focuses on the treatment of eye diseases using micellar polymers. The results demonstrate the effectiveness of this method in reducing intraocular pressure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Lei Guo, Jun Tao, Yang Tong, Shichao Chen, Xin Zhao, Rui Hua
Summary: This study investigated the morphological and vascular characteristics of the optic nerve head (ONH) in normal guinea pigs using optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA). The results showed significant differences in refractive error, intraocular pressure (IOP), and circumpapillary retinal nerve fibre layer (cpRNFL) thickness between the 3-week and 4-week groups. There were no significant differences in vascular characteristics between the two groups, but a positive correlation was found between total vessel length and cpRNFL thickness, and a negative correlation was found between total vessel length and IOP.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Yangfan Yang, Xinyi Zhang, Zidong Chen, Yifan Wei, Qiaona Ye, Yanmei Fan, Neil Nathwani, Gus Gazzard, Minbin Yu
Summary: This study aimed to report the baseline characteristics and diurnal fluctuation of intraocular pressure (IOP) in a Chinese cohort of patients with glaucoma and ocular hypertension. The results showed that younger age, male gender, and thicker central corneal thickness were correlated with higher IOP in patients with primary open-angle glaucoma, while only thicker central corneal thickness was related to higher IOP in patients with ocular hypertension. Peak IOP occurred mostly in the early morning or late afternoon, and trough IOP occurred mostly in the early afternoon.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ilka Schmidt, Niklas Plange, Peter Walter, Antonis Koutsonas
Summary: This study investigates the use of implantable telemetric IOP sensors for glaucoma patients. The results show that these sensors demonstrate good long-term safety, tolerability, and functionality, allowing patients to self-measure their IOP.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Hsun- Chiu, Huan- Su, Yu-Chieh Ko, Catherine Jui-Ling Liu
Summary: The study aimed to determine long-term outcomes and risk factors for failure after MMC-augmented IT in Taiwanese patients. The results showed that despite satisfactory long-term success rates, most eyes still required medication for IOP control, and eyes with poor preoperative visual acuity had lower qualified success rates, while patients aged >70 years had higher complete success rates.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Chaoxu Qian, Simon Nusinovici, Sahil Thakur, Zhi Da Soh, Shivani Majithia, Miao Li Chee, Hua Zhong, Yih-Chung Tham, Charumathi Sabanayagam, Pirro G. Hysi, Ching-Yu Cheng
Summary: This study identifies several blood metabolites that are associated with intraocular pressure (IOP). The findings provide insights into the physiological and pathological processes underlying IOP control.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ahmed Alaa Kassem, Abeer Salama, Amira Mohamed Mohsen
Summary: The present study successfully developed dorzolamide HCl loaded cationic nanoemulsions (CNEs) for enhanced ocular delivery. The optimized formulation exhibited sustained drug release and enhanced lowering effect of intraocular pressure in animal experiments. The results indicated the potential of this nanoemulsion for successful ocular delivery with improved therapeutic efficacy and safety.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Ophthalmology
Gabriel A. Villasana, Chris Bradley, Pradeep Ramulu, Mathias Unberath, Jithin Yohannan
Summary: Failing to achieve target intraocular pressure (IOP) was associated with more rapid visual field (VF) worsening in treated patients, especially in those with moderate glaucoma. The impact of missing target IOP on VF worsening was more pronounced compared to the effect of absolute level of IOP on VF worsening.
Review
Biochemistry & Molecular Biology
Anna-Sophie Mursch-Edlmayr, Matthias Bolz, Clemens Strohmaier
Summary: Glaucomatous optic neuropathies have long been considered diseases caused by high intraocular pressure, but recent research has shown that vascular factors also play an important role in glaucoma. Advances in the study of ocular vasculature, ciliary circulation, retinal circulation, etc., may bring new breakthroughs in the treatment of glaucoma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Medicinal
Debora Collotta, Simona Colletta, Virginia Carlucci, Claudia Fruttero, Antonio Maria Fea, Massimo Collino
Summary: Glaucoma is a disease that causes optic nerve damage and visual field loss. Lowering intraocular pressure is the only modifiable factor, and medication, laser treatment, or surgery can manage disease progression. Filtering procedures are used when less invasive methods cannot achieve the target pressure. Accurate control of the fibrotic process during these procedures is crucial for surgical success. This review explores available and potential pharmacological treatments that modulate scarring after glaucoma surgery, highlighting the limitations of current strategies and suggesting the need for multi-target approaches to inhibit excessive scarring.
