Article
Engineering, Environmental
Chenyang Ji, Jason T. Magnuson, Wen Zhang, Meirong Zhao
Summary: The study revealed that Cypermethrin enantiomers induce different cytotoxic responses and the enantioselective toxicity may be related to differential expression of cell cycle and apoptosis-related genes.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemistry & Molecular Biology
Amelia M. Silva, Carlos Martins-Gomes, Sandrine S. Ferreira, Eliana B. Souto, Tatiana Andreani
Summary: This study evaluated the cytotoxicity of three pesticides on Caco-2 and HepG2 cells and found that the toxicity of pesticides is related to their molecular physicochemical parameters. Oxidative stress is the main mechanism of toxicity, with IMZ showing higher toxicity. The toxicity profile of pesticides is directly correlated with their Log P-ow.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Pengju Wang, Qing Yao, Dan Zhu, Xiaosong Yang, Qingjie Chen, Qirong Lu, Aimei Liu
Summary: The study explored the role of ferroptosis in DON-induced HepG2 cytotoxicity and the antagonistic effect of resveratrol (Res) on its toxicity. The results showed that DON induced ferroptosis through promoting the accumulation of 4-HNE, lipid ROS, and Fe(II), while pretreatment with Res reversed these changes, attenuated DON-induced ferroptosis, and improved cell viability and cell proliferation.
Article
Environmental Sciences
Xiangrong Chen, Mohamed F. Abdallah, Charlotte Grootaert, Filip Van Nieuwerburgh, Andreja Rajkovic
Summary: This study investigated the combined toxicity of Aflatoxin B1 (AFB1) and fumonisin B1 (FB1) on mitochondrial and glycolytic activity in HepG2 cells. The results showed that the co-exposure, especially at high doses, significantly inhibited mitochondrial respiration. Moreover, RNA transcriptome sequencing revealed differential expression of the p53 signaling pathway and downregulation of genes encoding for Complexes I, II, III, and IV.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Mohamed M. Tawfik, Nourhan Eissa, Fayez Althobaiti, Eman Fayad, Ali H. Abu Almaaty
Summary: The study demonstrated the significant cytotoxic effect of Rhopilema nomadica jellyfish venom on liver cancer cells, inducing apoptosis in hepatocellular carcinoma cells. This is the first scientific evidence of the induction of apoptosis and cell cycle arrest by Rhopilema nomadica jellyfish venom.
Article
Plant Sciences
Moonmun Dhara, Raja Majumder, Lopamudra Adhikari
Summary: The study confirmed the hepatoprotective and antioxidant efficacy of Heliconia rostrata rhizome extracts, with safety established through toxicity studies. The results demonstrated significant hepatoprotective potency of the extracts, indicating their potential therapeutic uses.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Olivier J. M. Bequignon, Jose C. Gomez-Tamayo, Eelke B. Lenselink, Steven Wink, Steven Hiemstra, Chi Chung Lam, Domenico Gadaleta, Alessandra Roncaglioni, Ulf Norinder, Bob van de Water, Manuel Pastor, Gerard J. P. van Westen
Summary: Oxidative stress, caused by an abnormal increase in reactive oxygen species (ROS), can result in oxidative damage when ROS accumulation exceeds the cell's ability to detoxify. This study used a GFP-tagged NRF2-regulated sulfiredoxin reporter to measure the antioxidant response of HepG2 cells to a large series of compounds. SAR models were then established to predict oxidative stress induced by new compounds, which were experimentally tested for validation. This study highlights the challenges in developing SAR models of a phenotypic cellular readout, including model combination, chemical space selection, and results interpretation.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2023)
Article
Pharmacology & Pharmacy
Isis Coalova, March Hugo, Maria del Carmen Rios de Molina, Gabriela Chaufan
Summary: In this study, we evaluated the presence of redox balance alterations in HEp-2 and A549 cell lines exposed to formulations of glyphosate and cypermethrin used separately or in combination. We determined the activity of catalase, superoxide dismutase, glutathione S-transferase, intracellular GSH content, content of oxidized proteins, and intracellular ROS content in both cell lines at two different mixture concentrations. Additionally, we used statistical interaction approaches to determine if the effect of the mixture was additive, synergistic, or antagonistic.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Mohamed A. Ismail, Ghada A. Abdelwahab, Wafaa S. Hamama, Ehab Abdel-Latif, Fardous F. El-Senduny, Wael M. El-Sayed
Summary: Fourteen new thienylnicotinamidines and their analogs were prepared and evaluated for their antiproliferative potential against cancer cell growth. The compounds showed strong antiproliferative efficacy against various cancer cell lines and were found to be safe for normal cells.
