Article
Biochemistry & Molecular Biology
Andrila E. Collins, Tarek M. Saleh, Bettina E. Kalisch
Summary: This study aimed to assess the cytoprotective effects of the novel antioxidant compound VANL-100 in a cellular model of beta-amyloid (A beta)-induced toxicity. The results demonstrate that VANL-100 significantly attenuated A beta-induced cell death, indicating its cytoprotective effects against A beta-induced toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Keren Zohar, Elyad Lezmi, Tsiona Eliyahu, Michal Linial
Summary: The compound ladostigil has been shown to alleviate cell damage induced by oxidation, inhibit microglial activation, and improve learning deficits under conditions of chronic oxidative stress in the aging brain.
Article
Oncology
Qiang Sun, Yueliang Zhang, Songlin Wang, Fang Yang, Hongxia Cai, Yu Xing, Liping Zhou, Sen Chen, Yunfu Wang
Summary: The study aimed to investigate the role of long non-coding RNA HOTAIR in Parkinson's disease (PD) and its underlying mechanism. The results showed that HOTAIR attenuated MPP+-induced SH-SY5Y cell injury via the miR-221-3p/alpha-synuclein axis.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Hironori Mizutani, Yoshifumi Sato, Masaya Yamazaki, Tatsuya Yoshizawa, Yukio Ando, Mitsuharu Ueda, Kazuya Yamagata
Summary: This study found that the expression of SIRT7 is increased in the brain of Alzheimer's disease patients. Treatment with A beta(42) increased the expression of NOX4, leading to the production of reactive oxygen species (ROS) and apoptosis. Knockdown of SIRT7 inhibited A beta(42)-induced ROS production and apoptosis by suppressing the upregulation of NOX4. These findings suggest that inhibiting SIRT7 may be beneficial in the pathogenesis of AD by regulating ROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yujian Lin, Lei Zhang, Mengyue Gao, Zixin Tang, Xiang Cheng, Haoming Li, Jianbing Qin, Meiling Tian, Guohua Jin, Xinhua Zhang, Wen Li
Summary: This study found that miR-6076 attenuates A beta(1-42)-induced neuronal damage by targeting BCL6, providing a potential target for prevention and treatment of Alzheimer's disease.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biology
Jason C. Sang, Eric Hidari, Georg Meisl, Rohan T. Ranasinghe, Maria Grazia Spillantini, David Klenerman
Summary: Researchers found that cells respond to disruption of protein homeostasis by alpha-synuclein seeds primarily by secreting nanoscopic aggregates. This mechanism may represent an important protective response by cells to protein aggregation.
COMMUNICATIONS BIOLOGY
(2021)
Article
Neurosciences
Wen-ying Liu, Yan Li, Yan Li, Ling-zhi Xu, Jian-ping Jia
Summary: Neuronal death and synaptic loss are major pathological features of Alzheimer's disease (AD), which is caused by the neurotoxin amyloid beta oligomers (AβOs). Carnosic acid (CA) extracted from Salvia rosmarinus has been shown to have neuroprotective effects in AD. This study investigated the mechanisms by which CA promotes synaptic protection in an in vitro AD model. The results showed that CA improved neuronal survival by suppressing apoptosis and restored synaptic impairments by increasing the expression of BDNF, PSD-95, and Syn. These effects were dependent on the inhibition of NMDAR2B phosphorylation and activation of the ERK-CREB pathway.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yanjun Zhou, Nanqu Huang, Yuanyuan Li, Zhisheng Ba, Yong Luo
Summary: This study investigated the protective effect of icaritin (ICT) in SH-SY5Y cells infected with TAR DNA-binding domain protein 43 (TDP-43) and its underlying mechanism by examining the expression of autophagy-related proteins. The results showed that ICT intervention increased cell viability, decreased TDP-43 expression, and reduced the expression of cleaved Caspase-3, Beclin-1, and LC3-II/I, while increasing the expression of p62. This suggests that ICT has a protective effect on TDP-43-induced neuronal cell injury by reducing TDP-43 protein expression and inhibiting autophagy.
Article
Neurosciences
Ran Gu, Rui Liu, Lu Wang, Man Tang, Shi-Rong Li, Xiao Hu
Summary: The study demonstrated that lncRNA RPPH1 can attenuate A beta(25-35)-induced ERS and apoptosis in SH-SY5Y cells by regulating the miR-326/PKM2 axis, improving cell viability. This provides therapeutic options for AD patients.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Thomas S. Webberley, Ryan J. Bevan, Joshua Kerry-Smith, Jordanna Dally, Daryn R. Michael, Sophie Thomas, Meg Rees, James E. Morgan, Julian R. Marchesi, Mark A. Good, Sue F. Plummer, Duolao Wang, Timothy R. Hughes
Summary: This study assessed the neuroprotective potential of the Lab4P probiotic consortium in aging and metabolic syndrome-associated neurodegenerative pathologies. The results showed that supplementation with probiotics prevented cognitive decline, hippocampal neuron deterioration, and inflammation in mice. In human cell culture models, probiotic metabolites demonstrated a neuroprotective capability against beta-amyloid challenge. Overall, these findings suggest that Lab4P has the potential to be a neuroprotective agent and support further research in other neurodegenerative conditions in animal models and human studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Ping Wang, Peipei Wang, Hengfei Luan, Yong Wu, Ying Chen
Summary: The study suggests that Midazolam has potential therapeutic effects in Alzheimer's disease (AD) by reducing oligomerized amyloid beta (A beta)-associated neuronal senescence and restoring telomerase activity and gene expressions associated with cellular senescence.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Chao-Hsuan Chen, Pei-Chen Hsu, Shih-Wei Hsu, Kun-Ting Hong, Kai-Yuan Chen, Jie-Long He, Der-Yang Cho, Yun-Chi Wang, Wen-Shin Chang, Da-Tian Bau, Chia-Wen Tsai
Summary: Jujuboside A and B can protect neurons from 6-OHDA-induced toxicity by rebalancing the redox system and resetting the PI3K/AKT apoptotic signaling cascade.
Article
Biochemical Research Methods
Rocio Gallego, Alberto Valdes, Jose David Sanchez-Martinez, Zully J. Suarez-Montenegro, Elena Ibanez, Alejandro Cifuentes, Miguel Herrero
Summary: This study investigated the potential neuroprotective effect of a carotenoid-enriched extract from Dunaliella salina microalgae on AD, as well as its impact on cellular metabolism using metabolomics. The findings suggest that the extract may exert neuroprotective effects by modulating lipid metabolism in cells. Further in vivo experiments are needed to confirm these results.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Yuchen Sun, Joseph Bressler
Summary: Ethyl Maltol (EM) is a commonly used flavoring compound that can bind iron and facilitate iron transport. This study found that EM disrupts intracellular iron homeostasis by increasing the labile iron pool and iron-responsive protein activity. EM also affects the expression of iron-responsive genes and leads to decreased cell viability and increased DNA damage through the p53 pathway. The effects of EM on iron homeostasis are attenuated by the expression of amyloid precursor protein (APP).
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Nutrition & Dietetics
Aitor Blanco-Miguez, Hector Tames, Patricia Ruas-Madiedo, Borja Sanchez
Summary: This study presents evidence of A beta-like peptides released from the gut microbiome, with one peptide inducing pathways related to Alzheimer's disease in neuron cell-line model. It opens new approaches for understanding the relationship between gut microbiota and AD, suggesting potential implications for targeted microbiota modification in animal models to study the role of gut bacteria in this progressive disease.