Article
Ophthalmology
Peizeng Yang, Chaokui Wang, Guannan Su, Su Pan, Yang Qin, Jun Zhang, Qingfeng Cao, Zhenyu Zhong, Chunjiang Zhou, Yao Wang, Aize Kijlstra
Summary: This study examined the prevalence, risk factors, and treatment outcomes of OHT/glaucoma in Chinese patients with VKH. Risk factors included poorer visual acuity, longer intervals between uveitis attacks and referral, more recurrent episodes, and posterior synechiae. Medical treatment and surgical interventions were effective in achieving normalized intraocular pressure in affected eyes.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Poemen PuiMan Chan, Ruyue Shen, Carol Y. Cheung, Anni Ling, Marco Yu, Chi-Pui Pang, Clement C. Tham
Summary: This study compared the rates of peripapillary vessel density (pVD) loss and retinal nerve fibre layer (RNFL) thinning in normal tension glaucoma (NTG) and primary angle closure glaucoma (PACG). The results showed that NTG eyes had more extensive and faster pVD loss compared to PACG eyes, while the rates of RNFL thinning did not differ significantly between the two groups. Baseline global pVD and mean deviation (MD) were independently associated with the rate of pVD loss in NTG.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Sushmita Kaushik, Manni Luthra-Guptasarma, Dimple Prasher, Deepika Dhingra, Nirbhai Singh, Aman Kumar, Surya Prakash Sharma, Harpreet Kaur, Sagarika Snehi, Faisal Thattaruthody, Surinder Singh Pandav
Summary: This study compared CYP1B1 and MYOC gene variants in neonatal-onset and infantile-onset primary congenital glaucoma (PCG). The results showed that patients with CYP1B1 mutations had a more severe disease and worse outcomes. The higher prevalence of CYP1B1 mutations in neonatal-onset PCG could be a contributing factor to the poorer prognosis observed in this group.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Medicine, Research & Experimental
Masaru Inatani, Yusuke Orii, Kentaro Iwasaki, Shogo Arimura, Hiromi Sunagawa, Minako Shiokawa, Kenji Inoue, Takuto Sakono, Takato Sakono, Rika Kuwamura, Akiko Yoshida, Junko Oi, Yasuaki Kuwayama, Kiyoshi Kano, Noriaki Kido, Akiko Matsuyama, Mineo Ozaki, Hideki Abe, Chizuru Inoue, Satoko Nakagawa, Kunihiro Musashi, Akiyasu Kanamori, Jinhee Lee, Shinichiro Otani, Ryota Aoki, Hirotaka Tanabe, Shunsuke Nakakura, Katsuyoshi Suzuki, Takeshi Sagara, Yoshiaki Saito, Motoyasu Sameshima, Mai Urahashi, Fumika Watanabe-Kitamura, Toshihiro Inoue, Fumie Kagaya, Yusuke Murai, Sotaro Mori, Kaori Ueda, Takuji Kurimoto, Yuko Yamada-Nakanishi, Makoto Nakamura, Takehiro Yamashita, Sosuke Ishiyama, Shinichi Manabe, Keiko Takaki, Ken Hayashi, Akiko Ishida, Aika Tsutsui, Kaoru Manabe, Masaki Tanito
Summary: This study compared the efficacy and tolerability of BTFC and DTFC as adjunctive therapies to prostaglandin analogues. The results showed that BTFC was non-inferior to DTFC in reducing intraocular pressure, but had better tolerability. More patients preferred BTFC over DTFC.
ADVANCES IN THERAPY
(2023)
Article
Multidisciplinary Sciences
Ai Kido, Tadamichi Akagi, Hanako Ohashi Ikeda, Takanori Kameda, Kenji Suda, Masahiro Miyake, Tomoko Hasegawa, Shogo Numa, Akitaka Tsujikawa
Summary: Optical coherence tomography angiography (OCTA) is a new technique for non-invasive imaging of blood vessels and can be used to evaluate changes in blood vessels post-trabeculectomy. CAAs were detected in most cases after surgery and their extent decreased over time, but they were not significantly associated with surgical success. Using OCTA for objective evaluation of bleb vascularity may be helpful.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Akram Ahangarpour, Ali Akbar Oroojan, Layasadat Khorsandi, Maryam Kouchak, Mohammad Badavi
Summary: The study demonstrated that Myricitrin and its solid lipid nanoparticles can alleviate oxidative stress, inflammation, and apoptosis induced by hyperglycemia in kidney tubular cells. These findings suggest the potential of Myricitrin and its solid lipid nanoparticles in preventing and treating hyperglycemia-induced damage in proximal tubules.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Ophthalmology
Mohammad Malekahmadi, Sadegh Kazemi, Farideh Sharifipour, Farshad Ostadian, Atefeh Mandian Rad, Mohammad Sadegh Mirdehghan
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
(2020)
Article
Pharmacology & Pharmacy
Golnaz Shams, Amirhossein Nayeri Rad, Mehdi Safdarian, Annahita Rezaie, Neda Bavarsad, Mohammadreza Abbaspour
Summary: This study aimed to design a patient-friendly topical formulation containing tacrolimus for Atopic Dermatitis (AD). Tacrolimus was dispersed through a self-microemulsifying drug delivery system (SMEDDS) incorporated into a polymeric nanofibrous membrane, showing sustained release and promising effects in an AD model induced in mice.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hanieh Abbasi, Nadereh Rahbar, Maryam Kouchak, Parna Khalil Dezfuli, Somayeh Handali
Summary: Targeted liposomes have shown promising results in cancer treatment, with reduced side effects and toxicity compared to traditional methods. This systematic review highlights the development of liposomes targeted with various molecules for improved drug delivery to cancer cells.