ARCHIV DER PHARMAZIE
(2022)
Article
Environmental Sciences
Susu Wang, Yang Zhang, Jufang Gao, Jingdi Zhang, Liming Tao, Wenping Xu
Summary: Acetochlor, a widely used chiral herbicide, can induce toxicity in human liver cells primarily through its S configuration, leading to cell apoptosis. The study provides a theoretical basis for reducing the impact on human health through the production of single pesticides.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Public, Environmental & Occupational Health
Junyu Shen, Lushan Wang, Xuxu Wang, Jiafei Xie, Tingting Yao, Yue Yu, Qi Wang, Zhen Ding, Jinpeng Zhang, Meirong Zhang, Lichun Xu
Summary: This study investigates the effects of cypermethrin on apoptosis in TM4 cells and finds that it regulates TM4 cell apoptosis through the endoplasmic reticulum pathway. The results show that as the concentration of cypermethrin increases, both the apoptosis rate and the protein expressions related to the ER stress pathway increase.
TOXICOLOGY AND INDUSTRIAL HEALTH
(2022)
Article
Engineering, Environmental
Fengbang Wang, Zihan Chen, Yuanyuan Wang, Chunyan Ma, Lei Bi, Maoyong Song, Guibin Jiang
Summary: In this study, the toxic effects of two citrate-coated AgNPs and Ag+ on HepG2 cells were investigated. The results showed that AgNPs and Ag+ induced cell apoptosis through different pathways, and the toxicity of AgNPs was mainly attributed to their specific effects on mitochondria.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Yingying Zhu, Yongan Xu, Yaoyao Dai, Guizhen Zhang, Chenyang Ji, Quan Zhang, Meirong Zhao
Summary: This study aims to investigate the enantioselective toxicity mechanism of the herbicide Glufosinate (Glu) on non-target organisms. Results showed that L-Glu had a selective cytotoxic effect on cell cycle and apoptosis, possibly through gene transcription and signal transduction pathways.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biotechnology & Applied Microbiology
Xiao Wang, Na Xu, Qinglin Li, Shengqi Chen, Hui Cheng, Mo Yang, Ting Jiang, Jun Chu, Xiaojing Ma, Dengke Yin
Summary: Lactonic sophorolipids (LSL) has the potential to inhibit proliferation and induce apoptosis in HepG2 cells, possibly through regulating the expression of genes and proteins associated with apoptosis via the Caspase-3 pathway. These findings suggest that LSL could be a potential drug candidate for liver cancer treatment.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Medicine, Research & Experimental
Steve Harakeh, Rajaa Al-Raddadi, Turki Alamri, Soad Al-Jaouni, Mohammed Qari, Yousef Qari, Ajay Kumar, Hanaa M. Tashkandi, Mohammed Moulay, Alia M. Aldahlawi, Petr Slama, Shafiul Haque
Summary: In this study, the antiproliferative activities of trans-Anethole towards human liver cancer (HepG2), cervical cancer (HeLa) and breast cancer (MCF-7) cells were explored. The results showed that trans-Anethole exhibited strong antiproliferative potential towards HepG2 cells and induced apoptosis by upregulating the protein expressions of p53, Caspase-3, and Caspase-9.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Huma Ali, Yashwant Kumar Yadav, Daoud Ali, Gokhlesh Kumar, Saud Alarifi
Summary: Due to the fast development of microbial resistance to antibiotic drugs, it is crucial to synthesize efficient, secure, and affordable nanoparticles for the treatment of various infections. This study aimed to biosynthesize cobalt nanoparticles using a combined extract from garlic and onion peels. The synthesis of cobalt nanoparticles was confirmed by SEM, FTIR, and XRD. Both the crude extract and biosynthesized cobalt nanoparticles demonstrated efficacy against bacteria, with the latter displaying a higher zone of inhibition than the former.