JOURNAL OF LIPOSOME RESEARCH
(2022)
Article
Spectroscopy
Maryam Shirani, Heibatullah Kalantari, Mohammad Javad Khodayar, Maryam Kouchak, Nadereh Rahbar
Summary: A novel nanobiosensor was developed using aptamer and gold nanoparticles conjugate in poly vinyl alcohol hydrogel for sensitive detection of digoxin in human plasma samples. The sensor performance was optimized and linear calibration curves were obtained for both external and plasma samples, with detection limits of 2.9 and 3.1 ng L-1, respectively. The nanofluoroprobe showed good reproducibility and was able to detect digoxin in spiked plasma samples without pretreatment.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Pharmacology & Pharmacy
Lena Tamaddon, Negar Mohamadi, Neda Bavarsad
Summary: This study aimed to develop mucoadhesive liposomes for intranasal delivery of loratadine to improve drug bioavailability and efficacy. Liposomes coated with 0.05% chitosan showed optimal particle size, release rate, and enhanced mucoadhesiveness, overcoming limitations of nasal drug delivery.
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Food Science & Technology
A. Fattahian, A. Fazlara, S. Maktabi, M. Pourmahdi, N. Bavarsad
Summary: The study focuses on using chitosan coating and encapsulated cumin essential oil nanocapsules to improve the chemical and microbial properties of veal samples. Modified atmosphere packaging can effectively extend the shelf life of food products.
JOURNAL OF FOOD MEASUREMENT AND CHARACTERIZATION
(2022)
Article
Ophthalmology
Farideh Sharifipour, Mohammad Malekahmadi, Mehdi Azimi, Bahman Cheraghian
Summary: Surgically treated glaucomatous eyes exhibit lower intraocular pressure fluctuations and peak IOP after the water-drinking test compared to medically controlled and normal eyes.
JOURNAL OF CURRENT OPHTHALMOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mona Sharififard, Maryam Kouchak, Ismaeil Alizadeh, Elham Jahanifard
Summary: The study encapsulated Origanum vulgar subsp. viride essential oils in chitosan-carbomer nanoparticles using the ionic gelation method to enhance stability, resulting in regularly shaped, uniform nanoparticles dispersed in the solution. Results confirmed the formation of OEO-CSNPS, suggesting further evaluation of antimicrobial, insecticidal, and insect repelling activities.
JUNDISHAPUR JOURNAL OF NATURAL PHARMACEUTICAL PRODUCTS
(2021)
Article
Nanoscience & Nanotechnology
Neda Bavarsad, Neda Sistani Karampour, Golnaz Hemmati, Anahita Rezaie
Summary: Encapsulation of quercetin in liposomes improved its solubility and stability, leading to enhanced drug release in the skin layers for potential treatment of pressure ulcers.
NANOMEDICINE JOURNAL
(2021)
Article
Dermatology
Neda Bavarsad, Mohammad Ali Mapar, Mona Safaezadeh, Seyed Mahmoud Latifi
Summary: The cream formulation containing tomato lycopene and wheat bran extract was effective in reducing the size and color of melasma after three months of treatment. The intervention group showed significant improvement in skin condition compared to the placebo group, with no recurrence observed one month after the treatment.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Chemistry, Analytical
Maryam Shirani, Heibatullah Kalantari, Mohammad Javad Khodayar, Maryam Kouchak, Nadereh Rahbar
Article
Medicine, Research & Experimental
Akram Ahangarpour, Ali Akbar Oroojan, Layasadat Khorsandi, Maryam Kouchak, Mohammad Badavi
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Neda Bavarsad, Golnaz Hemmati, Shirin Ataee, Neda Sistani Karampour
Article
Pharmacology & Pharmacy
Maryam Kouchak, Saeed Rezaee, Nasrin Moshabeh, Somayeh Handali
JOURNAL OF REPORTS IN PHARMACEUTICAL SCIENCES
(2019)