BIOSCIENCE REPORTS
(2023)
Article
Chemistry, Physical
Sundus Azhar, Khuram Shahzad Ahmad, Isaac Abrahams, Shaan Bibi Jaffri, Tenzin Ingsel, Ram K. Gupta, Daoud Ali
Summary: The study investigates the role of phyto-metabolites of Amaranthus viridis in the development of energy-active nanocomplex. The synthesis of doped nanocomplexes using a green route shows economic viability and ecological friendliness. The biomimetically prepared nanoparticles with different doping concentrations exhibit a bandgap range of 2.5 to 3.2 eV. XRD analysis reveals average crystallite sizes of 13.97, 19.64, 16.11, and 11.16 nm for doping concentrations of 2.5, 5, 7.5, and 10%, respectively. The synthesized doped nanoparticles have a porous sheet-like morphology. The material shows promising potential for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) with overpotential values of 154 mV and 445 mV, respectively. Cyclic voltammetry demonstrates the highest capacitance of 287 F/g at 2 mV/s.
Article
Polymer Science
Alexander Marimuthu, Ramesh Periyannan, Daoud Ali, Vasudeva Reddy Minnam Reddy
Summary: The pure semiconductor SnO2 hollow nanosphere (HNS) with a diameter ranging from 300-500 nm and a wall thickness of 40-50 nm was synthesized using a carbon sphere (CS) template-assisted method. The SnO2 nanoparticle size was found to be 20-30 nm. The dimension of the HNS was controlled by adjusting parameters such as SnCl4 concentration, aging time, temperature, and carbon sphere size. The SnO2 HNS exhibited excellent electrocatalytic activity for the reduction of hydrogen peroxide (H2O2) and ethanol, as well as the oxidation of bioactive molecules.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Chemistry, Physical
Sonaimuthu Mohandoss, Kuppu Sakthi Velu, Thambusamy Stalin, Naushad Ahmad, Suliman Yousef Alomar, Yong Rok Lee
Summary: This study aims to synthesize and characterize the inclusion complex of β-cyclodextrin (B-CD) with tenofovir (TFR) and investigate its interaction with the SARS-CoV-2 (MPro) protein. The prepared B-CD:TFR inclusion complex was characterized using various techniques, confirming its formation. The results showed that the B-CD:TFR inclusion complex has excellent solubility, stability, and antiviral activity, making it a potential carrier for the treatment of viral infections.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Suliman Yousef Alomar
Summary: Multiple spectroscopic and computational methods were used to investigate the binding mechanism of doxofylline with lysozyme. The formation of complex between doxofylline and lysozyme was confirmed by UV-vis spectroscopy and fluorescence quenching. Synchronous spectroscopy showed changes in the microenvironment of lysozyme upon binding. Molecular docking and MD simulations revealed the stability and binding affinity of the lysozyme-doxofylline complex. The MM-PBSA binding energy was calculated to be -30.55 kcal mol(-1).
Article
Neurosciences
Mohd Imran Khan, Park Taehwan, Yunseong Cho, Marcus Scotti, Renata Priscila Barros de Menezes, Fohad Mabood Husain, Suliman Yousef Alomar, Mohammad Hassan Baig, Jae-June Dong
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting a large population worldwide. This study used machine learning modeling to search for potential drug candidates that inhibit acetylcholinesterase, providing a new approach for the treatment of AD.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Genetics & Heredity
Nouf Al-Harbi, Maha-Hamadien Abdulla, Mansoor-Ali Vaali-Mohammed, Thamer Bin Traiki, Mohammed Alswayyed, Omar Al-Obeed, Islem Abid, Suliman Al-Omar, Lamjed Mansour
Summary: This study explored the association between CTLA-4 single nucleotide polymorphisms (SNP) and the risk of colorectal cancer (CRC) in the Saudi population. The results showed a significant correlation between CTLA-4 rs231775 and rs3087243 polymorphisms and CRC risk. Further validation with a larger sample size is necessary.
Article
Crystallography
Muhammad Zubair, Muhammad Shahid Rafique, Afshan Khalid, Tahir Yaqub, Muhammad Furqan Shahid, Suliman Yousef Alomar, Muhammad Ali Shar
Summary: Fructose-stabilized gold, silver, and gold-silver bimetallic colloids were synthesized using the atmospheric pressure microplasma technique. The formation of gold-silver bimetallic alloy particles was confirmed through X-Ray Diffraction patterns, FE-SEM images, and EDS spectra. The size distribution of gold-silver bimetallic colloids was narrow and compatible with the size of influenza viruses, leading to an effective bio-conjunction. The antiviral activity of the bimetallic nanostructures was significantly improved compared to monometallic AuNPs and AgNPs, demonstrating their high antiviral efficacy.
Article
Plant Sciences
Md. Amir Hossain, Umakanta Sarker, Md. Golam Azam, Md. Shahriar Kobir, Rajib Roychowdhury, Sezai Ercisli, Daoud Ali, Shinya Oba, Kirill S. Golokhvast
Summary: This study aimed to identify stable genotypes and superior genotypes of lentils through collaborative use of the AMMI and GGE biplot methods. The results showed that IPCA1 played a significant role in determining days to flowering, days to maturity, plant height, pods per plant, and hundred seed weight. Furthermore, the study found that G2, G7, and G8 were the most stable genotypes with high grain yield. In terms of environmental variation, the lentil yield varied significantly across different conditions, with the highest yield reaching 1658 kg per ha.
Article
Microbiology
Shiva Hadimani, Savitha De Britto, Arakere C. Udayashankar, Nagaraj Geetha, Chandra S. Nayaka, Daoud Ali, Saud Alarifi, Shin-ichi Ito, Sudisha Jogaiah
Summary: This study identified and characterized effector genes in Sclerospora graminicola for the first time, providing insights into how pearl millet responds to effector protein interactions. These results will aid in the use of newer bioinformatics tools to identify functional effector proteins and protect pearl millet against downy mildew stress.
Article
Chemistry, Multidisciplinary
R. Lakshmipathy, V. Andal, B. Vivekanandan, Daoud Ali, Mukesh Goel
Summary: In this study, watermelon rind was protonated to remove alkali and alkaline metal ions and enhance its adsorption capacity for Cd2+ ions. Protonation successfully eliminated K+ and Mg2+ ions from the surface of watermelon rind, as confirmed by FTIR and EDX techniques. Comparative investigations were conducted between native and protonated watermelon rind, and optimal conditions were determined for flow rate, bed depth, and initial concentration. The adsorption capacity of protonated watermelon rind was higher than that of the native rind due to the removal of alkali and alkaline metal ions that blocked the active sites. Mathematical models were used to explain the adsorption process, and regeneration experiments showed that 0.1 M HCl was more effective than 0.1 M acetic acid. These results indicate that protonated watermelon rind is an effective adsorbent for Cd ions.
Article
Environmental Sciences
Usaal Tahir, Mariam Zameer, Qurban Ali, Ayesha Rafique, Syeda Maham Ali, Muhammad Umer Arif, Imtiaz Nawaz, Saif ul Malook, Daoud Ali
Summary: The study aimed to examine the toxic effects of lead on animals and identified lead-resistant bacterial strains with high biodegradation potential. The results showed severe health issues caused by lead exposure in mice, but the lead-resistant bacterial strains could survive in a lead-contaminated environment and effectively degrade lead. This biological strategy provides an ideal alternative for remediating heavy metal contamination and cleaning up the environment.
ENVIRONMENTAL MONITORING AND ASSESSMENT
(2023)
Article
Biology
Laraib Mumtaz, Arshad Farid, Suliman Yousef Alomar, Naushad Ahmad, Asif Nawaz, Saadia Andleeb, Adnan Amin
Summary: This study investigated the efficacy of plant polyphenols against antimicrobial-resistant Acinetobacter baumanii. The results showed that these polyphenols exhibited antimicrobial and antibiofilm activities, suggesting their potential use in the treatment of multidrug-resistant A. baumannii infections.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Environmental Sciences
Saif Ali Ali Sultan, Fawad Ahmed Khan, Abdul Wahab, Batool Fatima, Hira Khalid, Ali Bahader, Sher Zaman Safi, Chandrabose Selvaraj, Abid Ali, Suliman Yousef Alomar, Muhammad Imran
Summary: The use of inexpensive aluminum cookware without knowledge of its potential health risks is a growing concern. Leaching of toxic metals into food from cookware poses a serious health risk to individuals.
Article
Horticulture
Dharmendra Prajapati, Anil Patani, Margi Patel, Daoud Ali, Saud Alarifi, Virendra Kumar Yadav, Jigna Tank, Ashish Patel
Summary: This study investigated the effects of atmospheric hydrogen sulfide deposition on soil sulfur nutrition in Brassica pekinensis plants. The research revealed the regulatory mechanisms involved in sulfate uptake and assimilation by studying gene expression levels of sulfate transporter genes and physiological changes. It was found that sulfur deficiency increased nitrate and amino acid concentrations in the plant, while decreasing biomass, chlorophyll content, and thiol content. However, this also increased the plants' capacity to take up sulfur from the atmosphere through foliar absorption. The expression levels of sulfate transporter genes were influenced by sulfur availability in the atmosphere, but not by excess sulfur levels up to 0.3μL l(-1).